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TimeTeller: a New Tool for Precision Circadian Medicine and Cancer Prognosis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Refinement of breast cancer classification by molecular characterization of histological special types
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Regression Models and Life-Tables
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Molecular Components of the Mammalian Circadian Clock
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A multicenter randomized phase II study of sequential epirubicin/cyclophosphamide followed by docetaxel with or without celecoxib or trastuzumab according to HER2 status, as primary chemotherapy for localized invasive breast cancer patients
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Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work history
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Sleep and Cardio-Metabolic Disease
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Chronopharmacodynamics and mechanisms of antitumor effect induced by erlotinib in xenograft-bearing nude mice
inferredcites →https://doi.org/10.1016/j.breast.2013.08.015openalex-snapshot
Challenging single- and multi-probesets gene expression signatures of pathological complete response to neoadjuvant chemotherapy in breast cancer: Experience of the REMAGUS 02 phase II trial
inferredcites →https://doi.org/10.1016/j.ccell.2016.10.007openalex-snapshot
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
inferredcites →https://doi.org/10.1016/j.cell.2014.10.022openalex-snapshot
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
inferredcites →https://doi.org/10.1016/j.cels.2018.01.013openalex-snapshot
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
inferredcites →https://doi.org/10.1016/j.ejca.2017.01.008openalex-snapshot
Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status
inferredcites →https://doi.org/10.1016/j.ejps.2017.11.021openalex-snapshot
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats
inferredcites →https://doi.org/10.1016/j.febslet.2010.03.017openalex-snapshot
Circadian clock control of the cellular response to DNA damage
inferredcites →https://doi.org/10.1016/j.mce.2015.06.030openalex-snapshot
The role of sleep in the regulation of body weight
inferredcites →https://doi.org/10.1016/j.molmed.2016.03.004openalex-snapshot
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy
inferredcites →https://doi.org/10.1016/j.oraloncology.2014.12.004openalex-snapshot
Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas
inferredcites →https://doi.org/10.1016/j.smrv.2017.06.011openalex-snapshot
Long sleep duration and health outcomes: A systematic review, meta-analysis and meta-regression
inferredcites →https://doi.org/10.1016/s0369-8114(03)00024-5openalex-snapshot
Modèles déterministes et stochastiques pour les rythmes circadiens
inferredcites →https://doi.org/10.1038/nature25170openalex-snapshot
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
inferredcites →https://doi.org/10.1038/s41574-018-0142-xopenalex-snapshot
The arrival of circadian medicine
inferredcites →https://doi.org/10.1053/j.gastro.2017.12.019openalex-snapshot
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice
inferredcites →https://doi.org/10.1056/nejmra0801289openalex-snapshot
Gene-Expression Signatures in Breast Cancer
inferredcites →https://doi.org/10.1073/pnas.022628299openalex-snapshot
Robustness of circadian rhythms with respect to molecular noise
inferredcites →https://doi.org/10.1073/pnas.0401882101openalex-snapshot
Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles
inferredcites →https://doi.org/10.1073/pnas.1106284108openalex-snapshot
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
inferredcites →https://doi.org/10.1073/pnas.1320474111openalex-snapshot
Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle
inferredcites →https://doi.org/10.1073/pnas.1408886111openalex-snapshot
A circadian gene expression atlas in mammals: Implications for biology and medicine
inferredcites →https://doi.org/10.1073/pnas.1619320114openalex-snapshot
CYCLOPS reveals human transcriptional rhythms in health and disease
inferredcites →https://doi.org/10.1073/pnas.2036281100openalex-snapshot
A detailed predictive model of the mammalian circadian clock
inferredcites →https://doi.org/10.1080/07420528.2017.1301462openalex-snapshot
Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer?
