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Sustained exposure to trypsin causes cells to transition into a state of reversible stemness that is amenable to transdifferentiation
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0215(19960503)66:3<326::aid-ijc10>3.0.co;2-9openalex-snapshot
Serum trypsinogen-2 and trypsin-2-α1-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas
inferredcites →https://doi.org/10.1002/bit.26531openalex-snapshot
Computer‐assisted engineering of hyperstable fibroblast growth factor 2
inferredcites →https://doi.org/10.1002/jcb.26753openalex-snapshot
Stemness and chemoresistance are imparted to the OC cells through TGFβ1 driven EMT
inferredcites →https://doi.org/10.1002/mc.22891openalex-snapshot
Protease‐activated receptor 2 promotes actomyosin dependent transforming microvesicles generation from human breast cancer
inferredcites →https://doi.org/10.1002/sctm.16-0343openalex-snapshot
Microfluidic Screening Reveals Heparan Sulfate Enhances Human Mesenchymal Stem Cell Growth by Modulating Fibroblast Growth Factor-2 Transport
inferredcites →https://doi.org/10.1002/sctm.18-0134openalex-snapshot
Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells—Ready for Take-Off
inferredcites →https://doi.org/10.1002/sctm.18-0259openalex-snapshot
Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering
inferredcites →https://doi.org/10.1002/stem.2243openalex-snapshot
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1007/978-1-61779-191-8_12openalex-snapshot
Measuring Permeability in Human Retinal Epithelial Cells (ARPE-19): Implications for the Study of Diabetic Retinopathy
inferredcites →https://doi.org/10.1007/s12015-015-9622-8openalex-snapshot
Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies
inferredcites →https://doi.org/10.1007/s12015-018-9861-6openalex-snapshot
An Insight into DNA-free Reprogramming Approaches to Generate Integration-free Induced Pluripotent Stem Cells for Prospective Biomedical Applications
inferredcites →https://doi.org/10.1007/s13277-011-0194-1openalex-snapshot
Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620
inferredcites →https://doi.org/10.1016/0014-4800(87)90063-3openalex-snapshot
Effect of acute ozone exposure on the proteinase—Antiproteinase balance in the rat lung
inferredcites →https://doi.org/10.1016/bs.ircmb.2018.03.001openalex-snapshot
Advances in Membrane Trafficking and Endosomal Signaling of G Protein-Coupled Receptors
inferredcites →https://doi.org/10.1016/j.bbrc.2005.03.058openalex-snapshot
Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers
inferredcites →https://doi.org/10.1016/j.bbrc.2006.05.086openalex-snapshot
A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells
inferredcites →https://doi.org/10.1016/j.bbrc.2012.03.140openalex-snapshot
Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines
inferredcites →https://doi.org/10.1016/j.ceb.2005.01.003openalex-snapshot
Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes
inferredcites →https://doi.org/10.1016/j.ceb.2018.12.001openalex-snapshot
Mechanical regulation of genome architecture and cell-fate decisions
inferredcites →https://doi.org/10.1016/j.cell.2006.07.024openalex-snapshot
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
inferredcites →https://doi.org/10.1016/j.cell.2007.11.019openalex-snapshot
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
inferredcites →https://doi.org/10.1016/j.celrep.2016.02.003openalex-snapshot
NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming
inferredcites →https://doi.org/10.1016/j.celrep.2018.07.027openalex-snapshot
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
inferredcites →https://doi.org/10.1016/j.celrep.2019.03.053openalex-snapshot
PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation
inferredcites →https://doi.org/10.1016/j.cmet.2011.06.011openalex-snapshot
Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
inferredcites →https://doi.org/10.1016/j.cmet.2015.02.002openalex-snapshot
Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.gde.2017.06.008openalex-snapshot
Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development
inferredcites →https://doi.org/10.1016/j.gde.2018.06.002openalex-snapshot
Cellular trajectories and molecular mechanisms of iPSC reprogramming
inferredcites →https://doi.org/10.1016/j.gpb.2013.09.008openalex-snapshot
Integration-Free Methods for Generating Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/j.humpath.2007.12.003openalex-snapshot
The clinicopathologic and prognostic significance of CD44+/CD24−/low and CD44−/CD24+ tumor cells in invasive breast carcinomas
inferredcites →https://doi.org/10.1016/j.intimp.2018.02.022openalex-snapshot
Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C
inferredcites →https://doi.org/10.1016/j.jbiosc.2017.08.004openalex-snapshot
Effects of glucose, lactate and basic FGF as limiting factors on the expansion of human induced pluripotent stem cells
inferredcites →https://doi.org/10.1016/j.jid.2018.09.008openalex-snapshot
Targeting PAR2 with Pepducins
inferredcites →https://doi.org/10.1016/j.jmb.2014.07.012openalex-snapshot
Unconventional Secretion of Fibroblast Growth Factor 2—A Novel Type of Protein Translocation across Membranes?
