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Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneur.56.3.303openalex-snapshot
Mild Cognitive Impairment
inferredcites →https://doi.org/10.1006/jmre.1999.1835openalex-snapshot
Time-Domain Quantification of Series of Biomedical Magnetic Resonance Spectroscopy Signals
inferredcites →https://doi.org/10.1007/s10974-017-9467-7openalex-snapshot
Energy demand and supply in human skeletal muscle
inferredcites →https://doi.org/10.1016/s0010-4825(01)00006-3openalex-snapshot
Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals
inferredcites →https://doi.org/10.1038/s41598-019-45602-4openalex-snapshot
The Metabolic Cost of Walking in healthy young and older adults – A Systematic Review and Meta Analysis
inferredcites →https://doi.org/10.1046/j.1532-5415.2001.4911247.xopenalex-snapshot
Measuring Fitness in Healthy Older Adults: The Health ABC Long Distance Corridor Walk
inferredcites →https://doi.org/10.1056/nejm199503023320902openalex-snapshot
Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability
inferredcites →https://doi.org/10.1073/pnas.1321881111openalex-snapshot
Mitochondria impact brain function and cognition
inferredcites →https://doi.org/10.1093/ageing/afw185openalex-snapshot
The relative temporal sequence of decline in mobility and cognition among initially unimpaired older adults: Results from the Baltimore Longitudinal Study of Aging
inferredcites →https://doi.org/10.1093/gerona/63.12.1416openalex-snapshot
The Baltimore Longitudinal Study of Aging (BLSA): A 50-Year-Long Journey and Plans for the Future
inferredcites →https://doi.org/10.1093/gerona/gls196openalex-snapshot
Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults
inferredcites →https://doi.org/10.1093/gerona/glu033openalex-snapshot
Are Estimates of Meaningful Decline in Mobility Performance Consistent Among Clinically Important Subgroups? (Health ABC Study)
inferredcites →https://doi.org/10.1093/gerona/glv070openalex-snapshot
Reconsidering the Role of Mitochondria in Aging
inferredcites →https://doi.org/10.1093/gerona/glv126openalex-snapshot
Gait Speed Predicts Incident Disability: A Pooled Analysis
inferredcites →https://doi.org/10.1093/gerona/glw043openalex-snapshot
Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience
inferredcites →https://doi.org/10.1093/gerona/glw059openalex-snapshot
31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging
inferredcites →https://doi.org/10.1093/geronj/40.6.767openalex-snapshot
Normal Human Aging: The Baltimore Longitudinal Study of Aging
inferredcites →https://doi.org/10.1093/oxfordjournals.bmb.a072636openalex-snapshot
Free radicals and muscle damage
inferredcites →https://doi.org/10.1097/phm.0b013e3182644165openalex-snapshot
The Relationship of the Energetic Cost of Slow Walking and Peak Energy Expenditure to Gait Speed in Mid-to-Late Life
inferredcites →https://doi.org/10.1111/acel.12568openalex-snapshot
Muscle strength mediates the relationship between mitochondrial energetics and walking performance
inferredcites →https://doi.org/10.1111/acel.12725openalex-snapshot
Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging
inferredcites →https://doi.org/10.1111/acel.13552openalex-snapshot
Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging
inferredcites →https://doi.org/10.1111/j.1469-7793.2000.t01-1-00203.xopenalex-snapshot
Oxidative capacity and ageing in human muscle
inferredcites →https://doi.org/10.1111/j.1532-5415.2000.tb03873.xopenalex-snapshot
Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study
inferredcites →https://doi.org/10.1111/j.1748-1716.2006.01522.xopenalex-snapshot
Metabolic cost, mechanical work, and efficiency during walking in young and older men
inferredcites →https://doi.org/10.1111/joim.12894openalex-snapshot
A prospective study of focal brain atrophy, mobility and fitness
inferredcites →https://doi.org/10.1136/bmj.c4467openalex-snapshot
Objectively measured physical capability levels and mortality: systematic review and meta-analysis
inferredcites →https://doi.org/10.1136/jnnp.2005.074294openalex-snapshot
Community walking activity in neurological disorders with leg weakness
inferredcites →https://doi.org/10.1139/y91-084openalex-snapshot
Muscle metabolism in older subjects using 31P magnetic resonance spectroscopy
inferredcites →https://doi.org/10.1152/jappl.1993.75.2.813openalex-snapshot
Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles
inferredcites →https://doi.org/10.1155/2012/194821openalex-snapshot
Skeletal Muscle Mitochondria and Aging: A Review
inferredcites →https://doi.org/10.1159/000172832openalex-snapshot
Reproducibility of an Isokinetic Strength-Testing Protocol of the Knee and Ankle in Older Adults
inferredcites →https://doi.org/10.1212/wnl.0b013e3181a82634openalex-snapshot
Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
inferredcites →https://doi.org/10.1212/wnl.34.7.939openalex-snapshot
Clinical diagnosis of Alzheimer's disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Effect of Frailty and Somatic Mutation Burden on the Association between Mitochondrial DNA Copy Number and Dementia Risk
inferred← citeshttps://doi.org/10.1002/alz.13388openalex-snapshot
Skeletal muscle mitochondrial function predicts cognitive impairment and is associated with biomarkers of Alzheimer's disease and neurodegeneration
inferred← citeshttps://doi.org/10.1002/jcsm.13413openalex-snapshot
The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility
inferred← citeshttps://doi.org/10.1002/oby.24048openalex-snapshot
Unraveling the roles of ectopic adipose depots and physical activity in age‐related mitochondrial decline
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Postoperative Stress, Metabolism, and Catabolism
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Role of Obesity-Triggered Inflammation in Aging
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Mitochondrial transplantation as a possible therapeutic option for sarcopenia
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Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice
inferred← citeshttps://doi.org/10.1007/s11357-023-00754-0openalex-snapshot
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice
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Plasma metabolomic signatures of dual decline in memory and gait in older adults
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Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging
inferred← citeshttps://doi.org/10.1007/s11357-024-01212-1openalex-snapshot
Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults
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Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty
inferred← citeshttps://doi.org/10.1007/s11357-024-01373-zopenalex-snapshot
Sex differences in the association between skeletal muscle energetics and perceived physical fatigability: the Study of Muscle, Mobility and Aging (SOMMA)
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Nervonic acid and 15-epi-PGA1 mediate systemic mitochondrial dysfunction in AD dementia
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Associations between mitochondrial copy number, exercise capacity, physiologic cost of walking, and cardiac strain in young adult survivors of childhood cancer
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Weight of time: exploring the link between obesity and aging
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Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions
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From organ age gaps to precision geromedicine: Multi-omic and imaging frameworks for heterogeneous biological aging
inferred← citeshttps://doi.org/10.1016/j.ekir.2025.103737openalex-snapshot
Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease
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Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop
inferred← citeshttps://doi.org/10.1016/j.lanhl.2026.100904openalex-snapshot
Sarcopenia as a manifestation of systemic energetic failure with ageing
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101755openalex-snapshot
Chronic inflammation and the hallmarks of aging
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108345openalex-snapshot
Rethinking frailty as a disorder of mitochondrial adaptability, from energetic congestion to systemic vulnerability
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103371openalex-snapshot
Interplay of ROS, mitochondrial quality, and exercise in aging: Potential role of spatially discrete signaling
inferred← citeshttps://doi.org/10.1016/j.smhs.2026.07.005openalex-snapshot
Targeting fibro-adipogenic progenitor cells in aging muscle: Exercise regulation and strategies to enhance regeneration and repair
inferred← citeshttps://doi.org/10.1016/j.xcrm.2025.101968openalex-snapshot
Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men
inferred← citeshttps://doi.org/10.1038/s41467-024-55009-zopenalex-snapshot
Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade
inferred← citeshttps://doi.org/10.1038/s41514-026-00449-8openalex-snapshot
The blood proteome predicts the impact of circulating factors on age-related mitochondrial health
inferred← citeshttps://doi.org/10.1038/s41580-023-00606-xopenalex-snapshot
Exercise metabolism and adaptation in skeletal muscle
inferred← citeshttps://doi.org/10.1038/s41598-024-52570-xopenalex-snapshot
Exploring the links of skeletal muscle mitochondrial oxidative capacity, physical functionality, and mental well-being of cancer survivors
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Mitophagy in human health, ageing and disease
inferred← citeshttps://doi.org/10.1038/s42255-026-01563-3openalex-snapshot
Mitochondrial quality control in human ageing and longevity
inferred← citeshttps://doi.org/10.1039/9781839167690-00271openalex-snapshot
NMR in living systems
inferred← citeshttps://doi.org/10.1042/cs20230319openalex-snapshot
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
inferred← citeshttps://doi.org/10.1093/ageing/afae079openalex-snapshot
Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function
inferred← citeshttps://doi.org/10.1093/ageing/afag022openalex-snapshot
Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing
inferred← citeshttps://doi.org/10.1093/eurjpc/zwaf432openalex-snapshot
Influence of exercise and nutrition on sarcopenia in cardiovascular disease: a Scientific Statement of the European Association of Preventive Cardiology of the European Society of Cardiology
inferred← citeshttps://doi.org/10.1093/function/zqad066openalex-snapshot
Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1093/gerona/glac227openalex-snapshot
Mitochondrial Dysfunction and Intrinsic Capacity: Insights From a Narrative Review
inferred← citeshttps://doi.org/10.1093/gerona/glac238openalex-snapshot
Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging
inferred← citeshttps://doi.org/10.1093/gerona/glad283openalex-snapshot
Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging
inferred← citeshttps://doi.org/10.1093/gerona/glae101openalex-snapshot
Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging
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Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA)
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Role of Walking Energetics and Perceived Fatigability on Mobility Differ by Walking Speed: The Study of Muscle, Mobility and Aging (SOMMA)
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The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan
inferred← citeshttps://doi.org/10.1101/2025.05.27.25328460openalex-snapshot
A Pilot Randomized Trial of Home-Based, Video-Supervised Exercise on Muscle Metabolism and Physical Endurance in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1111/acel.14129openalex-snapshot
The cellular bases of mobility from the Study of Muscle, Mobility and Aging ( SOMMA )
inferred← citeshttps://doi.org/10.1111/acel.14323openalex-snapshot
Unacylated Ghrelin Protects Against Age‐Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle
inferred← citeshttps://doi.org/10.1111/acel.14386openalex-snapshot
Skeletal muscle mitochondrial fragmentation predicts age‐associated decline in physical capacity
inferred← citeshttps://doi.org/10.1111/acel.70637openalex-snapshot
Muscle Mitochondrial Oxidative Capacity and Cognitive Decline Over up to a Decade: Sex Differences
inferred← citeshttps://doi.org/10.1111/acel.70703openalex-snapshot
Inhibiting Glutaminase Reverses Senescence‐Associated Mitochondrial Dysfunction and Skeletal Muscle Decline
inferred← citeshttps://doi.org/10.1111/apha.14107openalex-snapshot
Mitochondrial involvement in sarcopenia
inferred← citeshttps://doi.org/10.1111/jgs.18763openalex-snapshot
Energetics and clinical factors for the time required to walk 400 m: The Study of Muscle, Mobility and Aging ( SOMMA )
inferred← citeshttps://doi.org/10.1113/jp285040openalex-snapshot
Reduced oxidative capacity of skeletal muscle mitochondria IS a fundamental consequence of adult ageing
inferred← citeshttps://doi.org/10.1126/sciadv.adj6411openalex-snapshot
Childhood adverse life events and skeletal muscle mitochondrial function
inferred← citeshttps://doi.org/10.1126/science.adl2116openalex-snapshot
Is taurine an aging biomarker?
inferred← citeshttps://doi.org/10.1152/japplphysiol.00659.2022openalex-snapshot
Early-stage Alzheimer’s disease: are skeletal muscle and exercise the key?
inferred← citeshttps://doi.org/10.1155/ina/7882633openalex-snapshot
Association Between Indoor Ventilation Frequency and IADL Disability Among Chinese Older Adults
inferred← citeshttps://doi.org/10.1172/jci158448openalex-snapshot
Connecting aging biology and inflammation in the omics era
inferred← citeshttps://doi.org/10.1212/wnl.0000000000201646openalex-snapshot
Associations of Olfaction With Longitudinal Trajectories of Brain Volumes and Neuropsychological Function in Older Adults
inferred← citeshttps://doi.org/10.1249/jes.0000000000000315openalex-snapshot
Energizing Mitochondria to Prevent Mobility Loss in Aging: Rationale and Hypotheses
inferred← citeshttps://doi.org/10.1249/jes.0000000000000364openalex-snapshot
Novel Insights to Mitochondrial Impact in Aging Skeletal Muscle
inferred← citeshttps://doi.org/10.1249/mss.0000000000003646openalex-snapshot
Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults
inferred← citeshttps://doi.org/10.14814/phy2.70359openalex-snapshot
The association of mitochondrial morphology and supercomplex redistribution with skeletal muscle oxidative capacity in older adults
inferred← citeshttps://doi.org/10.18632/aging.204649openalex-snapshot
Beyond the relationship between mitochondria and mobility in aging
inferred← citeshttps://doi.org/10.3389/fragi.2024.1442323openalex-snapshot
Aging mitochondria in the context of SARS-CoV-2: exploring interactions and implications
inferred← citeshttps://doi.org/10.3390/biom14040415openalex-snapshot
Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia
inferred← citeshttps://doi.org/10.3390/ijms25042052openalex-snapshot
Mitochondrial Quantity and Quality in Age-Related Sarcopenia
inferred← citeshttps://doi.org/10.3390/ijms26167787openalex-snapshot
A Reassessment of Sarcopenia from a Redox Perspective as a Basis for Preventive and Therapeutic Interventions
inferred← citeshttps://doi.org/10.3390/s24237427openalex-snapshot
Validity of Linear and Nonlinear Measures of Gait Variability to Characterize Aging Gait with a Single Lower Back Accelerometer
inferred← citeshttps://doi.org/10.3791/64628openalex-snapshot
Use of Minimally Invasive Methods to Assess Fuel Utilization and Circadian Rhythms in Older Adults
inferred← citeshttps://doi.org/10.3791/64628-vopenalex-snapshot
JoVE Video Dataset
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Abstract 067 | Special lecture: cardiolipin and mitochondrial quality control in aging
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Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wasting
inferred← citeshttps://doi.org/10.64898/2026.07.05.736613openalex-snapshot
Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis
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Encouraging a move toward precision geromedicine
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Effects of aging and BMI level on relationships between skeletal muscle fibers, capillaries, and mitochondria
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