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Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

https://doi.org/10.1101/729541
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00125-009-1562-xopenalex-snapshot
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
inferredcites →https://doi.org/10.1007/s00125-010-1673-4openalex-snapshot
Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study
inferredcites →https://doi.org/10.1007/s00125-011-2313-3openalex-snapshot
Do men develop type 2 diabetes at lower body mass indices than women?
inferredcites →https://doi.org/10.1007/s00125-015-3625-5openalex-snapshot
Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas)
inferredcites →https://doi.org/10.1007/s00125-015-3699-0openalex-snapshot
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment
inferredcites →https://doi.org/10.1016/j.cell.2008.11.037openalex-snapshot
Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells
inferredcites →https://doi.org/10.1016/j.cell.2012.07.029openalex-snapshot
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
inferredcites →https://doi.org/10.1016/j.cell.2013.07.037openalex-snapshot
Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures
inferredcites →https://doi.org/10.1016/j.cell.2017.09.004openalex-snapshot
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns
inferredcites →https://doi.org/10.1016/j.cels.2015.08.012openalex-snapshot
Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
inferredcites →https://doi.org/10.1016/j.cmet.2008.08.006openalex-snapshot
The Emerging Genetic Architecture of Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.cmet.2015.07.025openalex-snapshot
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
inferredcites →https://doi.org/10.1016/j.cmet.2016.04.002openalex-snapshot
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
inferredcites →https://doi.org/10.1016/j.cmet.2016.06.020openalex-snapshot
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.018openalex-snapshot
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.020openalex-snapshot
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.cmet.2016.09.007openalex-snapshot
Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas
inferredcites →https://doi.org/10.1016/j.cmet.2017.03.015openalex-snapshot
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2017.03.017openalex-snapshot
Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets
inferredcites →https://doi.org/10.1016/j.cmet.2019.05.010openalex-snapshot
Age Mosaicism across Multiple Scales in Adult Tissues
inferredcites →https://doi.org/10.1016/j.cmet.2020.04.005openalex-snapshot
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes
inferredcites →https://doi.org/10.1016/j.molmet.2018.05.017openalex-snapshot
Sex differences underlying pancreatic islet biology and its dysfunction
inferredcites →https://doi.org/10.1016/s0021-9258(19)36615-3openalex-snapshot
Pancreatic beta cell heterogeneity in glucose-induced insulin secretion.
inferredcites →https://doi.org/10.1038/ncomms11756openalex-snapshot
Human islets contain four distinct subtypes of β cells
inferredcites →https://doi.org/10.1038/nm.4054openalex-snapshot
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
inferredcites →https://doi.org/10.1038/nmeth.3734openalex-snapshot
Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis
inferredcites →https://doi.org/10.1038/nmeth.4402openalex-snapshot
Reversed graph embedding resolves complex single-cell trajectories
inferredcites →https://doi.org/10.1038/s41467-017-00322-zopenalex-snapshot
Nucleolar expansion and elevated protein translation in premature aging
inferredcites →https://doi.org/10.1073/pnas.0510790103openalex-snapshot
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
inferredcites →https://doi.org/10.1073/pnas.1006639107openalex-snapshot
Paracrinology of islets and the paracrinopathy of diabetes
inferredcites →https://doi.org/10.1073/pnas.1414053111openalex-snapshot
Young capillary vessels rejuvenate aged pancreatic islets
inferredcites →https://doi.org/10.1101/cshperspect.a004440openalex-snapshot
Aging as an Event of Proteostasis Collapse
inferredcites →https://doi.org/10.1111/j.1464-5491.2007.02362.xopenalex-snapshot
Differences in height explain gender differences in the response to the oral glucose tolerance test— the AusDiab study
inferredcites →https://doi.org/10.1111/j.1748-1716.1993.tb09551.xopenalex-snapshot
Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin‐dependent diabetic GK (Goto‐Kakizaki) rats
inferredcites →https://doi.org/10.1126/science.1082889openalex-snapshot
