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Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Radiation chronotherapy—clinical impact of treatment time-of-day: a systematic review
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The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm
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The Suprachiasmatic Nucleus and the Circadian Timing System
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The circadian system and the balance of the autonomic nervous system
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Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep–wake rhythm disorders
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Defining the Independence of the Liver Circadian Clock
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Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice
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Medicine in the Fourth Dimension
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The Circadian Clock and Human Health
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Bedtime Chronotherapy with Conventional Hypertension Medications to Target Increased Asleep Blood Pressure Results in Markedly Better Chronoprevention of Cardiovascular and Other Risks than Customary On-awakening Therapy
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Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets
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Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker
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Circadian system, sleep and endocrinology
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Circadian regulation of glucose, lipid, and energy metabolism in humans
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Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome
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Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO)
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Why the dim light melatonin onset (DLMO) should be measured before treatment of patients with circadian rhythm sleep disorders
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Circadian System and Glucose Metabolism: Implications for Physiology and Disease
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Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
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Tasimelteon for non-24-hour sleep–wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials
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Circadian rhythm and epilepsy
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Association between circadian rhythms and neurodegenerative diseases
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Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank
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Light-induced suppression of endogenous circadian amplitude in humans
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Dose-response relationships for resetting of human circadian clock by light
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Rhythms of life: circadian disruption and brain disorders across the lifespan
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Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis
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Application of a Limit-Cycle Oscillator Model for Prediction of Circadian Phase in Rotating Night Shift Workers
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Generalizability of A Neural Network Model for Circadian Phase Prediction in Real-World Conditions
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Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure
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The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing: a modeling approach
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Exposure to Bright Light and Darkness to Treat Physiologic Maladaptation to Night Work
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Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles
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Homer1a is a core brain molecular correlate of sleep loss
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Measurement of internal body time by blood metabolomics
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Sex difference in the near-24-hour intrinsic period of the human circadian timing system
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The human circadian metabolome
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Human blood metabolite timetable indicates internal body time
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Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
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Mistimed sleep disrupts circadian regulation of the human transcriptome
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Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
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Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
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Universal method for robust detection of circadian state from gene expression
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Population-level rhythms in human skin with implications for circadian medicine
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Universal and robust assessment of circadian time?
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Reply to Laing et al.: Accurate prediction of circadian time across platforms
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High sensitivity and interindividual variability in the response of the human circadian system to evening light
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Sleep–wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex
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Circadian Rhythms and Masking: An Overview
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Correcting for Optimistic Prediction in Small Data Sets
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Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders
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Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm
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Identifying and validating blood mRNA biomarkers for acute and chronic insufficient sleep in humans: a machine learning approach
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Assessment of circadian rhythms in humans: comparison of real‐time fibroblast reporter imaging with plasma melatonin
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TimeTeller: a New Tool for Precision Circadian Medicine and Cancer Prognosis
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Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
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Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory
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How sleep and wakefulness influence circadian rhythmicity: effects of insufficient and mistimed sleep on the animal and human transcriptome
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Home dim light melatonin onsets with measures of compliance in delayed sleep phase disorder
inferredcites →https://doi.org/10.1111/jsr.12521openalex-snapshot
Sex and ancestry determine the free‐running circadian period
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Phase‐shifting human circadian rhythms: influence of sleep timing, social contact and light exposure.
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Human responses to bright light of different durations
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Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker
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Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker
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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
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What evidence do we need for biomarker qualification?
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Central and Peripheral Circadian Clocks in Mammals
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Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans
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Mathematical model of the human circadian system with two interacting oscillators
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Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men
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Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period
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Functional link between distal vasodilation and sleep-onset latency?
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Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity
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Cancer and the Circadian Clock
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High-accuracy determination of internal circadian time from a single blood sample
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Role of the circadian system in cardiovascular disease
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Getting Through to Circadian Oscillators: Why Use Constant Routines?
