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Screening the MMV Open Access Pathogen box unveils novel and potent inhibitors of Amoebiasis agent: Entamoeba histolytica

https://doi.org/10.1101/723361
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/14651858.cd006085.pub3openalex-snapshot
Antiamoebic drugs for treating amoebic colitis
inferredcites →https://doi.org/10.1002/cmdc.201200428openalex-snapshot
Fueling Open‐Source Drug Discovery: 177 Small‐Molecule Leads against Tuberculosis
inferredcites →https://doi.org/10.1007/s40268-015-0083-yopenalex-snapshot
Auranofin: Repurposing an Old Drug for a Golden New Age
inferredcites →https://doi.org/10.1016/0022-1759(83)90303-4openalex-snapshot
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
inferredcites →https://doi.org/10.1016/0169-4758(93)90143-4openalex-snapshot
Metronidazole and drug resistance
inferredcites →https://doi.org/10.1016/j.bmcl.2015.06.091openalex-snapshot
Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies
inferredcites →https://doi.org/10.1016/j.exppara.2010.03.005openalex-snapshot
The immunopathogenesis of Entamoeba histolytica
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2006.12.021openalex-snapshot
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
inferredcites →https://doi.org/10.1016/j.jns.2004.06.012openalex-snapshot
Metronidazole-induced encephalopathy
inferredcites →https://doi.org/10.1016/j.tube.2011.06.004openalex-snapshot
Open source drug discovery– A new paradigm of collaborative research in tuberculosis drug development
inferredcites →https://doi.org/10.1016/s0140-6736(03)12830-9openalex-snapshot
Amoebiasis
inferredcites →https://doi.org/10.1016/s0924-8579(03)00210-3openalex-snapshot
ABC transporters and drug resistance in parasitic protozoa
inferredcites →https://doi.org/10.1021/jm00052a011openalex-snapshot
2,4-Diamino-5-chloroquinazoline Analogs of Trimetrexate and Piritrexim: Synthesis and Antifolate Activity
inferredcites →https://doi.org/10.1038/cddis.2014.132openalex-snapshot
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo
inferredcites →https://doi.org/10.1038/nm.2758openalex-snapshot
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
inferredcites →https://doi.org/10.1073/pnas.77.10.5802openalex-snapshot
Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.
inferredcites →https://doi.org/10.1074/jbc.274.37.26051openalex-snapshot
Metronidazole Resistance in the Protozoan Parasite Entamoeba histolytica Is Associated with Increased Expression of Iron-containing Superoxide Dismutase and Peroxiredoxin and Decreased Expression of Ferredoxin 1 and Flavin Reductase
inferredcites →https://doi.org/10.1093/ofid/ofy161openalex-snapshot
A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis
inferredcites →https://doi.org/10.1096/fasebj.4.8.2185970openalex-snapshot
Dihydrofolate reductase as a therapeutic target
inferredcites →https://doi.org/10.1097/wnf.0b013e3182334b35openalex-snapshot
Metronidazole-Induced Central Nervous System Toxicity
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.01127.xopenalex-snapshot
Principles of early drug discovery
inferredcites →https://doi.org/10.1128/aac.00870-13openalex-snapshot
Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay
inferredcites →https://doi.org/10.1128/aac.01500-13openalex-snapshot
Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box
inferredcites →https://doi.org/10.1128/aac.01640-17openalex-snapshot
Discovery of New Inhibitors of Toxoplasma gondii via the Pathogen Box
inferredcites →https://doi.org/10.1128/aac.02541-14openalex-snapshot
Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica
inferredcites →https://doi.org/10.1128/aac.02641-13openalex-snapshot
Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box
inferredcites →https://doi.org/10.1128/aac.03666-14openalex-snapshot
A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs
inferredcites →https://doi.org/10.1128/aac.45.1.187-195.2001openalex-snapshot
Efficacies of Lipophilic Inhibitors of Dihydrofolate Reductase against Parasitic Protozoa
inferredcites →https://doi.org/10.1128/aac.49.8.3234-3238.2005openalex-snapshot
Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi : Prospect for Chemotherapy of Chagas' Disease
inferredcites →https://doi.org/10.1128/cmr.00004-07openalex-snapshot
Laboratory Diagnostic Techniques for Entamoeba Species
inferredcites →https://doi.org/10.1146/annurev.micro.56.012302.160959openalex-snapshot
The Bittersweet Interface of Parasite and Host: Lectin-Carbohydrate Interactions During Human Invasion by the ParasiteEntamoeba histolytica
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0968openalex-snapshot
Drug Repurposing for Gastrointestinal Stromal Tumor
inferredcites →https://doi.org/10.1158/1535-7163.mct-15-0511openalex-snapshot
Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box
inferredcites →https://doi.org/10.1177/1087057115569155openalex-snapshot
Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids
inferredcites →https://doi.org/10.1371/journal.pntd.0002610openalex-snapshot
Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box
inferredcites →https://doi.org/10.1371/journal.pntd.0006437openalex-snapshot
Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma
inferredcites →https://doi.org/10.1371/journal.pntd.0006673openalex-snapshot
Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum
inferredcites →https://doi.org/10.1371/journal.pone.0142293openalex-snapshot
Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery
inferredcites →https://doi.org/10.1371/journal.pone.0195595openalex-snapshot
Pathogen Box screening for hit identification against Mycobacterium abscessus
inferredcites →https://doi.org/10.1371/journal.ppat.1005763openalex-snapshot
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
inferredcites →https://doi.org/10.2807/1560-7917.es.2017.22.30.30581openalex-snapshot
Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017
inferredcites →https://doi.org/10.3389/fcimb.2018.00210openalex-snapshot
Evaluating New Compounds to Treat Burkholderia pseudomallei Infections
inferredcites →https://doi.org/10.3389/fmicb.2017.01539openalex-snapshot
Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates
inferredcites →https://doi.org/10.3390/molecules20069929openalex-snapshot
Potential Amoebicidal Activity of Hydrazone Derivatives: Synthesis, Characterization, Electrochemical Behavior, Theoretical Study and Evaluation of the Biological Activity
inferredcites →https://doi.org/10.3748/wjg.v23.i2.357openalex-snapshot
Areas of research and clinical approaches to the study of liver abscess
inferredcites →https://doi.org/10.4155/fmc.11.85openalex-snapshot
Drug Discovery for Neglected Tropical Diseases at the Sandler Center
inferredcites →https://doi.org/10.4155/fmc.15.26openalex-snapshot
Repurposing Pharma Assets: An Accelerated Mechanism for Strengthening the Schistosomiasis Drug Development Pipeline
inferredcites →https://doi.org/10.4155/fmc.15.28openalex-snapshot
Using an Open Source Model to Accelerate Schistosomiasis Drug Research
inferredcites →https://doi.org/10.4161/gmic.22596openalex-snapshot
Reprofiled drug targets ancient protozoans
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