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Reply: Evidence that APP gene copy number changes reflect recombinant vector contamination

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dneu.22626openalex-snapshot

Genomic mosaicism in the developing and adult brain

inferredcites →https://doi.org/10.1016/j.cell.2012.09.035openalex-snapshot

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

inferredcites →https://doi.org/10.1016/j.celrep.2014.07.043openalex-snapshot

Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain

inferredcites →https://doi.org/10.1016/j.neuron.2014.12.028openalex-snapshot

Cell Lineage Analysis in Human Brain Using Endogenous Retroelements

inferredcites →https://doi.org/10.1016/j.tibs.2015.08.006openalex-snapshot

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

inferredcites →https://doi.org/10.1038/s41467-017-02295-5openalex-snapshot

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

inferredcites →https://doi.org/10.1038/s41467-019-11000-7openalex-snapshot

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

inferredcites →https://doi.org/10.1038/s41586-018-0718-6openalex-snapshot

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

inferredcites →https://doi.org/10.1073/pnas.1812702115openalex-snapshot

Submegabase copy number variations arise during cerebral cortical neurogenesis as revealed by single-cell whole-genome sequencing

inferredcites →https://doi.org/10.1093/bioinformatics/btw383openalex-snapshot

Vecuum: identification and filtration of false somatic variants caused by recombinant vector contamination

inferredcites →https://doi.org/10.1101/706788openalex-snapshot

Evidence that APP gene copy number changes reflect recombinant vector contamination

inferredcites →https://doi.org/10.1186/alzrt269openalex-snapshot

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

inferredcites →https://doi.org/10.1371/journal.pgen.1006368openalex-snapshot

Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining

inferredcites →https://doi.org/10.7554/elife.05116openalex-snapshot

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.nbd.2020.105021openalex-snapshot

Somatic mutations in neurodegeneration: An update

inferred← citeshttps://doi.org/10.1074/jbc.rev120.009192openalex-snapshot

Brain cell somatic gene recombination and its phylogenetic foundations

inferred← citeshttps://doi.org/10.1101/706788openalex-snapshot

Evidence that APP gene copy number changes reflect recombinant vector contamination

inferred← citeshttps://doi.org/10.3389/fgene.2020.00390openalex-snapshot

Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer’s Disease

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