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Comparisons of the Variability of Three Markers of the Human Circadian Pacemaker
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Sleep Processes Exert a Predominant Influence on the 24-h Profile of Heart Rate Variability
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The Effects of Low-Dose 0.5-mg Melatonin on the Free-Running Circadian Rhythms of Blind Subjects
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Intrinsic Period and Light Intensity Determine the Phase Relationship between Melatonin and Sleep in Humans
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Entrainment of the Human Circadian System by Light
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Estimation of Human Circadian Phase via a Multi-Channel Ambulatory Monitoring System and a Multiple Regression Model
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Human Circadian Phase Estimation from Signals Collected in Ambulatory Conditions Using an Autoregressive Model
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Circadian Melatonin and Temperature Taus in Delayed Sleep-wake Phase Disorder and Non-24-hour Sleep-wake Rhythm Disorder Patients
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Daily Light Exposure Patterns Reveal Phase and Period of the Human Circadian Clock
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Revised Limit Cycle Oscillator Model of Human Circadian Pacemaker
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The Endogenous Melatonin Profile as a Marker for Circadian Phase Position
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Linear Demasking Techniques Are Unreliable for Estimating the Circadian Phase of Ambulatory Temperature Data
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Relationship of Endogenous Circadian Melatonin and Temperature Rhythms to Self-Reported Preference for Morning or Evening Activity in Young and Older People
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Diurnal oscillation of CSF Aβ and other AD biomarkers
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Machine learning identifies a compact gene set for monitoring the circadian clock in human blood
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The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
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The Physiological Period Length of the Human Circadian Clock In Vivo Is Directly Proportional to Period in Human Fibroblasts
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Amplitude Reduction and Phase Shifts of Melatonin, Cortisol and Other Circadian Rhythms after a Gradual Advance of Sleep and Light Exposure in Humans
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Human Chronotypes from a Theoretical Perspective
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Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
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The interrelationship between sleep regulation and thermoregulation
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Identification of Human Plasma Metabolites Exhibiting Time-of-Day Variation Using an Untargeted Liquid Chromatography–Mass Spectrometry Metabolomic Approach
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An Improved Method for Estimating Human Circadian Phase Derived From Multichannel Ambulatory Monitoring and Artificial Neural Networks
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The hockey-stick method to estimate evening dim light melatonin onset (DLMO) in humans
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Circadian rhythms – from genes to physiology and disease
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Blood-Gene Expression Reveals Reduced Circadian Rhythmicity in Individuals Resistant to Sleep Deprivation
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Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health
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Blood transcriptome based biomarkers for human circadian phase
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Evidence for widespread dysregulation of circadian clock progression in human cancer
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1016/j.spen.2023.101091openalex-snapshot
Current Considerations in the Diagnosis and Treatment of Circadian Rhythm Sleep-Wake Disorders in Children
inferred← citeshttps://doi.org/10.1016/j.tsep.2022.101470openalex-snapshot
An innovative fan control strategy aimed at responding to human physiological characteristics for comfort sleeping
inferred← citeshttps://doi.org/10.1016/j.yfrne.2022.100978openalex-snapshot
Timing is everything: Circadian rhythms and their role in the control of sleep
inferred← citeshttps://doi.org/10.1016/s0140-6736(22)00877-7openalex-snapshot
Circadian rhythms and disorders of the timing of sleep
inferred← citeshttps://doi.org/10.1021/acs.est.4c12466openalex-snapshot
