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A biophysical model of Epithelial-Mesenchymal Transition uncovers the frequency and size distribution of Circulating Tumor Cell clusters across cancer types

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1878-0261.12083openalex-snapshot
EMT and MET : necessary or permissive for metastasis?
inferredcites →https://doi.org/10.1007/s40778-019-0150-3openalex-snapshot
Deciphering the Dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in Tumor Progression
inferredcites →https://doi.org/10.1016/j.ajpath.2010.12.003openalex-snapshot
Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer
inferredcites →https://doi.org/10.1016/j.bbcan.2018.07.001openalex-snapshot
Hybrid epithelial/mesenchymal phenotype(s): The ‘fittest’ for metastasis?
inferredcites →https://doi.org/10.1016/j.biomaterials.2014.04.086openalex-snapshot
The effect of fibrillar matrix architecture on tumor cell invasion of physically challenging environments
inferredcites →https://doi.org/10.1016/j.biomaterials.2016.11.014openalex-snapshot
A novel 3D in vitro metastasis model elucidates differential invasive strategies during and after breaching basement membrane
inferredcites →https://doi.org/10.1016/j.ccr.2012.09.022openalex-snapshot
Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
inferredcites →https://doi.org/10.1016/j.ccr.2012.10.012openalex-snapshot
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
inferredcites →https://doi.org/10.1016/j.cell.2006.11.001openalex-snapshot
Cancer Metastasis: Building a Framework
inferredcites →https://doi.org/10.1016/j.cell.2013.11.029openalex-snapshot
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
inferredcites →https://doi.org/10.1016/j.cell.2014.07.013openalex-snapshot
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
inferredcites →https://doi.org/10.1016/j.cell.2016.06.028openalex-snapshot
EMT: 2016
inferredcites →https://doi.org/10.1016/j.devcel.2017.02.009openalex-snapshot
Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning
inferredcites →https://doi.org/10.1016/j.jsamd.2019.01.006openalex-snapshot
Novel approaches in cancer management with circulating tumor cell clusters
inferredcites →https://doi.org/10.1016/j.physrep.2015.03.003openalex-snapshot
Recent advances in percolation theory and its applications
inferredcites →https://doi.org/10.1016/j.stemcr.2013.11.009openalex-snapshot
Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts
inferredcites →https://doi.org/10.1038/bjc.2011.405openalex-snapshot
Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer
inferredcites →https://doi.org/10.1038/nmeth.3404openalex-snapshot
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
inferredcites →https://doi.org/10.1038/nrc.2017.118openalex-snapshot
EMT in cancer
inferredcites →https://doi.org/10.1038/s41416-018-0186-7openalex-snapshot
Detection of circulating tumour cell clusters in human glioblastoma
inferredcites →https://doi.org/10.1038/s41523-017-0023-9openalex-snapshot
Inflammatory breast cancer: a model for investigating cluster-based dissemination
inferredcites →https://doi.org/10.1038/s41586-018-0040-3openalex-snapshot
Identification of the tumour transition states occurring during EMT
inferredcites →https://doi.org/10.1038/s41586-019-0915-yopenalex-snapshot
Neutrophils escort circulating tumour cells to enable cell cycle progression
inferredcites →https://doi.org/10.1038/s41598-018-23276-8openalex-snapshot
Three-dimensional Epigenome Statistical Model: Genome-wide Chromatin Looping Prediction
inferredcites →https://doi.org/10.1038/srep41707openalex-snapshot
Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters
inferredcites →https://doi.org/10.1073/pnas.1212834109openalex-snapshot
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium
inferredcites →https://doi.org/10.1073/pnas.1310490110openalex-snapshot
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development
inferredcites →https://doi.org/10.1073/pnas.1416287112openalex-snapshot
Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype
inferredcites →https://doi.org/10.1073/pnas.1508541113openalex-snapshot
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters
inferredcites →https://doi.org/10.1073/pnas.1618298114openalex-snapshot
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells
inferredcites →https://doi.org/10.1073/pnas.1705921114openalex-snapshot
Correlating cell shape and cellular stress in motile confluent tissues
inferredcites →https://doi.org/10.1073/pnas.1722609115openalex-snapshot
Topography of epithelial–mesenchymal plasticity
