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Systematic mapping of drug metabolism by the human gut microbiome
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s10434-000-0674-9openalex-snapshot
A Prospective Randomized Trial Comparing Intravenous 5- Fluorouracil and Oral Doxifluridine As Postoperative Adjuvant Treatment for Advanced Rectal Cancer
inferredcites →https://doi.org/10.1007/s10637-016-0409-9openalex-snapshot
A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone
inferredcites →https://doi.org/10.1016/0163-7258(90)90036-2openalex-snapshot
Mebolism of drugs and other xenobiotics in the gut lumen and wall
inferredcites →https://doi.org/10.1016/j.biocel.2006.10.009openalex-snapshot
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines
inferredcites →https://doi.org/10.1016/j.ctrv.2015.06.001openalex-snapshot
TAS-102, a novel antitumor agent: A review of the mechanism of action
inferredcites →https://doi.org/10.1016/s0016-5085(79)80079-7openalex-snapshot
Transformation of Chenodeoxycholic Acid and Ursodeoxycholic Acid by Human Intestinal Bacteria
inferredcites →https://doi.org/10.1016/s0022-3565(25)29238-2openalex-snapshot
THE ROLE OF INTESTINAL BACTERIA IN THE METABOLISM OF SALICYLAZOSULFAPYRIDINE
inferredcites →https://doi.org/10.1016/s0031-6997(25)06622-0openalex-snapshot
Metabolism of Foreign Compounds by Gastrointestinal Microorganisms
inferredcites →https://doi.org/10.1016/s0090-9556(25)08211-xopenalex-snapshot
Absorption, metabolism, and excretion of risperidone in humans.
inferredcites →https://doi.org/10.1016/s0090-9556(25)08286-8openalex-snapshot
The metabolism and excretion of risperidone after oral administration in rats and dogs.
inferredcites →https://doi.org/10.1038/clpt.2013.157openalex-snapshot
Cometabolism of Microbes and Host: Implications for Drug Metabolism and Drug-Induced Toxicity
inferredcites →https://doi.org/10.1038/ismej.2011.139openalex-snapshot
An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea
inferredcites →https://doi.org/10.1038/ismej.2012.8openalex-snapshot
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
inferredcites →https://doi.org/10.1038/msb4100050openalex-snapshot
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
inferredcites →https://doi.org/10.1038/nature08821openalex-snapshot
A human gut microbial gene catalogue established by metagenomic sequencing
inferredcites →https://doi.org/10.1038/nature17940openalex-snapshot
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
inferredcites →https://doi.org/10.1038/nature23889openalex-snapshot
Strains, functions and dynamics in the expanded Human Microbiome Project
inferredcites →https://doi.org/10.1038/nature25979openalex-snapshot
Extensive impact of non-antibiotic drugs on human gut bacteria
inferredcites →https://doi.org/10.1038/ncomms5714openalex-snapshot
Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria
inferredcites →https://doi.org/10.1038/nmeth.3869openalex-snapshot
DADA2: High-resolution sample inference from Illumina amplicon data
inferredcites →https://doi.org/10.1038/nrc1074openalex-snapshot
5-Fluorouracil: mechanisms of action and clinical strategies
inferredcites →https://doi.org/10.1038/nrmicro.2016.17openalex-snapshot
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
inferredcites →https://doi.org/10.1038/s41564-018-0123-9openalex-snapshot
Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies
inferredcites →https://doi.org/10.1073/pnas.0904489106openalex-snapshot
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
inferredcites →https://doi.org/10.1073/pnas.1102938108openalex-snapshot
Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
inferredcites →https://doi.org/10.1073/pnas.120163297openalex-snapshot
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
inferredcites →https://doi.org/10.1093/jjco/hye009openalex-snapshot
Intravenous 5-Fluorouracil Versus Oral Doxifluridine as Preoperative Concurrent Chemoradiation for Locally Advanced Rectal Cancer: Prospective Randomized Trials
inferredcites →https://doi.org/10.1097/00008571-199702000-00005openalex-snapshot
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil
inferredcites →https://doi.org/10.1111/imm.12159openalex-snapshot
Microbiota signalling through MyD88 is necessary for a systemic neutrophilic inflammatory response
inferredcites →https://doi.org/10.1111/j.1365-2125.1982.tb01415.xopenalex-snapshot
The disposition and metabolism of sulphasalazine (salicylazosulphapyridine) in man.