inferredcites →https://doi.org/10.1088/0951-7715/4/2/001openalex-snapshot
Local adaptive Galerkin bases for large-dimensional dynamical systems
inferredcites →https://doi.org/10.1093/acprof:oso/9780199566594.001.0001openalex-snapshot
Sleep, Health and Society: From Aetiology to Public Health
inferredcites →https://doi.org/10.1093/bib/bbl016openalex-snapshot
Partial least squares: a versatile tool for the analysis of high-dimensional genomic data
inferredcites →https://doi.org/10.1093/bioinformatics/btw243openalex-snapshot
What time is it? Deep learning approaches for circadian rhythms
inferredcites →https://doi.org/10.1093/bioinformatics/btw504openalex-snapshot
What time is it? Deep learning approaches for circadian rhythms
inferredcites →https://doi.org/10.1093/jnci/dji083openalex-snapshot
Effects of Light and Food Schedules on Liver and Tumor Molecular Clocks in Mice
inferredcites →https://doi.org/10.1093/nar/gkw030openalex-snapshot
ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system
inferredcites →https://doi.org/10.1111/j.2517-6161.1972.tb00899.xopenalex-snapshot
Regression Models and Life-Tables
inferredcites →https://doi.org/10.1126/science.1086271openalex-snapshot
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
inferredcites →https://doi.org/10.1126/science.aao0318openalex-snapshot
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
inferredcites →https://doi.org/10.1126/scitranslmed.aat8806openalex-snapshot
A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine
inferredcites →https://doi.org/10.1136/bmj.k4641openalex-snapshot
Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses
inferredcites →https://doi.org/10.1146/annurev.pharmtox.47.120505.105208openalex-snapshot
Circadian Rhythms: Mechanisms and Therapeutic Implications
inferredcites →https://doi.org/10.1146/annurev.pharmtox.48.113006.094626openalex-snapshot
Circadian Timing in Cancer Treatments
inferredcites →https://doi.org/10.1152/physrev.00016.2012openalex-snapshot
Metabolism and the Circadian Clock Converge
inferredcites →https://doi.org/10.1158/0008-5472.can-06-2086openalex-snapshot
Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor
inferredcites →https://doi.org/10.1158/0008-5472.can-17-4034openalex-snapshot
Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor
inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0177openalex-snapshot
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index
inferredcites →https://doi.org/10.1158/1940-6207.capr-09-0192openalex-snapshot
Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome
inferredcites →https://doi.org/10.1172/jci120874openalex-snapshot
High-accuracy determination of internal circadian time from a single blood sample
inferredcites →https://doi.org/10.1177/0748730410379711openalex-snapshot
JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets
inferredcites →https://doi.org/10.1186/1471-2407-11-215openalex-snapshot
Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients
inferredcites →https://doi.org/10.1186/1742-4682-11-s1-s2openalex-snapshot
Seeking genetic signature of radiosensitivity - a novel method for data analysis in case of small sample sizes
inferredcites →https://doi.org/10.1186/s12915-016-0342-6openalex-snapshot
How flies are flirting on the fly
inferredcites →https://doi.org/10.1186/s12915-017-0349-7openalex-snapshot
Enhancing circadian clock function in cancer cells inhibits tumor growth
inferredcites →https://doi.org/10.1186/s13058-018-1053-4openalex-snapshot
Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours
inferredcites →https://doi.org/10.1186/s13073-017-0406-4openalex-snapshot
Machine learning identifies a compact gene set for monitoring the circadian clock in human blood
inferredcites →https://doi.org/10.1186/s13073-017-0430-4openalex-snapshot
Lost in translation: returning germline genetic results in genome-scale cancer research
inferredcites →https://doi.org/10.1198/016214505000000628openalex-snapshot
Prediction by Supervised Principal Components
inferredcites →https://doi.org/10.1200/jco.2007.25.18_suppl.2507openalex-snapshot
Diurnal rhythms (DR) in gene expression in human oral mucosa: Implications for gender differences in toxicity, response and survival and optimal timing of targeted therapy (Rx)
inferredcites →https://doi.org/10.1371/journal.pbio.1001442openalex-snapshot
Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles
inferredcites →https://doi.org/10.1371/journal.pbio.1001840openalex-snapshot
Machine Learning Helps Identify CHRONO as a Circadian Clock Component
inferredcites →https://doi.org/10.1371/journal.pbio.2002940openalex-snapshot
The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
inferredcites →https://doi.org/10.1371/journal.pcbi.1002240openalex-snapshot
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome
inferredcites →https://doi.org/10.1371/journal.pcbi.1002309openalex-snapshot
Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
inferredcites →https://doi.org/10.1371/journal.pcbi.1005659openalex-snapshot
OpenMM 7: Rapid development of high performance algorithms for molecular dynamics