inferredcites →https://doi.org/10.1073/pnas.1815345116openalex-snapshot
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
inferredcites →https://doi.org/10.1088/1478-3975/aaf7b7openalex-snapshot
Stability and mean residence times for hybrid epithelial/mesenchymal phenotype
inferredcites →https://doi.org/10.1088/1478-3975/aaf8d4openalex-snapshot
Testing the gene expression classification of the EMT spectrum
inferredcites →https://doi.org/10.1088/1478-3975/aaf928openalex-snapshot
Intermediate cell states in epithelial-to-mesenchymal transition
inferredcites →https://doi.org/10.1093/intbio/zyz021openalex-snapshot
NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
inferredcites →https://doi.org/10.1097/jto.0b013e31823c5c16openalex-snapshot
Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches
inferredcites →https://doi.org/10.1098/rsif.2012.0448openalex-snapshot
Collective cell migration: leadership, invasion and segregation
inferredcites →https://doi.org/10.1098/rsif.2015.1106openalex-snapshot
Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype
inferredcites →https://doi.org/10.1098/rsif.2017.0512openalex-snapshot
Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
inferredcites →https://doi.org/10.1117/1.jbo.24.8.085004openalex-snapshot
Fluorescence monitoring of rare circulating tumor cell and cluster dissemination in a multiple myeloma xenograft model in vivo
inferredcites →https://doi.org/10.1126/science.1228522openalex-snapshot
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
inferredcites →https://doi.org/10.1126/science.aaf6546openalex-snapshot
A collective route to metastasis: Seeding by tumor cell clusters
inferredcites →https://doi.org/10.1158/0008-5472.can-08-1444openalex-snapshot
Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth
inferredcites →https://doi.org/10.1158/0008-5472.can-14-3476openalex-snapshot
Tracking and Functional Characterization of Epithelial–Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis
inferredcites →https://doi.org/10.1158/0008-5472.can-16-3521openalex-snapshot
Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0120openalex-snapshot
Pancreatic Cancer Metastases Harbor Evidence of Polyclonality
inferredcites →https://doi.org/10.1158/2159-8290.cd-18-0065openalex-snapshot
Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models
inferredcites →https://doi.org/10.1172/jci59218openalex-snapshot
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
inferredcites →https://doi.org/10.1242/dev.139071openalex-snapshot
A common framework for EMT and collective cell migration
inferredcites →https://doi.org/10.1371/journal.pcbi.1004569openalex-snapshot
An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States
inferredcites →https://doi.org/10.1371/journal.pone.0126522openalex-snapshot
Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival
inferredcites →https://doi.org/10.18632/oncotarget.25034openalex-snapshot
Loss of inter-cellular cooperation by complete epithelial-mesenchymal transition supports favorable outcomes in basal breast cancer patients
inferredcites →https://doi.org/10.18632/oncotarget.25692openalex-snapshot
A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling
inferredcites →https://doi.org/10.18632/oncotarget.3623openalex-snapshot
OVOL guides the epithelial-hybrid-mesenchymal transition
inferredcites →https://doi.org/10.18632/oncotarget.8166openalex-snapshot
Stability of the hybrid epithelial/mesenchymal phenotype
inferredcites →https://doi.org/10.3389/fonc.2014.00254openalex-snapshot
The Notch ligand Jagged1 as a target for anti-tumor therapy
inferredcites →https://doi.org/10.3389/fonc.2015.00155openalex-snapshot
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
inferredcites →https://doi.org/10.3389/fonc.2018.00063openalex-snapshot
In Vitro Model-Systems to Understand the Biology and Clinical Significance of Circulating Tumor Cell Clusters

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41540-019-0097-0openalex-snapshot
Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1007343openalex-snapshot
Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
inferred← citeshttps://doi.org/10.3389/fcell.2023.1209846openalex-snapshot
In vitro cross-talk between metastasis-competent circulating tumor cells and platelets in colon cancer: a malicious association during the harsh journey in the blood
inferred← citeshttps://doi.org/10.3390/jcm8101542openalex-snapshot
Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression
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