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Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
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Multidrug Resistance Is Common in Escherichia coli Associated with Ileal Crohnʼs Disease
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The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications
inferredcites →https://doi.org/10.1007/s10350-004-7256-zopenalex-snapshot
Bacterial Translocation in Patients With Crohn's Disease Undergoing Surgery
inferredcites →https://doi.org/10.1007/s10620-012-2371-5openalex-snapshot
Recent Trends in the Prevalence of Crohn’s Disease and Ulcerative Colitis in a Commercially Insured US Population
inferredcites →https://doi.org/10.1007/s11938-014-0042-7openalex-snapshot
Therapeutic Manipulation of the Microbiome in IBD: Current Results and Future Approaches
inferredcites →https://doi.org/10.1016/j.bcp.2010.08.022openalex-snapshot
Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells
inferredcites →https://doi.org/10.1016/j.chom.2014.02.005openalex-snapshot
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
inferredcites →https://doi.org/10.1016/j.cmet.2006.08.004openalex-snapshot
Xenobiotic receptor meets NF-κB, a collision in the small bowel
inferredcites →https://doi.org/10.1016/j.crohns.2007.11.002openalex-snapshot
European evidence-based Consensus on the management of ulcerative colitis: Current management
inferredcites →https://doi.org/10.1016/j.crohns.2009.12.002openalex-snapshot
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
inferredcites →https://doi.org/10.1016/j.crohns.2013.09.001openalex-snapshot
National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States
inferredcites →https://doi.org/10.1016/j.crohns.2014.05.010openalex-snapshot
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report
inferredcites →https://doi.org/10.1016/j.dci.2013.05.005openalex-snapshot
Drosophila as a model for intestinal dysbiosis and chronic inflammatory diseases
inferredcites →https://doi.org/10.1016/j.ejphar.2011.06.058openalex-snapshot
Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells
inferredcites →https://doi.org/10.1016/j.ejps.2014.01.007openalex-snapshot
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
inferredcites →https://doi.org/10.1016/j.it.2013.04.001openalex-snapshot
From genetics of inflammatory bowel disease towards mechanistic insights
inferredcites →https://doi.org/10.1016/j.tips.2012.03.003openalex-snapshot
Pregnane X receptor as a target for treatment of inflammatory bowel disorders
inferredcites →https://doi.org/10.1038/ajg.2008.168openalex-snapshot
Management of Crohn's Disease in Adults
inferredcites →https://doi.org/10.1038/ajg.2009.727openalex-snapshot
Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee
inferredcites →https://doi.org/10.1038/ajg.2010.84openalex-snapshot
Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial
inferredcites →https://doi.org/10.1038/ajg.2011.72openalex-snapshot
Antibiotic Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.1038/ja.2014.106openalex-snapshot
Rifaximin: beyond the traditional antibiotic activity
inferredcites →https://doi.org/10.1038/nature11582openalex-snapshot
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
inferredcites →https://doi.org/10.1038/ncpgasthep0528openalex-snapshot
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
inferredcites →https://doi.org/10.1038/nrgastro.2012.58openalex-snapshot
Acute and chronic pouchitis—pathogenesis, diagnosis and treatment
inferredcites →https://doi.org/10.1053/gast.2003.50010openalex-snapshot
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
inferredcites →https://doi.org/10.1053/j.gastro.2004.04.019openalex-snapshot
Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes
