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Gclc deletion in surface-ectoderm tissues induces microphthalmia

https://doi.org/10.1101/700591
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Outgoing claims: the papers this work cites, builds on, or argues with.

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A detailed characterization of congenital defects and mortality following moderate X‐ray doses during neurulation
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Updated national birth prevalence estimates for selected birth defects in the United States, 2004–2006
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Elevated congenital anomaly rates and incorporated cesium‐137 in the Polissia region of Ukraine
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Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure†
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Thymosin β4 promotes matrix metalloproteinase expression during wound repair
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Primary congenital aphakia and the rubella syndrome
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An Impediment to Glutathione Diffusion in Older Normal Human Lenses: a Possible Precondition for Nuclear Cataract
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Thymosin Beta 4 Promotes Corneal Wound Healing and Decreases Inflammation in Vivo Following Alkali Injury
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Up-regulation of Cytochrome Oxidase in the Retina Following Optic Nerve Injury
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Cell proliferation, survival, and death in the Drosophila eye
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Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos
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High-resolution MALDI mass spectrometric imaging of lipids in the mammalian retina
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Adverse neonatal outcome after maternal biliopancreatic diversion operation: report of nine cases
inferredcites →https://doi.org/10.1007/s00431-006-0120-5openalex-snapshot
Maternal vitamin A deficiency and neonatal microphthalmia: complications of biliopancreatic diversion?
inferredcites →https://doi.org/10.1007/s00439-019-01977-yopenalex-snapshot
Genetics of anophthalmia and microphthalmia. Part 1: Non-syndromic anophthalmia/microphthalmia
inferredcites →https://doi.org/10.1016/0014-4835(77)90126-9openalex-snapshot
The state of sulphydryl groups in normal and cataractous human lenses
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Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry
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Comparative biochemistry of cytochrome c oxidase in animals
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Programmed Cell Death in Animal Development and Disease
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The genetic architecture of microphthalmia, anophthalmia and coloboma
inferredcites →https://doi.org/10.1016/j.exer.2011.06.010openalex-snapshot
Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye
inferredcites →https://doi.org/10.1016/j.exer.2016.11.008openalex-snapshot
Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging
inferredcites →https://doi.org/10.1016/j.exer.2019.04.016openalex-snapshot
Age-related spatial differences of human lens UV filters revealed by negative ion mode MALDI imaging mass spectrometry
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Genetically altered mice to evaluate glutathione homeostasis in health and disease
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2011.09.011openalex-snapshot
Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2013.06.011openalex-snapshot
Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.03.002openalex-snapshot
A rapid in vivo zebrafish model to elucidate oxidative stress-mediated PCB126-induced apoptosis and developmental toxicity
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.09.019openalex-snapshot
Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins
inferredcites →https://doi.org/10.1016/j.ijms.2017.10.008openalex-snapshot
A quantitative map of glutathione in the aging human lens
inferredcites →https://doi.org/10.1016/j.omtn.2017.05.002openalex-snapshot
Efficacy of Postnatal In Vivo Nonsense Suppression Therapy in a Pax6 Mouse Model of Aniridia
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Toxicity testing in the 21st century: A vision and a strategy
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Differential requirement for β-catenin in epithelial and fiber cells during lens development
inferredcites →https://doi.org/10.1016/j.ydbio.2015.12.027openalex-snapshot
FGFR and PTEN signaling interact during lens development to regulate cell survival
inferredcites →https://doi.org/10.1016/s0890-6238(99)00068-4openalex-snapshot
International clearinghouse for birth defects monitoring systems
inferredcites →https://doi.org/10.1016/s0959-437x(03)00026-1openalex-snapshot
Structure and dynamic behavior of nucleosomes
inferredcites →https://doi.org/10.1021/ac970888iopenalex-snapshot
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
inferredcites →https://doi.org/10.1021/acs.analchem.7b04733openalex-snapshot
Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights
inferredcites →https://doi.org/10.1038/ncomms10953openalex-snapshot
FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1
inferredcites →https://doi.org/10.1038/ng.3743openalex-snapshot
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
inferredcites →https://doi.org/10.1038/s41434-018-0043-6openalex-snapshot
Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials
inferredcites →https://doi.org/10.1038/s41586-019-1057-yopenalex-snapshot
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
inferredcites →https://doi.org/10.1038/s41586-019-1064-zopenalex-snapshot
Genetic compensation triggered by mutant mRNA degradation
inferredcites →https://doi.org/10.1038/srep24999openalex-snapshot
Solution structure of the isolated histone H2A-H2B heterodimer
inferredcites →https://doi.org/10.1038/srep44601openalex-snapshot
Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration
inferredcites →https://doi.org/10.1073/pnas.93.20.10887openalex-snapshot
Ligand-activated site-specific recombination in mice.
