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Cardiac interstitial tetraploid cells that escape replicative senescence are found in rodents but not large mammals

https://doi.org/10.1101/521716
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2 of the 96 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.yexmp.2016.09.002 (notice 2022-06-01), 10.1161/circresaha.110.223024 (notice 2018-12-12).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver
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The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice
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Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit+ Cardiac Progenitor Cells
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Rapid Transition of Cardiac Myocytes from Hyperplasia to Hypertrophy During Postnatal Development
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Nuclear DNA Content of Human Myocardial Cells
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Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts
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Active Wnt signaling in response to cardiac injury
inferredcites →https://doi.org/10.1007/s00395-011-0178-8openalex-snapshot
Oxidative stress-induced formation of a positive-feedback loop for the sustained activation of p38 MAPK leading to the loss of cell division in cardiomyocytes soon after birth
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DNA synthesis in the non-infarcted cardiac interstitium after left coronary artery ligation in the rat: Effects of captopril
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Polyploidy and nuclear phenotype characteristics of cardiomyocytes from diabetic adult and normoglycemic aged mice
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Polyploidization in Liver Tissue
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Fibroblasts in post-infarction inflammation and cardiac repair
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Limiting the Proliferation of Polyploid Cells
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
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On the Dependency of Cellular Protein Levels on mRNA Abundance
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Cell reproduction and genome multiplication in the proliferative and invasive trophoblast cell populations of mammalian placenta
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Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart
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Genomic Clues to the Evolutionary Success of Polyploid Plants
inferredcites →https://doi.org/10.1016/j.devcel.2014.06.013openalex-snapshot
TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition
inferredcites →https://doi.org/10.1016/j.devcel.2018.01.010openalex-snapshot
The Polyploid State Plays a Tumor-Suppressive Role in the Liver
inferredcites →https://doi.org/10.1016/j.devcel.2018.01.021openalex-snapshot
Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish
inferredcites →https://doi.org/10.1016/j.devcel.2018.10.020openalex-snapshot
The Polyploid State Plays a Tumor-Suppressive Role in the Liver
inferredcites →https://doi.org/10.1016/j.exger.2010.01.018openalex-snapshot
Quantitative assessment of markers for cell senescence
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Neonatal cardiomyocyte ploidy reveals critical windows of heart development
inferredcites →https://doi.org/10.1016/j.jacc.2012.04.047openalex-snapshot
Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair
inferredcites →https://doi.org/10.1016/j.jacc.2014.09.086openalex-snapshot
Nucleostemin Rejuvenates Cardiac Progenitor Cells and Antagonizes Myocardial Aging
inferredcites →https://doi.org/10.1016/j.jacc.2016.09.925openalex-snapshot
Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine
inferredcites →https://doi.org/10.1016/j.neo.2015.11.008openalex-snapshot
Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
inferredcites →https://doi.org/10.1016/j.semcdb.2013.01.003openalex-snapshot
Aneuploidy, polyploidy and ploidy reversal in the liver
inferredcites →https://doi.org/10.1016/j.stem.2017.02.012openalex-snapshot
Amitosis of Polyploid Cells Regenerates Functional Stem Cells in the Drosophila Intestine
inferredcites →https://doi.org/10.1016/j.tcb.2013.06.002openalex-snapshot
Physiological significance of polyploidization in mammalian cells