inferredcites →https://doi.org/10.1053/j.gastro.2010.10.036openalex-snapshot
Genetics and Environmental Interactions Shape the Intestinal Microbiome to Promote Inflammatory Bowel Disease Versus Mucosal Homeostasis
inferredcites →https://doi.org/10.1053/j.gastro.2011.11.032openalex-snapshot
Rifaximin-Extended Intestinal Release Induces Remission in Patients With Moderately Active Crohn's Disease
inferredcites →https://doi.org/10.1053/j.gastro.2014.02.009openalex-snapshot
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
inferredcites →https://doi.org/10.1093/jac/dkq345openalex-snapshot
Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system
inferredcites →https://doi.org/10.1097/01.mib.0000215092.85116.6copenalex-snapshot
Rifaximin for active ulcerative colitis
inferredcites →https://doi.org/10.1097/01.mib.0000435441.30107.8bopenalex-snapshot
Challenges in Designing a National Surveillance Program for Inflammatory Bowel Disease in the United States
inferredcites →https://doi.org/10.1097/mib.0b013e318281f423openalex-snapshot
Bile Acid Malabsorption Deactivates Pregnane X Receptor in Patients with Crohn’s Disease
inferredcites →https://doi.org/10.1097/mog.0b013e32833f1195openalex-snapshot
The role of mucosal immunity and host genetics in defining intestinal commensal bacteria
inferredcites →https://doi.org/10.1097/qco.0b013e32832a8a5dopenalex-snapshot
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
inferredcites →https://doi.org/10.1111/apt.12688openalex-snapshot
Adjunct antibiotic combination therapy for steroid‐refractory or ‐dependent ulcerative colitis: an open‐label multicentre study
inferredcites →https://doi.org/10.1111/j.1440-1746.2007.04933.xopenalex-snapshot
Bacterial translocation: Overview of mechanisms and clinical impact
inferredcites →https://doi.org/10.1124/jpet.107.121913openalex-snapshot
Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator
inferredcites →https://doi.org/10.1124/jpet.110.170225openalex-snapshot
Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation
inferredcites →https://doi.org/10.1126/science.1110591openalex-snapshot
Diversity of the Human Intestinal Microbial Flora
inferredcites →https://doi.org/10.1128/aac.00691-09openalex-snapshot
Pretreatment of Epithelial Cells with Rifaximin Alters Bacterial Attachment and Internalization Profiles
inferredcites →https://doi.org/10.1128/aac.02163-12openalex-snapshot
Rifaximin Resistance in Escherichia coli Associated with Inflammatory Bowel Disease Correlates with Prior Rifaximin Use, Mutations in rpoB , and Activity of Phe-Arg-β-Naphthylamide-Inhibitable Efflux Pumps
inferredcites →https://doi.org/10.1136/gutjnl-2012-303954openalex-snapshot
Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome
inferredcites →https://doi.org/10.1136/gutjnl-2013-304488openalex-snapshot
Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: a randomised, double-blind, placebo controlled trial (ADAFI)
inferredcites →https://doi.org/10.1152/ajpgi.00528.2006openalex-snapshot
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression
inferredcites →https://doi.org/10.1159/000068362openalex-snapshot
Inhibition of Intestinal Bacterial Translocation with Rifaximin Modulates Lamina propria Monocytic Cells Reactivity and Protects against Inflammation in a Rodent Model of Colitis
inferredcites →https://doi.org/10.1159/000081990openalex-snapshot
Rifaximin, a Poorly Absorbed Antibiotic: Pharmacology and Clinical Potential
inferredcites →https://doi.org/10.1159/000089776openalex-snapshot
Experimental and Clinical Pharmacology of Rifaximin, a Gastrointestinal Selective Antibiotic
inferredcites →https://doi.org/10.1159/000358141openalex-snapshot
Is Rifaximin Effective in Maintaining Remission in Crohn's Disease?