inferredcites →https://doi.org/10.1016/j.pharmthera.2011.01.003openalex-snapshot
Structure, function and pathophysiology of protease activated receptors
inferredcites →https://doi.org/10.1016/j.redox.2014.04.008openalex-snapshot
Redox status in mammalian cells and stem cells during culture in vitro: Critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance
inferredcites →https://doi.org/10.1016/j.semcdb.2018.03.016openalex-snapshot
Unconventional secretion of transmembrane proteins
inferredcites →https://doi.org/10.1016/j.stem.2007.12.001openalex-snapshot
c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts
inferredcites →https://doi.org/10.1016/j.stem.2008.07.001openalex-snapshot
NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs
inferredcites →https://doi.org/10.1016/j.stem.2010.01.003openalex-snapshot
Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2010.08.012openalex-snapshot
Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
inferredcites →https://doi.org/10.1016/j.stem.2011.11.003openalex-snapshot
Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2014.07.003openalex-snapshot
The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
inferredcites →https://doi.org/10.1016/j.stem.2016.08.008openalex-snapshot
Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State
inferredcites →https://doi.org/10.1016/j.ygeno.2014.08.012openalex-snapshot
DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: An emerging complex story
inferredcites →https://doi.org/10.1016/s0024-3205(01)01519-3openalex-snapshot
Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells
inferredcites →https://doi.org/10.1016/s0070-2153(10)92012-7openalex-snapshot
Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
inferredcites →https://doi.org/10.1021/acs.jcim.5b00500openalex-snapshot
Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2
inferredcites →https://doi.org/10.1021/acsami.7b05519openalex-snapshot
Efficient Encapsulation and Sustained Release of Basic Fibroblast Growth Factor in Nanofilm: Extension of the Feeding Cycle of Human Induced Pluripotent Stem Cell Culture
inferredcites →https://doi.org/10.1021/acsmedchemlett.8b00538openalex-snapshot
Design and Evaluation of Heterobivalent PAR1–PAR2 Ligands as Antagonists of Calcium Mobilization
inferredcites →https://doi.org/10.1021/jm400638vopenalex-snapshot
Toward Drugs for Protease-Activated Receptor 2 (PAR2)
inferredcites →https://doi.org/10.1038/cddis.2016.357openalex-snapshot
PAR2 regulates regeneration, transdifferentiation, and death
inferredcites →https://doi.org/10.1038/clpt.2011.14openalex-snapshot
Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development
inferredcites →https://doi.org/10.1038/nature06534openalex-snapshot
Reprogramming of human somatic cells to pluripotency with defined factors
inferredcites →https://doi.org/10.1038/ncb2835openalex-snapshot
Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq
inferredcites →https://doi.org/10.1038/ni1525openalex-snapshot
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
inferredcites →https://doi.org/10.1038/nmeth.3142openalex-snapshot
Small molecules facilitate rapid and synchronous iPSC generation
inferredcites →https://doi.org/10.1038/nmeth744openalex-snapshot
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
inferredcites →https://doi.org/10.1038/nrd3615openalex-snapshot
Targeting proteinase-activated receptors: therapeutic potential and challenges
inferredcites →https://doi.org/10.1038/nrm.2016.8openalex-snapshot
A decade of transcription factor-mediated reprogramming to pluripotency
inferredcites →https://doi.org/10.1038/onc.2017.299openalex-snapshot
Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells
inferredcites →https://doi.org/10.1038/s41419-017-0250-xopenalex-snapshot
ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
inferredcites →https://doi.org/10.1038/s41419-018-0995-xopenalex-snapshot
Protease-activated receptor 2 signaling modulates susceptibility of colonic epithelium to injury through stabilization of YAP in vivo
