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Modeling human TBX5 haploinsufficiency predicts regulatory networks for congenital heart disease

https://doi.org/10.1101/835603
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Outgoing claims: the papers this work cites, builds on, or argues with.

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CRISPR‐Mediated Gene Targeting of Human Induced Pluripotent Stem Cells
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Dorsal Gradient Networks in the Drosophila Embryo
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Incidence of congenital heart disease: II. Prenatal incidence
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Incidence of congenital heart disease: I. Postnatal incidence
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A generic tool for biotinylation of tagged proteins in transgenic mice
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Transcription Factor Pathways and Congenital Heart Disease
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Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency
inferredcites →https://doi.org/10.1016/j.cell.2016.01.004openalex-snapshot
Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis
inferredcites →https://doi.org/10.1016/j.cell.2016.11.033openalex-snapshot
Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis
inferredcites →https://doi.org/10.1016/j.cell.2017.05.004openalex-snapshot
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization
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Comprehensive Integration of Single-Cell Data
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A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
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Rational Reprogramming of Cellular States by Combinatorial Perturbation
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The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation
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Single-Cell Resolution of Temporal Gene Expression during Heart Development
inferredcites →https://doi.org/10.1016/j.devcel.2016.10.014openalex-snapshot
Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells
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Genetic basis of congenital cardiovascular malformations
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CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs
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Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia
inferredcites →https://doi.org/10.1016/j.ydbio.2006.05.023openalex-snapshot
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis
inferredcites →https://doi.org/10.1016/j.ydbio.2008.11.004openalex-snapshot
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development
inferredcites →https://doi.org/10.1016/s0092-8674(01)00493-7openalex-snapshot
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease
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The anatomy of a large-scale hypertextual Web search engine
inferredcites →https://doi.org/10.1016/s0735-1097(02)01886-7openalex-snapshot
The incidence of congenital heart disease
inferredcites →https://doi.org/10.1038/90123openalex-snapshot
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
inferredcites →https://doi.org/10.1038/nature01827openalex-snapshot
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
inferredcites →https://doi.org/10.1038/nature12141openalex-snapshot
De novo mutations in histone-modifying genes in congenital heart disease
inferredcites →https://doi.org/10.1038/nbt.1630openalex-snapshot
GREAT improves functional interpretation of cis-regulatory regions
inferredcites →https://doi.org/10.1038/nbt.3192openalex-snapshot
Spatial reconstruction of single-cell gene expression data
inferredcites →https://doi.org/10.1038/nbt.4096openalex-snapshot
Integrating single-cell transcriptomic data across different conditions, technologies, and species
inferredcites →https://doi.org/10.1038/nbt.4314openalex-snapshot
Dimensionality reduction for visualizing single-cell data using UMAP
inferredcites →https://doi.org/10.1038/ncomms5907openalex-snapshot
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
inferredcites →https://doi.org/10.1038/ng.2261openalex-snapshot
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
inferredcites →https://doi.org/10.1038/ng.2610openalex-snapshot
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
inferredcites →https://doi.org/10.1038/ng.2636openalex-snapshot
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations
inferredcites →https://doi.org/10.1038/ng.2637openalex-snapshot
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16
inferredcites →https://doi.org/10.1038/ng.3627openalex-snapshot
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing
inferredcites →https://doi.org/10.1038/ng.3970openalex-snapshot
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
inferredcites →https://doi.org/10.1038/ng.517openalex-snapshot
Genome-wide association study of PR interval
inferredcites →https://doi.org/10.1038/ng0197-21openalex-snapshot
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
inferredcites →https://doi.org/10.1038/ng0197-30openalex-snapshot
Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
inferredcites →https://doi.org/10.1038/nmeth.2840openalex-snapshot
Isolation of single-base genome-edited human iPS cells without antibiotic selection
inferredcites →https://doi.org/10.1038/s41467-018-07333-4openalex-snapshot
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
inferredcites →https://doi.org/10.1038/s41467-019-12812-3openalex-snapshot
A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
inferredcites →https://doi.org/10.1056/nejm199403313301302openalex-snapshot
The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)
