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Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

https://doi.org/10.18632/oncotarget.9746
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Tumor blood flow: The principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromilieu of human tumor xenografts in vivo
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Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy
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MRI of the tumor microenvironment
inferredcites →https://doi.org/10.1002/path.3978openalex-snapshot
Central role of lactic acidosis in cancer cell resistance to glucose deprivation‐induced cell death
inferredcites →https://doi.org/10.1016/0020-711x(90)90145-sopenalex-snapshot
Respiration of mitochondria isolated from differentiated and undifferentiated HT29 colon cancer cells in the presence of various substrates and ADP generating systems
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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
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Hallmarks of Cancer: The Next Generation
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Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization
inferredcites →https://doi.org/10.1016/j.semcancer.2005.04.009openalex-snapshot
Pyruvate kinase type M2 and its role in tumor growth and spreading
inferredcites →https://doi.org/10.1016/j.semcancer.2008.11.010openalex-snapshot
Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis
inferredcites →https://doi.org/10.1016/j.semradonc.2004.04.004openalex-snapshot
Lactate: mirror and motor of tumor malignancy
inferredcites →https://doi.org/10.1038/nature06734openalex-snapshot
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
inferredcites →https://doi.org/10.1038/nrc1093openalex-snapshot
Tumorigenesis and the angiogenic switch
inferredcites →https://doi.org/10.1038/nrc1478openalex-snapshot
Why do cancers have high aerobic glycolysis?
inferredcites →https://doi.org/10.1038/nrc2468openalex-snapshot
Hypoxia, HIF1 and glucose metabolism in the solid tumour
inferredcites →https://doi.org/10.1038/nrc2715openalex-snapshot
p53 and metabolism
inferredcites →https://doi.org/10.1038/nrd2803openalex-snapshot
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
inferredcites →https://doi.org/10.1038/nrd3137openalex-snapshot
Targeting mitochondria for cancer therapy
inferredcites →https://doi.org/10.1038/sj.onc.1209594openalex-snapshot
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
inferredcites →https://doi.org/10.1038/srep04927openalex-snapshot
Beyond Warburg effect – dual metabolic nature of cancer cells
inferredcites →https://doi.org/10.1038/srep05029openalex-snapshot
No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy
inferredcites →https://doi.org/10.1073/pnas.0502267102openalex-snapshot
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
inferredcites →https://doi.org/10.1074/jbc.272.28.17269openalex-snapshot
Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades
inferredcites →https://doi.org/10.1084/jem.20092506openalex-snapshot
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
inferredcites →https://doi.org/10.1093/jnci/djm135openalex-snapshot
Drug Resistance and the Solid Tumor Microenvironment
inferredcites →https://doi.org/10.1093/jnci/djq187openalex-snapshot
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
inferredcites →https://doi.org/10.1126/science.1126863openalex-snapshot
p53 Regulates Mitochondrial Respiration
inferredcites →https://doi.org/10.1126/science.1160809openalex-snapshot
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
inferredcites →https://doi.org/10.1126/science.1164382openalex-snapshot
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
inferredcites →https://doi.org/10.1126/science.1174229openalex-snapshot
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
inferredcites →https://doi.org/10.1126/science.1175689openalex-snapshot
SDH5 , a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-snapshot
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1128/mcb.13.7.4416openalex-snapshot
Posttranscriptional Down-Regulation of ras Oncogene Expression by Inhibitors of Cellular Glutathione
inferredcites →https://doi.org/10.1128/mcb.19.1.1openalex-snapshot
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
inferredcites →https://doi.org/10.1136/bmj.1.4032.829openalex-snapshot
On the Origin of Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2904openalex-snapshot
Akt Stimulates Aerobic Glycolysis in Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2394openalex-snapshot
The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
inferredcites →https://doi.org/10.1158/0008-5472.can-10-2828openalex-snapshot
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
inferredcites →https://doi.org/10.1172/jci36843openalex-snapshot
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
inferredcites →https://doi.org/10.1172/jci38331openalex-snapshot
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice
inferredcites →https://doi.org/10.1259/bjr/12913493openalex-snapshot
Microenvironmental and cellular consequences of altered blood flow in tumours
inferredcites →https://doi.org/10.1371/journal.pgen.1000293openalex-snapshot
The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
inferredcites →https://doi.org/10.1371/journal.pgen.1001093openalex-snapshot
Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA
inferredcites →https://doi.org/10.1371/journal.pone.0034525openalex-snapshot
Biochemical Issues in Estimation of Cytosolic Free NAD/NADH Ratio
inferredcites →https://doi.org/10.1371/journal.pone.0063054openalex-snapshot
