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Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

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1 of the 42 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1158/0008-5472.can-06-3996 (notice 2018-07-15).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcb.22185openalex-snapshot

Histone deacetylase inhibitors: Potential in cancer therapy

inferredcites →https://doi.org/10.1007/1-4020-5466-1_9openalex-snapshot

Reversible Acetylation Of Non Histone Proteins

inferredcites →https://doi.org/10.1007/s00018-009-8736-zopenalex-snapshot

DNA Repair in Mammalian Cells

inferredcites →https://doi.org/10.1007/s00018-009-8740-3openalex-snapshot

DNA Repair in Mammalian Cells

inferredcites →https://doi.org/10.1007/s10637-006-9000-0openalex-snapshot

Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines

inferredcites →https://doi.org/10.1016/j.canlet.2008.06.005openalex-snapshot

Histone deacetylase inhibitors and genomic instability

inferredcites →https://doi.org/10.1016/j.canlet.2009.01.002openalex-snapshot

Development of vorinostat: Current applications and future perspectives for cancer therapy

inferredcites →https://doi.org/10.1016/j.canlet.2009.02.027openalex-snapshot

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer

inferredcites →https://doi.org/10.1016/j.canlet.2009.02.042openalex-snapshot

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

inferredcites →https://doi.org/10.1016/j.cell.2005.09.038openalex-snapshot

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

inferredcites →https://doi.org/10.1016/j.cell.2009.04.003openalex-snapshot

DNA Replication Reaches the Breaking Point

inferredcites →https://doi.org/10.1016/j.gene.2005.09.010openalex-snapshot

Acetylation and deacetylation of non-histone proteins

inferredcites →https://doi.org/10.1016/j.leukres.2009.08.021openalex-snapshot

Histone deacetylase inhibitors: A new perspective for the treatment of leukemia

inferredcites →https://doi.org/10.1016/s0092-8674(00)81958-3openalex-snapshot

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

inferredcites →https://doi.org/10.1038/nature08768openalex-snapshot

Signatures of mutation and selection in the cancer genome

inferredcites →https://doi.org/10.1038/nbt1272openalex-snapshot

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

inferredcites →https://doi.org/10.1038/nchembio.313openalex-snapshot

Chemical phylogenetics of histone deacetylases

inferredcites →https://doi.org/10.1038/ncponc0106openalex-snapshot

Drug Insight: histone deacetylase inhibitors—development of the new targeted anticancer agent suberoylanilide hydroxamic acid

inferredcites →https://doi.org/10.1038/nrc1779openalex-snapshot

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

inferredcites →https://doi.org/10.1038/nrd2681openalex-snapshot

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

inferredcites →https://doi.org/10.1038/nrg2485openalex-snapshot

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

inferredcites →https://doi.org/10.1038/sj.bjc.6690493openalex-snapshot

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

inferredcites →https://doi.org/10.1038/sj.bjp.0707166openalex-snapshot

HDAC inhibitors as anti‐inflammatory agents

inferredcites →https://doi.org/10.1073/pnas.0408732102openalex-snapshot

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

inferredcites →https://doi.org/10.1073/pnas.0803749105openalex-snapshot

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

inferredcites →https://doi.org/10.1073/pnas.191208598openalex-snapshot

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

inferredcites →https://doi.org/10.1073/pnas.95.6.3003openalex-snapshot

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

inferredcites →https://doi.org/10.1126/science.1175371openalex-snapshot

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

inferredcites →https://doi.org/10.1139/o03-042openalex-snapshot

Characteristics of γ-H2AX foci at DNA double-strand breaks sites

inferredcites →https://doi.org/10.1158/0008-5472.can-03-2043openalex-snapshot

Selective Growth Inhibition of Tumor Cells by a Novel Histone Deacetylase Inhibitor, NVP-LAQ824

inferredcites →https://doi.org/10.1158/0008-5472.can-06-3996openalex-snapshot

Histone Deacetylase Inhibitors Sensitize Prostate Cancer Cells to Agents that Produce DNA Double-Strand Breaks by Targeting Ku70 Acetylation

inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-2088openalex-snapshot

Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0162openalex-snapshot

Phase I and Pharmacokinetic Study of Vorinostat, A Histone Deacetylase Inhibitor, in Combination with Carboplatin and Paclitaxel for Advanced Solid Malignancies

