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Roscovitine is a proteostasis regulator that corrects the trafficking defect of F 508del‐ CFTR by a CDK ‐independent mechanism
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1 of the 82 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1074/jbc.m111.329078 (notice 2017-07-28).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/0470080124.ch3openalex-snapshot
Purification and Characterization
inferredcites →https://doi.org/10.1002/chin.200336265openalex-snapshot
Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials
inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
inferredcites →https://doi.org/10.1006/bbrc.1993.2378openalex-snapshot
Purification and Characterization of a Z-Leu-Leu-Leu-MCA Degrading Protease Expected to Regulate Neurite Formation: A Novel Catalytic Activity in Proteasome
inferredcites →https://doi.org/10.1006/bbrc.2001.4935openalex-snapshot
S-Nitrosoglutathione Increases Cystic Fibrosis Transmembrane Regulator Maturation
inferredcites →https://doi.org/10.1007/s002329900537openalex-snapshot
Rescue of Dysfunctional ΔF508-CFTR Chloride Channel Activity by IBMX
inferredcites →https://doi.org/10.1007/s40272-013-0035-3openalex-snapshot
Managing the Underlying Cause of Cystic Fibrosis: A Future Role for Potentiators and Correctors
inferredcites →https://doi.org/10.1016/0092-8674(95)90240-6openalex-snapshot
Degradation of CFTR by the ubiquitin-proteasome pathway
inferredcites →https://doi.org/10.1016/0092-8674(95)90241-4openalex-snapshot
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
inferredcites →https://doi.org/10.1016/j.bbrc.2004.10.070openalex-snapshot
Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein
inferredcites →https://doi.org/10.1016/j.cardiores.2005.03.024openalex-snapshot
Brugada syndrome and fever: Genetic and molecular characterization of patients carrying mutations
inferredcites →https://doi.org/10.1016/j.cell.2006.09.043openalex-snapshot
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
inferredcites →https://doi.org/10.1016/j.coph.2004.08.001openalex-snapshot
Pharmacological chaperone action on G-protein-coupled receptors
inferredcites →https://doi.org/10.1016/j.febslet.2006.03.010openalex-snapshot
Rescue of functional delF508‐CFTR channels in cystic fibrosis epithelial cells by the α‐glucosidase inhibitor miglustat
inferredcites →https://doi.org/10.1016/j.molmed.2011.10.003openalex-snapshot
CFTR: folding, misfolding and correcting the ΔF508 conformational defect
inferredcites →https://doi.org/10.1016/j.neulet.2009.11.061openalex-snapshot
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells
inferredcites →https://doi.org/10.1016/j.pep.2007.02.020openalex-snapshot
Purification of CK1 by affinity chromatography on immobilised axin
inferredcites →https://doi.org/10.1016/j.tetlet.2010.10.173openalex-snapshot
4-C-Me-DAB and 4-C-Me-LAB—enantiomeric alkyl-branched pyrrolidine iminosugars—are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group
inferredcites →https://doi.org/10.1016/s0165-6147(02)02071-0openalex-snapshot
Pharmacological inhibitors of cyclin-dependent kinases
inferredcites →https://doi.org/10.1021/op800284kopenalex-snapshot
Practical Synthesis of Roscovitine and CR8
inferredcites →https://doi.org/10.1038/358761a0openalex-snapshot
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
inferredcites →https://doi.org/10.1038/nature05348openalex-snapshot
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
inferredcites →https://doi.org/10.1038/nature09855openalex-snapshot
Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
inferredcites →https://doi.org/10.1038/ncb0805-766openalex-snapshot
ERAD: the long road to destruction
inferredcites →https://doi.org/10.1038/nchembio.275openalex-snapshot
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
inferredcites →https://doi.org/10.1038/nm0502-485openalex-snapshot
Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells
inferredcites →https://doi.org/10.1038/nm1468openalex-snapshot
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
inferredcites →https://doi.org/10.1038/nprot.2006.172openalex-snapshot
Measuring calcium signaling using genetically targetable fluorescent indicators
inferredcites →https://doi.org/10.1038/nrm1052openalex-snapshot
Quality control in the endoplasmic reticulum
