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Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotype

https://doi.org/10.1101/818245
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1878-0261.12095openalex-snapshot
EMT and inflammation: inseparable actors of cancer progression
inferredcites →https://doi.org/10.1002/cpt.782openalex-snapshot
The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation
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Quantitative Proteomics Identifies the Membrane-Associated Peroxidase Gpx8 as a Cellular Substrate of the Hepatitis C Virus NS3–4A Protease
inferredcites →https://doi.org/10.1007/s00018-014-1564-9openalex-snapshot
Role of p75 neurotrophin receptor in stem cell biology: more than just a marker
inferredcites →https://doi.org/10.1007/s10549-009-0674-9openalex-snapshot
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
inferredcites →https://doi.org/10.1007/s10549-016-4013-7openalex-snapshot
miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients
inferredcites →https://doi.org/10.1016/0003-9861(89)90205-1openalex-snapshot
Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor
inferredcites →https://doi.org/10.1016/j.canlet.2016.02.048openalex-snapshot
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
inferredcites →https://doi.org/10.1016/j.ccell.2018.05.003openalex-snapshot
Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling
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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
inferredcites →https://doi.org/10.1016/j.ccr.2013.08.005openalex-snapshot
Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
inferredcites →https://doi.org/10.1016/j.ceb.2016.06.002openalex-snapshot
Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?
inferredcites →https://doi.org/10.1016/j.cell.2008.03.027openalex-snapshot
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
inferredcites →https://doi.org/10.1016/j.cell.2013.12.010openalex-snapshot
Regulation of Ferroptotic Cancer Cell Death by GPX4
inferredcites →https://doi.org/10.1016/j.cell.2014.07.032openalex-snapshot
Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
inferredcites →https://doi.org/10.1016/j.cell.2015.09.033openalex-snapshot
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
inferredcites →https://doi.org/10.1016/j.cell.2016.05.042openalex-snapshot
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
inferredcites →https://doi.org/10.1016/j.cell.2016.06.028openalex-snapshot
EMT: 2016
inferredcites →https://doi.org/10.1016/j.cell.2016.12.039openalex-snapshot
Understanding the Intersections between Metabolism and Cancer Biology
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.01.018openalex-snapshot
GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.12.020openalex-snapshot
Glutathione peroxidase 8 is transcriptionally regulated by HIFα and modulates growth factor signaling in HeLa cells
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.07.021openalex-snapshot
ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity
inferredcites →https://doi.org/10.1016/j.immuni.2013.10.022openalex-snapshot
Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation
inferredcites →https://doi.org/10.1016/j.jmb.2010.12.039openalex-snapshot
Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation
inferredcites →https://doi.org/10.1016/j.mce.2013.03.024openalex-snapshot
Cytokines driving breast cancer stemness
inferredcites →https://doi.org/10.1016/j.redox.2016.12.011openalex-snapshot
Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles
inferredcites →https://doi.org/10.1016/j.smim.2014.01.001openalex-snapshot
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
inferredcites →https://doi.org/10.1016/s0076-6879(81)77046-0openalex-snapshot
[44] Glutathione peroxidase
inferredcites →https://doi.org/10.1016/s1040-1741(08)70352-xopenalex-snapshot
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
inferredcites →https://doi.org/10.1021/bi00183a018openalex-snapshot
Roles of Disulfide Bonds in Recombinant Human Interleukin 6 Conformation
inferredcites →https://doi.org/10.1038/cdd.2016.126openalex-snapshot
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer
inferredcites →https://doi.org/10.1038/nature10350openalex-snapshot
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
inferredcites →https://doi.org/10.1038/nature14363openalex-snapshot
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
inferredcites →https://doi.org/10.1038/nature19353openalex-snapshot
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
inferredcites →https://doi.org/10.1038/nature22379openalex-snapshot
Nutrient acquisition strategies of mammalian cells
inferredcites →https://doi.org/10.1038/nature23007openalex-snapshot
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
inferredcites →https://doi.org/10.1038/nature24297openalex-snapshot
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
inferredcites →https://doi.org/10.1038/nbt0297-142openalex-snapshot