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
inferredcites →https://doi.org/10.1172/jci65390openalex-snapshot
Inactivation of specific β cell transcription factors in type 2 diabetes
inferredcites →https://doi.org/10.1172/jci88017openalex-snapshot
Pancreatic β cell identity requires continual repression of non–β cell programs
inferredcites →https://doi.org/10.1186/s13059-014-0522-zopenalex-snapshot
Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets
inferredcites →https://doi.org/10.1210/en.2018-00469openalex-snapshot
Gene Signature of Proliferating Human Pancreatic α Cells
inferredcites →https://doi.org/10.1210/er.2016-1146openalex-snapshot
Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications
inferredcites →https://doi.org/10.1210/jc.2010-0932openalex-snapshot
Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating
inferredcites →https://doi.org/10.1210/jc.2010-1398openalex-snapshot
Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males
inferredcites →https://doi.org/10.2337/db05-1692openalex-snapshot
Effects of Age and Sex on Postprandial Glucose Metabolism
inferredcites →https://doi.org/10.2337/db08-0792openalex-snapshot
Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
inferredcites →https://doi.org/10.2337/db17-0137openalex-snapshot
Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets
inferredcites →https://doi.org/10.2337/db18-0365openalex-snapshot
Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response
inferredcites →https://doi.org/10.2337/dci17-0005openalex-snapshot
Diabetes and Aging: Unique Considerations and Goals of Care
inferredcites →https://doi.org/10.2337/diab.30.7.590openalex-snapshot
Islet Secretion in a New Experimental Model for Non-insulin-dependent Diabetes
inferredcites →https://doi.org/10.2337/diabetes.52.7.1738openalex-snapshot
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
inferredcites →https://doi.org/10.4161/isl.2.2.11025openalex-snapshot
Identification of genes selectively disallowed in the pancreatic islet

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00125-020-05159-8openalex-snapshot
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes
inferred← citeshttps://doi.org/10.1007/s00125-026-06728-zopenalex-snapshot
ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice
inferred← citeshttps://doi.org/10.1007/s11357-021-00426-xopenalex-snapshot
The San Diego Nathan Shock Center: tackling the heterogeneity of aging
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.12.021openalex-snapshot
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101678openalex-snapshot
Sex differences in islet stress responses support female β cell resilience
inferred← citeshttps://doi.org/10.1016/j.neuron.2020.05.031openalex-snapshot
Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging
inferred← citeshttps://doi.org/10.1038/s41574-021-00568-0openalex-snapshot
The physiological role of β-cell heterogeneity in pancreatic islet function
inferred← citeshttps://doi.org/10.1038/s41575-026-01211-xopenalex-snapshot
Understanding development and cellular plasticity in the pancreas in health and disease
inferred← citeshttps://doi.org/10.1038/s42255-023-00876-xopenalex-snapshot
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
inferred← citeshttps://doi.org/10.1096/fj.202300941ropenalex-snapshot
Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion
inferred← citeshttps://doi.org/10.1101/2022.05.10.491428openalex-snapshot
Sex differences in islet stress responses support female beta cell resilience
inferred← citeshttps://doi.org/10.1101/2025.05.12.652914openalex-snapshot
G Protein Coupled Estrogen Receptor Signaling Maintains β Cell Identity in Female Mice
inferred← citeshttps://doi.org/10.1186/s13293-024-00595-2openalex-snapshot
Consideration of sex as a biological variable in diabetes research across twenty years
inferred← citeshttps://doi.org/10.1530/joe-24-0135openalex-snapshot
The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner
inferred← citeshttps://doi.org/10.6084/m9.figshare.26685621openalex-snapshot
Additional file 1 of Consideration of sex as a biological variable in diabetes research across twenty years
inferred← citeshttps://doi.org/10.6084/m9.figshare.26685624openalex-snapshot
Additional file 2 of Consideration of sex as a biological variable in diabetes research across twenty years
inferred← citeshttps://doi.org/10.6084/m9.figshare.26685627openalex-snapshot
Additional file 3 of Consideration of sex as a biological variable in diabetes research across twenty years
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