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Missense mutations in the MLKL ‘brace’ region lead to lethal neonatal inflammation in mice and are present in high frequency in humans

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471142905.hg0720s76openalex-snapshot

Predicting Functional Effect of Human Missense Mutations Using PolyPhen‐2

inferredcites →https://doi.org/10.1002/humu.22932openalex-snapshot

dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs

inferredcites →https://doi.org/10.1016/0092-8674(95)90490-5openalex-snapshot

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

inferredcites →https://doi.org/10.1016/b978-0-12-595961-2.x5000-8openalex-snapshot

The Autoimmune Diseases

inferredcites →https://doi.org/10.1016/j.ccell.2016.06.002openalex-snapshot

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

inferredcites →https://doi.org/10.1016/j.cell.2011.11.031openalex-snapshot

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

inferredcites →https://doi.org/10.1016/j.cell.2013.04.025openalex-snapshot

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

inferredcites →https://doi.org/10.1016/j.cell.2014.04.018openalex-snapshot

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

inferredcites →https://doi.org/10.1016/j.cell.2014.04.019openalex-snapshot

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

inferredcites →https://doi.org/10.1016/j.cell.2017.03.020openalex-snapshot

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

inferredcites →https://doi.org/10.1016/j.celrep.2014.04.026openalex-snapshot

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

inferredcites →https://doi.org/10.1016/j.immuni.2013.06.018openalex-snapshot

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

inferredcites →https://doi.org/10.1016/j.immuni.2016.07.016openalex-snapshot

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

inferredcites →https://doi.org/10.1016/j.immuni.2017.06.001openalex-snapshot

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

inferredcites →https://doi.org/10.1016/j.jid.2017.05.031openalex-snapshot

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

inferredcites →https://doi.org/10.1016/j.jneuroim.2018.07.016openalex-snapshot

Genome-wide association study in Guillain-Barré syndrome

inferredcites →https://doi.org/10.1016/j.molcel.2016.01.011openalex-snapshot

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

inferredcites →https://doi.org/10.1016/j.molcel.2018.05.010openalex-snapshot

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2018.03.006openalex-snapshot

A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population

inferredcites →https://doi.org/10.1016/j.stem.2013.05.014openalex-snapshot

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

inferredcites →https://doi.org/10.1016/j.str.2014.07.014openalex-snapshot

A Plug Release Mechanism for Membrane Permeation by MLKL

inferredcites →https://doi.org/10.1016/s1074-7613(00)80535-xopenalex-snapshot

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

inferredcites →https://doi.org/10.1016/s1074-7613(00)80596-8openalex-snapshot

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

inferredcites →https://doi.org/10.1016/s1074-7613(00)80609-3openalex-snapshot

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

inferredcites →https://doi.org/10.1017/s0016672319000065openalex-snapshot

In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth.

inferredcites →https://doi.org/10.1038/cdd.2015.169openalex-snapshot

Evolutionary divergence of the necroptosis effector MLKL

inferredcites →https://doi.org/10.1038/cdd.2015.70openalex-snapshot

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

inferredcites →https://doi.org/10.1038/cdd.2016.147openalex-snapshot

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

inferredcites →https://doi.org/10.1038/cdd.2016.46openalex-snapshot

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

inferredcites →https://doi.org/10.1038/cddis.2015.386openalex-snapshot

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

inferredcites →https://doi.org/10.1038/cr.2013.171openalex-snapshot

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

inferredcites →https://doi.org/10.1038/cr.2013.91openalex-snapshot

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

inferredcites →https://doi.org/10.1038/icb.2016.120openalex-snapshot

Relevance of necroptosis in cancer

inferredcites →https://doi.org/10.1038/jhg.2015.94openalex-snapshot

Genetics of autoimmune diseases: insights from population genetics

inferredcites →https://doi.org/10.1038/nature09852openalex-snapshot

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

inferredcites →https://doi.org/10.1038/nature09857openalex-snapshot

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

inferredcites →https://doi.org/10.1038/nature09878openalex-snapshot

Functional complementation between FADD and RIP1 in embryos and lymphocytes

inferredcites →https://doi.org/10.1038/nature13608openalex-snapshot

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot

A global reference for human genetic variation

inferredcites →https://doi.org/10.1038/nature19057openalex-snapshot

Analysis of protein-coding genetic variation in 60,706 humans

inferredcites →https://doi.org/10.1038/ncb2883openalex-snapshot

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

inferredcites →https://doi.org/10.1038/ng.2924openalex-snapshot

Ancestry estimation and control of population stratification for sequence-based association studies

