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Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real‐world settings? A prospective study

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/14651858.cd000031.pub4openalex-snapshot

Antidepressants for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd000031.pub5openalex-snapshot

Antidepressants for smoking cessation

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Nicotine replacement therapy for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd000165.pub4openalex-snapshot

Physician advice for smoking cessation

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Group behaviour therapy programmes for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd001007.pub3openalex-snapshot

Group behaviour therapy programmes for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd001292.pub2openalex-snapshot

Individual behavioural counselling for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd001292.pub3openalex-snapshot

Individual behavioural counselling for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd006103openalex-snapshot

Nicotine receptor partial agonists for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd006103.pub2openalex-snapshot

Nicotine receptor partial agonists for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd006103.pub7openalex-snapshot

Nicotine receptor partial agonists for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd008286.pub3openalex-snapshot

Combined pharmacotherapy and behavioural interventions for smoking cessation

inferredcites →https://doi.org/10.1002/14651858.cd011823.pub2openalex-snapshot

Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers

inferredcites →https://doi.org/10.1007/978-3-540-69248-5_2openalex-snapshot

Nicotine Chemistry, Metabolism, Kinetics and Biomarkers

inferredcites →https://doi.org/10.1007/s00213-011-2341-1openalex-snapshot

Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence

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Post-Traumatic Growth After a Myocardial Infarction: A Matter of Personality, Psychological Health, or Cognitive Coping?

inferredcites →https://doi.org/10.1007/s11481-016-9656-yopenalex-snapshot

Precision Medicine for Tobacco Dependence: Development and Validation of the Nicotine Metabolite Ratio

inferredcites →https://doi.org/10.1007/s40263-015-0243-1openalex-snapshot

Biomarkers of Response to Smoking Cessation Pharmacotherapies: Progress to Date

inferredcites →https://doi.org/10.1016/j.clpt.2004.02.011openalex-snapshot

Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1

inferredcites →https://doi.org/10.1016/j.clpt.2006.02.006openalex-snapshot

Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation

inferredcites →https://doi.org/10.1016/j.clpt.2006.06.011openalex-snapshot

Determinants of the rate of nicotine metabolism and effects on smoking behavior

inferredcites →https://doi.org/10.1016/j.clpt.2006.08.011openalex-snapshot

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine

inferredcites →https://doi.org/10.1016/j.drugalcdep.2015.11.017openalex-snapshot

Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers

inferredcites →https://doi.org/10.1016/j.jpba.2016.08.041openalex-snapshot

Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting

inferredcites →https://doi.org/10.1016/j.pbb.2008.10.016openalex-snapshot

Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: A validation study

inferredcites →https://doi.org/10.1016/s0022-3565(24)36947-2openalex-snapshot

A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

inferredcites →https://doi.org/10.1016/s0090-9556(25)08453-3openalex-snapshot

Role of human cytochrome P4502A6 in C-oxidation of nicotine.

inferredcites →https://doi.org/10.1016/s0140-6736(16)30272-0openalex-snapshot

Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial

inferredcites →https://doi.org/10.1016/s2213-2600(14)70294-2openalex-snapshot

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial

inferredcites →https://doi.org/10.1038/clpt.2008.57openalex-snapshot

Toward Personalized Therapy for Smoking Cessation: A Randomized Placebo-controlled Trial of Bupropion

inferredcites →https://doi.org/10.1038/clpt.2013.57openalex-snapshot

Biomarkers for Smoking Cessation

inferredcites →https://doi.org/10.1038/ng.573openalex-snapshot

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

inferredcites →https://doi.org/10.1038/s41598-017-17994-8openalex-snapshot

Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England

inferredcites →https://doi.org/10.1046/j.1360-0443.2003.00295.xopenalex-snapshot

A meta‐analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins

inferredcites →https://doi.org/10.1056/nejmsb1609216openalex-snapshot

Real-World Evidence — What Is It and What Can It Tell Us?