Pattern Recognition-Driven Detection of Circadian-Disruptive Compounds from Gene Expressions: High-Throughput Screening and Experimental Verification
inferred← citeshttps://doi.org/10.1038/s41531-025-01009-9openalex-snapshot
Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy
inferred← citeshttps://doi.org/10.1038/s41596-022-00746-yopenalex-snapshot
Desynchronizing the sleep–wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period
inferred← citeshttps://doi.org/10.1038/s41598-021-94522-9openalex-snapshot
Data-driven modelling approach to circadian temperature rhythm profiles in free-living conditions
inferred← citeshttps://doi.org/10.1038/s41598-024-67297-yopenalex-snapshot
Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans
inferred← citeshttps://doi.org/10.1038/s41746-023-00865-0openalex-snapshot
CARE as a wearable derived feature linking circadian amplitude to human cognitive functions
inferred← citeshttps://doi.org/10.1038/s41746-024-01404-1openalex-snapshot
A novel sweat sensor detects inflammatory differential rhythmicity patterns in inpatients and outpatients with cirrhosis
inferred← citeshttps://doi.org/10.1038/s44323-025-00039-zopenalex-snapshot
The complexity and commonness of the two-process model of sleep regulation from a mathematical perspective
inferred← citeshttps://doi.org/10.1039/bk9781839167553-00536openalex-snapshot
Chronotherapeutic Approaches
inferred← citeshttps://doi.org/10.1039/bk9781839167553-00579openalex-snapshot
Chronobiological Study Designs
inferred← citeshttps://doi.org/10.1042/cs20220061openalex-snapshot
Circadian regulation of pulmonary disease: the importance of timing
inferred← citeshttps://doi.org/10.1073/pnas.2214756121openalex-snapshot
The sleep–circadian interface: A window into mental disorders
inferred← citeshttps://doi.org/10.1073/pnas.2514928123openalex-snapshot
HairTime: A noninvasive assay for estimating circadian phase from a single hair sample
inferred← citeshttps://doi.org/10.1080/07420528.2024.2305218openalex-snapshot
Administration of blue light in the morning and no blue-ray light in the evening improves the circadian functions of non-24-hour shift workers
inferred← citeshttps://doi.org/10.1080/07420528.2025.2546008openalex-snapshot
Multi-pulse chronotherapeutic approaches for circadian rhythm disease management
inferred← citeshttps://doi.org/10.1080/07420528.2026.2696432openalex-snapshot
Circadian rhythms in the wild: Skin temperature versus actimetry for short-term field assessment in varying sleep conditions
inferred← citeshttps://doi.org/10.1080/09291016.2025.2541247openalex-snapshot
Circadian rhythms and human studies: methodology, challenges, and future directions in research
inferred← citeshttps://doi.org/10.1093/nargab/lqac097openalex-snapshot
Inter-layer and inter-subject variability of diurnal gene expression in human skin
inferred← citeshttps://doi.org/10.1093/schbul/sbab124openalex-snapshot
Extracting Circadian and Sleep Parameters from Longitudinal Data in Schizophrenia for the Design of Pragmatic Light Interventions
inferred← citeshttps://doi.org/10.1093/sleep/zsaa281openalex-snapshot
Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities
inferred← citeshttps://doi.org/10.1093/sleep/zsac272openalex-snapshot
The circadian variation of sleep and alertness of postmenopausal women
inferred← citeshttps://doi.org/10.1093/sleep/zsad033openalex-snapshot
The dim light melatonin onset across ages, methodologies, and sex and its relationship with morningness/eveningness
inferred← citeshttps://doi.org/10.1093/sleep/zsae066openalex-snapshot
Circadian photoentrainment varies by season and depressed state: associations between light sensitivity and sleep and circadian timing
inferred← citeshttps://doi.org/10.1101/2021.08.13.456271openalex-snapshot
Overlap of expression and alignment of diurnal and circadian rhythmicity in the human blood transcriptome with organ and tissue specific rhythmicity in a non-human primate
inferred← citeshttps://doi.org/10.1101/2022.06.03.494693openalex-snapshot
Inter-layer and inter-subject variability of circadian gene expression in human skin
inferred← citeshttps://doi.org/10.1101/2023.04.06.23288232openalex-snapshot
CARE: a novel wearable-derived feature linking circadian amplitude to human cognitive functions
inferred← citeshttps://doi.org/10.1101/2024.09.30.615784openalex-snapshot
Irregular light schedules induce alterations on daily rhythms and gene expression in mice
inferred← citeshttps://doi.org/10.1101/2025.09.14.676090openalex-snapshot
Beyond circadian: a yearlong prospective cohort study into human sleep using subcutaneously implanted electroencephalography
inferred← citeshttps://doi.org/10.1111/apha.13915openalex-snapshot
The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1111/apha.13951openalex-snapshot
Data integration and analysis for circadian medicine
inferred← citeshttps://doi.org/10.1111/fcp.12659openalex-snapshot
Can chronopharmacology improve the therapeutic management of neurological diseases?