inferredcites →https://doi.org/10.1016/j.tig.2015.03.011openalex-snapshot
When bigger is better: the role of polyploidy in organogenesis
inferredcites →https://doi.org/10.1016/j.tips.2017.03.001openalex-snapshot
Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps
inferredcites →https://doi.org/10.1016/j.yexcr.2009.08.004openalex-snapshot
p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells
inferredcites →https://doi.org/10.1016/j.yexcr.2010.08.017openalex-snapshot
Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover
inferredcites →https://doi.org/10.1016/j.yexmp.2016.09.002openalex-snapshot
RETRACTED: The role of cardiac fibroblasts in post-myocardial heart tissue repair
inferredcites →https://doi.org/10.1016/j.ygeno.2006.08.014openalex-snapshot
Genome multiplication as adaptation to tissue survival: Evidence from gene expression in mammalian heart and liver
inferredcites →https://doi.org/10.1016/j.yjmcc.2013.11.015openalex-snapshot
Fibroblasts in myocardial infarction: A role in inflammation and repair
inferredcites →https://doi.org/10.1016/j.yjmcc.2018.12.007openalex-snapshot
Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI)
inferredcites →https://doi.org/10.1016/s0008-6363(97)00140-5openalex-snapshot
DNA content, ploidy level and number of nuclei in the human heart after myocardial infarction
inferredcites →https://doi.org/10.1038/261614a0openalex-snapshot
DNA endoreduplication and polyteny understood as evolutionary strategies
inferredcites →https://doi.org/10.1038/387299a0openalex-snapshot
Regulation of p53 stability by Mdm2
inferredcites →https://doi.org/10.1038/cddis.2016.205openalex-snapshot
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury
inferredcites →https://doi.org/10.1038/emboj.2010.11openalex-snapshot
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
inferredcites →https://doi.org/10.1038/hdy.2012.79openalex-snapshot
Polyploidy and its effect on evolutionary success: old questions revisited with new tools
inferredcites →https://doi.org/10.1038/nature09414openalex-snapshot
The ploidy conveyor of mature hepatocytes as a source of genetic variation
inferredcites →https://doi.org/10.1038/nature13309openalex-snapshot
c-kit+ cells minimally contribute cardiomyocytes to the heart
inferredcites →https://doi.org/10.1038/ncomms1825openalex-snapshot
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
inferredcites →https://doi.org/10.1038/ng.3929openalex-snapshot
Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration
inferredcites →https://doi.org/10.1038/nprot.2015.016openalex-snapshot
Cell cycle staging of individual cells by fluorescence microscopy
inferredcites →https://doi.org/10.1038/nrc3139openalex-snapshot
TRIM proteins and cancer
inferredcites →https://doi.org/10.1038/nrg1711openalex-snapshot
The advantages and disadvantages of being polyploid
inferredcites →https://doi.org/10.1038/nri2413openalex-snapshot
TRIM family proteins and their emerging roles in innate immunity
inferredcites →https://doi.org/10.1038/nrmicro1248openalex-snapshot
TRIM family proteins: retroviral restriction and antiviral defence
inferredcites →https://doi.org/10.1038/s41467-017-02762-zopenalex-snapshot
Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
inferredcites →https://doi.org/10.1038/s41598-018-30551-1openalex-snapshot
In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells
inferredcites →https://doi.org/10.1038/sj.emboj.7600791openalex-snapshot
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
inferredcites →https://doi.org/10.1038/srep08907openalex-snapshot
p53 Suppresses Tetraploid Development in Mice
inferredcites →https://doi.org/10.1038/srep23756openalex-snapshot
Three-dimensional direct measurement of cardiomyocyte volume, nuclearity, and ploidy in thick histological sections
inferredcites →https://doi.org/10.1073/pnas.1214608110openalex-snapshot
Cardiomyocyte proliferation contributes to heart growth in young humans
inferredcites →https://doi.org/10.1074/jbc.m308406200openalex-snapshot
Vascular Smooth Muscle Polyploidization as a Biomarker for Aging and Its Impact on Differential Gene Expression
inferredcites →https://doi.org/10.1080/23723556.2015.1088503openalex-snapshot
Different cell fates after mitotic slippage: From aneuploidy to polyploidy
inferredcites →https://doi.org/10.1083/jcb.66.1.188openalex-snapshot
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.