inferredcites →https://doi.org/10.1038/onc.2008.191openalex-snapshot
CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases
inferredcites →https://doi.org/10.1038/sj.bjc.6603509openalex-snapshot
A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days
inferredcites →https://doi.org/10.1038/sj.gt.3301741openalex-snapshot
Isolation of CF cell lines corrected at ΔF508-CFTR locus by SFHR-mediated targeting
inferredcites →https://doi.org/10.1042/bj20070478openalex-snapshot
Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants
inferredcites →https://doi.org/10.1073/pnas.1105787108openalex-snapshot
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
inferredcites →https://doi.org/10.1074/jbc.m109.076448openalex-snapshot
Roscovitine Binds to Novel L-channel (CaV1.2) Sites That Separately Affect Activation and Inactivation
inferredcites →https://doi.org/10.1074/jbc.m111.295733openalex-snapshot
Transient Receptor Potential Canonical Channels Are Required for in Vitro Endothelial Tube Formation
inferredcites →https://doi.org/10.1074/jbc.m111.329078openalex-snapshot
Proteasomal Inhibition Restores Biological Function of Mis-sense Mutated Dysferlin in Patient-derived Muscle Cells
inferredcites →https://doi.org/10.1074/jbc.m500805200openalex-snapshot
Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives
inferredcites →https://doi.org/10.1074/jbc.m500806200openalex-snapshot
Roscovitine Targets, Protein Kinases and Pyridoxal Kinase
inferredcites →https://doi.org/10.1074/jbc.m511765200openalex-snapshot
Mechanisms of Pharmacological Rescue of Trafficking-defective hERG Mutant Channels in Human Long QT Syndrome
inferredcites →https://doi.org/10.1074/jbc.m600509200openalex-snapshot
Selective Inhibition of Endoplasmic Reticulum-associated Degradation Rescues ΔF508-Cystic Fibrosis Transmembrane Regulator and Suppresses Interleukin-8 Levels
inferredcites →https://doi.org/10.1093/nar/gkt1143openalex-snapshot
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
inferredcites →https://doi.org/10.1096/fj.07-099671openalex-snapshot
Molecular and cellular aspects of protein misfolding and disease
inferredcites →https://doi.org/10.1111/bph.12451openalex-snapshot
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
inferredcites →https://doi.org/10.1111/bph.14749openalex-snapshot
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
inferredcites →https://doi.org/10.1111/j.1432-1033.1994.00771.xopenalex-snapshot
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
inferredcites →https://doi.org/10.1111/j.1432-1033.1997.t01-2-00527.xopenalex-snapshot
Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5
inferredcites →https://doi.org/10.1111/j.1523-1755.2004.00967.xopenalex-snapshot
The relationship between cell proliferation, Cl− secretion, and renal cyst growth: A study using CFTR inhibitors
inferredcites →https://doi.org/10.1111/j.1600-0854.2006.00409.xopenalex-snapshot
Maintaining Low Ca2+ Level in the Endoplasmic Reticulum Restores Abnormal Endogenous F508del‐CFTR Trafficking in Airway Epithelial Cells
inferredcites →https://doi.org/10.1111/j.1749-6632.1993.tb38058.xopenalex-snapshot
Inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator By ATP‐Sensitive K+ Channel Regulatorsa
inferredcites →https://doi.org/10.1113/expphysiol.2003.027003openalex-snapshot
Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl− conductance in human sweat ducts
inferredcites →https://doi.org/10.1113/jphysiol.2005.096669openalex-snapshot
Failure of cAMP agonists to activate rescued ΔF508 CFTR in CFBE41o–airway epithelial monolayers
inferredcites →https://doi.org/10.1124/jpet.107.134502openalex-snapshot
Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622
inferredcites →https://doi.org/10.1124/mol.105.015149openalex-snapshot
Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations
inferredcites →https://doi.org/10.1126/science.1093941openalex-snapshot
Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects
inferredcites →https://doi.org/10.1126/science.281.5376.533openalex-snapshot
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors
inferredcites →https://doi.org/10.1126/science.7732382openalex-snapshot
Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
inferredcites →https://doi.org/10.1128/jvi.72.11.8861-8872.1998openalex-snapshot
