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Summary statistic analyses do not correct confounding bias
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/gepi.22161openalex-snapshot
The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome‐wide association studies
inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot
GCTA: A Tool for Genome-wide Complex Trait Analysis
inferredcites →https://doi.org/10.1016/j.ajhg.2012.10.010openalex-snapshot
Improved Heritability Estimation from Genome-wide SNPs
inferredcites →https://doi.org/10.1016/j.ajhg.2016.05.013openalex-snapshot
Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data
inferredcites →https://doi.org/10.1016/j.ajhg.2018.06.002openalex-snapshot
Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics
inferredcites →https://doi.org/10.1038/ejhg.2011.39openalex-snapshot
Genomic inflation factors under polygenic inheritance
inferredcites →https://doi.org/10.1038/nature09410openalex-snapshot
Hundreds of variants clustered in genomic loci and biological pathways affect human height
inferredcites →https://doi.org/10.1038/nature10405openalex-snapshot
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
inferredcites →https://doi.org/10.1038/ng.3190openalex-snapshot
Efficient Bayesian mixed-model analysis increases association power in large cohorts
inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1038/ng.3552openalex-snapshot
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
inferredcites →https://doi.org/10.1038/ng.3698openalex-snapshot
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
inferredcites →https://doi.org/10.1038/ng.3865openalex-snapshot
Reevaluation of SNP heritability in complex human traits
inferredcites →https://doi.org/10.1038/ng.3954openalex-snapshot
Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
inferredcites →https://doi.org/10.1038/nmeth.1681openalex-snapshot
FaST linear mixed models for genome-wide association studies
inferredcites →https://doi.org/10.1038/s41588-018-0279-5openalex-snapshot
SumHer better estimates the SNP heritability of complex traits from summary statistics
inferredcites →https://doi.org/10.1073/pnas.1510497113openalex-snapshot
Linear mixed model for heritability estimation that explicitly addresses environmental variation
inferredcites →https://doi.org/10.1079/9781780643915.0000openalex-snapshot
Linear models for the prediction of animal breeding values
inferredcites →https://doi.org/10.1093/bioinformatics/btq340openalex-snapshot
METAL: fast and efficient meta-analysis of genomewide association scans
inferredcites →https://doi.org/10.1093/bioinformatics/btw613openalex-snapshot
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
inferredcites →https://doi.org/10.1101/211821openalex-snapshot
Equivalence of LD-Score Regression and Individual-Level-Data Methods
inferredcites →https://doi.org/10.1111/jeb.13232openalex-snapshot
Fixed-effect variance and the estimation of repeatabilities and heritabilities: issues and solutions
inferredcites →https://doi.org/10.1214/12-aoas586openalex-snapshot
Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies
inferredcites →https://doi.org/10.1214/17-aoas1046openalex-snapshot
Bayesian large-scale multiple regression with summary statistics from genome-wide association studies
inferredcites →https://doi.org/10.2307/1907330openalex-snapshot
Partial Time Regressions as Compared with Individual Trends
inferredcites →https://doi.org/10.2337/db16-1253openalex-snapshot
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
inferredcites →https://doi.org/10.3389/fgene.2014.00001openalex-snapshot
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
inferredcites →https://doi.org/10.7554/elife.39725openalex-snapshot
Reduced signal for polygenic adaptation of height in UK Biobank
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1038/s41467-021-24485-yopenalex-snapshot
Improved genetic prediction of complex traits from individual-level data or summary statistics
inferred← citeshttps://doi.org/10.1038/s41576-019-0137-zopenalex-snapshot
Genetic correlations of polygenic disease traits: from theory to practice
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