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Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

https://doi.org/10.1101/610220
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Outgoing claims: the papers this work cites, builds on, or argues with.

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ATF4 regulates lipid metabolism and thermogenesis
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LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
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Synchronized mitochondrial and cytosolic translation programs
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Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
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Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
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Bi-directional interconversion of brite and white adipocytes
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UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
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LRPPRC-mediated folding of the mitochondrial transcriptome
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Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
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Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements
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Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids
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A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells
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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
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MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments
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SLIRP stabilizes LRPPRC via an RRM–PPR protein interface
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βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
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LRPPRC mutations cause a phenotypically distinct form of Leigh syndrome with cytochrome c oxidase deficiency
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Brown Adipose Tissue: Function and Physiological Significance
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Cellular energy utilization and molecular origin of standard metabolic rate in mammals
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Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
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Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man.
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Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
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Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
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Nonshivering thermogenesis and its adequate measurement in metabolic studies
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A Model of Proteostatic Energy Cost and Its Use in Analysis of Proteome Trends and Sequence Evolution
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The integrated stress response
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Effects of Habitat Conversion on Temporal Activity Patterns of Phyllostomid Bats in Lowland Amazonian Rain Forest
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Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
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A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes
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Human Brown Adipose Tissue: What We Have Learned So Far
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Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4
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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
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