inferredcites →https://doi.org/10.1080/01677060802572887openalex-snapshot

Nicotine Dependence Pharmacogenetics: Role of Genetic Variation in Nicotine-Metabolizing Enzymes

inferredcites →https://doi.org/10.1093/jat/30.6.386openalex-snapshot

Within-Subject Variation of the Salivary 3HC/COT Ratio in Regular Daily Smokers: Prospects for Estimating CYP2A6 Enzyme Activity in Large-Scale Surveys of Nicotine Metabolic Rate

inferredcites →https://doi.org/10.1093/jnci/djr237openalex-snapshot

Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk

inferredcites →https://doi.org/10.1093/ntr/ntp161openalex-snapshot

Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: A round-robin study

inferredcites →https://doi.org/10.1093/ntr/nts272openalex-snapshot

Race, Gender, and Nicotine Metabolism in Adolescent Smokers

inferredcites →https://doi.org/10.1093/ntr/ntu342openalex-snapshot

The Nicotine Metabolite Ratio in Pregnancy Measured bytrans-3′-Hydroxycotinine to Cotinine Ratio: Characteristics and Relationship With Smoking Cessation: Table 1.

inferredcites →https://doi.org/10.1093/ntr/ntv031openalex-snapshot

Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers

inferredcites →https://doi.org/10.1093/ntr/ntv125openalex-snapshot

The Nicotine Metabolite Ratio is Associated With Early Smoking Abstinence Even After Controlling for Factors That Influence the Nicotine Metabolite Ratio

inferredcites →https://doi.org/10.1093/ntr/ntw258openalex-snapshot

Prevalence and Impact of Long-term Use of Nicotine Replacement Therapy in UK Stop-Smoking Services: Findings From the ELONS Study

inferredcites →https://doi.org/10.1093/ntr/ntx083openalex-snapshot

Nicotine Metabolite Ratio (NMR) Prospectively Predicts Smoking Relapse: Longitudinal Findings From ITC Surveys in Five Countries

inferredcites →https://doi.org/10.1093/pubmed/fdp074openalex-snapshot

The effectiveness of NHS smoking cessation services: a systematic review

inferredcites →https://doi.org/10.1111/add.12285openalex-snapshot

The prevalence, predictors and associated health outcomes of high nicotine dependence using three measures among US smokers

inferredcites →https://doi.org/10.1111/add.12353openalex-snapshot

Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene ( CYP2A6 )

inferredcites →https://doi.org/10.1111/add.12390openalex-snapshot

Commentary on C hen et al. (2014): Another step on the road to clinical utility of pharmacogenetics for smoking cessation?

inferredcites →https://doi.org/10.1111/add.12429openalex-snapshot

‘Real-world’ effectiveness of smoking cessation treatments: a population study

inferredcites →https://doi.org/10.1111/add.14032openalex-snapshot

Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

inferredcites →https://doi.org/10.1111/add.14450openalex-snapshot

Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real‐world settings? A prospective study

inferredcites →https://doi.org/10.1111/j.1360-0443.1989.tb03059.xopenalex-snapshot

Measuring the Heaviness of Smoking: using self‐reported time to the first cigarette of the day and number of cigarettes smoked per day

inferredcites →https://doi.org/10.1111/j.1360-0443.2004.00995.xopenalex-snapshot

Outcome criteria in smoking cessation trials: proposal for a common standard

inferredcites →https://doi.org/10.1111/j.1360-0443.2005.01027.xopenalex-snapshot

The English smoking treatment services: short‐term outcomes

inferredcites →https://doi.org/10.1111/j.1360-0443.2005.01028.xopenalex-snapshot

The English smoking treatment services: one‐year outcomes

inferredcites →https://doi.org/10.1111/j.1360-0443.2011.03565.xopenalex-snapshot

Predictors of attempts to stop smoking and their success in adult general population samples: a systematic review

inferredcites →https://doi.org/10.1158/1055-9965.epi-08-0242openalex-snapshot

Stability of the Nicotine Metabolite Ratio inad Libitumand Reducing Smokers

inferredcites →https://doi.org/10.1158/1055-9965.epi-10-0674openalex-snapshot

Nicotine Metabolite Ratio Predicts Smoking Topography and Carcinogen Biomarker Level

inferredcites →https://doi.org/10.1158/1055-9965.epi-12-0236openalex-snapshot

Reproducibility of the Nicotine Metabolite Ratio in Cigarette Smokers

inferredcites →https://doi.org/10.1158/1055-9965.epi-14-0427openalex-snapshot

Known and Novel Sources of Variability in the Nicotine Metabolite Ratio in a Large Sample of Treatment-Seeking Smokers

inferredcites →https://doi.org/10.1158/1055-9965.epi-14-1381openalex-snapshot

Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation

inferredcites →https://doi.org/10.1159/000376585openalex-snapshot

The WHO-5 Well-Being Index: A Systematic Review of the Literature

inferredcites →https://doi.org/10.1371/journal.pgen.1005498openalex-snapshot

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

inferredcites →https://doi.org/10.2217/pme.11.60openalex-snapshot

Treatment for Tobacco Dependence: A Potential Application for Stratified Medicine?

