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The genomic architecture of blood metabolites based on a decade of genome-wide analyses
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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MaCH‐Admix: Genotype Imputation for Admixed Populations
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Robust variance estimation in meta‐regression with dependent effect size estimates
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Modern Applied Statistics with S
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Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height
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Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics
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Targeted metabolomics profiles are strongly correlated with nutritional patterns in women
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GCTA: A Tool for Genome-wide Complex Trait Analysis
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Improved Heritability Estimation from Genome-wide SNPs
inferredcites →https://doi.org/10.1016/j.cmet.2013.06.013openalex-snapshot
A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
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Metabolomics and Metabolic Diseases: Where Do We Stand?
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Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies
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Familial resemblances in human plasma metabolites are attributable to both genetic and common environmental effects
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Short overview on metabolomic approach and redox changes in psychiatric disorders
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The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection
inferredcites →https://doi.org/10.1017/thg.2013.59openalex-snapshot
Familial Resemblance for Serum Metabolite Concentrations
inferredcites →https://doi.org/10.1021/ac404191aopenalex-snapshot
Integrating Metabolomics Profiling Measurements Across Multiple Biobanks
inferredcites →https://doi.org/10.1021/cr300484sopenalex-snapshot
New Advances in Separation Science for Metabolomics: Resolving Chemical Diversity in a Post-Genomic Era
inferredcites →https://doi.org/10.1038/ejhg.2013.118openalex-snapshot
The Genome of the Netherlands: design, and project goals
inferredcites →https://doi.org/10.1038/ejhg.2013.48openalex-snapshot
Population structure, migration, and diversifying selection in the Netherlands
inferredcites →https://doi.org/10.1038/ejhg.2014.19openalex-snapshot
Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands’
inferredcites →https://doi.org/10.1038/msb.2009.11openalex-snapshot
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
inferredcites →https://doi.org/10.1038/msb.2011.57openalex-snapshot
Human metabolic profiles are stably controlled by genetic and environmental variation
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/ncomms11122openalex-snapshot
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
inferredcites →https://doi.org/10.1038/ncomms8208openalex-snapshot
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
inferredcites →https://doi.org/10.1038/ng.1073openalex-snapshot
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
inferredcites →https://doi.org/10.1038/ng.3390openalex-snapshot
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
inferredcites →https://doi.org/10.1038/ng.3571openalex-snapshot
Fast and accurate long-range phasing in a UK Biobank cohort
inferredcites →https://doi.org/10.1038/ng.3656openalex-snapshot
Next-generation genotype imputation service and methods
inferredcites →https://doi.org/10.1038/ng.3865openalex-snapshot
Reevaluation of SNP heritability in complex human traits
inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot
Principal components analysis corrects for stratification in genome-wide association studies
inferredcites →https://doi.org/10.1038/nmeth.1785openalex-snapshot
A linear complexity phasing method for thousands of genomes
inferredcites →https://doi.org/10.1038/nrm3314openalex-snapshot
Metabolomics: the apogee of the omics trilogy
inferredcites →https://doi.org/10.1038/s41467-017-01972-9openalex-snapshot
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
inferredcites →https://doi.org/10.1038/s41467-018-02974-xopenalex-snapshot
No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird
inferredcites →https://doi.org/10.1038/s41467-019-08936-1openalex-snapshot
Assessing the causal association of glycine with risk of cardio-metabolic diseases
inferredcites →https://doi.org/10.1038/s41467-019-09078-0openalex-snapshot
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
inferredcites →https://doi.org/10.1038/s41467-019-12703-7openalex-snapshot
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context
inferredcites →https://doi.org/10.1038/s41588-021-00997-7openalex-snapshot
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
inferredcites →https://doi.org/10.1038/s41598-017-03965-6openalex-snapshot
Heritability and responses to high fat diet of plasma lipidomics in a twin study
inferredcites →https://doi.org/10.1038/srep41926openalex-snapshot
Limb proportions show developmental plasticity in response to embryo movement
inferredcites →https://doi.org/10.1053/j.ajkd.2012.01.014openalex-snapshot
Serum Metabolite Concentrations and Decreased GFR in the General Population
inferredcites →https://doi.org/10.1073/pnas.1119675109openalex-snapshot
