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FLIP(L) determines p53 induced life or death

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0092-8674(92)90644-ropenalex-snapshot

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

inferredcites →https://doi.org/10.1016/0092-8674(93)90499-gopenalex-snapshot

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

inferredcites →https://doi.org/10.1016/0092-8674(93)90500-popenalex-snapshot

WAF1, a potential mediator of p53 tumor suppression

inferredcites →https://doi.org/10.1016/j.bbcan.2014.07.010openalex-snapshot

Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis

inferredcites →https://doi.org/10.1016/j.ccr.2004.08.012openalex-snapshot

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

inferredcites →https://doi.org/10.1016/j.cell.2008.03.025openalex-snapshot

Acetylation Is Indispensable for p53 Activation

inferredcites →https://doi.org/10.1016/j.cell.2016.03.025openalex-snapshot

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

inferredcites →https://doi.org/10.1016/j.cell.2017.08.028openalex-snapshot

Putting p53 in Context

inferredcites →https://doi.org/10.1016/j.celrep.2017.04.010openalex-snapshot

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

inferredcites →https://doi.org/10.1016/j.devcel.2010.10.015openalex-snapshot

Hdac1 and Hdac2 Act Redundantly to Control p63 and p53 Functions in Epidermal Progenitor Cells

inferredcites →https://doi.org/10.1016/j.dnarep.2011.10.014openalex-snapshot

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage

inferredcites →https://doi.org/10.1016/j.molcel.2006.11.026openalex-snapshot

Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction

inferredcites →https://doi.org/10.1016/j.molcel.2013.08.048openalex-snapshot

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

inferredcites →https://doi.org/10.1016/j.molcel.2015.02.015openalex-snapshot

The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

inferredcites →https://doi.org/10.1016/s0092-8674(00)80416-xopenalex-snapshot

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

inferredcites →https://doi.org/10.1016/s1097-2765(01)00214-3openalex-snapshot

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

inferredcites →https://doi.org/10.1016/s1535-6108(04)00114-xopenalex-snapshot

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

inferredcites →https://doi.org/10.1021/jm501092zopenalex-snapshot

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

inferredcites →https://doi.org/10.1038/35042675openalex-snapshot

Surfing the p53 network

inferredcites →https://doi.org/10.1038/cdd.2012.89openalex-snapshot

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

inferredcites →https://doi.org/10.1038/cddis.2015.213openalex-snapshot

DED or alive: assembly and regulation of the death effector domain complexes

inferredcites →https://doi.org/10.1038/nchembio.313openalex-snapshot

Chemical phylogenetics of histone deacetylases

inferredcites →https://doi.org/10.1038/ncomms4350openalex-snapshot

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

inferredcites →https://doi.org/10.1038/nrc2731openalex-snapshot

20 years studying p53 functions in genetically engineered mice

inferredcites →https://doi.org/10.1038/nrc2763openalex-snapshot

Awakening guardian angels: drugging the p53 pathway

inferredcites →https://doi.org/10.1038/nrc3430openalex-snapshot

MDM2, MDMX and p53 in oncogenesis and cancer therapy

inferredcites →https://doi.org/10.1038/nrd4236openalex-snapshot

Drugging the p53 pathway: understanding the route to clinical efficacy

inferredcites →https://doi.org/10.1038/nrd4288openalex-snapshot

Erratum: Drugging the p53 pathway: understanding the route to clinical efficacy

inferredcites →https://doi.org/10.1038/nrd4583openalex-snapshot

HDAC inhibitors still need a home run, despite recent approval

inferredcites →https://doi.org/10.1038/onc.2008.366openalex-snapshot

Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells

inferredcites →https://doi.org/10.1038/onc.2014.86openalex-snapshot

Targeting colon cancer cell NF-κB promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis

inferredcites →https://doi.org/10.1038/s41467-019-11046-7openalex-snapshot

Chemical genomics reveals histone deacetylases are required for core regulatory transcription

inferredcites →https://doi.org/10.1038/sj.leu.2404760openalex-snapshot

Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa

inferredcites →https://doi.org/10.1038/sj.onc.1203489openalex-snapshot

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

inferredcites →https://doi.org/10.1038/sj.onc.1209122openalex-snapshot

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

inferredcites →https://doi.org/10.1073/pnas.0507493103openalex-snapshot

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy

inferredcites →https://doi.org/10.1073/pnas.0813333106openalex-snapshot

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

inferredcites →https://doi.org/10.1073/pnas.1008522107openalex-snapshot

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

inferredcites →https://doi.org/10.1073/pnas.1417549111openalex-snapshot

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

inferredcites →https://doi.org/10.1073/pnas.241358198openalex-snapshot

Caspase-10 is an initiator caspase in death receptor signaling

inferredcites →https://doi.org/10.1074/jbc.m000202200openalex-snapshot

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

inferredcites →https://doi.org/10.1074/jbc.m110.184663openalex-snapshot

Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis

inferredcites →https://doi.org/10.1080/13543784.2017.1353077openalex-snapshot

Entinostat for the treatment of breast cancer

inferredcites →https://doi.org/10.1083/jcb.200512059openalex-snapshot

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate

inferredcites →https://doi.org/10.1084/jem.188.11.2033openalex-snapshot

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

inferredcites →https://doi.org/10.1093/emboj/cdf441openalex-snapshot

Caspase‐10 is recruited to and activated at the native TRAIL and CD95 death‐inducing signalling complexes in a FADD‐dependent manner but can not functionally substitute caspase‐8

inferredcites →https://doi.org/10.1093/emboj/cdf616openalex-snapshot

MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradation

inferredcites →https://doi.org/10.1093/nar/30.1.207openalex-snapshot

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

inferredcites →https://doi.org/10.1093/nar/gku299openalex-snapshot

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

inferredcites →https://doi.org/10.1093/nar/gkw523openalex-snapshot

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

inferredcites →https://doi.org/10.1111/febs.14523openalex-snapshot

FLIP as a therapeutic target in cancer

inferredcites →https://doi.org/10.1126/science.1090072openalex-snapshot

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

inferredcites →https://doi.org/10.1126/science.1092472openalex-snapshot

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

inferredcites →https://doi.org/10.1126/science.1247005openalex-snapshot

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

inferredcites →https://doi.org/10.1128/mcb.00494-07openalex-snapshot

Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

inferredcites →https://doi.org/10.1158/0008-5472.can-06-4397openalex-snapshot

Histone Deacetylase 2 Modulates p53 Transcriptional Activities through Regulation of p53-DNA Binding Activity

inferredcites →https://doi.org/10.1186/s13059-014-0554-4openalex-snapshot

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

inferredcites →https://doi.org/10.1242/jcs.084723openalex-snapshot

p63 maintains keratinocyte proliferative capacity through regulation of Skp2–p130 levels

inferredcites →https://doi.org/10.1523/jneurosci.5214-12.2013openalex-snapshot

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

inferredcites →https://doi.org/10.1593/neo.81358openalex-snapshot

Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment

inferredcites →https://doi.org/10.18632/oncotarget.1436openalex-snapshot

Lysine-specific modifications of p53: a matter of life and death?

inferredcites →https://doi.org/10.4161/15384101.2014.949083openalex-snapshot

The transcription factor p53: Not a repressor, solely an activator

inferredcites →https://doi.org/10.4161/cc.6420openalex-snapshot

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.70675/1a8e6d5bzc60fz4d57z9f05zbbc81aeec00aopenalex-snapshot

Étude de l’origine moléculaire de l’hétérogénéité de réponse cellulaire à TRAIL et son rôle dans la résistance non-génétique

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