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Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/978-981-10-6955-0_11openalex-snapshot
Replication Domains: Genome Compartmentalization into Functional Replication Units
inferredcites →https://doi.org/10.1007/s10577-009-9087-1openalex-snapshot
Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches
inferredcites →https://doi.org/10.1007/s12064-012-0162-3openalex-snapshot
Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples
inferredcites →https://doi.org/10.1016/j.ceb.2009.08.002openalex-snapshot
Eukaryotic DNA replication control: Lock and load, then fire
inferredcites →https://doi.org/10.1016/j.cell.2017.07.043openalex-snapshot
Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
inferredcites →https://doi.org/10.1016/j.gdata.2016.07.003openalex-snapshot
Characterization of the replication timing program of 6 human model cell lines
inferredcites →https://doi.org/10.1016/j.jmb.2013.09.021openalex-snapshot
From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains
inferredcites →https://doi.org/10.1016/j.jmb.2014.05.027openalex-snapshot
Chromatin Structure and Replication Origins: Determinants of Chromosome Replication and Nuclear Organization
inferredcites →https://doi.org/10.1016/j.molcel.2013.03.004openalex-snapshot
Quantitative, Genome-Wide Analysis of Eukaryotic Replication Initiation and Termination
inferredcites →https://doi.org/10.1016/j.tibs.2005.06.007openalex-snapshot
Pumps, paradoxes and ploughshares: mechanism of the MCM2–7 DNA helicase
inferredcites →https://doi.org/10.1016/s1097-2765(00)80227-0openalex-snapshot
The Spatial Position and Replication Timing of Chromosomal Domains Are Both Established in Early G1 Phase
inferredcites →https://doi.org/10.1038/nature10895openalex-snapshot
Intrinsic coupling of lagging-strand synthesis to chromatin assembly
inferredcites →https://doi.org/10.1038/nature13986openalex-snapshot
Topologically associating domains are stable units of replication-timing regulation
inferredcites →https://doi.org/10.1038/ncb2113openalex-snapshot
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
inferredcites →https://doi.org/10.1038/ncomms10208openalex-snapshot
Replication landscape of the human genome
inferredcites →https://doi.org/10.1038/nprot.2012.101openalex-snapshot
Identifying ChIP-seq enrichment using MACS
inferredcites →https://doi.org/10.1038/nprot.2012.145openalex-snapshot
Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm
inferredcites →https://doi.org/10.1038/nrm4002openalex-snapshot
DNA replication origin activation in space and time
inferredcites →https://doi.org/10.1038/nsmb.2339openalex-snapshot
Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
inferredcites →https://doi.org/10.1038/s41467-018-06066-8openalex-snapshot
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
inferredcites →https://doi.org/10.1038/s41556-019-0282-9openalex-snapshot
H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids
inferredcites →https://doi.org/10.1038/s41594-018-0171-0openalex-snapshot
Transcription shapes DNA replication initiation and termination in human cells
inferredcites →https://doi.org/10.1073/pnas.0911500106openalex-snapshot
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
inferredcites →https://doi.org/10.1073/pnas.1609060113openalex-snapshot
Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers
inferredcites →https://doi.org/10.1073/pnas.55.3.599openalex-snapshot
Autoradiography of chromosomal DNA fibers from Chinese hamster cells.