inferredcites →https://doi.org/10.1159/000360674openalex-snapshot
The Intestinal Microbiota in Inflammatory Bowel Diseases
inferredcites →https://doi.org/10.1159/000360713openalex-snapshot
Antibiotics, Probiotics and Prebiotics in IBD
inferredcites →https://doi.org/10.1172/jci26283openalex-snapshot
Mutual repression between steroid and xenobiotic receptor and NF- B signaling pathways links xenobiotic metabolism and inflammation
inferredcites →https://doi.org/10.1172/jci75436openalex-snapshot
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
inferredcites →https://doi.org/10.1179/joc.2002.14.3.290openalex-snapshot
Effects of Rifaximin Administration on the Intestinal Microbiota in Patients with Ulcerative Colitis
inferredcites →https://doi.org/10.1185/0300799009117003openalex-snapshot
Effect of Rifaximin on Intestinal Bacterial Overgrowth in Crohn's Disease as Assessed by the H2-Glucose Breath Test
inferredcites →https://doi.org/10.1186/s13073-014-0107-1openalex-snapshot
Complex host genetics influence the microbiome in inflammatory bowel disease
inferredcites →https://doi.org/10.1371/journal.pone.0068550openalex-snapshot
Rifaximin-Mediated Changes to the Epithelial Cell Proteome: 2-D Gel Analysis
inferredcites →https://doi.org/10.1385/ir:31:2:151openalex-snapshot
The mdr1a–/– Mouse Model of Spontaneous Colitis: A Relevant and Appropriate Animal Model to Study Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1586/egh.13.6openalex-snapshot
The role of antimicrobials in Crohn’s disease
inferredcites →https://doi.org/10.2174/1389200211314030009openalex-snapshot
Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease
inferredcites →https://doi.org/10.2217/14622416.9.11.1695openalex-snapshot
PXR: A Xenobiotic Receptor of Diverse Function Implicated in Pharmacogenetics
inferredcites →https://doi.org/10.3748/wjg.v19.i5.648openalex-snapshot
Use of antibiotics in the treatment of Crohn’s disease
inferredcites →https://doi.org/10.3892/etm.2012.718openalex-snapshot
Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Gut Microbiota and Inflammatory Bowel Diseases
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pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1002/ame2.12262openalex-snapshot
Research progress on the relationship between intestinal microecology and intestinal bowel disease
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Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting
inferred← citeshttps://doi.org/10.1002/ctm2.1227openalex-snapshot
P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis
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Probing gut‐brain links in Alzheimer's disease with rifaximin
inferred← citeshttps://doi.org/10.1002/ygh2.423openalex-snapshot
Rifaximin for the treatment of Crohn’s disease
inferred← citeshttps://doi.org/10.1007/978-3-030-59642-2_3openalex-snapshot
Gut Microbiome and Gastrointestinal Disorders
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Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases
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Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases
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The Effects of Rifampin, Povidone-Iodine and Hydrogen Peroxide on the Formation of Epidural Fibrosis in the Experimental Epidural Fibrosis Model
inferred← citeshttps://doi.org/10.1007/s11596-025-00061-zopenalex-snapshot
Rifaximin Inhibits Small Bowel Angiodysplasia-Associated Angiogenesis by Attenuating LncRNA-HIF1A-AS2/miR-153-3p/HIF-1 α/Ang-2 Axis
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Redox nanoparticles in colon drug targeting
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Role of the gut microbiome in the pathogenesis of inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/bs.pmch.2018.01.002openalex-snapshot
Current Trends in Macrocyclic Drug Discovery and beyond -Ro5
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History of antimicrobial drug discovery: Major classes and health impact
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In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6
inferred← citeshttps://doi.org/10.1016/j.dld.2018.04.020openalex-snapshot
New concepts on intestinal microbiota and the role of the non-absorbable antibiotics with special reference to rifaximin in digestive diseases
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Rifamycin SV exhibits strong anti-inflammatory in vitro activity through pregnane X receptor stimulation and NFκB inhibition
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Citrobacter rodentium infection inhibits colonic P-glycoprotein expression
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Modulation of intestinal immune cell responses by eubiotic or dysbiotic microbiota in inflammatory bowel diseases
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Targeting nuclear receptors for the treatment of fatty liver disease
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Microbiota-targeted therapies in inflammation resolution
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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand
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Plant-derived vesicle-like nanoparticles: A new tool for inflammatory bowel disease and colitis-associated cancer treatment
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Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor
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Design and Optimization of 1H-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR
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BactDNA as an Independent Risk Factor for Short-Term Crohn’s Disease Recurrence
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Bugging inflammation: role of the gut microbiota
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‘Brain Fogginess’ and D-Lactic Acidosis: Probiotics Are Not the Cause
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Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
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Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis
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The intriguing role of Rifaximin in gut barrier chronic inflammation and in the treatment of Crohn’s disease
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Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice
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The potential for development of clinically relevant microbial resistance to rifaximin-α: a narrative review
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Rifaximin induces and maintains clinical remission in a dachshund with chronic enteropathy: antibiotic‐responsive diarrhoea or inflammatory bowel disease?
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The Intricate Link among Gut “Immunological Niche,” Microbiota, and Xenobiotics in Intestinal Pathology
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Effects of Vitamin D3 on Intestinal Flora in a Mouse Model of Inflammatory Bowel Disease Treated with Rifaximin
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