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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

https://doi.org/10.1101/2020.06.29.133702

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

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GCTA: A Tool for Genome-wide Complex Trait Analysis

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A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

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Leveraging Polygenic Functional Enrichment to Improve GWAS Power

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The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

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Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

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Ageing as a Risk Factor for Disease

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Age-related clonal haemopoiesis is associated with increased epigenetic age

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Development of a forensically useful age prediction method based on DNA methylation analysis

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CD46 processing: A means of expression

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Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

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Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

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Quality control and conduct of genome-wide association meta-analyses

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

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An epigenetic predictor of death captures multi-modal measures of brain health

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Functional mapping and annotation of genetic associations with FUMA

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GWAS of epigenetic aging rates in blood reveals a critical role for TERT

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Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

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DNA methylation-based biomarkers and the epigenetic clock theory of ageing

inferredcites →https://doi.org/10.1038/s41588-017-0014-7openalex-snapshot

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

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GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

inferredcites →https://doi.org/10.1038/srep34508openalex-snapshot

SMC4, which is essentially involved in lung development, is associated with lung adenocarcinoma progression

inferredcites →https://doi.org/10.1053/j.gastro.2014.07.021openalex-snapshot

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

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MendelVar: gene prioritization at GWAS loci using phenotypic enrichment of Mendelian disease genes

inferredcites →https://doi.org/10.1093/bioinformatics/btq340openalex-snapshot

METAL: fast and efficient meta-analysis of genomewide association scans

inferredcites →https://doi.org/10.1093/bioinformatics/bts191openalex-snapshot

INRICH: interval-based enrichment analysis for genome-wide association studies

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PRSice: Polygenic Risk Score software

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

inferredcites →https://doi.org/10.1093/hmg/ddx280openalex-snapshot

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

inferredcites →https://doi.org/10.1093/ije/dyw041openalex-snapshot

The epigenetic clock and telomere length are independently associated with chronological age and mortality

inferredcites →https://doi.org/10.1093/ije/dyx102openalex-snapshot

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

inferredcites →https://doi.org/10.1093/nar/gky1120openalex-snapshot

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

inferredcites →https://doi.org/10.1101/126102openalex-snapshot

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

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Lipid associated polygenic enrichment in Alzheimer’s disease

inferredcites →https://doi.org/10.1101/660506openalex-snapshot

Genetics of 38 blood and urine biomarkers in the UK Biobank

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A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and Disease

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Accelerated epigenetic aging in Down syndrome

inferredcites →https://doi.org/10.1111/acel.13143openalex-snapshot

Nuclear envelope dysfunction and its contribution to the aging process

inferredcites →https://doi.org/10.1111/j.1365-2567.2008.02821.xopenalex-snapshot

T‐cell regulation by CD46 and its relevance in multiple sclerosis

inferredcites →https://doi.org/10.1126/science.1235488openalex-snapshot

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

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Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk

inferredcites →https://doi.org/10.1161/circgenetics.116.001506openalex-snapshot

Epigenetic Signatures of Cigarette Smoking

inferredcites →https://doi.org/10.1172/jci.insight.135204openalex-snapshot

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

inferredcites →https://doi.org/10.1186/gb-2013-14-10-r115openalex-snapshot

DNA methylation age of human tissues and cell types

inferredcites →https://doi.org/10.1186/s13059-015-0584-6openalex-snapshot

DNA methylation age of blood predicts all-cause mortality in later life

inferredcites →https://doi.org/10.1186/s13059-018-1514-1openalex-snapshot

Epigenetic prediction of complex traits and death

inferredcites →https://doi.org/10.1186/s13059-020-01990-9openalex-snapshot

A multidimensional systems biology analysis of cellular senescence in aging and disease

inferredcites →https://doi.org/10.1186/s13073-019-0693-zopenalex-snapshot

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Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

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MAGMA: Generalized Gene-Set Analysis of GWAS Data

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Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

