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Clonal Architecture of the Epidermis: Homeostasis Limits Keratinocyte Evolution

https://doi.org/10.1101/548131
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-0-387-21706-2openalex-snapshot
Modern Applied Statistics with S
inferredcites →https://doi.org/10.1016/j.stem.2018.08.017openalex-snapshot
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations
inferredcites →https://doi.org/10.1038/nature12213openalex-snapshot
Mutational heterogeneity in cancer and the search for new cancer-associated genes
inferredcites →https://doi.org/10.1038/ncomms15183openalex-snapshot
Differences between germline and somatic mutation rates in humans and mice
inferredcites →https://doi.org/10.1038/s41467-017-00993-8openalex-snapshot
Spatial constraints govern competition of mutant clones in human epidermis
inferredcites →https://doi.org/10.1038/s41586-018-0811-xopenalex-snapshot
Age-related remodelling of oesophageal epithelia by mutated cancer drivers
inferredcites →https://doi.org/10.1038/s41586-020-2214-zopenalex-snapshot
The mutational landscape of normal human endometrial epithelium
inferredcites →https://doi.org/10.1038/s41588-018-0128-6openalex-snapshot
Quantification of subclonal selection in cancer from bulk sequencing data
inferredcites →https://doi.org/10.1073/pnas.0912629107openalex-snapshot
Rate, molecular spectrum, and consequences of human mutation
inferredcites →https://doi.org/10.1073/pnas.1516123113openalex-snapshot
Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis
inferredcites →https://doi.org/10.1073/pnas.1600910113openalex-snapshot
Constrained positive selection on cancer mutations in normal skin
inferredcites →https://doi.org/10.1073/pnas.1601045113openalex-snapshot
Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking
inferredcites →https://doi.org/10.1093/nar/gkq603openalex-snapshot
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
inferredcites →https://doi.org/10.1098/rsif.2019.0230openalex-snapshot
Relating evolutionary selection and mutant clonal dynamics in normal epithelia
inferredcites →https://doi.org/10.1101/411538openalex-snapshot
Hybrid Automata Library: A modular platform for efficient hybrid modeling with real-time visualization
inferredcites →https://doi.org/10.1126/science.aaa6806openalex-snapshot
High burden and pervasive positive selection of somatic mutations in normal human skin
inferredcites →https://doi.org/10.1126/science.aab4082openalex-snapshot
Somatic mutation in cancer and normal cells
inferredcites →https://doi.org/10.1126/science.aau3879openalex-snapshot
Somatic mutant clones colonize the human esophagus with age
inferredcites →https://doi.org/10.1126/science.aaw0726openalex-snapshot
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1198openalex-snapshot
A Quantitative Measurement of the Human Somatic Mutation Rate
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3957openalex-snapshot
The Role of Transforming Growth Factor-β–Mediated Tumor-Stroma Interactions in Prostate Cancer Progression: An Integrative Approach
inferredcites →https://doi.org/10.1158/0008-5472.can-13-1720openalex-snapshot
Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
inferredcites →https://doi.org/10.32614/cran.package.veganopenalex-snapshot
vegan: Community Ecology Package
inferredcites →https://doi.org/10.32614/r.manualsopenalex-snapshot
R: A Language and Environment for Statistical Computing

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1098/rsif.2021.0607openalex-snapshot
Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia
inferred← citeshttps://doi.org/10.1186/s12859-019-3173-yopenalex-snapshot
EvoFreq: visualization of the Evolutionary Frequencies of sequence and model data
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.