inferredcites →https://doi.org/10.1038/s41467-018-03190-3openalex-snapshot
High-efficiency RNA-based reprogramming of human primary fibroblasts
inferredcites →https://doi.org/10.1038/s41556-018-0086-3openalex-snapshot
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity
inferredcites →https://doi.org/10.1038/s41596-018-0108-4openalex-snapshot
Microfluidic reprogramming to pluripotency of human somatic cells
inferredcites →https://doi.org/10.1038/s41598-018-25725-wopenalex-snapshot
The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles
inferredcites →https://doi.org/10.1038/s41598-019-42298-4openalex-snapshot
Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
inferredcites →https://doi.org/10.1038/srep00657openalex-snapshot
Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA
inferredcites →https://doi.org/10.1038/srep30872openalex-snapshot
Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody
inferredcites →https://doi.org/10.1039/c8cc08080aopenalex-snapshot
DNA aptamer assemblies as fibroblast growth factor mimics and their application in stem cell culture
inferredcites →https://doi.org/10.1054/bjoc.2001.1976openalex-snapshot
Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2
inferredcites →https://doi.org/10.1073/pnas.0806136105openalex-snapshot
Heparin promotes the growth of human embryonic stem cells in a defined serum-free medium
inferredcites →https://doi.org/10.1073/pnas.1721891115openalex-snapshot
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
inferredcites →https://doi.org/10.1074/jbc.m110.201988openalex-snapshot
Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
inferredcites →https://doi.org/10.1074/jbc.m114.599712openalex-snapshot
Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4
inferredcites →https://doi.org/10.1074/jbc.m115.659029openalex-snapshot
Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium
inferredcites →https://doi.org/10.1074/jbc.m410312200openalex-snapshot
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2
inferredcites →https://doi.org/10.1074/jbc.ra119.006974openalex-snapshot
Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover
inferredcites →https://doi.org/10.1074/jbc.tm117.000832openalex-snapshot
Metabolism in pluripotency: Both driver and passenger?
inferredcites →https://doi.org/10.1111/bph.12544openalex-snapshot
Biased signalling and proteinase‐activated receptors ( PAR s): targeting inflammatory disease
inferredcites →https://doi.org/10.1111/bph.12757openalex-snapshot
Pathway‐selective antagonism of proteinase activated receptor 2
inferredcites →https://doi.org/10.1111/j.1538-7836.2005.01377.xopenalex-snapshot
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
inferredcites →https://doi.org/10.1111/j.1742-4658.2009.06926.xopenalex-snapshot
Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
inferredcites →https://doi.org/10.1111/tra.12628openalex-snapshot
Regulation of G protein‐coupled receptor signaling by plasma membrane organization and endocytosis
inferredcites →https://doi.org/10.1124/jpet.117.245027openalex-snapshot
A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells
inferredcites →https://doi.org/10.1124/mol.115.102723openalex-snapshot
Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling
inferredcites →https://doi.org/10.1126/science.1239278openalex-snapshot
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
inferredcites →https://doi.org/10.1136/annrheumdis-2011-200703openalex-snapshot
PAR2 expression in peripheral blood monocytes of patients with rheumatoid arthritis
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0619openalex-snapshot
CD24 Expression Causes the Acquisition of Multiple Cellular Properties Associated with Tumor Growth and Metastasis
inferredcites →https://doi.org/10.1167/iovs.14-14934openalex-snapshot
Targeting the Fibronectin Type III Repeats in Tenascin-C Inhibits Epithelial-Mesenchymal Transition in the Context of Posterior Capsular Opacification
inferredcites →https://doi.org/10.1182/blood-2002-08-2497openalex-snapshot
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
