On the public citation graph

A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

https://doi.org/10.1101/820084

0 signed · 66 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-59745-251-9_6openalex-snapshot

Estimating Maximum Likelihood Phylogenies with PhyML

inferredcites →https://doi.org/10.1007/978-1-62703-435-7_20openalex-snapshot

PharmGKB: The Pharmacogenomics Knowledge Base

inferredcites →https://doi.org/10.1007/s004390050637openalex-snapshot

Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W

inferredcites →https://doi.org/10.1007/s00520-013-1741-7openalex-snapshot

Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases

inferredcites →https://doi.org/10.1016/0006-2952(94)90056-6openalex-snapshot

(R)-5-Fluoro-5,6-dihydrouracil: Kinetics of oxidation by dihydropyrimidine dehydrogenase and hydrolysis by dihydropyrimidine aminohydrolase

inferredcites →https://doi.org/10.1016/j.cell.2017.03.040openalex-snapshot

Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans

inferredcites →https://doi.org/10.1016/j.cell.2017.03.046openalex-snapshot

Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics

inferredcites →https://doi.org/10.1016/j.cell.2020.05.001openalex-snapshot

Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

inferredcites →https://doi.org/10.1016/j.celrep.2021.109930openalex-snapshot

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

inferredcites →https://doi.org/10.1016/j.chembiol.2015.08.005openalex-snapshot

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

inferredcites →https://doi.org/10.1016/j.clbc.2011.06.005openalex-snapshot

Dose-Adjusting Capecitabine Minimizes Adverse Effects While Maintaining Efficacy: A Retrospective Review of Capecitabine for Metastatic Breast Cancer

inferredcites →https://doi.org/10.1016/j.clinthera.2005.01.005openalex-snapshot

Capecitabine: A review

inferredcites →https://doi.org/10.1016/j.ejca.2015.11.008openalex-snapshot

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time

inferredcites →https://doi.org/10.1016/j.phrs.2004.01.006openalex-snapshot

Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients

inferredcites →https://doi.org/10.1016/s0021-9258(18)53709-1openalex-snapshot

Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies.

inferredcites →https://doi.org/10.1016/s0021-9258(18)62172-6openalex-snapshot

Dihydrouracil Dehydrogenase of Rat Liver

inferredcites →https://doi.org/10.1016/s0021-9258(19)51065-1openalex-snapshot

Dehalogenating and NADPH-modifying activities of dihydropyrimidine dehydrogenase.

inferredcites →https://doi.org/10.1016/s0021-9258(20)81349-0openalex-snapshot

Effects of Fluoropyrimidines on the Synthesis of Bacterial Proteins and Nucleic Acids

inferredcites →https://doi.org/10.1021/acs.biochem.0c00223openalex-snapshot

Transient-State Analysis of Porcine Dihydropyrimidine Dehydrogenase Reveals Reductive Activation by NADPH

inferredcites →https://doi.org/10.1034/j.1399-302x.2003.00075.xopenalex-snapshot

Oral and intestinal microflora in 5‐fluorouracil treated rats, translocation to cervical and mesenteric lymph nodes and effects of probiotic bacteria

