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Why the tumor cell metabolism is not that abnormal

https://doi.org/10.1101/865048
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH
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Using Seahorse Machine to Measure OCR and ECAR in Cancer Cells
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Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K
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Can metabolic plasticity be a cause for cancer? Warburg–Waddington legacy revisited
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P/O ratios of mitochondrial oxidative phosphorylation
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Cancer metabolism in space and time: Beyond the Warburg effect
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Drug discovery strategies in the field of tumor energy metabolism: Limitations by metabolic flexibility and metabolic resistance to chemotherapy
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Cancer metabolism: facts, fantasy, and fiction
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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
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The Emerging Hallmarks of Cancer Metabolism
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Advances in Hypoxia-Inducible Factor Biology
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Cancer metabolism: New insights into classic characteristics
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Incorporating energy metabolism into a growth model of multicellular tumor spheroids
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An old paper revisited: “A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load” by V.V. Dynnik, R. Heinrich and E.E. Sel’kov
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A microscale mathematical model for metabolic symbiosis: Investigating the effects of metabolic inhibition on ATP turnover in tumors
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Transient alleviation of tumor hypoxia during first days of antiangiogenic therapy as a result of therapy-induced alterations in nutrient supply and tumor metabolism – Analysis by mathematical modeling
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A mathematical model of HiF-1-mediated response to hypoxia on the G1/S transition
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Carcinogenesis explained within the context of a theory of organisms
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The Warburg effect: Insights from the past decade
inferredcites →https://doi.org/10.1016/j.semcancer.2005.04.009openalex-snapshot
Pyruvate kinase type M2 and its role in tumor growth and spreading
inferredcites →https://doi.org/10.1016/j.semcancer.2015.10.002openalex-snapshot
Dysregulated metabolism contributes to oncogenesis
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The Warburg Effect: How Does it Benefit Cancer Cells?
inferredcites →https://doi.org/10.1016/s0021-9258(18)55378-3openalex-snapshot
In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate.
inferredcites →https://doi.org/10.1016/s0021-9258(18)94442-xopenalex-snapshot
Factors That Control the Effect of pH on Glycolysis in Leukocytes
inferredcites →https://doi.org/10.1038/bjc.1986.58openalex-snapshot
Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids
inferredcites →https://doi.org/10.1038/nrc1478openalex-snapshot
Why do cancers have high aerobic glycolysis?
inferredcites →https://doi.org/10.1038/sigtrans.2016.47openalex-snapshot
Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation
inferredcites →https://doi.org/10.1038/srep04331openalex-snapshot
Correction: Corrigendum: Quantum Limit of Quality Factor in Silicon Micro and Nano Mechanical Resonators
inferredcites →https://doi.org/10.1038/srep04927openalex-snapshot
Beyond Warburg effect – dual metabolic nature of cancer cells
inferredcites →https://doi.org/10.1042/bst0311095openalex-snapshot
The molecular machinery of Keilin's respiratory chain
inferredcites →https://doi.org/10.1042/bst20120352openalex-snapshot
Parallels between embryo and cancer cell metabolism
inferredcites →https://doi.org/10.1073/pnas.0700690104openalex-snapshot
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
inferredcites →https://doi.org/10.1073/pnas.1010459107openalex-snapshot
Regional aerobic glycolysis in the human brain
inferredcites →https://doi.org/10.1074/jbc.m116.774471openalex-snapshot
Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements
inferredcites →https://doi.org/10.1113/jp273839openalex-snapshot
Oxidative phosphorylation: regulation and role in cellular and tissue metabolism
inferredcites →https://doi.org/10.1126/science.1193494openalex-snapshot
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-snapshot
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1186/1752-0509-4-58openalex-snapshot
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
inferredcites →https://doi.org/10.1186/2041-9414-4-5openalex-snapshot
Tumor hypoxia as a driving force in genetic instability
inferredcites →https://doi.org/10.1186/s12935-015-0171-7openalex-snapshot
Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues
inferredcites →https://doi.org/10.1186/s13046-015-0221-yopenalex-snapshot
Metabolic reprogramming: the emerging concept and associated therapeutic strategies
inferredcites →https://doi.org/10.1200/jco.2012.46.3653openalex-snapshot
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
inferredcites →https://doi.org/10.12688/f1000research.15635.2openalex-snapshot
The dynamic side of the Warburg effect: glycolytic intermediate storage as buffer for fluctuating glucose and O2 supply in tumor cells
inferredcites →https://doi.org/10.1371/journal.pcbi.1004412openalex-snapshot
Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data
inferredcites →https://doi.org/10.1371/journal.pcbi.1005991openalex-snapshot
PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems
inferredcites →https://doi.org/10.1371/journal.pcbi.1006584openalex-snapshot
Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors
inferredcites →https://doi.org/10.1371/journal.pone.0179159openalex-snapshot
Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae
inferredcites →https://doi.org/10.1593/neo.04430openalex-snapshot
Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors
inferredcites →https://doi.org/10.1667/rr1926.1openalex-snapshot
Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress
inferredcites →https://doi.org/10.18632/oncotarget.9746openalex-snapshot
Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation
inferredcites →https://doi.org/10.2174/13816128113199990462openalex-snapshot
Role of Monocarboxylate Transporters in Drug Delivery to the Brain
inferredcites →https://doi.org/10.2307/3577466openalex-snapshot
Influence of Extracellular pH on Intracellular pH and Cell Energy Status: Relationship to Hyperthermic Sensitivity
inferredcites →https://doi.org/10.2967/jnumed.107.047258openalex-snapshot
Causes and Consequences of Increased Glucose Metabolism of Cancers
inferredcites →https://doi.org/10.3389/fcell.2018.00100openalex-snapshot
The Warburg Effect in Endothelial Cells and its Potential as an Anti-angiogenic Target in Cancer
inferredcites →https://doi.org/10.3389/fgene.2016.00171openalex-snapshot
Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts
inferredcites →https://doi.org/10.3389/fonc.2019.01144openalex-snapshot
Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models
inferredcites →https://doi.org/10.3892/ol.2012.928openalex-snapshot
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
inferredcites →https://doi.org/10.3934/mbe.2013.10.121openalex-snapshot
A multiple time-scale computational model of a tumor and its micro environment
inferredcites →https://doi.org/10.4049/jimmunol.0902584openalex-snapshot
Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
inferredcites →https://doi.org/10.4161/cc.6.7.4084openalex-snapshot
HIF-1-Regulated Glucose Metabolism: A Key to Apoptosis Resistance?
inferredcites →https://doi.org/10.5334/jors.151openalex-snapshot
DifferentialEquations.jl – A Performant and Feature-Rich Ecosystem for Solving Differential Equations in Julia
inferredcites →https://doi.org/10.5860/choice.35-0264openalex-snapshot
The cell: a molecular approach
inferredcites →https://doi.org/10.7150/jca.14274openalex-snapshot
Warburg Effect - a Consequence or the Cause of Carcinogenesis?
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