inferredcites →https://doi.org/10.1074/jbc.m111.320135openalex-snapshot
Mycobacterial Induction of Autophagy Varies by Species and Occurs Independently of Mammalian Target of Rapamycin Inhibition
inferredcites →https://doi.org/10.1074/jbc.m209372200openalex-snapshot
Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse
inferredcites →https://doi.org/10.1076/0928-6586(200006)721-zft127openalex-snapshot
Regional variation in blindness in children due to microphthalmos, anophthalmos and coloboma
inferredcites →https://doi.org/10.1080/10937404.2010.483176openalex-snapshot
Toxicity Testing in the 21st Century: A Vision and a Strategy
inferredcites →https://doi.org/10.1089/jop.2000.16.121openalex-snapshot
Glutathione: A Vital Lens Antioxidant
inferredcites →https://doi.org/10.1093/glycob/8.2.183openalex-snapshot
Changes in ganglioside composition of photoreceptors during postnatal maturation of the rat retina
inferredcites →https://doi.org/10.1093/hmg/ddx040openalex-snapshot
Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration
inferredcites →https://doi.org/10.1093/nar/gku936openalex-snapshot
Easy quantitative assessment of genome editing by sequence trace decomposition
inferredcites →https://doi.org/10.1093/nar/gkw398openalex-snapshot
CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering
inferredcites →https://doi.org/10.1093/toxsci/kfy250openalex-snapshot
Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens
inferredcites →https://doi.org/10.1096/fj.10-167940openalex-snapshot
Thymosin β 4 inhibits TNF‐α‐induced NF‐κB activation, IL‐8 expression, and the sensitizing effects by its partners PINCH‐1 and ILK
inferredcites →https://doi.org/10.1101/gad.184000openalex-snapshot
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
inferredcites →https://doi.org/10.1128/mcb.25.20.8854-8863.2005openalex-snapshot
Severe Defects in Proliferation and Differentiation of Lens Cells in Foxe3 Null Mice
inferredcites →https://doi.org/10.1136/bmj.1.5848.269openalex-snapshot
Defects and Disabilities of Thalidomide Children
inferredcites →https://doi.org/10.1136/bmj.307.6900.340openalex-snapshot
"Clusters" of anophthalmia in Britain.
inferredcites →https://doi.org/10.1136/jmg.30.8.664openalex-snapshot
Classification of microphthalmos and coloboma.
