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Donepezil across the spectrum of Alzheimer's disease: dose optimization and clinical relevance

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gps.1133openalex-snapshot
Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta‐analysis of individual patient data from randomised controlled trials
inferredcites →https://doi.org/10.1016/j.clinthera.2010.06.019openalex-snapshot
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study
inferredcites →https://doi.org/10.1016/j.jalz.2014.05.613openalex-snapshot
P1‐371: EFFICACY AND TOLERABILITY OF DONEPEZIL 23MG/D VERSUS DONEPEZIL 10MG/D IN PATIENTS WITH MODERATE TO SEVERE AD IN AN ASIAN POPULATION: STUDY 326 SUBANALYSIS
inferredcites →https://doi.org/10.1016/s0140-6736(06)68350-5openalex-snapshot
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
inferredcites →https://doi.org/10.1046/j.1532-5415.2001.t01-1-49266.xopenalex-snapshot
A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease in the Nursing Home Setting
inferredcites →https://doi.org/10.1056/nejmoa1106668openalex-snapshot
Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease
inferredcites →https://doi.org/10.1111/ane.12195openalex-snapshot
Galantamine treatment in outpatients with mild Alzheimer's disease
inferredcites →https://doi.org/10.1111/cns.12076openalex-snapshot
High‐Dose Donepezil (23 mg/day) for the Treatment of Moderate and Severe Alzheimer's Disease: Drug Profile and Clinical Guidelines
inferredcites →https://doi.org/10.1159/000091790openalex-snapshot
3-Year Study of Donepezil Therapy in Alzheimer’s Disease: Effects of Early and Continuous Therapy
inferredcites →https://doi.org/10.1159/000122961openalex-snapshot
Donepezil Treatment of Patients with Severe Alzheimer’s Disease in a Japanese Population: Results from a 24-Week, Double-Blind, Placebo-Controlled, Randomized Trial
inferredcites →https://doi.org/10.1159/000203887openalex-snapshot
Long-Term Safety and Efficacy of Donepezil in Patients with Severe Alzheimer’s Disease: Results from a 52-Week, Open-Label, Multicenter, Extension Study in Japan
inferredcites →https://doi.org/10.1159/000338236openalex-snapshot
Efficacy and Safety of Donepezil 23 mg versus Donepezil 10 mg for Moderate-to-Severe Alzheimer’s Disease: A Subgroup Analysis in Patients Already Taking or Not Taking Concomitant Memantine
inferredcites →https://doi.org/10.1159/000345279openalex-snapshot
Persistence of Cholinesterase Inhibitor Treatment in Dementia: Insights from a Naturalistic Study
inferredcites →https://doi.org/10.1185/03007990903236731openalex-snapshot
Donepezil treatment in severe Alzheimer's disease: a pooled analysis of three clinical trials
inferredcites →https://doi.org/10.1186/1471-2377-11-57openalex-snapshot
Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease
inferredcites →https://doi.org/10.1186/1756-0500-5-283openalex-snapshot
Long-term safety and tolerability of donepezil 23 mg in patients with moderate to severe Alzheimer’s disease
inferredcites →https://doi.org/10.1186/alzrt166openalex-snapshot
Effects of donepezil 23 mg on Severe Impairment Battery domains in patients with moderate to severe Alzheimer's disease: evaluating the impact of baseline severity
inferredcites →https://doi.org/10.1212/01.wnl.0000134664.80320.92openalex-snapshot
Efficacy of donepezil in mild cognitive impairment
inferredcites →https://doi.org/10.1212/01.wnl.0000266627.96040.5aopenalex-snapshot
Donepezil preserves cognition and global function in patients with severe Alzheimer disease
inferredcites →https://doi.org/10.1212/01.wnl.0000344650.95823.03openalex-snapshot
Donepezil treatment of patients with MCI
inferredcites →https://doi.org/10.2147/cia.s39959openalex-snapshot
Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors
inferredcites →https://doi.org/10.2165/00002512-200825020-00008openalex-snapshot
Safety and Tolerability of Donepezil at Doses up to 20 mg/day

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Action Mechanisms of Donepezil in Cardiac and Vascular Aspects: A Review
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Direct Reductive Amination of Carbonyl Compounds with H2 Using Heterogeneous Catalysts in Continuous Flow as an Alternative to N‐Alkylation with Alkyl Halides
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Design and Development of Cholinesterase Dual Inhibitors towards Alzheimer's Disease Treatment: A Focus on Recent Contributions from Computational and Theoretical Perspective
inferred← citeshttps://doi.org/10.1002/trc2.12168openalex-snapshot
Prescribing cholinesterase inhibitors in mild cognitive impairment—Observations from the Alzheimer's Disease Neuroimaging Initiative
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Mesenchymal stem cell therapies for Alzheimer’s disease: preclinical studies
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Pharmacophore mapping of the crucial mediators of acetylcholinesterase and butyrylcholinesterase dual inhibition in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-818697-8.00108-4openalex-snapshot
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Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders
inferred← citeshttps://doi.org/10.1016/j.bbrep.2022.101392openalex-snapshot
The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.11.115openalex-snapshot
The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches
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inferred← citeshttps://doi.org/10.1016/j.cger.2022.07.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173193openalex-snapshot
