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A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and Disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The serial cultivation of human diploid cell strains
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Cellular senescence: Immunosurveillance and future immunotherapy
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The signaling hubs at the crossroad of longevity and age-related disease networks
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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
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Connecting autophagy to senescence in pathophysiology
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Stressing the cell cycle in senescence and aging
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Hallmarks of Cancer: The Next Generation
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Programmed Cell Senescence during Mammalian Embryonic Development
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Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
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Geroscience: Linking Aging to Chronic Disease
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
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Ageing as a Risk Factor for Disease
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Unmasking Transcriptional Heterogeneity in Senescent Cells
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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
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Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage
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ONGene: A literature-based database for human oncogenes
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Bias tradeoffs in the creation and analysis of protein–protein interaction networks
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Longevity network: Construction and implications
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Common gene signature of cancer and longevity
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Stress, cell senescence and organismal ageing
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Hallmarks of Cellular Senescence
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The Business of Anti-Aging Science
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Evolutionary mutant models for human disease
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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
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Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
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Error and attack tolerance of complex networks
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A DNA damage checkpoint response in telomere-initiated senescence
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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The role of senescent cells in ageing
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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
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Polycomb CBX7 has a unifying role in cellular lifespan
inferredcites →https://doi.org/10.1038/ncb2784openalex-snapshot
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
inferredcites →https://doi.org/10.1038/ncomms11190openalex-snapshot
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
inferredcites →https://doi.org/10.1038/ng.2653openalex-snapshot
The Genotype-Tissue Expression (GTEx) project
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Living on a break: cellular senescence as a DNA-damage response
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How ageing processes influence cancer
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Forging a signature of in vivo senescence
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RNA-Seq: a revolutionary tool for transcriptomics
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Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
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The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma
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SMC4, which is essentially involved in lung development, is associated with lung adenocarcinoma progression
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Evolutionary perspectives on health and medicine
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Metabolism of benzo[a]pyrene by human mammary epithelial cells: toxicity and DNA adduct formation.
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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at Senescence
inferredcites →https://doi.org/10.1074/jbc.ra117.001068openalex-snapshot
The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine
inferredcites →https://doi.org/10.1080/15384101.2015.1049778openalex-snapshot
A novel role for the condensin II complex in cellular senescence
inferredcites →https://doi.org/10.1093/bioinformatics/btp073openalex-snapshot
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
inferredcites →https://doi.org/10.1093/bioinformatics/bts565openalex-snapshot
CD-HIT: accelerated for clustering the next-generation sequencing data
inferredcites →https://doi.org/10.1093/carcin/bgs124openalex-snapshot
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
inferredcites →https://doi.org/10.1093/database/bar030openalex-snapshot
Ensembl BioMarts: a hub for data retrieval across taxonomic space
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A Proposal to Sequence Genomes of Unique Interest for Research on Aging
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Systematic analysis of the gerontome reveals links between aging and age-related diseases
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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
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TSGene: a web resource for tumor suppressor genes
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GeneFriends: a human RNA-seq-based gene and transcript co-expression database
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The OMA orthology database in 2015: function predictions, better plant support, synteny view and other improvements
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COXPRESdb in 2015: coexpression database for animal species by DNA-microarray and RNAseq-based expression data with multiple quality assessment systems
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The BioMart community portal: an innovative alternative to large, centralized data repositories
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The BioGRID interaction database: 2017 update
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Human Ageing Genomic Resources: new and updated databases
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WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit
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Approaches for Extracting Practical Information from Gene Co-expression Networks in Plant Biology
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The Origins and Evolution of the p53 Family of Genes
inferredcites →https://doi.org/10.1101/gad.1971610openalex-snapshot
The essence of senescence: Figure 1.
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Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
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Has gene duplication impacted the evolution of Eutherian longevity?
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The DrugAge database of aging-related drugs
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Wide‐scale comparative analysis of longevity genes and interventions
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A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence
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Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
inferredcites →https://doi.org/10.1128/mcb.19.3.2109openalex-snapshot
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts
inferredcites →https://doi.org/10.1146/annurev-physiol-030212-183653openalex-snapshot
Aging, Cellular Senescence, and Cancer
inferredcites →https://doi.org/10.1186/1471-2164-11-532openalex-snapshot
Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma
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Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
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Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells
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Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods
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Network propagation in the cytoscape cyberinfrastructure
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The Human Blood Metabolome-Transcriptome Interface
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REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
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When Is Hub Gene Selection Better than Standard Meta-Analysis?
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Beta-galactosidase staining on bone marrow. The osteoclast pitfall.
inferredcites →https://doi.org/10.18632/aging.100413openalex-snapshot
Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective
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R: A Language and Environment for Statistical Computing
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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies
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CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks
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RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis
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Medical subject headings (MeSH) terms
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The meaning of p16ink4aexpression in tumors
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Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Aging of the cells: Insight into cellular senescence and detection Methods
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Computational analysis identified accelerated senescence as a significant contribution to preeclampsia pathophysiology
inferred← citeshttps://doi.org/10.1038/s43587-021-00051-5openalex-snapshot
Common genetic associations between age-related diseases
inferred← citeshttps://doi.org/10.1101/2020.06.29.133702openalex-snapshot
Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing
inferred← citeshttps://doi.org/10.1136/bmjopen-2020-039560openalex-snapshot
Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a prospective cohort study
inferred← citeshttps://doi.org/10.18632/aging.202648openalex-snapshot
Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues
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