inferred← citeshttps://doi.org/10.1111/jne.13144openalex-snapshot
Misaligned hormonal rhythmicity: Mechanisms of origin and their clinical significance
inferred← citeshttps://doi.org/10.1111/jpi.12745openalex-snapshot
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data
inferred← citeshttps://doi.org/10.1111/jpi.70075openalex-snapshot
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice
inferred← citeshttps://doi.org/10.1111/jsr.13976openalex-snapshot
Circadian aspects in the aetiology and pathophysiology of insomnia
inferred← citeshttps://doi.org/10.1111/jsr.14219openalex-snapshot
Dampened circadian amplitude of EEG power in women after menopause
inferred← citeshttps://doi.org/10.1111/jsr.70011openalex-snapshot
Stuck in time: The slow march of circadian medicine and how to speed it up
inferred← citeshttps://doi.org/10.1161/hypertensionaha.120.16545openalex-snapshot
Two-Year Responses of Heart Rate and Heart Rate Variability to First Occupational Lead Exposure
inferred← citeshttps://doi.org/10.1164/rccm.202301-0184stopenalex-snapshot
Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement
inferred← citeshttps://doi.org/10.1172/jci162775openalex-snapshot
ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
inferred← citeshttps://doi.org/10.1177/0748730420962598openalex-snapshot
The Role of Light Sensitivity and Intrinsic Circadian Period in Predicting Individual Circadian Timing
inferred← citeshttps://doi.org/10.1177/07487304211025402openalex-snapshot
Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans
inferred← citeshttps://doi.org/10.1177/07487304231215844openalex-snapshot
Mathematical Analysis of Light-sensitivity Related Challenges in Assessment of the Intrinsic Period of the Human Circadian Pacemaker
inferred← citeshttps://doi.org/10.1177/07487304251358950openalex-snapshot
Performance of Blood-Based Biomarkers for Human Circadian Pacemaker Phase: Training Sets Matter As Much As Feature-Selection Methods
inferred← citeshttps://doi.org/10.1177/07487304261487544openalex-snapshot
Characterization of 24-Hour Rhythms in Vital Signs in Intensive Care Populations: A Scoping Review
inferred← citeshttps://doi.org/10.1177/09727531261473463openalex-snapshot
Decoding of Nocturnal Fasting and Health: Possible Role of Zeitgebers and Melatonin
inferred← citeshttps://doi.org/10.1177/15347354221123525openalex-snapshot
Holistic Needs Assessment of Cancer Survivors—Supporting the Process Through Digital Monitoring of Circadian Physiology
inferred← citeshttps://doi.org/10.1177/20552076241288724openalex-snapshot
Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers
inferred← citeshttps://doi.org/10.1186/s12915-022-01258-7openalex-snapshot
Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate
inferred← citeshttps://doi.org/10.1186/s40798-026-01067-0openalex-snapshot
Home-Court Advantage and the Associations of Travel and Jet Lag with Team Performance in the Women’s National Basketball Association (WNBA)
inferred← citeshttps://doi.org/10.12688/f1000research.127234.1openalex-snapshot
Different levels of circadian (de)synchrony – where does it hurt?