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1587openalex-snapshot

Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-2786openalex-snapshot

Rational Combinations Using HDAC Inhibitors

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-2788openalex-snapshot

Epigenetic Modifiers: Basic Understanding and Clinical Development

inferredcites →https://doi.org/10.1358/dot.2007.43.9.1112980openalex-snapshot

Vorinostat in cutaneous T-cell lymphoma

inferredcites →https://doi.org/10.1517/13543784.16.7.1111openalex-snapshot

Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma

inferredcites →https://doi.org/10.1517/14728222.12.8.1035openalex-snapshot

DNA methylation: A promising target for the twenty-first century

inferredcites →https://doi.org/10.1517/14728222.9.4.809openalex-snapshot

Histone deacetylase inhibitors: insights into mechanisms of lethality

inferredcites →https://doi.org/10.1586/14737140.7.10.1439openalex-snapshot

Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents

inferredcites →https://doi.org/10.2165/11315680-000000000-00000openalex-snapshot

Histone Deacetylase Inhibitors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Histone Deacetylase 2 (HDAC2) Inhibitors Containing Boron

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Histone Deacetylases (HDAC)

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Histone Deacetylases (HDAC)

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Mechanisms of Resistance to Histone Deacetylase Inhibitors

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Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo

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p53-mediated regulation of LINE1 retrotransposon-derived R-loops

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Synergistic antitumor effect of histone deacetylase inhibitor and Doxorubicin in peripheral T-cell lymphoma

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DNA damage in the oligodendrocyte lineage and its role in brain aging

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Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression

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The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy

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Role of acetylation in doxorubicin-induced cardiotoxicity

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El papel del microambiente tumoral y los fibroblastos asociados a cáncer en el desarrollo y la progresión del cáncer de mama

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Inducing iPSCs to Escape the Dish

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Investigation of belinostat-induced genomic instability by molecular cytogenetic analysis and pathway-focused gene expression profiling

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Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis

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Vorinostat is genotoxic and epigenotoxic in the mouse bone marrow cells at the human equivalent doses

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HDAC modulation and cell death in the clinic

inferred← citeshttps://doi.org/10.1016/j.yexcr.2013.02.022openalex-snapshot

Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells

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SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

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Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer

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Molecular Signatures Associated with Treatment of Triple-Negative MDA-MB231 Breast Cancer Cells with Histone Deacetylase Inhibitors JAHA and SAHA

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00491openalex-snapshot

Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00541openalex-snapshot

Hydrazides as Inhibitors of Histone Deacetylases

inferred← citeshttps://doi.org/10.1021/acsami.8b10901openalex-snapshot

Cancer Chemoradiotherapy Duo: Nano-Enabled Targeting of DNA Lesion Formation and DNA Damage Response

inferred← citeshttps://doi.org/10.1021/acsomega.0c03180openalex-snapshot

A Translational Study of a Silicon Phthalocyanine Substituted with a Histone Deacetylase Inhibitor for Photodynamic Therapy

inferred← citeshttps://doi.org/10.1021/mp200329fopenalex-snapshot

Histone Deacetylase Inhibitors: Emerging Mechanisms of Resistance

inferred← citeshttps://doi.org/10.1021/mp300038fopenalex-snapshot

Valuable Insight into the Anticancer Activity of the Platinum-Histone Deacetylase Inhibitor Conjugate, cis-[Pt(NH3)2malSAHA–2H)]