inferredcites →https://doi.org/10.1182/blood-2015-11-636472openalex-snapshot
Protease-activated receptors in hemostasis
inferredcites →https://doi.org/10.1186/s12959-019-0194-8openalex-snapshot
Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases
inferredcites →https://doi.org/10.1186/s13287-019-1242-9openalex-snapshot
R-spondin2 promotes hematopoietic differentiation of human pluripotent stem cells by activating TGF beta signaling
inferredcites →https://doi.org/10.1189/jlb.0704422openalex-snapshot
Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1β
inferredcites →https://doi.org/10.1242/dev.050146openalex-snapshot
The role of FGF/Erk signaling in pluripotent cells
inferredcites →https://doi.org/10.1242/dev.10.4.622openalex-snapshot
The Developmental Capacity of Nuclei taken from Intestinal Epithelium Cells of Feeding Tadpoles
inferredcites →https://doi.org/10.1309/ajcpmeejk32acyfpopenalex-snapshot
Reference and Interpretive Ranges for α1-Antitrypsin Quantitation by Phenotype in Adult and Pediatric Populations
inferredcites →https://doi.org/10.1358/dof.2008.033.03.1184546openalex-snapshot
Protease-activated receptor-2 (PAR-2): A potential new target in arthritis
inferredcites →https://doi.org/10.1371/journal.pone.0056289openalex-snapshot
Sustained Levels of FGF2 Maintain Undifferentiated Stem Cell Cultures with Biweekly Feeding
inferredcites →https://doi.org/10.1371/journal.pone.0069343openalex-snapshot
Fibrotic Remodeling of the Extracellular Matrix through a Novel (Engineered, Dual-Function) Antibody Reactive to a Cryptic Epitope on the N-Terminal 30 kDa Fragment of Fibronectin
inferredcites →https://doi.org/10.1371/journal.pone.0076667openalex-snapshot
Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma
inferredcites →https://doi.org/10.1371/journal.pone.0099702openalex-snapshot
Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
inferredcites →https://doi.org/10.1517/13543776.2016.1154540openalex-snapshot
Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)
inferredcites →https://doi.org/10.1634/stemcells.2005-0247openalex-snapshot
Basic Fibroblast Growth Factor Support of Human Embryonic Stem Cell Self-Renewal
inferredcites →https://doi.org/10.33549/physiolres.933269openalex-snapshot
The Role of Protease-Activated Receptor Type 2 in Nociceptive Signaling and Pain
inferredcites →https://doi.org/10.3389/fendo.2013.00196openalex-snapshot
Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer
inferredcites →https://doi.org/10.3389/fendo.2018.00257openalex-snapshot
Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology
inferredcites →https://doi.org/10.3389/fgene.2017.00100openalex-snapshot
New Insights into 5hmC DNA Modification: Generation, Distribution and Function
inferredcites →https://doi.org/10.3389/fgene.2018.00640openalex-snapshot
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
inferredcites →https://doi.org/10.3389/fgene.2019.00041openalex-snapshot
Maternal LINE-1 DNA Methylation and Congenital Heart Defects in Down Syndrome
inferredcites →https://doi.org/10.3390/jcm8030288openalex-snapshot
iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?
inferredcites →https://doi.org/10.3390/jcm8040432openalex-snapshot
Predictors of Sexual Dysfunction in Veterans with Post-Traumatic Stress Disorder
inferredcites →https://doi.org/10.3892/ijo.23.1.61openalex-snapshot
Protease-activated receptor-2 expression and the role of trypsin in cell proliferation in human pancreatic cancers
inferredcites →https://doi.org/10.4172/2157-7412.1000200openalex-snapshot
Trypsin-antitrypsin Imbalance in Immune Escape and Clonal Proliferation of Pancreatic Cancer
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Facile Bead-to-Bead Cell-Transfer Method for Serial Subculture and Large-Scale Expansion of Human Mesenchymal Stem Cells in Bioreactors
inferred← citeshttps://doi.org/10.1111/exd.15029openalex-snapshot
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Replacement of Trypsin by Proteases for Medical Applications
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