The mystery of missing heritability: Genetic interactions create phantom heritability
inferredcites →https://doi.org/10.1073/pnas.1603023113openalex-snapshot
Individual variability in human blood metabolites identifies age-related differences
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/aje/kwx016openalex-snapshot
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Large-Scale Epidemiology: A Primer on -Omic Technologies
inferredcites →https://doi.org/10.1093/aje/kwx024openalex-snapshot
Skin Pigmentation and Risk of Hearing Loss in Women
inferredcites →https://doi.org/10.1093/bioinformatics/btq559openalex-snapshot
Robust relationship inference in genome-wide association studies
inferredcites →https://doi.org/10.1093/hmg/ddr581openalex-snapshot
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci
inferredcites →https://doi.org/10.1093/hmg/ddv263openalex-snapshot
Genetics of human metabolism: an update
inferredcites →https://doi.org/10.1093/jn/130.7.1835sopenalex-snapshot
Dispensable and Indispensable Amino Acids for Humans
inferredcites →https://doi.org/10.1093/nar/29.1.308openalex-snapshot
dbSNP: the NCBI database of genetic variation
inferredcites →https://doi.org/10.1093/nar/gkl923openalex-snapshot
HMDB: the Human Metabolome Database
inferredcites →https://doi.org/10.1093/nar/gkn810openalex-snapshot
HMDB: a knowledgebase for the human metabolome
inferredcites →https://doi.org/10.1093/nar/gks1065openalex-snapshot
HMDB 3.0—The Human Metabolome Database in 2013
inferredcites →https://doi.org/10.1093/nar/gkv1031openalex-snapshot
ChEBI in 2016: Improved services and an expanding collection of metabolites
inferredcites →https://doi.org/10.1093/nar/gkx1089openalex-snapshot
HMDB 4.0: the human metabolome database for 2018
inferredcites →https://doi.org/10.1093/nar/gky1033openalex-snapshot
PubChem 2019 update: improved access to chemical data
inferredcites →https://doi.org/10.1093/nar/gky1095openalex-snapshot
The UCSC Genome Browser database: 2019 update
inferredcites →https://doi.org/10.1101/457960openalex-snapshot
Genetics of human plasma lipidome: Understanding lipid metabolism and its link to diseases beyond traditional lipids
inferredcites →https://doi.org/10.1101/621334openalex-snapshot
Genome-wide association study of plasma triglycerides, phospholipids and relation to cardio-metabolic risk factors
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1161/circgenetics.114.000216openalex-snapshot
Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
inferredcites →https://doi.org/10.1161/circgenetics.114.000600openalex-snapshot
Human Plasma Lipidome Is Pleiotropically Associated With Cardiovascular Risk Factors and Death
inferredcites →https://doi.org/10.1186/s13321-014-0049-zopenalex-snapshot
Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
inferredcites →https://doi.org/10.1186/s13321-015-0068-4openalex-snapshot
InChI, the IUPAC International Chemical Identifier
inferredcites →https://doi.org/10.1194/jlr.m700338-jlr200openalex-snapshot
The lipoprotein subfraction profile: heritability and identification of quantitative trait loci
inferredcites →https://doi.org/10.1212/wnl.0000000000007313openalex-snapshot
Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
inferredcites →https://doi.org/10.1371/journal.pgen.1000282openalex-snapshot
Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
inferredcites →https://doi.org/10.1371/journal.pgen.1002215openalex-snapshot
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
inferredcites →https://doi.org/10.1371/journal.pgen.1004269openalex-snapshot
Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples
inferredcites →https://doi.org/10.1371/journal.pgen.1004835openalex-snapshot
Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses
inferredcites →https://doi.org/10.1371/journal.pgen.1005804openalex-snapshot
Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation
inferredcites →https://doi.org/10.1371/journal.pgen.1005944openalex-snapshot
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
inferredcites →https://doi.org/10.1371/journal.pmed.1001878openalex-snapshot
Changes in Intake of Fruits and Vegetables and Weight Change in United States Men and Women Followed for Up to 24 Years: Analysis from Three Prospective Cohort Studies
inferredcites →https://doi.org/10.1371/journal.pone.0153672openalex-snapshot
Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms
inferredcites →https://doi.org/10.1375/183242706779462426openalex-snapshot
Netherlands Twin Register: From Twins to Twin Families
inferredcites →https://doi.org/10.1375/twin.13.3.231openalex-snapshot
The Netherlands Twin Register Biobank: A Resource for Genetic Epidemiological Studies
inferredcites →https://doi.org/10.1534/genetics.115.175760openalex-snapshot
Nonadditive Effects of Genes in Human Metabolomics
inferredcites →https://doi.org/10.18637/jss.v036.i03openalex-snapshot
Conducting Meta-Analyses in R with the metafor Package
inferredcites →https://doi.org/10.18637/jss.v036.i11openalex-snapshot
Feature Selection with the Boruta Package
inferredcites →https://doi.org/10.18637/jss.v045.i03openalex-snapshot
mice: Multivariate Imputation by Chained Equations inR
inferredcites →https://doi.org/10.2307/2530561openalex-snapshot
Modification of Estimates of Parameters in the Construction of Genetic Selection Indices ('Bending')
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inferred← citeshttps://doi.org/10.1017/thg.2019.93openalex-snapshot
The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs
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