inferredcites →https://doi.org/10.1074/jbc.m705905200openalex-snapshot
ATP-dependent Assembly of the Human Origin Recognition Complex
inferredcites →https://doi.org/10.1083/jcb.201109105openalex-snapshot
Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus
inferredcites →https://doi.org/10.1091/mbc.e06-04-0298openalex-snapshot
DNA Replication Origin Interference Increases the Spacing between Initiation Events in Human Cells
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/btu638openalex-snapshot
HTSeq—a Python framework to work with high-throughput sequencing data
inferredcites →https://doi.org/10.1093/bioinformatics/btw069openalex-snapshot
Integrated genome browser: visual analytics platform for genomics
inferredcites →https://doi.org/10.1093/emboj/20.16.4588openalex-snapshot
Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein–Barr virus
inferredcites →https://doi.org/10.1093/nar/gkt012openalex-snapshot
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
inferredcites →https://doi.org/10.1093/nar/gkv509openalex-snapshot
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture
inferredcites →https://doi.org/10.1093/nar/gkw760openalex-snapshot
Genome-wide identification and characterisation of human DNA replication origins by initiation site sequencing (ini-seq)
inferredcites →https://doi.org/10.1093/nar/gkx1265openalex-snapshot
Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors
inferredcites →https://doi.org/10.1093/nar/gky476openalex-snapshot
Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells
inferredcites →https://doi.org/10.1093/nar/gky797openalex-snapshot
Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions
inferredcites →https://doi.org/10.1101/cshperspect.a010124openalex-snapshot
Helicase Loading at Chromosomal Origins of Replication
inferredcites →https://doi.org/10.1101/gad.177444.111openalex-snapshot
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
inferredcites →https://doi.org/10.1101/gad.285114.116openalex-snapshot
DNA replication origins—where do we begin?
inferredcites →https://doi.org/10.1101/gr.097873.109openalex-snapshot
Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading
inferredcites →https://doi.org/10.1101/gr.121830.111openalex-snapshot
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features
inferredcites →https://doi.org/10.1101/gr.142331.112openalex-snapshot
Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing
inferredcites →https://doi.org/10.1101/gr.155218.113openalex-snapshot
Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins
inferredcites →https://doi.org/10.1101/gr.192799.115openalex-snapshot
The chromatin environment shapes DNA replication origin organization and defines origin classes
inferredcites →https://doi.org/10.1101/gr.195305.115openalex-snapshot
Replication timing is regulated by the number of MCMs loaded at origins
inferredcites →https://doi.org/10.1126/science.1066101openalex-snapshot
Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae : High-Resolution Mapping of Replication Origins
inferredcites →https://doi.org/10.1126/science.1536007openalex-snapshot
A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements
inferredcites →https://doi.org/10.1126/science.aau0294openalex-snapshot
MCM2 promotes symmetric inheritance of modified histones during DNA replication
inferredcites →https://doi.org/10.1128/mcb.01392-06openalex-snapshot
Identification of New Human Origins of DNA Replication by an Origin-Trapping Assay
inferredcites →https://doi.org/10.1186/gb-2008-9-9-r137openalex-snapshot
Model-based Analysis of ChIP-Seq (MACS)
inferredcites →https://doi.org/10.1186/gb-2009-10-3-r25openalex-snapshot
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
inferredcites →https://doi.org/10.1186/gb-2013-14-4-r36openalex-snapshot
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
inferredcites →https://doi.org/10.1242/jcs.00087openalex-snapshot
The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells
inferredcites →https://doi.org/10.1242/jcs.00708openalex-snapshot
Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus
inferredcites →https://doi.org/10.1242/jcs.115.1.51openalex-snapshot
Mammalian nuclei become licensed for DNA replication during late telophase
inferredcites →https://doi.org/10.1242/jcs.115.5.869openalex-snapshot
The chromosome replication cycle
inferredcites →https://doi.org/10.12688/f1000research.9008.1openalex-snapshot
How MCM loading and spreading specify eukaryotic DNA replication initiation sites
inferredcites →https://doi.org/10.1371/journal.pcbi.1002322openalex-snapshot
Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome
inferredcites →https://doi.org/10.1371/journal.pcbi.1002443openalex-snapshot
Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines
inferredcites →https://doi.org/10.1371/journal.pgen.1004282openalex-snapshot
The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells
inferredcites →https://doi.org/10.15252/embj.201488307openalex-snapshot
Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle
inferredcites →https://doi.org/10.15252/embj.201796541openalex-snapshot
Histone H4K20 tri‐methylation at late‐firing origins ensures timely heterochromatin replication
inferredcites →https://doi.org/10.3390/genes10030199openalex-snapshot
Origin Firing Regulations to Control Genome Replication Timing
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1186/s13059-021-02390-3openalex-snapshot
Transcription shapes DNA replication initiation to preserve genome integrity
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