Effect of Host Modification and Age on Airway Epithelial Gene Transfer Mediated by a Murine Leukemia Virus-Derived Vector
inferredcites →https://doi.org/10.1128/mcb.25.12.5242-5252.2005openalex-snapshot
Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin
inferredcites →https://doi.org/10.1136/thoraxjnl-2011-200393openalex-snapshot
Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
inferredcites →https://doi.org/10.1136/thx.2003.019778openalex-snapshot
Sildenafil (Viagra) corrects F508-CFTR location in nasal epithelial cells from patients with cystic fibrosis
inferredcites →https://doi.org/10.1136/thx.2007.082388openalex-snapshot
Neutrophils in cystic fibrosis
inferredcites →https://doi.org/10.1146/annurev.biochem.75.103004.142532openalex-snapshot
CFTR Function and Prospects for Therapy
inferredcites →https://doi.org/10.1152/ajpcell.00633.2008openalex-snapshot
State-dependent block of HERG potassium channels byR-roscovitine: implications for cancer therapy
inferredcites →https://doi.org/10.1152/ajpcell.1998.275.3.c653openalex-snapshot
Prostaglandin F2αstimulates CFTR activity by PKA- and PKC-dependent phosphorylation
inferredcites →https://doi.org/10.1152/ajpcell.2000.278.2.c259openalex-snapshot
Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of ΔF508-CFTR
inferredcites →https://doi.org/10.1152/ajplung.00169.2005openalex-snapshot
Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
inferredcites →https://doi.org/10.1152/ajplung.1990.259.6.l496openalex-snapshot
Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1748openalex-snapshot
Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer
inferredcites →https://doi.org/10.1159/000295791openalex-snapshot
In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance
inferredcites →https://doi.org/10.1164/ajrccm.157.2.9706088openalex-snapshot
A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in Δ F508-Homozygous Cystic Fibrosis Patients: Partial Restoration of Nasal Epithelial CFTR Function
inferredcites →https://doi.org/10.1164/rccm.200901-0049ocopenalex-snapshot
Airway Delivery of Low-Dose Miglustat Normalizes Nasal Potential Difference in F508del Cystic Fibrosis Mice
inferredcites →https://doi.org/10.1165/rcmb.2008-0285ocopenalex-snapshot
A Cystic Fibrosis Respiratory Epithelial Cell Chronically Treated by Miglustat Acquires a Non–Cystic Fibrosis–Like Phenotype
inferredcites →https://doi.org/10.1177/1947601910369817openalex-snapshot
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
inferredcites →https://doi.org/10.1371/journal.pone.0048690openalex-snapshot
The β1-Subunit of Nav1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction
inferredcites →https://doi.org/10.1517/13543770903524284openalex-snapshot
Cyclin-dependent kinase inhibitors: a survey of recent patent literature
inferredcites →https://doi.org/10.1523/jneurosci.20-02-00589.2000openalex-snapshot
Proteasome Involvement and Accumulation of Ubiquitinated Proteins in Cerebellar Granule Neurons Undergoing Apoptosis
inferredcites →https://doi.org/10.1523/jneurosci.22-07-02590.2002openalex-snapshot
Cdk5/p35 Regulates Neurotransmitter Release through Phosphorylation and Downregulation of P/Q-Type Voltage-Dependent Calcium Channel Activity
inferredcites →https://doi.org/10.2165/11316160-000000000-00000openalex-snapshot
Cystic Fibrosis Transmembrane Conductance Regulator Modulators for Personalized Drug Treatment of Cystic Fibrosis
inferredcites →https://doi.org/10.4049/jimmunol.0803312openalex-snapshot
Coronin-1 Is Associated with Neutrophil Survival and Is Cleaved during Apoptosis: Potential Implication in Neutrophils from Cystic Fibrosis Patients
inferredcites →https://doi.org/10.4155/fmc.09.110openalex-snapshot
Novel Potent Pharmacological Cyclin-Dependent Kinase Inhibitors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4785543openalex-extracted
Impact of Overexpression of Wild-Type Cftr and Elexacaftor-Texacaftor-Ivacaftor on Oxylipin Production by Cystic Fibrosis Bronchial Epithelial Cells
inferred← citeshttps://doi.org/10.1002/ppul.24129openalex-snapshot
Inflammation in cystic fibrosis: An update
inferred← citeshttps://doi.org/10.1007/s10337-015-2980-1openalex-snapshot
Determination of Repertaxin Enantiomeric Purity by HPLC on Chiral Stationary Phase
inferred← citeshttps://doi.org/10.1007/s10337-016-3067-3openalex-snapshot
Determination of Roscovitine Enantiomeric Purity by HPLC on Chiral Stationary Phase
