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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression
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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits
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Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage
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Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms
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DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence
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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
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RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
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Wiring the Human Brain: A User’s Handbook
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Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC
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Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment
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Making Dopamine Connections in Adolescence
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Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
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Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies
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Meta-analysis of genome-wide association studies of anxiety disorders
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Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
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Biological insights from 108 schizophrenia-associated genetic loci
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Chromosome conformation elucidates regulatory relationships in developing human brain
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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
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Zhou et al. reply
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
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A general framework for estimating the relative pathogenicity of human genetic variants
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Defining the role of common variation in the genomic and biological architecture of adult human height
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High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
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A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
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An atlas of genetic correlations across human diseases and traits
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
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Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
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Genome-wide analysis identifies 12 loci influencing human reproductive behavior
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Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance
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Biallelic mutations in human DCC cause developmental split-brain syndrome
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Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity
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Pleiotropy in complex traits: challenges and strategies
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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
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Psychiatric genetics and the structure of psychopathology
inferredcites →https://doi.org/10.1038/s41380-018-0017-5openalex-snapshot
Depression and obesity: evidence of shared biological mechanisms
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Functional mapping and annotation of genetic associations with FUMA
inferredcites →https://doi.org/10.1038/s41588-017-0009-4openalex-snapshot
Multi-trait analysis of genome-wide association summary statistics using MTAG
inferredcites →https://doi.org/10.1038/s41588-018-0090-3openalex-snapshot
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
inferredcites →https://doi.org/10.1038/s41588-018-0269-7openalex-snapshot
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
inferredcites →https://doi.org/10.1038/s41588-019-0397-8openalex-snapshot
Genome-wide association study identifies 30 loci associated with bipolar disorder
inferredcites →https://doi.org/10.1038/s41593-018-0320-0openalex-snapshot
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
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Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development
inferredcites →https://doi.org/10.1038/srep32730openalex-snapshot
Body mass index and psychiatric disorders: a Mendelian randomization study
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A survey of human brain transcriptome diversity at the single cell level
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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
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FINEMAP: efficient variable selection using summary data from genome-wide association studies
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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
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Autoimmune diseases: insights from genome-wide association studies
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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
inferredcites →https://doi.org/10.1093/nar/gky399openalex-snapshot
SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine
inferredcites →https://doi.org/10.1101/224774openalex-snapshot
Common risk variants identified in autism spectrum disorder
inferredcites →https://doi.org/10.1101/305029openalex-snapshot
Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
inferredcites →https://doi.org/10.1101/gad.1864410openalex-snapshot
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
inferredcites →https://doi.org/10.1101/gr.097857.109openalex-snapshot
Detection of nonneutral substitution rates on mammalian phylogenies
inferredcites →https://doi.org/10.1101/gr.137323.112openalex-snapshot
Annotation of functional variation in personal genomes using RegulomeDB
inferredcites →https://doi.org/10.1101/gr.3715005openalex-snapshot
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
inferredcites →https://doi.org/10.1126/science.aap8757openalex-snapshot
Analysis of shared heritability in common disorders of the brain
inferredcites →https://doi.org/10.1126/science.aat8464openalex-snapshot
Comprehensive functional genomic resource and integrative model for the human brain
inferredcites →https://doi.org/10.1146/annurev.publhealth.29.020907.090847openalex-snapshot
The Descriptive Epidemiology of Commonly Occurring Mental Disorders in the United States
inferredcites →https://doi.org/10.1159/000350502openalex-snapshot
Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation
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Nox4 Is a Major Source of Superoxide Production in Human Brain Pericytes
inferredcites →https://doi.org/10.1176/appi.ajp.2017.16121402openalex-snapshot
Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa
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Psychiatric Genomics: An Update and an Agenda
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The p Factor
inferredcites →https://doi.org/10.1186/s13229-015-0049-5openalex-snapshot
Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex
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Low-frequency and common genetic variation in ischemic stroke
inferredcites →https://doi.org/10.1371/journal.pcbi.1001025openalex-snapshot
Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
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MAGMA: Generalized Gene-Set Analysis of GWAS Data
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Interpreting Meta-Analyses of Genome-Wide Association Studies
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Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency
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Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
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Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies
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Mesocorticolimbic Connectivity and Volumetric Alterations inDCCMutation Carriers
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Genotype Imputation with Thousands of Genomes

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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