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Cancer control is a key functionality underlying evolution of extended lifespan in mammals

https://doi.org/10.1101/615914
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0047-6374(79)90006-xopenalex-snapshot
Effect of low dose rate irradiation on the division potential of cells in vitro. VI. Changes in DNA and in radiosensitivity during aging of human fibroblasts
inferredcites →https://doi.org/10.1016/0047-6374(84)90114-3openalex-snapshot
A correlation between aging and DNA repair in human epidermal cells
inferredcites →https://doi.org/10.1016/0921-8734(90)90018-mopenalex-snapshot
DNA damage and rpair with age in individual human lymphocytes
inferredcites →https://doi.org/10.1016/j.arr.2007.09.002openalex-snapshot
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
inferredcites →https://doi.org/10.1016/j.bbagrm.2012.01.002openalex-snapshot
Chromatin dynamics in DNA double-strand break repair
inferredcites →https://doi.org/10.1016/j.cell.2008.10.025openalex-snapshot
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
inferredcites →https://doi.org/10.1016/j.celrep.2012.08.032openalex-snapshot
A “Forward Genomics” Approach Links Genotype to Phenotype using Independent Phenotypic Losses among Related Species
inferredcites →https://doi.org/10.1016/j.celrep.2014.12.008openalex-snapshot
Insights into the Evolution of Longevity from the Bowhead Whale Genome
inferredcites →https://doi.org/10.1016/j.mad.2010.08.005openalex-snapshot
Plasma IGF-1 is negatively correlated with body mass in a comparison of 36 mammalian species
inferredcites →https://doi.org/10.1038/366461a0openalex-snapshot
A C. elegans mutant that lives twice as long as wild type
inferredcites →https://doi.org/10.1038/emm.2006.81openalex-snapshot
Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
inferredcites →https://doi.org/10.1038/msb.2013.35openalex-snapshot
Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
inferredcites →https://doi.org/10.1038/nature01298openalex-snapshot
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
inferredcites →https://doi.org/10.1038/nature01960openalex-snapshot
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
inferredcites →https://doi.org/10.1038/nature10533openalex-snapshot
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
inferredcites →https://doi.org/10.1038/nature11861openalex-snapshot
mTOR is a key modulator of ageing and age-related disease
inferredcites →https://doi.org/10.1038/ncomms3212openalex-snapshot
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
inferredcites →https://doi.org/10.1038/ncomms7790openalex-snapshot
Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
inferredcites →https://doi.org/10.1038/sj.bjc.6602627openalex-snapshot
Role of insulin-like growth factor 1 receptor signalling in cancer
inferredcites →https://doi.org/10.1073/pnas.111158898openalex-snapshot
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
inferredcites →https://doi.org/10.1073/pnas.1200583109openalex-snapshot
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
inferredcites →https://doi.org/10.1073/pnas.92.16.7540openalex-snapshot
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.
inferredcites →https://doi.org/10.1086/284325openalex-snapshot
Phylogenies and the Comparative Method
inferredcites →https://doi.org/10.1093/bioinformatics/btz468openalex-snapshot
RERconverge: an R package for associating evolutionary rates with convergent traits
inferredcites →https://doi.org/10.1093/ije/dyv199openalex-snapshot
Epidemiology, multistage models, and short-term mutagenicity tests
inferredcites →https://doi.org/10.1093/molbev/msm088openalex-snapshot
PAML 4: Phylogenetic Analysis by Maximum Likelihood
inferredcites →https://doi.org/10.1093/molbev/msw098openalex-snapshot
Controlling for Phylogenetic Relatedness and Evolutionary Rates Improves the Discovery of Associations Between Species’ Phenotypic and Genomic Differences
inferredcites →https://doi.org/10.1093/molbev/msw112openalex-snapshot
Hundreds of Genes Experienced Convergent Shifts in Selective Pressure in Marine Mammals
inferredcites →https://doi.org/10.1093/molbev/msz107openalex-snapshot
Robust Method for Detecting Convergent Shifts in Evolutionary Rates
inferredcites →https://doi.org/10.1093/nar/gkx1042openalex-snapshot
Human Ageing Genomic Resources: new and updated databases
inferredcites →https://doi.org/10.1111/j.2041-210x.2011.00169.xopenalex-snapshot
phytools: an R package for phylogenetic comparative biology (and other things)
inferredcites →https://doi.org/10.1126/sciadv.aao0926openalex-snapshot
Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
inferredcites →https://doi.org/10.1126/science.1137045openalex-snapshot
A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
inferredcites →https://doi.org/10.1126/science.277.5328.942openalex-snapshot
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
inferredcites →https://doi.org/10.1152/ajpendo.00296.2003openalex-snapshot
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
inferredcites →https://doi.org/10.1353/book.59141openalex-snapshot
Walker's Mammals of the World
inferredcites →https://doi.org/10.7554/elife.11994openalex-snapshot
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
inferredcites →https://doi.org/10.7554/elife.24307openalex-snapshot
Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
inferredcites →https://doi.org/10.7554/elife.25884openalex-snapshot
Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling
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