inferredcites →https://doi.org/10.1371/journal.pcbi.1005676openalex-snapshot
Long-time analytic approximation of large stochastic oscillators: Simulation, analysis and inference
inferredcites →https://doi.org/10.1371/journal.pgen.1000442openalex-snapshot
Harmonics of Circadian Gene Transcription in Mammals
inferredcites →https://doi.org/10.1371/journal.pone.0037150openalex-snapshot
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
inferredcites →https://doi.org/10.15252/msb.20145218openalex-snapshot
Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
inferredcites →https://doi.org/10.18632/oncotarget.16358openalex-snapshot
Transcriptome analysis reveals differentially expressed lncRNAs between oral squamous cell carcinoma and healthy oral mucosa
inferredcites →https://doi.org/10.3389/fpls.2014.00394openalex-snapshot
Elucidating gene function and function evolution through comparison of co-expression networks of plants
inferredcites →https://doi.org/10.3389/fpls.2014.00564openalex-snapshot
Stochastic models of cellular circadian rhythms in plants help to understand the impact of noise on robustness and clock structure
inferredcites →https://doi.org/10.4161/15384101.2014.954454openalex-snapshot
Loss of circadian clock gene expression is associated with tumor progression in breast cancer
inferredcites →https://doi.org/10.6084/m9.figshare.3756375.v1openalex-snapshot
Reproducible results for: Machine learning identifies a compact gene set for monitoring the circadian clock in human blood (Hughey 2017)
inferredcites →https://doi.org/10.7554/elife.20010openalex-snapshot
Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development
inferredcites →https://doi.org/10.7554/elife.20214openalex-snapshot
Blood transcriptome based biomarkers for human circadian phase
inferredcites →https://doi.org/10.7717/peerj.4327openalex-snapshot
Evidence for widespread dysregulation of circadian clock progression in human cancer
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/978-3-031-63657-8_2openalex-snapshot
Misalignment of Circadian Rhythms in Diet-Induced Obesity
inferred← citeshttps://doi.org/10.1007/s00109-021-02106-xopenalex-snapshot
Exploring the link between chronobiology and drug delivery: effects on cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ceb.2020.07.003openalex-snapshot
Circadian clock effects on cellular proliferation: Insights from theory and experiments
inferred← citeshttps://doi.org/10.1016/j.coisb.2020.07.007openalex-snapshot
Wearable technology and systems modeling for personalized chronotherapy
inferred← citeshttps://doi.org/10.1016/j.csbj.2021.08.051openalex-snapshot
A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.smrv.2024.102031openalex-snapshot
Circadian immunometabolism: A future insight for targeted therapy in cancer
inferred← citeshttps://doi.org/10.1038/s41416-024-02704-9openalex-snapshot
Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
inferred← citeshttps://doi.org/10.1038/s41467-020-16890-6openalex-snapshot
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
inferred← citeshttps://doi.org/10.1073/pnas.1916118116openalex-snapshot
Emerging science of chronotherapy offers big opportunities to optimize drug delivery
inferred← citeshttps://doi.org/10.1080/14728222.2022.2029410openalex-snapshot
GDF15: a potential therapeutic target for type 1 diabetes
inferred← citeshttps://doi.org/10.1111/apha.14028openalex-snapshot
Detecting and exploiting the circadian clock in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-051920-095416openalex-snapshot
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
inferred← citeshttps://doi.org/10.1172/jci.insight.164767openalex-snapshot
Chemotherapy delivery time affects treatment outcomes of female patients with diffuse large B cell lymphoma
inferred← citeshttps://doi.org/10.1177/0748730420940483openalex-snapshot
Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review
inferred← citeshttps://doi.org/10.1186/s13046-021-01919-5openalex-snapshot
The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics
inferred← citeshttps://doi.org/10.12688/f1000research.26759.1openalex-snapshot
How to tell time: advances in decoding circadian phase from omics snapshots
inferred← citeshttps://doi.org/10.1530/erc-20-0475openalex-snapshot
Cancer clocks in tumourigenesis: the p53 pathway and beyond
inferred← citeshttps://doi.org/10.3389/fonc.2023.1269378openalex-snapshot
Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment
inferred← citeshttps://doi.org/10.3390/cancers12113103openalex-snapshot
An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling
inferred← citeshttps://doi.org/10.70675/5488e904z57a3z4fd6z83d2z795ca0557b09openalex-snapshot
On learning mechanistic models from time series data with applications to personalised chronotherapies
inferred← citeshttps://doi.org/10.70675/a6793073zd42dz4dacz843azd9606734d152openalex-snapshot
Role of the bone microenvironment in systemic breast cancer growth and metastasis
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