A bioactive designer cytokine for human hematopoietic progenitor cell expansion
inferredcites →https://doi.org/10.1038/ncb1691openalex-snapshot
Direct regulation of TWIST by HIF-1α promotes metastasis
inferredcites →https://doi.org/10.1038/ng.890openalex-snapshot
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
inferredcites →https://doi.org/10.1038/ng1180openalex-snapshot
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
inferredcites →https://doi.org/10.1038/nrclinonc.2017.44openalex-snapshot
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
inferredcites →https://doi.org/10.1038/nrclinonc.2018.8openalex-snapshot
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
inferredcites →https://doi.org/10.1038/oncsis.2013.37openalex-snapshot
Suppression of SCARA5 by Snail1 is essential for EMT-associated cell migration of A549 cells
inferredcites →https://doi.org/10.1038/s41556-018-0196-yopenalex-snapshot
Non-redundant functions of EMT transcription factors
inferredcites →https://doi.org/10.1038/s41580-018-0080-4openalex-snapshot
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
inferredcites →https://doi.org/10.1038/s41598-017-04561-4openalex-snapshot
IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model
inferredcites →https://doi.org/10.1038/sj.onc.1210508openalex-snapshot
The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
inferredcites →https://doi.org/10.1073/pnas.0530291100openalex-snapshot
Prospective identification of tumorigenic breast cancer cells
inferredcites →https://doi.org/10.1073/pnas.1004900107openalex-snapshot
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
inferredcites →https://doi.org/10.1073/pnas.1618298114openalex-snapshot
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells
inferredcites →https://doi.org/10.1074/jbc.274.11.7207openalex-snapshot
Disulfide Bond Structure and N-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor
inferredcites →https://doi.org/10.1089/ars.2008.2055openalex-snapshot
The Catalytic Site of Glutathione Peroxidases
inferredcites →https://doi.org/10.1089/ars.2008.2057openalex-snapshot
Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily
inferredcites →https://doi.org/10.1089/ars.2016.6866openalex-snapshot
Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane
inferredcites →https://doi.org/10.1093/nar/gkv1337openalex-snapshot
MERAV: a tool for comparing gene expression across human tissues and cell types
inferredcites →https://doi.org/10.1126/science.aad3680openalex-snapshot
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
inferredcites →https://doi.org/10.1126/science.aaf4405openalex-snapshot
Hypoxic control of metastasis
inferredcites →https://doi.org/10.1126/scisignal.2004088openalex-snapshot
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3719openalex-snapshot
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
inferredcites →https://doi.org/10.1158/1541-7786.mcr-07-0344openalex-snapshot
Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0095openalex-snapshot
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0345openalex-snapshot
Cancer Cell Metabolism: One Hallmark, Many Faces
inferredcites →https://doi.org/10.1172/jci36183openalex-snapshot
Biomarkers for epithelial-mesenchymal transitions
inferredcites →https://doi.org/10.1172/jci39104openalex-snapshot
The basics of epithelial-mesenchymal transition
inferredcites →https://doi.org/10.1172/jci73531openalex-snapshot
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
inferredcites →https://doi.org/10.1186/1755-8794-4-77openalex-snapshot
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
inferredcites →https://doi.org/10.1186/bcr1982openalex-snapshot
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
inferredcites →https://doi.org/10.1371/journal.pone.0033066openalex-snapshot
Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes
inferredcites →https://doi.org/10.1371/journal.pone.0051136openalex-snapshot
Meta-Analysis of Gene Expression Signatures Defining the Epithelial to Mesenchymal Transition during Cancer Progression
inferredcites →https://doi.org/10.1371/journal.pone.0082241openalex-snapshot
Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
inferredcites →https://doi.org/10.14348/molcells.2016.0310openalex-snapshot
Cancer Metabolism: Fueling More than Just Growth
inferredcites →https://doi.org/10.18632/oncotarget.10337openalex-snapshot
Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients
inferredcites →https://doi.org/10.2217/pgs.11.72openalex-snapshot
Dihydropyrimidine Dehydrogenase Gene as a Major Predictor of Severe 5-Fluorouracil Toxicity
inferredcites →https://doi.org/10.4143/crt.2005.37.1.1openalex-snapshot
Biology of SNU Cell Lines

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inferred← citeshttps://doi.org/10.3389/fonc.2020.01309openalex-snapshot
Analysis of Epithelial-Mesenchymal Transition Metabolism Identifies Possible Cancer Biomarkers Useful in Diverse Genetic Backgrounds
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