inferred← citeshttps://doi.org/10.1371/journal.pbio.3003196openalex-snapshot
Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo
inferred← citeshttps://doi.org/10.1371/journal.pdig.0000511openalex-snapshot
Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges
inferred← citeshttps://doi.org/10.17721/1728_2748.2020.83.17-23openalex-snapshot
Morpho-functional state of rats pineal gland and suprachismatic nucleus of hypothalamus after different regimes of exogenous melatonin administration
inferred← citeshttps://doi.org/10.2139/ssrn.5066198openalex-snapshot
Irregular Light Schedules Disrupt Daily Rhythms and Dysregulate Genes Involved in Neuroplasticity, Motivation, and Stress Responses
inferred← citeshttps://doi.org/10.2139/ssrn.7122705openalex-snapshot
An adaptive split-combine Gaussian mixture filter for nonlinear and multimodal state estimation
inferred← citeshttps://doi.org/10.2174/0115672050381989250626071304openalex-snapshot
Mapping the Connection Between Circadian Rhythms, Metabolism, and Neurodegeneration: Exploring Therapeutic Strategies
inferred← citeshttps://doi.org/10.2196/51540openalex-snapshot
Investigating Rhythmicity in App Usage to Predict Depressive Symptoms: Protocol for Personalized Framework Development and Validation Through a Countrywide Study
inferred← citeshttps://doi.org/10.3389/fimmu.2022.977525openalex-snapshot
Chronovaccination: Harnessing circadian rhythms to optimize immunisation strategies
inferred← citeshttps://doi.org/10.3389/fnagi.2026.1863929openalex-snapshot
Exercise and neural circuit stability in early Alzheimer’s disease: evidence across memory, executive, cholinergic, and circadian systems
inferred← citeshttps://doi.org/10.3389/fnins.2024.1421026openalex-snapshot
Inclusion, reporting and analysis of demographic variables in chronobiology and sleep research
inferred← citeshttps://doi.org/10.3389/fonc.2023.1269378openalex-snapshot
Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment
inferred← citeshttps://doi.org/10.3389/fpsyt.2020.569864openalex-snapshot
DAILY—A Personalized Circadian Zeitgeber Therapy as an Adjunctive Treatment for Alcohol Use Disorder Patients: Study Protocol for a Randomized Controlled Trial
inferred← citeshttps://doi.org/10.3389/frsle.2025.1537997openalex-snapshot
Investigating the impact of sleep quality on cognitive functions among students in Tokyo, Japan, and London, UK
inferred← citeshttps://doi.org/10.3390/cancers17050732openalex-snapshot
Personalization of Cancer Treatment: Exploring the Role of Chronotherapy in Immune Checkpoint Inhibitor Efficacy
inferred← citeshttps://doi.org/10.3390/clockssleep6010010openalex-snapshot
A Protocol for Evaluating Digital Technology for Monitoring Sleep and Circadian Rhythms in Older People and People Living with Dementia in the Community
inferred← citeshttps://doi.org/10.3390/clockssleep7040063openalex-snapshot
The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review
inferred← citeshttps://doi.org/10.3390/diagnostics15030327openalex-snapshot
Wearables in Chronomedicine and Interpretation of Circadian Health
inferred← citeshttps://doi.org/10.3390/ijerph20010764openalex-snapshot
Integrative Analysis of Rhythmicity: From Biology to Urban Environments and Sustainability
inferred← citeshttps://doi.org/10.3390/ijms22147370openalex-snapshot
Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy
inferred← citeshttps://doi.org/10.3390/ijms23031331openalex-snapshot
Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology
inferred← citeshttps://doi.org/10.3390/ijms24010860openalex-snapshot
Multiplatform-Integrated Identification of Melatonin Targets for a Triad of Psychosocial-Sleep/Circadian-Cardiometabolic Disorders
inferred← citeshttps://doi.org/10.5664/jcsm.11650openalex-snapshot
The relationship between sleep and circadian-sleep phase angles based on dim light melatonin onset predicted from light and activity data
inferred← citeshttps://doi.org/10.6084/m9.figshare.19335926openalex-snapshot
Additional file 8 of Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate
inferred← citeshttps://doi.org/10.64898/2026.07.30.741635openalex-snapshot
Short-term, Long-term, and Genetic Determinants of Human Plasma Proteome Variability
inferred← citeshttps://doi.org/10.7554/elife.65419openalex-snapshot
Sex differences and sex bias in human circadian and sleep physiology research
inferred← citeshttps://doi.org/10.9758/cpn.2023.21.2.279openalex-snapshot
Machine Learning Algorithms for the Prediction of Locomotor Activity by an Infrared Motion Detector on the Sleep-wake States in Mice
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