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Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A CK19CreERT knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs
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The extracellular matrix – the under‐recognized element in lung disease?
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The Aging Lung and Idiopathic Pulmonary Fibrosis
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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
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Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming
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Squish and squeeze — the nucleus as a physical barrier during migration in confined environments
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Dynamics between Stem Cells, Niche, and Progeny in the Hair Follicle
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Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
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Nice Neighborhood: Emerging Concepts of the Stem Cell Niche
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
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Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung
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Comprehensive Integration of Single-Cell Data
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Cellular Senescence: Defining a Path Forward
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Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation
inferredcites →https://doi.org/10.1016/j.celrep.2016.11.007openalex-snapshot
p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway
inferredcites →https://doi.org/10.1016/j.celrep.2019.02.046openalex-snapshot
Dlk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair
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Regulation of Stem Cell Maintenance and Transit Amplifying Cell Proliferation by TGF-β Signaling in Drosophila Spermatogenesis
inferredcites →https://doi.org/10.1016/j.devcel.2018.01.008openalex-snapshot
The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells
inferredcites →https://doi.org/10.1016/j.gendis.2017.12.005openalex-snapshot
SOX4 contributes to TGF-β-induced epithelial–mesenchymal transition and stem cell characteristics of gastric cancer cells
inferredcites →https://doi.org/10.1016/j.matbio.2018.03.005openalex-snapshot
Extracellular matrix in lung development, homeostasis and disease
inferredcites →https://doi.org/10.1016/j.molcel.2010.05.004openalex-snapshot
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
inferredcites →https://doi.org/10.1016/j.molcel.2010.09.019openalex-snapshot
The DNA Damage Response: Making It Safe to Play with Knives
inferredcites →https://doi.org/10.1016/j.molcel.2015.11.003openalex-snapshot
A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes
inferredcites →https://doi.org/10.1016/j.stem.2011.04.003openalex-snapshot
Notch-Dependent Differentiation of Adult Airway Basal Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2014.07.012openalex-snapshot
Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function
inferredcites →https://doi.org/10.1016/j.stemcr.2019.02.013openalex-snapshot
IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
inferredcites →https://doi.org/10.1016/s0140-6736(12)61144-1openalex-snapshot
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1038/cddis.2015.206openalex-snapshot
Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling
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Alveolar progenitor and stem cells in lung development, renewal and cancer
inferredcites →https://doi.org/10.1038/nature25786openalex-snapshot
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
inferredcites →https://doi.org/10.1038/ncb2581openalex-snapshot
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
inferredcites →https://doi.org/10.1038/ncb3580openalex-snapshot
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
inferredcites →https://doi.org/10.1038/nmat3339openalex-snapshot
Extracellular-matrix tethering regulates stem-cell fate
inferredcites →https://doi.org/10.1038/nmeth762openalex-snapshot
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
inferredcites →https://doi.org/10.1038/nn.2467openalex-snapshot
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
inferredcites →https://doi.org/10.1038/nrm3060openalex-snapshot
DNA damage response in adult stem cells: pathways and consequences
inferredcites →https://doi.org/10.1038/nrm3823openalex-snapshot
Cellular senescence: from physiology to pathology
inferredcites →https://doi.org/10.1038/nrm3904openalex-snapshot
Remodelling the extracellular matrix in development and disease
inferredcites →https://doi.org/10.1038/s41556-019-0357-7openalex-snapshot
Cellular organization and biology of the respiratory system
inferredcites →https://doi.org/10.1038/s41580-019-0141-3openalex-snapshot
Cellular crosstalk in the development and regeneration of the respiratory system
inferredcites →https://doi.org/10.1038/s41586-018-0414-6openalex-snapshot
RNA velocity of single cells
inferredcites →https://doi.org/10.1038/sj.onc.1202778openalex-snapshot
Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor
inferredcites →https://doi.org/10.1038/sj.onc.1205896openalex-snapshot
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth
inferredcites →https://doi.org/10.1073/pnas.0810147106openalex-snapshot
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
inferredcites →https://doi.org/10.1073/pnas.1117988108openalex-snapshot
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
inferredcites →https://doi.org/10.1093/bioinformatics/btn615openalex-snapshot
AmiGO: online access to ontology and annotation data
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/btu170openalex-snapshot
Trimmomatic: a flexible trimmer for Illumina sequence data
inferredcites →https://doi.org/10.1093/jmcb/mju046openalex-snapshot
Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/gkw257openalex-snapshot
deepTools2: a next generation web server for deep-sequencing data analysis
inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
inferredcites →https://doi.org/10.1101/580498openalex-snapshot
Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
inferredcites →https://doi.org/10.1101/705244openalex-snapshot
Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration
inferredcites →https://doi.org/10.1111/j.1445-5994.1984.tb04343.xopenalex-snapshot
ALVEOLAR TYPE I AND TYPE II CELLS
inferredcites →https://doi.org/10.1126/sciadv.aba1972openalex-snapshot
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
inferredcites →https://doi.org/10.1126/sciadv.aba1983openalex-snapshot
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1126/science.aad7611openalex-snapshot
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
inferredcites →https://doi.org/10.1126/science.aam6603openalex-snapshot
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells
inferredcites →https://doi.org/10.1136/thoraxjnl-2014-206084openalex-snapshot
Accelerated ageing of the lung in COPD: new concepts
inferredcites →https://doi.org/10.1152/japplphysiol.01100.2009openalex-snapshot
Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach
inferredcites →https://doi.org/10.1158/0008-5472.can-12-1045openalex-snapshot
SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression
inferredcites →https://doi.org/10.1158/0008-5472.can-17-0337openalex-snapshot
Variant Review with the Integrative Genomics Viewer
inferredcites →https://doi.org/10.1158/1538-7445.am2012-4597openalex-snapshot
Abstract 4597: Telomere maintenance mechanism and expression in colorectal cancer
inferredcites →https://doi.org/10.1164/rccm.201409-1663oeopenalex-snapshot
On the Tricks Alveolar Epithelial Cells Play to Make a Good Lung
inferredcites →https://doi.org/10.1165/rcmb.2018-0061edopenalex-snapshot
Cellular Senescence in Chronic Obstructive Pulmonary Disease: Multifaceted and Multifunctional
inferredcites →https://doi.org/10.1165/rcmb.2018-0125ocopenalex-snapshot
Ager-CreER T2 : A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair
inferredcites →https://doi.org/10.1172/jci.insight.123637openalex-snapshot
Single-cell RNA sequencing identifies TGF-β as a key regenerative cue following LPS-induced lung injury
inferredcites →https://doi.org/10.1172/jci125014openalex-snapshot
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
inferredcites →https://doi.org/10.1172/jci68782openalex-snapshot
Type 2 alveolar cells are stem cells in adult lung
inferredcites →https://doi.org/10.1177/1947601911410224openalex-snapshot
p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome
inferredcites →https://doi.org/10.1182/blood-2007-08-078147openalex-snapshot
Stem-cell ecology and stem cells in motion
inferredcites →https://doi.org/10.1183/13993003.01994-2017openalex-snapshot
The DNA repair transcriptome in severe COPD
inferredcites →https://doi.org/10.1186/1471-2350-14-93openalex-snapshot
Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes
inferredcites →https://doi.org/10.1186/1755-1536-5-s1-s24openalex-snapshot
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
inferredcites →https://doi.org/10.1186/s12859-016-1284-2openalex-snapshot
Je, a versatile suite to handle multiplexed NGS libraries with unique molecular identifiers
inferredcites →https://doi.org/10.1186/s12931-018-0838-4openalex-snapshot
A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1242/dev.143784openalex-snapshot
Plasticity in the lung: making and breaking cell identity
inferredcites →https://doi.org/10.1242/dev.163014openalex-snapshot
Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation
inferredcites →https://doi.org/10.1242/dmm.010736openalex-snapshot
Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1371/journal.pone.0029423openalex-snapshot
Activity-Induced Remodeling of Olfactory Bulb Microcircuits Revealed by Monosynaptic Tracing
inferredcites →https://doi.org/10.1371/journal.pone.0030562openalex-snapshot
CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis
inferredcites →https://doi.org/10.15252/embj.201488017openalex-snapshot
Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67‐RFP allele
inferredcites →https://doi.org/10.4049/jimmunol.178.10.6504openalex-snapshot
Airway Epithelium Controls Lung Inflammation and Injury through the NF-κB Pathway
inferredcites →https://doi.org/10.4049/jimmunol.180.2.881openalex-snapshot
Alveolar Epithelial Type II Cells Induce T Cell Tolerance to Specific Antigen
inferredcites →https://doi.org/10.7555/jbr.27.20130030openalex-snapshot
The MDM2-p53 pathway revisited

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.stem.2020.06.020openalex-snapshot
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration
inferred← citeshttps://doi.org/10.1038/s41467-020-17358-3openalex-snapshot
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
inferred← citeshttps://doi.org/10.1038/s41467-020-18979-4openalex-snapshot
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
inferred← citeshttps://doi.org/10.1039/d2bm00827kopenalex-snapshot
Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
inferred← citeshttps://doi.org/10.1101/2020.06.06.136713openalex-snapshot
Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair
inferred← citeshttps://doi.org/10.1101/2020.06.14.151324openalex-snapshot
Reconstitution of Alveolar Regeneration via novel DATPs by Inflammatory Niches
inferred← citeshttps://doi.org/10.1111/joim.13075openalex-snapshot
Airway organoids as models of human disease
inferred← citeshttps://doi.org/10.1126/sciadv.aba1972openalex-snapshot
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
inferred← citeshttps://doi.org/10.3389/fmed.2020.606462openalex-snapshot
Senescence in Pulmonary Fibrosis: Between Aging and Exposure
inferred← citeshttps://doi.org/10.3390/ijms21093188openalex-snapshot
Mechanisms of ATII-to-ATI Cell Differentiation during Lung Regeneration
inferred← citeshttps://doi.org/10.7554/elife.64430openalex-snapshot
GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells
inferred← citeshttps://doi.org/10.7554/elife.85415openalex-snapshot
Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis
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