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A meta-analysis of genome-wide association studies of epigenetic age acceleration

inferredcites →https://doi.org/10.1371/journal.pone.0014821openalex-snapshot

Epigenetic Predictor of Age

inferredcites →https://doi.org/10.1371/journal.pone.0142596openalex-snapshot

TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins

inferredcites →https://doi.org/10.18632/aging.100859openalex-snapshot

Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients

inferredcites →https://doi.org/10.18632/aging.101168openalex-snapshot

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

inferredcites →https://doi.org/10.18632/aging.101414openalex-snapshot

An epigenetic biomarker of aging for lifespan and healthspan

inferredcites →https://doi.org/10.18632/aging.101515openalex-snapshot

Impact of demography and population dynamics on the genetic architecture of human longevity

inferredcites →https://doi.org/10.18632/aging.101684openalex-snapshot

DNA methylation GrimAge strongly predicts lifespan and healthspan

inferredcites →https://doi.org/10.3892/or.2017.5654openalex-snapshot

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway

inferredcites →https://doi.org/10.7554/elife.34408openalex-snapshot

The MR-Base platform supports systematic causal inference across the human phenome

inferredcites →https://doi.org/10.7554/elife.34408.012openalex-snapshot

Author response: The MR-Base platform supports systematic causal inference across the human phenome

inferredcites →https://doi.org/10.7554/elife.43657openalex-snapshot

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

inferredcites →https://doi.org/10.7554/elife.43657.021openalex-snapshot

Author response: An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

inferredcites →https://doi.org/10.7554/elife.51507openalex-snapshot

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

inferredcites →https://doi.org/10.7554/elife.51507.sa2openalex-snapshot

Author response: Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/978-3-031-35176-1_6openalex-snapshot

Epidemiology, Genetics and Epigenetics of Biological Aging: One or More Aging Systems?

inferred← citeshttps://doi.org/10.1038/s41576-021-00356-6openalex-snapshot

Germline risk of clonal haematopoiesis

inferred← citeshttps://doi.org/10.1038/s43856-021-00033-zopenalex-snapshot

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19

inferred← citeshttps://doi.org/10.1093/gerona/glac041openalex-snapshot

The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis

inferred← citeshttps://doi.org/10.1101/2020.08.06.20169854openalex-snapshot

Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19

inferred← citeshttps://doi.org/10.1101/2020.11.24.20237156openalex-snapshot

Associations between alcohol use and accelerated biological ageing

inferred← citeshttps://doi.org/10.1101/2020.12.01.404681openalex-snapshot

Epigenetic scores for the circulating proteome as tools for disease prediction

inferred← citeshttps://doi.org/10.1161/circulationaha.121.056456openalex-snapshot

Epigenetic Age and the Risk of Incident Atrial Fibrillation

inferred← citeshttps://doi.org/10.1186/s13148-021-01082-wopenalex-snapshot

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

inferred← citeshttps://doi.org/10.7554/elife.63425openalex-snapshot

Sex differences in biological aging with a focus on human studies

inferred← citeshttps://doi.org/10.7554/elife.71802openalex-snapshot

Epigenetic scores for the circulating proteome as tools for disease prediction

inferred← citeshttps://doi.org/10.7554/elife.80729.1.sa0openalex-snapshot

Reviewer #2 (Public Review): The role of adolescent lifestyle habits in biological aging: A prospective twin study

inferred← citeshttps://doi.org/10.7554/elife.80729.1.sa2openalex-snapshot

Reviewer #1 (Public Review): The role of adolescent lifestyle habits in biological aging: A prospective twin study

inferred← citeshttps://doi.org/10.7554/elife.80729.1.sa3openalex-snapshot

eLife assessment: The role of adolescent lifestyle habits in biological aging: A prospective twin study

inferred← citeshttps://doi.org/10.7554/elife.80729.1.sa4openalex-snapshot

Author Response: The role of adolescent lifestyle habits in biological aging: A prospective twin study

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