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Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/stem.1059openalex-snapshot
NOTCH1 Is Required for Regeneration of Clara Cells During Repair of Airway Injury
inferredcites →https://doi.org/10.1007/978-1-4614-0899-4_7openalex-snapshot
Notch Signaling in Lung Development and Disease
inferredcites →https://doi.org/10.1016/1010-7940(89)90110-3openalex-snapshot
Spontaneous pneumothorax and Fibrin glue sealant during thoracoscopy
inferredcites →https://doi.org/10.1016/j.acra.2011.03.004openalex-snapshot
Quantification of Regional Interstitial Lung Disease from CT-derived Fractional Tissue Volume
inferredcites →https://doi.org/10.1016/j.jprot.2013.04.033openalex-snapshot
Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors
inferredcites →https://doi.org/10.1016/j.stem.2015.01.002openalex-snapshot
Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations
inferredcites →https://doi.org/10.1016/j.taap.2003.11.011openalex-snapshot
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis
inferredcites →https://doi.org/10.1021/cc000019yopenalex-snapshot
Rapid Identification of Substrates for Novel Proteases Using a Combinatorial Peptide Library
inferredcites →https://doi.org/10.1034/j.1399-3003.1999.14c14.xopenalex-snapshot
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis
inferredcites →https://doi.org/10.1038/nature12930openalex-snapshot
Alveolar progenitor and stem cells in lung development, renewal and cancer
inferredcites →https://doi.org/10.1038/nature14112openalex-snapshot
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury
inferredcites →https://doi.org/10.1038/nature15715openalex-snapshot
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
inferredcites →https://doi.org/10.1038/ng.3278openalex-snapshot
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
inferredcites →https://doi.org/10.1038/s41598-017-10396-wopenalex-snapshot
Lipidomic dysregulation within the lung parenchyma following whole-thorax lung irradiation: Markers of injury, inflammation and fibrosis detected by MALDI-MSI
inferredcites →https://doi.org/10.1038/s41598-018-31214-xopenalex-snapshot
Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis
inferredcites →https://doi.org/10.1055/s-2006-957332openalex-snapshot
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
inferredcites →https://doi.org/10.1056/nejmoa033181openalex-snapshot
Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome
inferredcites →https://doi.org/10.1056/nejmra022387openalex-snapshot
Hydrophobic Surfactant Proteins in Lung Function and Disease
inferredcites →https://doi.org/10.1073/pnas.152238499openalex-snapshot
Early restriction of peripheral and proximal cell lineages during formation of the lung
inferredcites →https://doi.org/10.1073/pnas.2436557100openalex-snapshot
Notch signaling controls multiple steps of pancreatic differentiation
inferredcites →https://doi.org/10.1073/pnas.95.4.1579openalex-snapshot
Dynamics of surfactant release in alveolar type II cells
inferredcites →https://doi.org/10.1083/jcb.200704042openalex-snapshot
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
inferredcites →https://doi.org/10.1093/bja/ael275openalex-snapshot
Quantification of atelectatic lung volumes in two different porcine models of ARDS †
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1097/ccm.0b013e3181dfcb3bopenalex-snapshot
Dry powder aerosolization of a recombinant surfactant protein-C–based surfactant for inhalative treatment of the acutely inflamed lung*
inferredcites →https://doi.org/10.1097/maj.0b013e31821a9d8eopenalex-snapshot
Idiopathic Pulmonary Fibrosis: A Disorder of Epithelial Cell Dysfunction
inferredcites →https://doi.org/10.1111/j.0007-1013.2004.386_11.xopenalex-snapshot
The global virtual university
inferredcites →https://doi.org/10.1146/annurev.physiol.63.1.555openalex-snapshot
Function of Surfactant Proteins B and C
inferredcites →https://doi.org/10.1148/radiol.2016152362openalex-snapshot
Thin-Section CT Features of Idiopathic Pulmonary Fibrosis Correlated with Micro-CT and Histologic Analysis
inferredcites →https://doi.org/10.1152/ajplung.00033.2017openalex-snapshot
Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model
inferredcites →https://doi.org/10.1152/ajplung.00184.2012openalex-snapshot
Role of Sonic Hedgehog in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1152/ajplung.00484.2001openalex-snapshot
Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease
inferredcites →https://doi.org/10.1158/0008-5472.can-11-0595openalex-snapshot
Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma
inferredcites →https://doi.org/10.1159/000458466openalex-snapshot
Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications
inferredcites →https://doi.org/10.1164/ajrccm/136.1.113openalex-snapshot
Correlation of Changes in Pulmonary Surfactant Phospholipids with Compliance in Bleomycin-Induced Pulmonary Fibrosis in the Rat
inferredcites →https://doi.org/10.1164/ajrccm/141.4_pt_1.1006openalex-snapshot
Surface and Tissue Forces, Surfactant Protein A, and the Phospholipid Components of Pulmonary Surfactant in Bleomycin-induced Pulmonary Fibrosis in the Rat
inferredcites →https://doi.org/10.1164/rccm.200607-915ocopenalex-snapshot