Geranylgeranyl acetone prevents glutamate-induced cell death in HT-22 cells by increasing mitochondrial membrane potential
inferred← citeshttps://doi.org/10.1016/j.hermed.2019.100291openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ibneur.2022.11.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.02.020openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.lfs.2016.11.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.snb.2024.136895openalex-snapshot
A strategy of monitoring acetylcholinesterase and screening of natural inhibitors from Uncaria for Alzheimer's disease therapy based on near-infrared fluorescence probe
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c00836openalex-snapshot
Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the Akt/mTOR Signaling Pathway
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00450openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsnano.3c08823openalex-snapshot
Rational Design of Dual-Functionalized Gd@C82 Nanoparticles to Relieve Neuronal Cytotoxicity in Alzheimer’s Disease via Inhibition of Aβ Aggregation
inferred← citeshttps://doi.org/10.1021/acsomega.0c00057openalex-snapshot
Effects of α-Mangostin Derivatives on the Alzheimer’s Disease Model of Rats and Their Mechanism: A Combination of Experimental Study and Computational Systems Pharmacology Analysis
inferred← citeshttps://doi.org/10.1021/acsomega.6c07555openalex-snapshot
Rapid HPLC-Based ADME Profiling of Novel Donepezil and Rivastigmine Analogues for Potential Application in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1038/s41746-021-00452-1openalex-snapshot
Exploring the feasibility of using real-world data from a large clinical data research network to simulate clinical trials of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1055/a-2076-7939openalex-snapshot
Phytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders
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Silencing of LncRNA BDNF-AS attenuates Aβ25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress
inferred← citeshttps://doi.org/10.1080/07391102.2020.1826129openalex-snapshot
Multi-target approach for Alzheimer’s disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4- N -phenylaminoquinoline derivative reveal promising potentials
inferred← citeshttps://doi.org/10.1080/14740338.2022.2027905openalex-snapshot
Compared of efficacy and safety of high-dose donepezil vs standard-dose donepezil among elderly patients with Alzheimer’s disease: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1093/oso/9780190634230.003.0019openalex-snapshot
Management of Mild Cognitive Impairment
inferred← citeshttps://doi.org/10.1097/wnr.0000000000001659openalex-snapshot
Effects of donepezil on the amplitude of low-frequency fluctuations in the brain of patients with Alzheimer’s disease: evidence from resting-state functional magnetic resonance imaging
inferred← citeshttps://doi.org/10.1124/pharmrev.121.000524openalex-snapshot
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-061020-050936openalex-snapshot
Cholinergic Capsules and Academic Admonitions
inferred← citeshttps://doi.org/10.1159/000518470openalex-snapshot
Effects of Body Weight on the Safety of High-Dose Donepezil in Alzheimer’s Disease: Post hoc Analysis of a Multicenter, Randomized, Open-Label, Parallel Design, Three-Arm Clinical Trial
inferred← citeshttps://doi.org/10.1177/0269881120944155openalex-snapshot
An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish
inferred← citeshttps://doi.org/10.1177/25424823251356233openalex-snapshot
Healthcare related costs associated with donepezil use in patients with very mild dementia due to Alzheimer's disease: A retrospective observational study
inferred← citeshttps://doi.org/10.1186/s12885-022-09806-8openalex-snapshot
Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial
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Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials
inferred← citeshttps://doi.org/10.1186/s13195-019-0492-1openalex-snapshot
Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial
inferred← citeshttps://doi.org/10.12659/msm.896327openalex-snapshot
Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease
inferred← citeshttps://doi.org/10.12968/hmed.2024.1037openalex-snapshot
Combined Effects of Donepezil and Memantine on Behavioral and Psychological Symptoms, Cognitive Function, and Daily Living Abilities in Patients With Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1590/s2175-97902024e23618openalex-snapshot
Rational drug repurposing for alzheimer’s treatment using in-silico ligand and structure-based approaches
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Russian experience in using a combination of fixed doses of donepezil and memantine in the treatment of Alzheimer’s disease as an observational non-interventional multicenter program
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Preclinical systematic review of ginsenoside Rg1 for cognitive impairment in Alzheimer’s disease
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Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer's disease patients
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Combination Therapy of Donepezil and Environmental Enrichment on Memory Deficits in Amyloid-Beta-Induced Alzheimer's Disease Rats
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Neurodegeneration: Diagnosis, Prevention, and Therapy
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