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Discovery research: the scientific challenge of finding new antibiotics

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides

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A guide to successful bioprospecting: informed by actinobacterial systematics

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Mechanisms of RND multidrug efflux pumps

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Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use

inferredcites →https://doi.org/10.1016/j.jep.2005.04.025openalex-snapshot

Medicinal plants and antimicrobial activity

inferredcites →https://doi.org/10.1016/j.mib.2003.08.003openalex-snapshot

Why is big Pharma getting out of antibacterial drug discovery?

inferredcites →https://doi.org/10.1016/j.mib.2010.02.008openalex-snapshot

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

inferredcites →https://doi.org/10.1016/j.mib.2010.09.002openalex-snapshot

Polymyxins and their novel derivatives

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Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

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Drug-like properties and the causes of poor solubility and poor permeability

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8-Azatetracyclines: Synthesis and Evaluation of a Novel Class of Tetracycline Antibacterial Agents

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

inferredcites →https://doi.org/10.1038/nbt1265openalex-snapshot

Molecular engineering approaches to peptide, polyketide and other antibiotics

inferredcites →https://doi.org/10.1038/nrd2201openalex-snapshot

Drugs for bad bugs: confronting the challenges of antibacterial discovery

inferredcites →https://doi.org/10.1038/nrd3130openalex-snapshot

A Wellcome experiment in seeding drug discovery

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Boron-containing inhibitors of synthetases

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

inferredcites →https://doi.org/10.1086/428052openalex-snapshot

Mechanisms of Resistance to Quinolones

inferredcites →https://doi.org/10.1128/aac.00572-10openalex-snapshot

Synthesis and Spectrum of the Neoglycoside ACHN-490

inferredcites →https://doi.org/10.1128/aac.00756-10openalex-snapshot

Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae

inferredcites →https://doi.org/10.1128/aac.01397-09openalex-snapshot

In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo-β-Lactamase Inhibitor, against Metallo-β-Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates

inferredcites →https://doi.org/10.1128/aac.46.10.3118-3124.2002openalex-snapshot

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

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Challenges of Antibacterial Discovery

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Three Decades of β-Lactamase Inhibitors

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A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus

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inferred← citeshttps://doi.org/10.1093/jac/dkt039openalex-snapshot

Novel derivatives of polymyxins

inferred← citeshttps://doi.org/10.1093/jac/dkt139openalex-snapshot

Tigecycline: an antibiotic for the twenty-first century

inferred← citeshttps://doi.org/10.1093/jac/dkt216openalex-snapshot

Improving antimicrobial stewardship: AmWeb, a tool for helping microbiologists in England to 'Start Smart' when advising on antibiotic treatment

inferred← citeshttps://doi.org/10.1097/inf.0000000000001445openalex-snapshot

Conventional Versus Prolonged Infusion of Meropenem in Neonates With Gram-negative Late-onset Sepsis

inferred← citeshttps://doi.org/10.1099/jmm.0.050385-0openalex-snapshot

Rapid identification of Gram-positive pathogens and their resistance genes from positive blood culture broth using a multiplex tandem RT-PCR assay

inferred← citeshttps://doi.org/10.1099/jmm.0.052555-0openalex-snapshot

Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance

inferred← citeshttps://doi.org/10.1099/mic.0.001025openalex-snapshot

Predatory bacteria as living antibiotics – where are we now?

inferred← citeshttps://doi.org/10.1101/593244openalex-snapshot

PhenoMS-ML: Phenotypic Screening by Mass Spectrometry and Machine Learning

inferred← citeshttps://doi.org/10.1101/cshperspect.a030239openalex-snapshot

Appropriate Targets for Antibacterial Drugs

inferred← citeshttps://doi.org/10.1111/cbdd.12385openalex-snapshot

Computational Methods to Identify New Antibacterial Targets

inferred← citeshttps://doi.org/10.1111/cbdd.12614openalex-snapshot

Microscale Adaptation of In Vitro Transcription/Translation for High‐Throughput Screening of Natural Product Extract Libraries

inferred← citeshttps://doi.org/10.1111/eva.12254openalex-snapshot

Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health

inferred← citeshttps://doi.org/10.1111/mmi.13269openalex-snapshot

Protein aggregation as an antibiotic design strategy

inferred← citeshttps://doi.org/10.1111/nyas.12006openalex-snapshot

Viable screening targets related to the bacterial cell wall

inferred← citeshttps://doi.org/10.1111/nyas.12803openalex-snapshot

Unconventional screening approaches for antibiotic discovery

inferred← citeshttps://doi.org/10.1126/scitranslmed.3009650openalex-snapshot

A rapid antimicrobial susceptibility test based on single-cell morphological analysis