Tidal Hyperinflation during Low Tidal Volume Ventilation in Acute Respiratory Distress Syndrome
inferredcites →https://doi.org/10.1164/rccm.200810-1615ocopenalex-snapshot
Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis
inferredcites →https://doi.org/10.1164/rccm.2009-040glopenalex-snapshot
An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management
inferredcites →https://doi.org/10.1164/rccm.200909-1414ocopenalex-snapshot
Epithelial Stress and Apoptosis Underlie Hermansky-Pudlak Syndrome–associated Interstitial Pneumonia
inferredcites →https://doi.org/10.1164/rccm.201006-0894ciopenalex-snapshot
Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis
inferredcites →https://doi.org/10.1165/rcmb.2006-0429ocopenalex-snapshot
Stretch-Induced Alveolar Type II Cell Apoptosis
inferredcites →https://doi.org/10.1165/rcmb.2008-0011edopenalex-snapshot
Conditional Expression of Genes in the Respiratory Epithelium in Transgenic Mice
inferredcites →https://doi.org/10.1165/rcmb.2014-0246ocopenalex-snapshot
Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair
inferredcites →https://doi.org/10.1172/jci27183openalex-snapshot
Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury
inferredcites →https://doi.org/10.1172/jci33950openalex-snapshot
WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1172/jci68782openalex-snapshot
Type 2 alveolar cells are stem cells in adult lung
inferredcites →https://doi.org/10.1183/09031936.00034406openalex-snapshot
Surfactant protein C mutations in sporadic forms of idiopathic interstitial pneumonias
inferredcites →https://doi.org/10.1183/09031936.00097306openalex-snapshot
Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs
inferredcites →https://doi.org/10.1183/09031936.00149205openalex-snapshot
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study
inferredcites →https://doi.org/10.1186/1465-9921-14-123openalex-snapshot
LysoTracker is a marker of differentiated alveolar type II cells
inferredcites →https://doi.org/10.1186/1465-9921-6-109openalex-snapshot
Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension
inferredcites →https://doi.org/10.1186/s12863-016-0377-2openalex-snapshot
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia
inferredcites →https://doi.org/10.1214/aoms/1177704472openalex-snapshot
On Estimation of a Probability Density Function and Mode
inferredcites →https://doi.org/10.1242/dev.029249openalex-snapshot
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
inferredcites →https://doi.org/10.1242/dev.034884openalex-snapshot
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
inferredcites →https://doi.org/10.1242/dev.063727openalex-snapshot
Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development
inferredcites →https://doi.org/10.1242/dev.083840openalex-snapshot
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells
inferredcites →https://doi.org/10.1242/dev.127.18.3913openalex-snapshot
Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
inferredcites →https://doi.org/10.1371/journal.pone.0207915openalex-snapshot
Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1542/neo.15-6-e236openalex-snapshot
Surfactant for Respiratory Distress Syndrome
inferredcites →https://doi.org/10.2350/09-01-0586.1openalex-snapshot
Genetic Disorders of Surfactant Dysfunction
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/sctm.19-0433openalex-snapshot
Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-824064-9.00016-2openalex-snapshot
3D modeling of the lung in health and disease
inferred← citeshttps://doi.org/10.1101/855155openalex-snapshot
Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis
inferred← citeshttps://doi.org/10.1111/bph.15371openalex-snapshot
Hyperoxia‐induced miR‐342‐5p down‐regulation exacerbates neonatal bronchopulmonary dysplasia via the Raf1 regulator Spred3
inferred← citeshttps://doi.org/10.1177/2397198319899013openalex-snapshot
Therapeutic molecular targets of SSc-ILD
inferred← citeshttps://doi.org/10.1183/16000617.0280-2021openalex-snapshot
Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1183/2312508x.10010420openalex-snapshot
Epithelial stem cells at the intersection of tissue regeneration and pulmonary fibrosis
inferred← citeshttps://doi.org/10.1186/s12929-026-01281-8openalex-snapshot
MPT0E028, a pan-HDAC inhibitor, ameliorates bleomycin-induced pulmonary fibrosis by promoting AT2-to-AT1 differentiation through the ATM/AMPK/FoxO1 pathway
inferred← citeshttps://doi.org/10.3389/fcimb.2022.928704openalex-snapshot
NOTCH signaling in COVID-19: a central hub controlling genes, proteins, and cells that mediate SARS-CoV-2 entry, the inflammatory response, and lung regeneration
inferred← citeshttps://doi.org/10.3389/fitd.2023.1100526openalex-snapshot
Notch signaling: A potential target for the development of host-directed therapies against tuberculosis
inferred← citeshttps://doi.org/10.3389/fmed.2021.644678openalex-snapshot
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19
inferred← citeshttps://doi.org/10.3390/cells11020235openalex-snapshot
Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.3390/ijms21072269openalex-snapshot
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis
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