inferredcites →https://doi.org/10.1038/msb4100050openalex-snapshot

Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

inferredcites →https://doi.org/10.1038/nature25979openalex-snapshot

Extensive impact of non-antibiotic drugs on human gut bacteria

inferredcites →https://doi.org/10.1038/nbt.4229openalex-snapshot

A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life

inferredcites →https://doi.org/10.1038/ncomms9727openalex-snapshot

Gut mucosal microbiome across stages of colorectal carcinogenesis

inferredcites →https://doi.org/10.1038/nrc1074openalex-snapshot

5-Fluorouracil: mechanisms of action and clinical strategies

inferredcites →https://doi.org/10.1038/nrd3975openalex-snapshot

Platforms for antibiotic discovery

inferredcites →https://doi.org/10.1038/s41586-019-1058-xopenalex-snapshot

New insights from uncultivated genomes of the global human gut microbiome

inferredcites →https://doi.org/10.1038/s41586-019-1291-3openalex-snapshot

Mapping human microbiome drug metabolism by gut bacteria and their genes

inferredcites →https://doi.org/10.1038/srep26337openalex-snapshot

Mucosal adherent bacterial dysbiosis in patients with colorectal adenomas

inferredcites →https://doi.org/10.1056/nejmoa1713709openalex-snapshot

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer

inferredcites →https://doi.org/10.1073/pnas.1402358111openalex-snapshot

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria

inferredcites →https://doi.org/10.1080/00498250802017715openalex-snapshot

A regulatory viewpoint on transporter-based drug interactions

inferredcites →https://doi.org/10.1086/599346openalex-snapshot

Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut

inferredcites →https://doi.org/10.1089/omi.2011.0118openalex-snapshot

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

inferredcites →https://doi.org/10.1093/bioinformatics/btv382openalex-snapshot

MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome

inferredcites →https://doi.org/10.1093/nar/gkh340openalex-snapshot

MUSCLE: multiple sequence alignment with high accuracy and high throughput

inferredcites →https://doi.org/10.1093/nar/gky427openalex-snapshot

SWISS-MODEL: homology modelling of protein structures and complexes

inferredcites →https://doi.org/10.1101/538215openalex-snapshot

Systematic mapping of drug metabolism by the human gut microbiome

inferredcites →https://doi.org/10.1111/apt.13302openalex-snapshot

Chemotherapy‐driven dysbiosis in the intestinal microbiome

inferredcites →https://doi.org/10.1124/dmd.118.083402openalex-snapshot

How to Determine the Role of the Microbiome in Drug Disposition

inferredcites →https://doi.org/10.1126/science.1191175openalex-snapshot

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

inferredcites →https://doi.org/10.1126/science.aad3503openalex-snapshot

Population-level analysis of gut microbiome variation

inferredcites →https://doi.org/10.1126/science.aah5043openalex-snapshot

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

inferredcites →https://doi.org/10.1126/science.aat9931openalex-snapshot

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

inferredcites →https://doi.org/10.1128/aem.01235-16openalex-snapshot

The Microbiota of Breast Tissue and Its Association with Breast Cancer

inferredcites →https://doi.org/10.1128/br.34.3.278-343.1970openalex-snapshot

Pyrimidine metabolism in microorganisms

inferredcites →https://doi.org/10.1128/jb.01178-10openalex-snapshot

Escherichia coli Dihydropyrimidine Dehydrogenase Is a Novel NAD-Dependent Heterotetramer Essential for the Production of 5,6-Dihydrouracil

inferredcites →https://doi.org/10.1172/jci118830openalex-snapshot

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

inferredcites →https://doi.org/10.1186/1752-0509-7-99openalex-snapshot

Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

inferredcites →https://doi.org/10.1186/s13059-015-0611-7openalex-snapshot

Average genome size estimation improves comparative metagenomics and sheds light on the functional ecology of the human microbiome

inferredcites →https://doi.org/10.1200/jco.1988.6.10.1653openalex-snapshot

Fluorouracil: biochemistry and pharmacology.

inferredcites →https://doi.org/10.1200/jco.2007.15.2090openalex-snapshot

Potential Regional Differences for the Tolerability Profiles of Fluoropyrimidines

inferredcites →https://doi.org/10.1371/journal.pcbi.1006242openalex-snapshot

Phylogeny-corrected identification of microbial gene families relevant to human gut colonization

inferredcites →https://doi.org/10.1371/journal.pone.0028654openalex-snapshot

Changes in Human Fecal Microbiota Due to Chemotherapy Analyzed by TaqMan-PCR, 454 Sequencing and PCR-DGGE Fingerprinting

inferredcites →https://doi.org/10.1371/journal.pone.0078053openalex-snapshot

Evaluating Predictive Pharmacogenetic Signatures of Adverse Events in Colorectal Cancer Patients Treated with Fluoropyrimidines

inferredcites →https://doi.org/10.1371/journal.pone.0196506openalex-snapshot

Bacterial versus human thymidylate synthase: Kinetics and functionality

inferredcites →https://doi.org/10.15252/msb.20145645openalex-snapshot

Potential of fecal microbiota for early‐stage detection of colorectal cancer

inferredcites →https://doi.org/10.18632/oncotarget.16717openalex-snapshot

The ovarian cancer oncobiome

inferredcites →https://doi.org/10.3109/10601333.2012.752496openalex-snapshot

Comparative bioavailability study of capecitabine tablets of 500 mg in metastatic breast cancer and colorectal cancer patients under fed condition

inferredcites →https://doi.org/10.3181/0810-rm-301openalex-snapshot

Gastrointestinal Microflora and Mucins May Play a Critical Role in the Development of 5-Fluorouracil-Induced Gastrointestinal Mucositis

inferredcites →https://doi.org/10.3389/fmicb.2019.00826openalex-snapshot

Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

inferredcites →https://doi.org/10.3390/cancers3033279openalex-snapshot

Assessment of the Evolution of Cancer Treatment Therapies

inferredcites →https://doi.org/10.7554/elife.59831openalex-snapshot

Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111625openalex-snapshot

The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota

inferred← citeshttps://doi.org/10.15252/msb.202010116openalex-snapshot

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.