inferredcites →https://doi.org/10.1146/annurev.bi.52.070183.003431openalex-snapshot
GLUTATHIONE
inferredcites →https://doi.org/10.1152/physrev.00028.2012openalex-snapshot
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
inferredcites →https://doi.org/10.1167/iovs.03-0856openalex-snapshot
Insertion of a Pax6 Consensus Binding Site into the αA-Crystallin Promoter Acts as a Lens Epithelial Cell Enhancer in Transgenic Mice
inferredcites →https://doi.org/10.1167/iovs.06-0401openalex-snapshot
Phosphatidylinositol 3-Kinase Is Necessary for Lens Fiber Cell Differentiation and Survival
inferredcites →https://doi.org/10.1167/iovs.07-1630openalex-snapshot
Effects of Elevated Pax6 Expression and Genetic Background on Mouse Eye Development
inferredcites →https://doi.org/10.1167/iovs.09-3522openalex-snapshot
Age-Related Changes in the Spatial Distribution of Human Lens α-Crystallin Products by MALDI Imaging Mass Spectrometry
inferredcites →https://doi.org/10.1167/iovs.10-5302openalex-snapshot
Tissue Localization and Solubilities of αA-crystallin and its Numerous C-terminal Truncation Products in Pre- and Postcataractous ICR/f Rat Lenses
inferredcites →https://doi.org/10.1167/iovs.10-5421openalex-snapshot
Retinal Function and Structure in Ant1-Deficient Mice
inferredcites →https://doi.org/10.1167/iovs.14-13995openalex-snapshot
Effect of Reduced Retinal VLC-PUFA on Rod and Cone Photoreceptors
inferredcites →https://doi.org/10.1167/iovs.15-16968openalex-snapshot
Birc7 : A Late Fiber Gene of the Crystalline Lens
inferredcites →https://doi.org/10.1167/iovs.16-19592openalex-snapshot
Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis
inferredcites →https://doi.org/10.1167/iovs.16-21398openalex-snapshot
Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis
inferredcites →https://doi.org/10.1172/jci70462openalex-snapshot
Postnatal manipulation of Pax6 dosage reverses congenital tissue malformation defects
inferredcites →https://doi.org/10.1186/1471-213x-8-59openalex-snapshot
Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
inferredcites →https://doi.org/10.1186/s40246-019-0192-8openalex-snapshot
Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens
inferredcites →https://doi.org/10.1186/s40246-019-0239-xopenalex-snapshot
Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology
inferredcites →https://doi.org/10.1194/jlr.m007716openalex-snapshot
Sphingolipid distribution changes with age in the human lens
inferredcites →https://doi.org/10.1242/dev.032888openalex-snapshot
Pax6 is essential for lens fiber cell differentiation
inferredcites →https://doi.org/10.1242/dev.107953openalex-snapshot
The cellular and molecular mechanisms of vertebrate lens development
inferredcites →https://doi.org/10.1255/ejms.1350openalex-snapshot
Age-Related Changes in the Lateral Lipid Distribution in a Human Lens Described by Mass Spectrometry Imaging
inferredcites →https://doi.org/10.1371/journal.pone.0035495openalex-snapshot
Perceptions and Experiences of Research Participants on Gender-Based Violence Community Based Survey: Implications for Ethical Guidelines
inferredcites →https://doi.org/10.1371/journal.pone.0050832openalex-snapshot
The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis
inferredcites →https://doi.org/10.1371/journal.pone.0057828openalex-snapshot
Treatment with 670 nm Light Up Regulates Cytochrome C Oxidase Expression and Reduces Inflammation in an Age-Related Macular Degeneration Model
inferredcites →https://doi.org/10.1371/journal.pone.0063029openalex-snapshot
Generation of mRx-Cre Transgenic Mouse Line for Efficient Conditional Gene Deletion in Early Retinal Progenitors
inferredcites →https://doi.org/10.1371/journal.pone.0087182openalex-snapshot
c-myc Regulates Cell Proliferation during Lens Development
inferredcites →https://doi.org/10.1371/journal.pone.0109193openalex-snapshot
Hemizygous Le-Cre Transgenic Mice Have Severe Eye Abnormalities on Some Genetic Backgrounds in the Absence of LoxP Sites
inferredcites →https://doi.org/10.1517/14712598.2012.634793openalex-snapshot
Thymosin β 4 : a multi-functional regenerative peptide. Basic properties and clinical applications
inferredcites →https://doi.org/10.2147/opth.s27189openalex-snapshot
Congenital anophthalmia and microphthalmia: epidemiology and orbitofacial rehabilitation
inferredcites →https://doi.org/10.3390/biom8040156openalex-snapshot
Distribution of Glycerophospholipids in the Adult Human Lens
inferredcites →https://doi.org/10.3390/ijms19113516openalex-snapshot
Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone
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