inferredcites →https://doi.org/10.3310/hta19950openalex-snapshot

Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS): a prospective cohort study

inferredcites →https://doi.org/10.3389/fpsyg.2014.00781openalex-snapshot

Using Bayes to get the most out of non-significant results

inferredcites →https://doi.org/10.5860/choice.27-3338openalex-snapshot

Applied logistic regression

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4632941openalex-extracted

Association between Nicotine Metabolite Ratio and Smoking Cessation Medications in Chinese Male Smokers - Results of the China National Tobacco Cessation Cohort Study

inferred← citeshttps://doi.org/10.1016/j.addicn.2023.100076openalex-snapshot

The use of biomarkers to guide precision treatment for tobacco use

inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2026.113294openalex-snapshot

Role of nicotine metabolite ratio in pharmacological interventions on smoking cessation: A systematic review and meta-analyses of randomized controlled trials

inferred← citeshttps://doi.org/10.1037/pha0000252openalex-snapshot

Naltrexone and alcohol effects on craving for cigarettes in heavy drinking smokers.

inferred← citeshttps://doi.org/10.1080/17425255.2021.1863948openalex-snapshot

Pharmacogenetics factors influencing smoking cessation success; the importance of nicotine metabolism

inferred← citeshttps://doi.org/10.1080/17476348.2024.2429675openalex-snapshot

Is the nicotine metabolite ratio a useful tool to improve the effectiveness, safety, and adherence to quitting smoking? Systematic review of the literature and meta-analysis

inferred← citeshttps://doi.org/10.1093/ntr/ntaa022openalex-snapshot

Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study

inferred← citeshttps://doi.org/10.1093/ntr/ntad079openalex-snapshot

Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial

inferred← citeshttps://doi.org/10.1101/2024.10.23.24315983openalex-snapshot

Nicotine metabolite ratio as an informed biomarker to optimize acupuncture for smoking cessation: randomised controlled trial

inferred← citeshttps://doi.org/10.1111/adb.12930openalex-snapshot

Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence

inferred← citeshttps://doi.org/10.1111/resp.14702openalex-snapshot

Efficacy of varenicline or bupropion and its association with nicotine metabolite ratio among smokers with COPD

inferred← citeshttps://doi.org/10.1146/annurev-clinpsy-081219-090343openalex-snapshot

Smoking Treatment: A Report Card on Progress and Challenges

inferred← citeshttps://doi.org/10.1158/1940-6207.capr-19-0259openalex-snapshot

The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions

inferred← citeshttps://doi.org/10.1158/1940-6207.capr-24-0449openalex-snapshot

Nicotine Metabolite Ratio in People with HIV Who Smoke Cigarettes Receiving Pharmacologic and Behavioral Cessation Therapy

inferred← citeshttps://doi.org/10.11606/t.5.2020.tde-07072020-170623openalex-snapshot

Análise da associação dos perfis de expressão gênica e das concentrações de metabólitos com a resposta ao tratamento antitabagismo

inferred← citeshttps://doi.org/10.18332/tpc/217141openalex-snapshot

Nicotine metabolite ratio and attitude towards nicotine metabolite ratio informed smoking cessation care in Jordan

inferred← citeshttps://doi.org/10.3389/fphar.2022.900112openalex-snapshot

Evaluation of the nicotine metabolite ratio in smoking patients treated with varenicline and bupropion

inferred← citeshttps://doi.org/10.3390/ijerph22071040openalex-snapshot

The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa

inferred← citeshttps://doi.org/10.3390/ijerph23091171openalex-snapshot

Using Conditional Random Forest and Feature Ranking Algorithms to Determine the Relative Importance of the Nicotine Metabolite Ratio (NMR) and Demographic and Behavioral Factors on Nicotine Dependence Severity

inferred← citeshttps://doi.org/10.3390/jox15020044openalex-snapshot

Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation

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