inferred← citeshttps://doi.org/10.1038/bjc.2013.21openalex-snapshot

Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

inferred← citeshttps://doi.org/10.1038/bjc.2016.278openalex-snapshot

Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition

inferred← citeshttps://doi.org/10.1038/cddis.2013.260openalex-snapshot

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms

inferred← citeshttps://doi.org/10.1038/cddis.2014.412openalex-snapshot

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe

inferred← citeshttps://doi.org/10.1038/cddis.2014.76openalex-snapshot

Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo

inferred← citeshttps://doi.org/10.1038/cddis.2015.394openalex-snapshot

An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts

inferred← citeshttps://doi.org/10.1038/cddis.2016.115openalex-snapshot

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL

inferred← citeshttps://doi.org/10.1038/leu.2014.296openalex-snapshot

A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

inferred← citeshttps://doi.org/10.1038/nature11286openalex-snapshot

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

inferred← citeshttps://doi.org/10.1038/ncomms3735openalex-snapshot

Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease

inferred← citeshttps://doi.org/10.1038/onc.2011.267openalex-snapshot

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy

inferred← citeshttps://doi.org/10.1038/onc.2016.116openalex-snapshot

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

inferred← citeshttps://doi.org/10.1038/s41388-018-0550-3openalex-snapshot

Dual inhibition of PI3K signaling and histone deacetylation halts proliferation and induces lethality in mantle cell lymphoma

inferred← citeshttps://doi.org/10.1038/s41467-021-25332-wopenalex-snapshot

The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma

inferred← citeshttps://doi.org/10.1038/s41598-022-17296-8openalex-snapshot

Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate

inferred← citeshttps://doi.org/10.1038/s41598-025-20749-5openalex-snapshot

Histone deacetylase inhibitors sensitize glioblastoma models to temozolomide and reprogram immunosuppressive myeloid cells

inferred← citeshttps://doi.org/10.1038/srep18658openalex-snapshot

Predicting chemotherapeutic drug combinations through gene network profiling

inferred← citeshttps://doi.org/10.1038/srep30593openalex-snapshot

Vorinostat differentially alters 3D nuclear structure of cancer and non-cancerous esophageal cells

inferred← citeshttps://doi.org/10.1039/c2mb25151eopenalex-snapshot

Large scale phosphoproteome analysis of LNCaP human prostate cancer cells

inferred← citeshttps://doi.org/10.1039/c5tx00476dopenalex-snapshot

Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway

inferred← citeshttps://doi.org/10.1039/c9bm00051hopenalex-snapshot

Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

inferred← citeshttps://doi.org/10.1039/d1ra04227kopenalex-snapshot

Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol

inferred← citeshttps://doi.org/10.1039/d1ra05404jopenalex-snapshot

Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy

inferred← citeshttps://doi.org/10.1039/d2sc06036aopenalex-snapshot

Manganese( ii ) complexes stimulate antitumor immunity via aggravating DNA damage and activating the cGAS-STING pathway

inferred← citeshttps://doi.org/10.1039/d5na00845jopenalex-snapshot

Multimodal radiosensitization by hafnium oxide nanoparticles and HDAC inhibitors: mechanistic insights

inferred← citeshttps://doi.org/10.1053/j.gastro.2012.03.035openalex-snapshot

Pan-Histone Deacetylase Inhibitor Panobinostat Sensitizes Gastric Cancer Cells to Anthracyclines via Induction of CITED2

inferred← citeshttps://doi.org/10.1053/j.seminhematol.2018.04.008openalex-snapshot

Fetal Hemoglobin Induction by Epigenetic Drugs

inferred← citeshttps://doi.org/10.1053/j.seminoncol.2011.11.011openalex-snapshot

p53-Independent, Normal Stem Cell Sparing Epigenetic Differentiation Therapy for Myeloid and Other Malignancies

inferred← citeshttps://doi.org/10.1073/pnas.1105866108openalex-snapshot

Functional relevance of the histone γH2Ax in the response to DNA damaging agents

inferred← citeshttps://doi.org/10.1073/pnas.1117544108openalex-snapshot

Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors

inferred← citeshttps://doi.org/10.1073/pnas.1204429109openalex-snapshot

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

inferred← citeshttps://doi.org/10.1073/pnas.1313893110openalex-snapshot

Development of a histone deacetylase 6 inhibitor and its biological effects

inferred← citeshttps://doi.org/10.1073/pnas.1515882112openalex-snapshot

Creation of a histone deacetylase 6 inhibitor and its biological effects

inferred← citeshttps://doi.org/10.1080/07391102.2019.1598497openalex-snapshot

Molecular dynamics study of HDAC8-largazole analogues co-crystals for designing potential anticancer compounds