inferredcites →https://doi.org/10.1038/nrg.2015.33openalex-snapshot

Autoimmune diseases — connecting risk alleles with molecular traits of the immune system

inferredcites →https://doi.org/10.1038/nrg3734openalex-snapshot

Natural selection and infectious disease in human populations

inferredcites →https://doi.org/10.1038/s41418-018-0061-3openalex-snapshot

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

inferredcites →https://doi.org/10.1038/s41467-018-04714-7openalex-snapshot

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

inferredcites →https://doi.org/10.1038/s41467-018-06985-6openalex-snapshot

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

inferredcites →https://doi.org/10.1042/bsr20150246openalex-snapshot

Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death

inferredcites →https://doi.org/10.1073/pnas.1200012109openalex-snapshot

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

inferredcites →https://doi.org/10.1073/pnas.1301218110openalex-snapshot

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

inferredcites →https://doi.org/10.1073/pnas.1401857111openalex-snapshot

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

inferredcites →https://doi.org/10.1073/pnas.1408987111openalex-snapshot

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

inferredcites →https://doi.org/10.1073/pnas.1813582116openalex-snapshot

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

inferredcites →https://doi.org/10.1073/pnas.92.24.11284openalex-snapshot

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

inferredcites →https://doi.org/10.1074/jbc.ra117.001068openalex-snapshot

The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine

inferredcites →https://doi.org/10.1093/emboj/17.3.706openalex-snapshot

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

inferredcites →https://doi.org/10.1093/nar/gks1215openalex-snapshot

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

inferredcites →https://doi.org/10.1093/nar/gks539openalex-snapshot

SIFT web server: predicting effects of amino acid substitutions on proteins

inferredcites →https://doi.org/10.1101/gr.107524.110openalex-snapshot

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

inferredcites →https://doi.org/10.1101/gr.226589.117openalex-snapshot

Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation

inferredcites →https://doi.org/10.1111/febs.12419openalex-snapshot

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor

inferredcites →https://doi.org/10.1126/science.279.5358.1954openalex-snapshot

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

inferredcites →https://doi.org/10.1126/science.7535475openalex-snapshot

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

inferredcites →https://doi.org/10.1126/science.aar2641openalex-snapshot

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

inferredcites →https://doi.org/10.1128/mcb.24.4.1464-1469.2004openalex-snapshot

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

inferredcites →https://doi.org/10.1146/annurev-biochem-060815-014830openalex-snapshot

Necroptosis and Inflammation

inferredcites →https://doi.org/10.1182/blood-2007-10-119677openalex-snapshot

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl−/− mice

inferredcites →https://doi.org/10.1371/journal.pbio.2002711openalex-snapshot

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

inferredcites →https://doi.org/10.1371/journal.pone.0169687openalex-snapshot

Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO)

inferredcites →https://doi.org/10.18632/oncotarget.7924openalex-snapshot

Key roles of necroptotic factors in promoting tumor growth

inferredcites →https://doi.org/10.4049/jimmunol.160.2.943openalex-snapshot

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

inferredcites →https://doi.org/10.4049/jimmunol.173.5.2976openalex-snapshot

Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles

inferredcites →https://doi.org/10.4049/jimmunol.175.6.3469openalex-snapshot

Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8

inferredcites →https://doi.org/10.4161/fly.19695openalex-snapshot

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

inferredcites →https://doi.org/10.7554/elife.03464openalex-snapshot

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.fitote.2023.105652openalex-snapshot

Cocktail of three isoquinoline alkaloids derived from Glaucium grandiflorum Boiss. & A. Huet subsp. refractum (Nábelek) Mory inhibits the production of LPS-induced ROS, pro-inflammatory cytokines, and mediators through the down-regulation of p38 MAPK in BV-2 cells

inferred← citeshttps://doi.org/10.1038/s41418-021-00811-1openalex-snapshot

MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF

inferred← citeshttps://doi.org/10.1073/pnas.1919960117openalex-snapshot

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

inferred← citeshttps://doi.org/10.1101/cshperspect.a036376openalex-snapshot

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)

inferred← citeshttps://doi.org/10.1186/s12964-019-0437-0openalex-snapshot

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

inferred← citeshttps://doi.org/10.70675/94f28bbaz6c2dz4b48zb1aaze6b48ca72708openalex-snapshot

La nécroptose : une nouvelle cible thérapeutique dans la stéatohépatite non-alcoolique

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