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00700.xopenalex-snapshot
Biochemical and molecular analysis of carboxylesterase‐mediated hydrolysis of cocaine and heroin
inferredcites →https://doi.org/10.1124/dmd.104.000554openalex-snapshot
IDENTIFICATION OF THE CYTOSOLIC CARBOXYLESTERASE CATALYZING THE 5′-DEOXY-5-FLUOROCYTIDINE FORMATION FROM CAPECITABINE IN HUMAN LIVER
inferredcites →https://doi.org/10.1124/dmd.108.025916openalex-snapshot
Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat
inferredcites →https://doi.org/10.1124/jpet.104.081265openalex-snapshot
Hydrolysis of Capecitabine to 5′-Deoxy-5-fluorocytidine by Human Carboxylesterases and Inhibition by Loperamide
inferredcites →https://doi.org/10.1126/science.1104816openalex-snapshot
Host-Bacterial Mutualism in the Human Intestine
inferredcites →https://doi.org/10.1126/science.1191175openalex-snapshot
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
inferredcites →https://doi.org/10.1126/science.1235872openalex-snapshot
Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta
inferredcites →https://doi.org/10.1126/science.1240527openalex-snapshot
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
inferredcites →https://doi.org/10.1126/science.aac4255openalex-snapshot
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
inferredcites →https://doi.org/10.1126/science.aad1329openalex-snapshot
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
inferredcites →https://doi.org/10.1126/science.aad3503openalex-snapshot
Population-level analysis of gut microbiome variation
inferredcites →https://doi.org/10.1128/msystems.00031-18openalex-snapshot
American Gut: an Open Platform for Citizen Science Microbiome Research
inferredcites →https://doi.org/10.1136/gut.14.7.513openalex-snapshot
Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine
inferredcites →https://doi.org/10.1177/030089169908500110openalex-snapshot
Pharmacokinetics of Oral Doxifluridine in Patients with Colorectal Cancer
inferredcites →https://doi.org/10.1186/s40168-018-0470-zopenalex-snapshot
Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin
inferredcites →https://doi.org/10.1194/jlr.m038869openalex-snapshot
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens
inferredcites →https://doi.org/10.1194/jlr.m074914openalex-snapshot
Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058
inferredcites →https://doi.org/10.1248/bpb.17.327openalex-snapshot
Drug Absorption from Large Intestine: Physicochemical Factors Governing Drug Absorption.
inferredcites →https://doi.org/10.1248/yakushi1947.105.8_770openalex-snapshot
Reduction of Dantrolene by Enteric Bacteria
inferredcites →https://doi.org/10.2165/00003088-200140020-00002openalex-snapshot
Clinical Pharmacokinetics of Capecitabine
inferredcites →https://doi.org/10.3109/00498258409151481openalex-snapshot
Role of the intestinal microflora in clonazepam metabolism in the rat
inferredcites →https://doi.org/10.7287/peerj.preprints.27295v1openalex-snapshot
QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science
inferredcites →https://doi.org/10.7287/peerj.preprints.27295v2openalex-snapshot
QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/cpt.1677openalex-snapshot
The Future of Microbiome‐Based Therapeutics in Clinical Applications
inferred← citeshttps://doi.org/10.1007/978-981-15-2604-6_6openalex-snapshot
Recent Advances in Genetic Engineering Tools for Metabolic Engineering
inferred← citeshttps://doi.org/10.1016/b978-0-12-820018-6.00004-1openalex-snapshot
Methods for metabolite generation and characterization by NMR
inferred← citeshttps://doi.org/10.1016/j.apsb.2019.12.001openalex-snapshot
The gut microbiome: an orchestrator of xenobiotic metabolism
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107797openalex-snapshot
Predicting drug-microbiome interactions with machine learning
inferred← citeshttps://doi.org/10.1016/j.chom.2019.06.011openalex-snapshot
Precision Medicine Goes Microscopic: Engineering the Microbiome to Improve Drug Outcomes
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.05.002openalex-snapshot
Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides
inferred← citeshttps://doi.org/10.1101/676148openalex-snapshot
The Molecular and Microbial Microenvironments in Chronically Diseased Lungs
inferred← citeshttps://doi.org/10.1101/820084openalex-snapshot
A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy
inferred← citeshttps://doi.org/10.1128/msystems.00375-19openalex-snapshot
Molecular and Microbial Microenvironments in Chronically Diseased Lungs Associated with Cystic Fibrosis
inferred← citeshttps://doi.org/10.1128/msystems.00387-19openalex-snapshot
A Metabolome- and Metagenome-Wide Association Network Reveals Microbial Natural Products and Microbial Biotransformation Products from the Human Microbiota
inferred← citeshttps://doi.org/10.1186/s40168-019-0767-6openalex-snapshot
Advancing functional and translational microbiome research using meta-omics approaches
inferred← citeshttps://doi.org/10.12793/tcp.2020.28.e3openalex-snapshot
Complex influences of gut microbiome metabolism on various drug responses
inferred← citeshttps://doi.org/10.1371/journal.pone.0244876openalex-snapshot
Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes
inferred← citeshttps://doi.org/10.3390/biomedicines11113063openalex-snapshot
Gut–Kidney–Heart: A Novel Trilogy
inferred← citeshttps://doi.org/10.3390/jpm11040294openalex-snapshot
Gut Microbiome in a Russian Cohort of Pre- and Post-Cholecystectomy Female Patients
inferred← citeshttps://doi.org/10.3390/pharmaceutics13122001openalex-snapshot
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
inferred← citeshttps://doi.org/10.4314/ajcem.v21i2.1openalex-snapshot
Microbiome: pharmacokinetics, pharmacodynamics and drug/xenobiotic interactions
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