inferredcites →https://doi.org/10.1073/pnas.0801779105openalex-snapshot
Tbx5-dependent pathway regulating diastolic function in congenital heart disease
inferredcites →https://doi.org/10.1089/ten.tea.2018.0362openalex-snapshot
Phenotypic Variation Between Stromal Cells Differentially Impacts Engineered Cardiac Tissue Function
inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
inferredcites →https://doi.org/10.1093/bioinformatics/btt656openalex-snapshot
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
inferredcites →https://doi.org/10.1093/hmg/dds552openalex-snapshot
Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot
inferredcites →https://doi.org/10.1097/00001573-200405000-00004openalex-snapshot
TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed
inferredcites →https://doi.org/10.1101/531210openalex-snapshot
The mutational constraint spectrum quantified from variation in 141,456 humans
inferredcites →https://doi.org/10.1101/cshperspect.a013946openalex-snapshot
Insights into the Genetic Structure of Congenital Heart Disease from Human and Murine Studies on Monogenic Disorders
inferredcites →https://doi.org/10.1101/gad.9.13.1654openalex-snapshot
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
inferredcites →https://doi.org/10.1101/gr.230771.117openalex-snapshot
bigSCale: an analytical framework for big-scale single-cell data
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.1231143openalex-snapshot
Multiplex Genome Engineering Using CRISPR/Cas Systems
inferredcites →https://doi.org/10.1126/science.276.5317.1404openalex-snapshot
Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C
inferredcites →https://doi.org/10.1126/science.aac9396openalex-snapshot
De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies
inferredcites →https://doi.org/10.1126/science.aar3131openalex-snapshot
Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis
inferredcites →https://doi.org/10.1126/science.aat5056openalex-snapshot
Oligogenic inheritance of a human heart disease involving a genetic modifier
inferredcites →https://doi.org/10.1126/scitranslmed.aaf4891openalex-snapshot
Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm
inferredcites →https://doi.org/10.1128/mcb.01923-08openalex-snapshot
Physical Interaction between TBX5 and MEF2C Is Required for Early Heart Development
inferredcites →https://doi.org/10.1152/ajpheart.00027.2005openalex-snapshot
Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome
inferredcites →https://doi.org/10.1161/circresaha.108.181834openalex-snapshot
Atrial Fibrillation and Other Clinical Manifestations of Altered TBX5 Dosage in Typical Holt–Oram Syndrome
inferredcites →https://doi.org/10.1161/circresaha.116.309140openalex-snapshot
Genetics and Genomics of Congenital Heart Disease
inferredcites →https://doi.org/10.1161/circresaha.116.309948openalex-snapshot
A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell–Based Models for Cardiovascular Diseases
inferredcites →https://doi.org/10.1161/circresaha.119.315891openalex-snapshot
The Control of Diastolic Calcium in the Heart
inferredcites →https://doi.org/10.1172/jci.insight.94623openalex-snapshot
A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress
inferredcites →https://doi.org/10.1172/jci124231openalex-snapshot
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
inferredcites →https://doi.org/10.1186/gb-2013-14-4-r36openalex-snapshot
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
inferredcites →https://doi.org/10.1186/s13059-019-1713-4openalex-snapshot
Single-cell transcriptomics unveils gene regulatory network plasticity
inferredcites →https://doi.org/10.1186/s13059-019-1874-1openalex-snapshot
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
inferredcites →https://doi.org/10.1242/dev.01849openalex-snapshot
BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart
inferredcites →https://doi.org/10.1242/dev.02610openalex-snapshot
Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development
inferredcites →https://doi.org/10.1242/dev.126.6.1269openalex-snapshot
The cardiac homeobox gene Csx/Nkx2 . 5 lies genetically upstream of multiple genes essential for heart development
inferredcites →https://doi.org/10.1242/dev.154146openalex-snapshot
Heart morphogenesis gene regulatory networks revealed by temporal expression analysis
inferredcites →https://doi.org/10.1242/dev.174086openalex-snapshot
Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis
inferredcites →https://doi.org/10.1371/journal.pgen.1000718openalex-snapshot
A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1001304openalex-snapshot
Genome-Wide Association Studies of the PR Interval in African Americans
inferredcites →https://doi.org/10.1371/journal.pgen.1005963openalex-snapshot
De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects
inferredcites →https://doi.org/10.15252/emmm.201505719openalex-snapshot
TECRL, a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
inferredcites →https://doi.org/10.2307/4615733openalex-snapshot
A Simple Sequentially Rejective Multiple Test Procedure
inferredcites →https://doi.org/10.3389/fcvm.2017.00005openalex-snapshot
Assessment of Diastolic Function in Congenital Heart Disease
inferredcites →https://doi.org/10.3824/stembook.1.94.1openalex-snapshot
Genome editing in human pluripotent stem cells
inferredcites →https://doi.org/10.48550/arxiv.1201.0490openalex-snapshot
Scikit-learn: Machine Learning in Python
inferredcites →https://doi.org/10.7554/elife.03848openalex-snapshot
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
inferredcites →https://doi.org/10.7554/elife.41814openalex-snapshot
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

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inferred← citeshttps://doi.org/10.1016/j.cels.2021.07.003openalex-snapshot
Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro
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