inferred← citeshttps://doi.org/10.1007/s10545-016-0005-3openalex-snapshot
Small molecules as therapeutic agents for inborn errors of metabolism
inferred← citeshttps://doi.org/10.1007/s40291-018-0372-6openalex-snapshot
Innovative Therapies for Cystic Fibrosis: The Road from Treatment to Cure
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116468openalex-snapshot
ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110764openalex-snapshot
Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs
inferred← citeshttps://doi.org/10.1016/j.chest.2018.10.006openalex-snapshot
The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein
inferred← citeshttps://doi.org/10.1016/j.jcf.2021.10.013openalex-snapshot
Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study
inferred← citeshttps://doi.org/10.1016/j.prostaglandins.2025.107043openalex-snapshot
Impact of overexpression of wild-type CFTR and elexacaftor-tezacaftor-ivacaftor on oxylipin production by the CFBE41o- bronchial epithelial cell line
inferred← citeshttps://doi.org/10.1021/acs.jproteome.6b00421openalex-snapshot
Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus
inferred← citeshttps://doi.org/10.1038/s41598-019-43111-yopenalex-snapshot
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models
inferred← citeshttps://doi.org/10.1038/s41598-020-78817-xopenalex-snapshot
(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages
inferred← citeshttps://doi.org/10.1038/s41598-026-39840-6openalex-snapshot
Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues
inferred← citeshttps://doi.org/10.1080/21678707.2018.1483231openalex-snapshot
Repurposing therapies for the personalised treatment of cystic fibrosis
inferred← citeshttps://doi.org/10.1111/cge.13088openalex-snapshot
Protein misfolding diseases: Prospects of pharmacological treatment
inferred← citeshttps://doi.org/10.1159/000444256openalex-snapshot
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
inferred← citeshttps://doi.org/10.1159/000445967openalex-snapshot
From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0173822openalex-snapshot
In silico search for modifier genes associated with pancreatic and liver disease in Cystic Fibrosis
inferred← citeshttps://doi.org/10.3389/fcimb.2017.00243openalex-snapshot
Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis
inferred← citeshttps://doi.org/10.3389/fphar.2016.00275openalex-snapshot
CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis
inferred← citeshttps://doi.org/10.3390/cancers11121921openalex-snapshot
The Expression of Myeloproliferative Neoplasm-Associated Calreticulin Variants Depends on the Functionality of ER-Associated Degradation
inferred← citeshttps://doi.org/10.3390/cells11121868openalex-snapshot
One Size Does Not Fit All: The Past, Present and Future of Cystic Fibrosis Causal Therapies
inferred← citeshttps://doi.org/10.3390/cells11182907openalex-snapshot
Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update
inferred← citeshttps://doi.org/10.3390/ijms22041952openalex-snapshot
Dysfunctional Inflammation in Cystic Fibrosis Airways: From Mechanisms to Novel Therapeutic Approaches
inferred← citeshttps://doi.org/10.3390/ph12010023openalex-snapshot
Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease
inferred← citeshttps://doi.org/10.3390/pharmaceutics12111087openalex-snapshot
Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with Pseudomonas aeruginosa: A Study on Population Pharmacokinetics with Monte Carlo Simulations
inferred← citeshttps://doi.org/10.70675/aade8b2ez4194z4addza263z0496a36afc12openalex-snapshot
Role of Chloride in Modulating Autophagy : Cystic Fibrosis as a Disease Model
inferred← citeshttps://doi.org/10.70675/b42c8687z63b7z428dz84d2zaebb485d7c08openalex-snapshot
Régulation de l'expression membranaire du transporteur de phospholipides biliaires ABCB4 : effet de mutations
inferred← citeshttps://doi.org/10.70675/c623a964z49bdz4254z9029zd053ea8a9d62openalex-snapshot
Implication du chaperome de la protéine F508del-CFTR dans son transport intracellulaire et/ou sa dégradation : rôle des lectines EDEMs et la mannosidase du RE
inferred← citeshttps://doi.org/10.70675/f9c721f9z8c96z4e78z99d2z4116237dd668openalex-snapshot
Correction pharmacologique de la fonction et de la maturation du canal F508del-CFTR
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