inferred← citeshttps://doi.org/10.1128/9781555818845.ch25openalex-snapshot

Genetic Strategies for Identifying New Drug Targets

inferred← citeshttps://doi.org/10.1128/aac.00160-13openalex-snapshot

Potency and Spectrum of Activity of AN3365, a Novel Boron-Containing Protein Synthesis Inhibitor, Tested against Clinical Isolates of Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli

inferred← citeshttps://doi.org/10.1128/aac.00200-17openalex-snapshot

Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741

inferred← citeshttps://doi.org/10.1128/aac.00754-12openalex-snapshot

Inhibitors of Reactive Oxygen Species Accumulation Delay and/or Reduce the Lethality of Several Antistaphylococcal Agents

inferred← citeshttps://doi.org/10.1128/aac.01200-18openalex-snapshot

Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae

inferred← citeshttps://doi.org/10.1128/aac.01245-15openalex-snapshot

Antimicrobial Peptide Novicidin Synergizes with Rifampin, Ceftriaxone, and Ceftazidime against Antibiotic-Resistant Enterobacteriaceae In Vitro

inferred← citeshttps://doi.org/10.1128/aac.01426-19openalex-snapshot

Exploring Aztreonam in Combination with Ceftazidime-Avibactam or Meropenem-Vaborbactam as Potential Treatments for Metallo- and Serine-β-Lactamase-Producing Enterobacteriaceae

inferred← citeshttps://doi.org/10.1128/aac.01595-20openalex-snapshot

Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate

inferred← citeshttps://doi.org/10.1128/aac.01713-15openalex-snapshot

Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects

inferred← citeshttps://doi.org/10.1128/aac.01836-13openalex-snapshot

Penetration of GSK1322322 into Epithelial Lining Fluid and Alveolar Macrophages as Determined by Bronchoalveolar Lavage

inferred← citeshttps://doi.org/10.1128/aac.01842-15openalex-snapshot

Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection

inferred← citeshttps://doi.org/10.1128/aac.03774-14openalex-snapshot

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

inferred← citeshttps://doi.org/10.1128/aac.05870-11openalex-snapshot

In Vitro Activity of Telavancin in Combination with Colistin versus Gram-Negative Bacterial Pathogens

inferred← citeshttps://doi.org/10.1128/cmr.00059-12openalex-snapshot

Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?

inferred← citeshttps://doi.org/10.1128/jb.00105-21openalex-snapshot

Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo

inferred← citeshttps://doi.org/10.1128/jb.00345-12openalex-snapshot

Growing Unculturable Bacteria

inferred← citeshttps://doi.org/10.1128/microbiolspec.mgm2-0030-2013openalex-snapshot

Genetic Strategies for Identifying New Drug Targets

inferred← citeshttps://doi.org/10.1128/msystems.00724-22openalex-snapshot

Small Spatial Scale Drivers of Secondary Metabolite Biosynthetic Diversity in Environmental Microbiomes

inferred← citeshttps://doi.org/10.1136/gutjnl-2014-309072openalex-snapshot

Changing the narrative on antibiotics

inferred← citeshttps://doi.org/10.1139/cjm-2013-0089openalex-snapshot

Is the GAIN Act a turning point in new antibiotic discovery?

inferred← citeshttps://doi.org/10.1139/cjm-2015-0239openalex-snapshot

Antimicrobial use in swine production and its effect on the swine gut microbiota and antimicrobial resistance

inferred← citeshttps://doi.org/10.1142/s1088424618501031openalex-snapshot

The effect of elongation of a peptide substituent with ArgSer motif on the antimicrobial properties of hemin derivatives

inferred← citeshttps://doi.org/10.1146/annurev-micro-090816-093618openalex-snapshot

Predator Versus Pathogen: How Does Predatory Bdellovibrio bacteriovorus Interface with the Challenges of Killing Gram-Negative Pathogens in a Host Setting?

inferred← citeshttps://doi.org/10.1155/2014/561456openalex-snapshot

In VitroSynergistic Effect of Curcumin in Combination with Third Generation Cephalosporins against Bacteria Associated with Infectious Diarrhea

inferred← citeshttps://doi.org/10.11606/d.76.2022.tde-11112022-150745openalex-snapshot

Natural versus synthetic curcuminoids as photosensitizers: photobleaching and antimicrobial photodynamic therapy evaluation.

inferred← citeshttps://doi.org/10.11606/t.10.2021.tde-13122021-110425openalex-snapshot

>b /b<: alvos bacterianos e mecanismo de ação

inferred← citeshttps://doi.org/10.11606/t.60.2018.tde-11042017-155304openalex-snapshot

