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Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity

https://doi.org/10.1101/762310
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
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The Cellular and Molecular Basis of Translational Immunometabolism
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Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
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Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function
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Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease
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General Statistical Modeling of Data from Protein Relative Expression Isobaric Tags
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Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
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Hepatocytes: a key cell type for innate immunity
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Enhancing CD8 T-cell memory by modulating fatty acid metabolism
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A diverse range of gene products are effectors of the type I interferon antiviral response
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
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Inflammation, metaflammation and immunometabolic disorders
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Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
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Immune surveillance by the liver
inferredcites →https://doi.org/10.1038/ni.3323openalex-snapshot
Amino acid auxotrophy as a system of immunological control nodes
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Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior
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Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
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Immunology of hepatitis B virus and hepatitis C virus infection
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Living in the liver: hepatic infections
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Type I interferons in infectious disease
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Polyamine metabolism and cancer: treatments, challenges and opportunities
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Autophagy maintains tumour growth through circulating arginine
inferredcites →https://doi.org/10.1038/s41586-019-0996-7openalex-snapshot
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
inferredcites →https://doi.org/10.1038/s41590-019-0397-yopenalex-snapshot
CD8+ T cells induce cachexia during chronic viral infection
inferredcites →https://doi.org/10.1038/sdata.2017.140openalex-snapshot
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
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Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease
inferredcites →https://doi.org/10.1074/jbc.c116.763623openalex-snapshot
Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids
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T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?
inferredcites →https://doi.org/10.1084/jem.189.10.1555openalex-snapshot
Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte
inferredcites →https://doi.org/10.1084/jem.20151570openalex-snapshot
Immunometabolism governs dendritic cell and macrophage function
inferredcites →https://doi.org/10.1093/bioinformatics/btp101openalex-snapshot
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
inferredcites →https://doi.org/10.1093/bioinformatics/btt656openalex-snapshot
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
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KEGG: Kyoto Encyclopedia of Genes and Genomes
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Polyamine metabolism and cancer
inferredcites →https://doi.org/10.1111/j.1755-148x.2010.00798.xopenalex-snapshot
Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis
inferredcites →https://doi.org/10.1126/science.1260419openalex-snapshot
Tissue-based map of the human proteome
inferredcites →https://doi.org/10.1128/jvi.01347-16openalex-snapshot
Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses
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Nitrogen metabolism and ornithine cycle function
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1945openalex-snapshot
Pegylated Recombinant Human Arginase (rhArg-peg5,000mw) Inhibits the In vitro and In vivo Proliferation of Human Hepatocellular Carcinoma through Arginine Depletion
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voom: precision weights unlock linear model analysis tools for RNA-seq read counts
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Correction to: MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
inferredcites →https://doi.org/10.1186/s13045-018-0612-6openalex-snapshot
Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma
inferredcites →https://doi.org/10.1371/journal.pbio.1001759openalex-snapshot
Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
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Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
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Systemic Viral Infections and Collateral Damage in the Liver
inferredcites →https://doi.org/10.3109/08830189809084487openalex-snapshot
Type I Interferons
inferredcites →https://doi.org/10.4049/jimmunol.1501668openalex-snapshot
Hepatocytes as Immunological Agents
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