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Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

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Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis

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CRIg signals induce anti‐intracellular bacterial phagosome activity in a chloride intracellular channel 3‐dependent manner

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Leukaemia Inhibitory Factor (LIF): a Cytokine of Emerging Importance in Chronic Airway Inflammation

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IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

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Flow Cytometry Analyses of Adipose Tissue Macrophages

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CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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Co-inhibitory molecule VSIG4 negatively regulates helper T cell-dependent isotype switching and antibody response

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Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

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Fisetin is a senotherapeutic that extends health and lifespan

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Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

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Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity

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Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

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Aging-related inflammation in osteoarthritis

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Fisetin Inhibits Lipopolysaccharide-Induced Macrophage Activation and Dendritic Cell Maturation

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VSIG4 expression on macrophages facilitates lung cancer development

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Macrophage biology in development, homeostasis and disease

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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme

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Macrophages in age-related chronic inflammatory diseases

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VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism

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Senolytics improve physical function and increase lifespan in old age

inferredcites →https://doi.org/10.1038/sj.ijo.0803632openalex-snapshot

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production

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Predictable Components of ENSO Evolution in Real-time Multi-Model Predictions

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Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

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Appearance and disappearance of the mRNA signature characteristic of T reg cells in visceral adipose tissue: Age, diet, and PPARγ effects

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Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a)in vivoare not necessarily senescent

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A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

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Phagocytosis imprints heterogeneity in tissue-resident macrophages

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Advanced Age Impairs Macrophage Polarization

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TopHat: discovering splice junctions with RNA-Seq

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Trimmomatic: a flexible trimmer for Illumina sequence data

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HTSeq—a Python framework to work with high-throughput sequencing data

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Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6

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The Significance of VSIG4 Expression in Ovarian Cancer

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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

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Gene expression profile of mouse white adipose tissue during inflammatory stress: age‐dependent upregulation of major procoagulant factors

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Targeting macrophages rescues age‐related immune deficiencies in C57 BL /6J geriatric mice

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Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans

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Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue

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Serum soluble VSIG4 as a surrogate marker for the diagnosis of lymphoma‐associated hemophagocytic lymphohistiocytosis

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Fat tissue, aging, and cellular senescence

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VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1 β in macrophages

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Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system

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Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

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The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells

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Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells

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Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung

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VSIG4, a B7 family-related protein, is a negative regulator of T cell activation

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Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

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Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

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Differential expression analysis for sequence count data

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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

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Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis

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Heterogeneity of adipose tissue in development and metabolic function

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An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile

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Evaluation of Current and New Biomarkers in Severe Preeclampsia: A Microarray Approach Reveals the VSIG4 Gene as a Potential Blood Biomarker

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Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice

inferredcites →https://doi.org/10.1523/jneurosci.3030-17.2018openalex-snapshot

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice

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Influence of age and sex on serum concentrations of total dimeric activin A

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Orally administered fisetin as an immuno-modulatory and therapeutic agent in a mouse model of chronic allergic airway disease

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Changes in Adipose Tissue Macrophages and T Cells During Aging

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Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

inferredcites →https://doi.org/10.18632/aging.101206openalex-snapshot

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice

inferredcites →https://doi.org/10.18632/aging.101268openalex-snapshot

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

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The immune checkpoint molecule V-set Ig domain-containing 4 is an independent prognostic factor for multiple myeloma

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Commentary on Camell et al., Aging Induces Nlrp3 Inflammasome Dependent Adipose B Cell Expansion to Impair Metabolic Homeostasis

inferredcites →https://doi.org/10.2337/db06-1076openalex-snapshot

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

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Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis

inferredcites →https://doi.org/10.3389/fgene.2018.00059openalex-snapshot

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

inferredcites →https://doi.org/10.3389/fimmu.2018.02945openalex-snapshot

T Cells in Adipose Tissue in Aging

inferredcites →https://doi.org/10.4049/jimmunol.1102188openalex-snapshot

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

inferredcites →https://doi.org/10.4049/jimmunol.179.7.4829openalex-snapshot

Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue

inferredcites →https://doi.org/10.4049/jimmunol.196.supp.188.2openalex-snapshot

Visceral adipose tissue contributes to the generation of pro-inflammatory B cell subsets in aging mice

inferredcites →https://doi.org/10.4062/biomolther.2015.036openalex-snapshot

Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk

inferredcites →https://doi.org/10.4161/adip.28250openalex-snapshot

Gene expression differences in adipose tissue associated with breast tumorigenesis

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Complement receptor immunoglobulin: a control point in infection and immunity, inflammation and cancer

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Targeting senescent cells enhances adipogenesis and metabolic function in old age

inferredcites →https://doi.org/10.7554/elife.29540openalex-snapshot

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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RNA-seq analysis of phagocytic cells from murine epididymal white adipose tissue shows immunosenescence and age-related phosphorus metabolism

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V-set and immunoglobulin domain containing 4 as a potential predictor of Alzheimer's disease and advanced aging

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Shared and niche-specific transcriptional signatures of macrophage aging revealed by a cross-tissue meta-analysis

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Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics

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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1

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Identification of Key Biomarkers and Pathways for Maintaining Cognitively Normal Brain Aging Based on Integrated Bioinformatics Analysis

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Development and validation of prognostic models for colon adenocarcinoma based on combined immune-and metabolism-related genes

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Upregulation of VSIG4 in Type 2 Diabetic Kidney Disease

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VSIG4 Expression During Renal Aging Is Accelerated by Type 2 Diabetes in Mice

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Additional file 1 of Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics

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Additional file 2 of Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics

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