inferredcites →https://doi.org/10.1089/omi.2011.0118openalex-snapshot
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
inferredcites →https://doi.org/10.1089/wound.2014.0545openalex-snapshot
Wound-Induced Polyploidy Is Required for Tissue Repair
inferredcites →https://doi.org/10.1091/mbc.e14-03-0844openalex-snapshot
Failure of cell cleavage induces senescence in tetraploid primary cells
inferredcites →https://doi.org/10.1091/mbc.e14-09-1375openalex-snapshot
Ploidy variation in multinucleate cells changes under stress
inferredcites →https://doi.org/10.1093/cvr/cvq005openalex-snapshot
Cardiomyocyte cell cycle control and growth estimation in vivo—an analysis based on cardiomyocyte nuclei
inferredcites →https://doi.org/10.1093/femsyr/fow020openalex-snapshot
Ploidy plasticity: a rapid and reversible strategy for adaptation to stress
inferredcites →https://doi.org/10.1101/cshperspect.a028373openalex-snapshot
The Role of Aneuploidy in Cancer Evolution
inferredcites →https://doi.org/10.1101/gad.1829209openalex-snapshot
Endoreplication: polyploidy with purpose
inferredcites →https://doi.org/10.1111/exd.12305openalex-snapshot
The functional relevance of polyploidization in the skin
inferredcites →https://doi.org/10.1111/j.1365-2184.1986.tb00679.xopenalex-snapshot
Proliferation of Cardiomyocytes and Interstitial Cells In the Cardiac Muscle of the Mouse During Pre‐ and Postnatal Development
inferredcites →https://doi.org/10.1111/j.1469-8137.2009.02997.xopenalex-snapshot
Genome duplication and the evolution of physiological responses to water stress
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00274.xopenalex-snapshot
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence
inferredcites →https://doi.org/10.1126/science.264.5157.421openalex-snapshot
Stomatal Size in Fossil Plants: Evidence for Polyploidy in Majority of Angiosperms
inferredcites →https://doi.org/10.1126/science.282.5394.1711openalex-snapshot
Zebrafish hox Clusters and Vertebrate Genome Evolution
inferredcites →https://doi.org/10.1136/jcp.47.1.38openalex-snapshot
Polyploidy in non-neoplastic tissues.
inferredcites →https://doi.org/10.1146/annurev.genet.34.1.401openalex-snapshot
POLYPLOID INCIDENCE AND EVOLUTION
inferredcites →https://doi.org/10.1161/circresaha.110.223024openalex-snapshot
Cardiomyogenesis in the Adult Human Heart
inferredcites →https://doi.org/10.1161/circresaha.112.265207openalex-snapshot
Preservation of Myocardial Structure Is Enhanced by Pim-1 Engineering of Bone Marrow Cells
inferredcites →https://doi.org/10.1161/circresaha.113.301152openalex-snapshot
Fibronectin Is Essential for Reparative Cardiac Progenitor Cell Response After Myocardial Infarction
inferredcites →https://doi.org/10.1161/circresaha.113.302302openalex-snapshot
Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase
inferredcites →https://doi.org/10.1161/circresaha.115.306838openalex-snapshot
Cardiac Stem Cell Hybrids Enhance Myocardial Repair
inferredcites →https://doi.org/10.1161/circresaha.116.310494openalex-snapshot
Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy
inferredcites →https://doi.org/10.1172/jci64026openalex-snapshot
Aneuploidy as a mechanism for stress-induced liver adaptation
inferredcites →https://doi.org/10.1177/002215549704500107openalex-snapshot
DNA Staining for Fluorescence and Laser Confocal Microscopy
inferredcites →https://doi.org/10.1182/blood-2002-05-1553openalex-snapshot
Megakaryocyte polyploidization is associated with a functional gene amplification
inferredcites →https://doi.org/10.1182/blood-2006-10-054247openalex-snapshot
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability
inferredcites →https://doi.org/10.1186/scrt529openalex-snapshot
Relative genomic stability of adipose tissue derived mesenchymal stem cells: analysis of ploidy, H19 long non-coding RNA and p53 activity
inferredcites →https://doi.org/10.1242/dev.156034openalex-snapshot
Polyploidy in tissue homeostasis and regeneration
inferredcites →https://doi.org/10.1253/circj.cj-16-1228openalex-snapshot
Myocardial Regeneration for Humans ― Modifying Biology and Manipulating Evolution ―
inferredcites →https://doi.org/10.1634/stemcells.2007-0751openalex-snapshot
Evolution of the c-kit-Positive Cell Response to Pathological Challenge in the Myocardium
inferredcites →https://doi.org/10.2174/1389450116666150825113500openalex-snapshot
Is Senescence Reversible?
inferredcites →https://doi.org/10.21775/cimb.003.067openalex-snapshot
DNA Measurement and Cell Cycle Analysis by Flow Cytometry
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Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover
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