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Mechanistic Elucidation of the Antitumor Properties of a Novel Death Receptor 5 Activator

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Outgoing claims: the papers this work cites, builds on, or argues with.

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PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy

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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth

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c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance

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The unfolded protein response as a target for anticancer therapeutics

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Induction of TRAIL-mediated glioma cell death by human T cells

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Apoptosis control by death and decoy receptors

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Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

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Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling

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PEGylated TNF-Related Apoptosis-Inducing Ligand (TRAIL) Analogues: Pharmacokinetics and Antitumor Effects

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Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1 H -indol-5-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

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Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

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Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms

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Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

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The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5

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Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo

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Adenovirus-TRAIL can overcome TRAIL resistance and induce a bystander effect

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c‐Myc primed mitochondria determine cellular sensitivity to TRAIL‐induced apoptosis

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

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Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells

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Cleavage of epidermal growth factor receptor by caspase during apoptosis is independent of its internalization

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A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3β/FBW7 loss of function

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

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Crystal Structure of TRAIL-DR5 Complex Identifies a Critical Role of the Unique Frame Insertion in Conferring Recognition Specificity

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Deficient Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Death Receptor Transport to the Cell Surface in Human Colon Cancer Cells Selected for Resistance to TRAIL-induced Apoptosis

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CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

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3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5

inferredcites →https://doi.org/10.1097/cad.0000000000000213openalex-snapshot

A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression

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Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive Inhibitors

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Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL‐induced apoptosis

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Simultaneous Profiling of 194 Distinct Receptor Transcripts in Human Cells

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Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity

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Coupling of Endoplasmic Reticulum Stress to CDDO-Me–Induced Up-regulation of Death Receptor 5 via a CHOP–Dependent Mechanism Involving JNK Activation

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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

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PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells

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Abstract 447: A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers

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N-Acetyl-Glucosamine Sensitizes Non-Small Cell Lung Cancer Cells to TRAIL-Induced Apoptosis by Activating Death Receptor 5

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Safety and antitumor activity of recombinant soluble Apo2 ligand

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CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment

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Tumor Necrosis Factor-α Decreases Akt Protein Levels in 3T3-L1 Adipocytes via the Caspase-Dependent Ubiquitination of Akt

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Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints

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Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

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Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

inferredcites →https://doi.org/10.18632/oncotarget.15952openalex-snapshot

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells

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Novel agents that downregulate EGFR, HER2, and HER3 in parallel

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Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation

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Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin

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Histone Deacetylase Inhibitor Sensitizes Apoptosis-Resistant Melanomas to Cytotoxic Human T Lymphocytes through Regulation of TRAIL/DR5 Pathway

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Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines

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Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression

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TRAIL induces endocytosis of its death receptors in MDA-MB-231 breast cancer cells

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Potentiation of TRAIL killing activity by multimerization through isoleucine zipper hexamerization motif

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.canlet.2022.215604openalex-snapshot

Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death

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