Estudos de síntese total de peptídeos cíclicos naturais

inferred← citeshttps://doi.org/10.1177/1087057112448216openalex-snapshot

High-Throughput Screening of a Diversity Collection Using Biodefense Category A and B Priority Pathogens

inferred← citeshttps://doi.org/10.1177/2472555218818786openalex-snapshot

Perspective on Antibacterial Lead Identification Challenges and the Role of Hypothesis-Driven Strategies

inferred← citeshttps://doi.org/10.1183/2312508x.10006116openalex-snapshot

New antibiotic development for pulmonary infections: New Drugs for Bad Bugs and beyond

inferred← citeshttps://doi.org/10.1186/1471-2105-14-36openalex-snapshot

The evolutionary rate of antibacterial drug targets

inferred← citeshttps://doi.org/10.1186/cc11405openalex-snapshot

Clinical and microbiological efficacy of continuous versus intermittent application of meropenem in critically ill patients: a randomized open-label controlled trial

inferred← citeshttps://doi.org/10.1186/s12889-016-3057-2openalex-snapshot

Impact of a United Kingdom-wide campaign to tackle antimicrobial resistance on self-reported knowledge and behaviour change

inferred← citeshttps://doi.org/10.1186/s12906-016-1491-4openalex-snapshot

Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L

inferred← citeshttps://doi.org/10.1186/s12941-021-00485-0openalex-snapshot

Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms

inferred← citeshttps://doi.org/10.1186/s13065-025-01560-9openalex-snapshot

Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation

inferred← citeshttps://doi.org/10.1186/s40246-015-0037-zopenalex-snapshot

Whole-genome sequencing targets drug-resistant bacterial infections

inferred← citeshttps://doi.org/10.1186/s43094-025-00833-3openalex-snapshot

Repositioning of fluoxetine as anti-virulence agent against Pseudomonas aeruginosa

inferred← citeshttps://doi.org/10.12688/wellcomeopenres.16847.1openalex-snapshot

There is no market for new antibiotics: this allows an open approach to research and development

inferred← citeshttps://doi.org/10.12692/ijb/15.6.51-62openalex-snapshot

Quorum sensing inhibitors: a tool for resistance against biofilm

inferred← citeshttps://doi.org/10.1371/journal.pone.0078922openalex-snapshot

Meleagrin, a New FabI Inhibitor from Penicillium chryosogenum with at Least One Additional Mode of Action

inferred← citeshttps://doi.org/10.1371/journal.pone.0153023openalex-snapshot

Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants

inferred← citeshttps://doi.org/10.1371/journal.pone.0205166openalex-snapshot

Introduction and geographic availability of new antibiotics approved between 1999 and 2014

inferred← citeshttps://doi.org/10.14293/pr2199.000899.v1openalex-snapshot

Antibiotic Resistance: Actions to accelerate global response

inferred← citeshttps://doi.org/10.1517/17425247.2014.942639openalex-snapshot

Optimization of niosomes for enhanced antibacterial activity and reduced bacterial resistance:in vitroandin vivoevaluation

inferred← citeshttps://doi.org/10.18017/iuitfd.308493openalex-snapshot

YENİ BİR DOĞAL ANTİBİYOTİK: “TEİKSOBAKTİN”

inferred← citeshttps://doi.org/10.2139/ssrn.5148652openalex-snapshot

Is Novel Research Always Risky?

inferred← citeshttps://doi.org/10.2147/idr.s249628openalex-snapshot

The Antimicrobial Activity of Ciprofloxacin-Loaded Niosomes against Ciprofloxacin-Resistant and Biofilm-Forming Staphylococcus aureus

inferred← citeshttps://doi.org/10.2174/1389450119666180731142423openalex-snapshot

A Review on Quantum Dots: Synthesis to In- silico Analysis as Next Generation Antibacterial Agents

inferred← citeshttps://doi.org/10.2174/1874285801408010006openalex-snapshot

Essential Oils, A New Horizon in Combating Bacterial Antibiotic Resistance

inferred← citeshttps://doi.org/10.2174/9789815123975123010005openalex-snapshot

Antibody Therapy as Alternative to Antibiotics

inferred← citeshttps://doi.org/10.2217/fmb.15.33openalex-snapshot

Healthcare-Associated Infections, Infection Control and the Potential of new Antibiotics in Development in the USA

inferred← citeshttps://doi.org/10.22203/ecm.v028a09openalex-snapshot

Challenges in linking preclinical anti-microbial research strategies with clinical outcomes for device-associated infections

inferred← citeshttps://doi.org/10.22215/etd/2019-13711openalex-snapshot

Understanding the Genetics and Evolution of Antimicrobial Resistance in Escherichia Coli

inferred← citeshttps://doi.org/10.2478/s11535-013-0209-6openalex-snapshot

New perspectives on antibacterial drug research

inferred← citeshttps://doi.org/10.26512/2017.02.d.23315openalex-snapshot

Avaliação das atividades antioxidante, antimicrobiana e enzimática do extrato aquoso de folhas de Miconia chamissois Naudin

inferred← citeshttps://doi.org/10.30574/gscbps.2019.7.3.0047openalex-snapshot

Retrospective analysis of patterns of drug resistant bacteria isolated from swabs and discharges of patients at Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia

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