inferred← citeshttps://doi.org/10.1080/07391102.2020.1780940openalex-snapshot

Investigation of HDAC8-ligands’ intermolecular forces through molecular dynamics simulations: profiling of non-bonding energies to design potential compounds as new anti-cancer agents

inferred← citeshttps://doi.org/10.1080/13543784.2016.1250882openalex-snapshot

Investigational histone deacetylase inhibitors (HDACi) in myeloproliferative neoplasms

inferred← citeshttps://doi.org/10.1080/15384047.2017.1324374openalex-snapshot

Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC)

inferred← citeshttps://doi.org/10.1080/15384047.2023.2253586openalex-snapshot

Drug repurposing based on differentially expressed genes suggests drug combinations with possible synergistic effects in treatment of lung adenocarcinoma

inferred← citeshttps://doi.org/10.1080/15384047.2025.2589666openalex-snapshot

High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma

inferred← citeshttps://doi.org/10.1080/15384101.2020.1867790openalex-snapshot

DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly

inferred← citeshttps://doi.org/10.1080/15592294.2015.1039216openalex-snapshot

Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine

inferred← citeshttps://doi.org/10.1080/23723556.2019.1705731openalex-snapshot

Histone deacetylases facilitate the accurate repair of broken forks

inferred← citeshttps://doi.org/10.1089/ars.2014.5915openalex-snapshot

Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy

inferred← citeshttps://doi.org/10.1089/mdr.2019.0309openalex-snapshot

In Vitro and In Vivo Effects of the Polymyxin-Vorinostat Combination Therapy Against Multidrug-Resistant Gram-Negative Pathogens

inferred← citeshttps://doi.org/10.1093/nar/gkab293openalex-snapshot

The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity

inferred← citeshttps://doi.org/10.1093/nar/gkw922openalex-snapshot

The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

inferred← citeshttps://doi.org/10.1093/neuonc/nor017openalex-snapshot

A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03

inferred← citeshttps://doi.org/10.1093/toxsci/kfu105openalex-snapshot

Tissue-Specific Effects of Valproic Acid on DNA Repair Genes and Apoptosis in Postimplantation Mouse Embryos

inferred← citeshttps://doi.org/10.1097/cm9.0000000000000685openalex-snapshot

Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors

inferred← citeshttps://doi.org/10.1097/cmr.0000000000000791openalex-snapshot

Epigenetic therapy to enhance therapeutic effects of PD-1 inhibition in therapy-resistant melanoma

inferred← citeshttps://doi.org/10.1097/tp.0000000000001197openalex-snapshot

Modulation of Donor-Specific Antibody Production After Organ Transplantation by Valproic Acid

inferred← citeshttps://doi.org/10.1101/2020.04.29.066993openalex-snapshot

1q21.3 amplification modulates therapy sensitivity in Triple Negative Breast Cancer

inferred← citeshttps://doi.org/10.1101/2024.04.12.589154openalex-snapshot

p53 mediated regulation of LINE1 retrotransposition derived R-loops

inferred← citeshttps://doi.org/10.1101/2025.11.18.689006openalex-snapshot

HDAC1 has a role in double strand break repair by regulating γH2AX signalling

inferred← citeshttps://doi.org/10.1101/858688openalex-snapshot

FLIP(L) determines p53 induced life or death

inferred← citeshttps://doi.org/10.1111/cbdd.14366openalex-snapshot

Discussion on structure classification and regulation function of histone deacetylase and their inhibitor

inferred← citeshttps://doi.org/10.1111/febs.13746openalex-snapshot

How do tumor cells respond to HDAC inhibition?

