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Lysosomal cystine mobilization shapes the response of mTORC1 and tissue growth to fasting
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/brb3.208openalex-snapshot
N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
inferredcites →https://doi.org/10.1007/bf02797462openalex-snapshot
Cytotoxicity of cysteine in culture media
inferredcites →https://doi.org/10.1007/s00467-013-2705-3openalex-snapshot
N-acetyl-cysteine is associated to renal function improvement in patients with nephropathic cystinosis
inferredcites →https://doi.org/10.1007/s00726-011-0867-5openalex-snapshot
The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
inferredcites →https://doi.org/10.1007/s10545-016-9919-zopenalex-snapshot
Altered mTOR signalling in nephropathic cystinosis
inferredcites →https://doi.org/10.1007/s11357-006-9018-4openalex-snapshot
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
inferredcites →https://doi.org/10.1016/bs.mie.2015.05.016openalex-snapshot
Analysis of Cell Metabolism Using LC-MS and Isotope Tracers
inferredcites →https://doi.org/10.1016/j.cell.2013.06.043openalex-snapshot
Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation
inferredcites →https://doi.org/10.1016/j.cell.2014.11.048openalex-snapshot
Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits
inferredcites →https://doi.org/10.1016/j.cell.2016.05.042openalex-snapshot
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
inferredcites →https://doi.org/10.1016/j.celrep.2013.03.016openalex-snapshot
The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
inferredcites →https://doi.org/10.1016/j.celrep.2014.03.017openalex-snapshot
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System
inferredcites →https://doi.org/10.1016/j.celrep.2017.10.029openalex-snapshot
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
inferredcites →https://doi.org/10.1016/j.cmet.2009.08.002openalex-snapshot
Remote Control of Insulin Secretion by Fat Cells in Drosophila
inferredcites →https://doi.org/10.1016/j.cmet.2010.03.015openalex-snapshot
PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation
inferredcites →https://doi.org/10.1016/j.cmet.2015.07.027openalex-snapshot
Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis
inferredcites →https://doi.org/10.1016/j.cmet.2017.07.001openalex-snapshot
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
inferredcites →https://doi.org/10.1016/j.cmet.2019.03.014openalex-snapshot
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
inferredcites →https://doi.org/10.1016/j.devcel.2004.07.009openalex-snapshot
Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body
inferredcites →https://doi.org/10.1016/j.devcel.2015.03.013openalex-snapshot
REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1
inferredcites →https://doi.org/10.1016/s0092-8674(03)00713-xopenalex-snapshot
A Nutrient Sensor Mechanism Controls Drosophila Growth
inferredcites →https://doi.org/10.1038/cdd.2014.63openalex-snapshot
The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila
inferredcites →https://doi.org/10.1038/nature09076openalex-snapshot
Termination of autophagy and reformation of lysosomes regulated by mTOR
inferredcites →https://doi.org/10.1038/ng0498-319openalex-snapshot
A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis
inferredcites →https://doi.org/10.1038/nmeth.2731openalex-snapshot
A holidic medium for Drosophila melanogaster
inferredcites →https://doi.org/10.1038/s41467-017-00369-yopenalex-snapshot
Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
inferredcites →https://doi.org/10.1038/s41467-017-02536-7openalex-snapshot
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney
inferredcites →https://doi.org/10.1038/s41556-018-0125-0openalex-snapshot
Aspartate is an endogenous metabolic limitation for tumour growth
inferredcites →https://doi.org/10.1042/bj20051411openalex-snapshot
Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast
inferredcites →https://doi.org/10.1042/bj2280545openalex-snapshot
Cysteamine depletes cystinotic leucocyte granular fractions of cystine by the mechanism of disulphide interchange
inferredcites →https://doi.org/10.1073/pnas.1102008108openalex-snapshot
Increased transsulfuration mediates longevity and dietary restriction in Drosophila
inferredcites →https://doi.org/10.1073/pnas.1614102114openalex-snapshot
Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth
inferredcites →https://doi.org/10.1074/jbc.m116.764076openalex-snapshot
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A
inferredcites →https://doi.org/10.1074/jbc.m506736200openalex-snapshot
Autophagy Is Required for Maintenance of Amino Acid Levels and Protein Synthesis under Nitrogen Starvation
inferredcites →https://doi.org/10.1093/jn/137.2.331openalex-snapshot
Excess Dietary l-Cysteine, but Not l-Cystine, Is Lethal for Chicks but Not for Rats or Pigs
inferredcites →https://doi.org/10.1111/acel.13034openalex-snapshot
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
inferredcites →https://doi.org/10.1126/science.1144504openalex-snapshot
Domain Architecture of Pyruvate Carboxylase, a Biotin-Dependent Multifunctional Enzyme
inferredcites →https://doi.org/10.1126/science.aar2663openalex-snapshot
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
inferredcites →https://doi.org/10.1242/dev.088757openalex-snapshot
A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila
inferredcites →https://doi.org/10.1371/journal.pbio.1002392openalex-snapshot
Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation
inferredcites →https://doi.org/10.1371/journal.pone.0067308openalex-snapshot
Development and Characterization of a Chemically Defined Food for Drosophila
inferredcites →https://doi.org/10.15252/emmm.201404223openalex-snapshot
Impairment of chaperone‐mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis
inferredcites →https://doi.org/10.1681/asn.2014090937openalex-snapshot
Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling
inferredcites →https://doi.org/10.18632/aging.101561openalex-snapshot
Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans
inferredcites →https://doi.org/10.2174/1389200217666151210124713openalex-snapshot
Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
inferredcites →https://doi.org/10.3390/ijms161226225openalex-snapshot
Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1101/2020.02.10.941799openalex-snapshot
Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis
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