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Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models
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Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
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The Emerging Hallmarks of Cancer Metabolism
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Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1
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The role of cyclooxygenase-2 in prostate cancer
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Integrative molecular concept modeling of prostate cancer progression
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SpatialDE: identification of spatially variable genes
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Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
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Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
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Fatty acid transport protein 2 reprograms neutrophils in cancer
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Role of hepatic carbonic anhydrase in de novo lipogenesis
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Metabolic Positron Emission Tomography Imaging in Cancer Detection and Therapy Response
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15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
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Global reconstruction of the human metabolic network based on genomic and bibliomic data
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Spatially resolved metabolomics to discover tumor-associated metabolic alterations
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Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
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Biosynthesis of acyl‐CoAs sustains prostate cancer progression
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Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism
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Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
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Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
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Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution
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Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
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Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses
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15-Hydroxyprostaglandin Dehydrogenase Is a Tumor Suppressor of Human Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-07-6575openalex-snapshot
15-Hydroxyprostaglandin Dehydrogenase is a Target of Hepatocyte Nuclear Factor 3β and a Tumor Suppressor in Lung Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-07-6689openalex-snapshot
Prostaglandin E2 Regulates Tumor Angiogenesis in Prostate Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-08-0162openalex-snapshot
Extracellular Redox State Regulates Features Associated with Prostate Cancer Cell Invasion
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Imaging Cycling Tumor Hypoxia
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Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma
inferredcites →https://doi.org/10.1158/1541-7786.mcr-18-0347openalex-snapshot
Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer
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Cancer Cell Metabolism: One Hallmark, Many Faces
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Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining
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A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data
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Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5
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Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized
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Drug-induced amino acid deprivation as strategy for cancer therapy
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Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
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Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity
inferredcites →https://doi.org/10.1194/jlr.m009407openalex-snapshot
Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways
inferredcites →https://doi.org/10.1200/jco.2017.35.15_suppl.11585openalex-snapshot
Identification of novel fumarate hydratase gene alterations in prostate cancer.
inferredcites →https://doi.org/10.1371/journal.pone.0033823openalex-snapshot
SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids
inferredcites →https://doi.org/10.1371/journal.pone.0119473openalex-snapshot
Differential Expression of Lipid Metabolism-Related Proteins in Different Breast Cancer Subtypes
inferredcites →https://doi.org/10.1371/journal.pone.0153727openalex-snapshot
A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0155660openalex-snapshot
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer
inferredcites →https://doi.org/10.3389/fimmu.2013.00130openalex-snapshot
Proinflammatory and Immunoregulatory Roles of Eicosanoids in T Cells
inferredcites →https://doi.org/10.3389/fonc.2017.00131openalex-snapshot
The Metabolic Phenotype of Prostate Cancer
inferredcites →https://doi.org/10.3389/fonc.2018.00170openalex-snapshot
The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
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The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
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Manganese Superoxide Dismutase: Guardian of the Powerhouse
inferredcites →https://doi.org/10.4062/biomolther.2012.095openalex-snapshot
Emerging Roles of Human Prostatic Acid Phosphatase
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L-asparaginase in the treatment of patients with acute lymphoblastic leukemia
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Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2478/s11756-021-00678-0openalex-snapshot
Thermococcus kodakarensis-derived L-asparaginase: a candidate for the treatment of glioblastoma
inferred← citeshttps://doi.org/10.3390/cancers13184609openalex-snapshot
Genome Scale Modeling to Study the Metabolic Competition between Cells in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.3390/ijms21062044openalex-snapshot
Effects of Long-Chain Fatty Acyl-CoA Synthetase 1 on Diglyceride Synthesis and Arachidonic Acid Metabolism in Sheep Adipocytes
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