Tumor Environmental Factors Glucose Deprivation and Lactic Acidosis Induce Mitotic Chromosomal Instability – An Implication in Aneuploid Human Tumors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cancer cell metabolic plasticity in migration and metastasis
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Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells
inferred← citeshttps://doi.org/10.1007/s11010-020-03699-6openalex-snapshot
Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis
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p53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect
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The effect of acute and prolonged acidosis on a panel of carcinoma cell lines
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Metabolic tricks of cancer cells
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Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells through ROS-mediated mitochondrial damage and the inhibition of PI3K/Akt/mTOR pathway
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Lactic acidosis switches cancer cells from dependence on glycolysis to OXPHOS and renders them highly sensitive to OXPHOS inhibitors
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116469openalex-snapshot
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114371openalex-snapshot
Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment?
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Acidosis overrides molecular heterogeneity to shape therapeutically targetable metabolic phenotypes in colon cancers
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Metabolic plasticity in castration-resistant prostate cancer: reprogramming mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107613openalex-snapshot
Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells
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Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination
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ROS changes evoked by the natural sweetener Rebaudioside A in a neuronal system
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Rationale for LDH-targeted cancer immunotherapy
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Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids
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A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.prp.2025.156342openalex-snapshot
LDH-driven lactic acidosis in hypoxic solid tumors: Mechanisms of metastatic transformation and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.09.001openalex-snapshot
Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers
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Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
inferred← citeshttps://doi.org/10.1021/acs.jproteome.8b00926openalex-snapshot
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy
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Multifunctional Microspheres Dual-Loaded with Doxorubicin and Sodium Bicarbonate Nanoparticles to Introduce Synergistic Trimodal Interventional Therapy
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Dual-Modal Therapeutic Role of the Lactate Oxidase-Embedded Hierarchical Porous Zeolitic Imidazolate Framework as a Nanocatalyst for Effective Tumor Suppression
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Highly Efficient Photoswitchable Smart Polymeric Nanovehicle for Gene and Anticancer Drug Delivery in Triple-Negative Breast Cancer
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Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis
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T-cells produce acidic niches in lymph nodes to suppress their own effector functions
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Quantification of lactate from various metabolic pathways and quantification issues of lactate isotopologues and isotopmers
inferred← citeshttps://doi.org/10.1038/s41598-018-35020-3openalex-snapshot
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
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Long-term high-grain diet alters ruminal pH, fermentation, and epithelial transcriptomes, leading to restored mitochondrial oxidative phosphorylation in Japanese Black cattle
inferred← citeshttps://doi.org/10.1038/s41598-021-83708-wopenalex-snapshot
Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment
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Warburg-associated acidification represses lactic fermentation independently of lactate, contribution from real-time NMR on cell-free systems
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Central role of lactate and proton in cancer cell resistance to glucose deprivation and its clinical translation
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Biological protein mediated ferroptotic tumor nanotherapeutics
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Anti-tumor effect of pH-sensitive drug-loaded nanoparticles optimized via an integrated computational/experimental approach
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Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas
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Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer
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inferred← citeshttps://doi.org/10.3390/cimb48090907openalex-snapshot
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The impact of the acidic tumor microenvironment on ion channel expression and regulation, in the progression of pancreatic ductal adenocarcinoma
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Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism
inferred← citeshttps://doi.org/10.7150/thno.37472openalex-snapshot
ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells
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