inferred← citeshttps://doi.org/10.1111/j.1365-2141.2011.08591.xopenalex-snapshot

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF‐κB and Bim

inferred← citeshttps://doi.org/10.1111/j.1751-1097.2011.00995.xopenalex-snapshot

γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

inferred← citeshttps://doi.org/10.1111/jcmm.18342openalex-snapshot

New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma

inferred← citeshttps://doi.org/10.1124/mol.112.079624openalex-snapshot

Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway

inferred← citeshttps://doi.org/10.1124/mol.112.081059openalex-snapshot

Trichostatin A Inhibits Transforming Growth Factor-β–Induced Reactive Oxygen Species Accumulation and Myofibroblast Differentiation via Enhanced NF-E2-Related Factor 2-Antioxidant Response Element Signaling

inferred← citeshttps://doi.org/10.1128/jvi.00088-19openalex-snapshot

Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Suppresses Human Adenovirus Gene Expression and Replication

inferred← citeshttps://doi.org/10.1128/mcb.05155-11openalex-snapshot

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 + T-Regulatory Cells

inferred← citeshttps://doi.org/10.1134/s1990519x13040123openalex-snapshot

Genetic and epigenetic markers of gliomas

inferred← citeshttps://doi.org/10.1134/s1990519x15050065openalex-snapshot

The influence of histone deacetilase inhibitor on DNA repair through Gadd45 modulation

inferred← citeshttps://doi.org/10.1134/s1990519x23030045openalex-snapshot

The Function of MAP Kinases in Induced Histone H2AX Phosphorylation in Transformed Cells

inferred← citeshttps://doi.org/10.1155/2011/253529openalex-snapshot

Generation of Reactive Oxygen Species during Apoptosis Induced by DNA-Damaging Agents and/or Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1155/2022/4985781openalex-snapshot

Valproic Acid Inhibits Glioma and Its Mechanisms

inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-2799openalex-snapshot

Autophagic Survival in Resistance to Histone Deacetylase Inhibitors: Novel Strategies to Treat Malignant Peripheral Nerve Sheath Tumors

inferred← citeshttps://doi.org/10.1158/1078-0432.c.6518106openalex-snapshot

Data from HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1158/1078-0432.c.6518106.v1openalex-snapshot

Data from HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1158/1078-0432.c.6531362.v1openalex-snapshot

Data from Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-11-0234openalex-snapshot

HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-11-0767openalex-snapshot

Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-12-2799openalex-snapshot

PLK1 Inhibitors Synergistically Potentiate HDAC Inhibitor Lethality in Imatinib Mesylate–Sensitive or –Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-14-0034openalex-snapshot

PI3K/mTOR Inhibition Markedly Potentiates HDAC Inhibitor Activity in NHL Cells through BIM- and MCL-1–Dependent Mechanisms In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-14-1290openalex-snapshot

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-20-3724openalex-snapshot

Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-21-2139openalex-snapshot

Clinical Trials Assessing Hypomethylating Agents Combined with Other Therapies: Causes for Failure and Potential Solutions

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-23-1795openalex-snapshot

Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-12-0902openalex-snapshot

The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-12-1242openalex-snapshot

Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-14-0220openalex-snapshot

In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-15-0618openalex-snapshot

Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-17-0011openalex-snapshot

Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-17-0074openalex-snapshot

The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-14-0173openalex-snapshot

Synergistic Loss of Prostate Cancer Cell Viability by Coinhibition of HDAC and PARP

inferred← citeshttps://doi.org/10.1159/000441849openalex-snapshot

Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells

inferred← citeshttps://doi.org/10.1172/jci.insight.167081openalex-snapshot

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

inferred← citeshttps://doi.org/10.1177/13872877251352107openalex-snapshot

Low-dose dietary vorinostat increases brain histone acetylation levels and reduces oxidative stress in an Alzheimer's disease mouse model

inferred← citeshttps://doi.org/10.1182/blood-2015-06-653717openalex-snapshot

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR

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