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Appropriate Targets for Antibacterial Drugs

https://doi.org/10.1101/cshperspect.a030239

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Rational Approaches to Antibacterial Discovery: Pre-Genomic Directed and Phenotypic Screening

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Cell-Based Screening in Antibacterial Discovery

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Antibacterial drug discovery—Then, now and the genomics future

inferredcites →https://doi.org/10.1016/j.bcp.2005.11.025openalex-snapshot

When will the genomics investment pay off for antibacterial discovery?

inferredcites →https://doi.org/10.1016/j.coph.2008.06.008openalex-snapshot

How many modes of action should an antibiotic have?

inferredcites →https://doi.org/10.1016/s1359-6446(04)03285-4openalex-snapshot

Antibiotics: Where did we go wrong?

inferredcites →https://doi.org/10.1016/s1369-5274(00)00133-8openalex-snapshot

Will genomics revolutionize antimicrobial drug discovery?

inferredcites →https://doi.org/10.1016/s1471-4892(02)00197-2openalex-snapshot

New (and not so new) antibacterial targets – from where and when will the novel drugs come?

inferredcites →https://doi.org/10.1021/jm501552xopenalex-snapshot

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

inferredcites →https://doi.org/10.1038/ismej.2011.122openalex-snapshot

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inferredcites →https://doi.org/10.1038/nrd2201openalex-snapshot

Drugs for bad bugs: confronting the challenges of antibacterial discovery

inferredcites →https://doi.org/10.1038/nrd2202openalex-snapshot

Multi-targeting by monotherapeutic antibacterials

inferredcites →https://doi.org/10.1038/nrd4572openalex-snapshot

ESKAPEing the labyrinth of antibacterial discovery

inferredcites →https://doi.org/10.1046/j.1365-2672.92.5s1.16.xopenalex-snapshot

Novel targets for the future development of antibacterial agents

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A genome‐wide strategy for the identification of essential genes in Staphylococcus aureus

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Genetic analysis of temperature-sensitive lethal mutants of Salmonella typhimurium.

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Discovery research: the scientific challenge of finding new antibiotics

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Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens

inferredcites →https://doi.org/10.1093/jac/dks436openalex-snapshot

The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century

inferredcites →https://doi.org/10.1101/cshperspect.a025304openalex-snapshot

Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC

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Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections

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Virulence‐targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

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Can β-lactams be re-engineered to beat MRSA?

inferredcites →https://doi.org/10.1111/j.1749-6632.2010.05828.xopenalex-snapshot

Challenges of antibacterial discovery revisited

inferredcites →https://doi.org/10.1128/aac.03774-14openalex-snapshot

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

inferredcites →https://doi.org/10.1128/aac.37.3.377openalex-snapshot

Discovery and development of new antibiotics: the problem of antibiotic resistance

inferredcites →https://doi.org/10.1128/aac.47.9.2850-2858.2003openalex-snapshot

Biological Costs and Mechanisms of Fosfomycin Resistance in Escherichia coli

inferredcites →https://doi.org/10.1128/cmr.00030-10openalex-snapshot

Challenges of Antibacterial Discovery

inferredcites →https://doi.org/10.1586/eri.11.81openalex-snapshot

Screening strategies for discovery of antibacterial natural products

inferredcites →https://doi.org/10.2174/1381612023394764openalex-snapshot

Genomics and the Prospects for the Discovery of New Targets for Antibacterial and Antifungal Agents

inferredcites →https://doi.org/10.2174/138161207782110408openalex-snapshot

The Targets of Currently Used Antibacterial Agents: Lessons for Drug Discovery

inferredcites →https://doi.org/10.2174/1568005023342227openalex-snapshot

Novel Antibacterials: A Genomics Approach to Drug Discovery

inferredcites →https://doi.org/10.2174/1568005023342597openalex-snapshot

Antibacterial Drug Discovery in the Post-Genomics Era

inferredcites →https://doi.org/10.3109/07388559209069193openalex-snapshot

The Discovery of Cell Wall Active Antibacterial Antibiotics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/slct.202503965openalex-snapshot

Design, Synthesis, Biological Evaluation, and Molecular Docking of Furopyrazines as Antibacterial Agents

inferred← citeshttps://doi.org/10.1007/7355_2016_31openalex-snapshot

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

inferred← citeshttps://doi.org/10.1007/7355_2017_21openalex-snapshot

Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes

inferred← citeshttps://doi.org/10.1007/7355_2017_8openalex-snapshot

The Clinical Development of Antibacterial Drugs: A Guide for the Discovery Scientist

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Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile

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