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Impact of Overexpression of Wild-Type Cftr and Elexacaftor-Texacaftor-Ivacaftor on Oxylipin Production by Cystic Fibrosis Bronchial Epithelial Cells

https://doi.org/10.2139/ssrn.4785543
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Cystic Fibrosis
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Suppression of cyclooxygenase‐2 overexpression by 15S‐hydroxyeicosatrienoic acid in androgen‐dependent prostatic adenocarcinoma cells
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CFTR negatively regulates cyclooxygenase‐2‐PGE2 positive feedback loop in inflammation
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Elevated plasma levels of F2α isoprostane in cystic fibrosis
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PPARs and molecular mechanisms of transrepression
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Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients
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Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
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Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
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Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease
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Prostaglandin E2 and phagocytosis of inhaled particulate matter by airway macrophages in cystic fibrosis
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The treatment of the pulmonary and extrapulmonary manifestations of cystic fibrosis
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PPARγ as a therapeutic target in cystic fibrosis
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Cystic fibrosis and lipoxins
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Role of epoxyeicosatrienoic acids in the lung
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Improved quantification of lipid mediators in plasma and tissues by liquid chromatography tandem mass spectrometry demonstrates mouse strain specific differences
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Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.
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Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate.
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Induction of term labor with intravenous PGF2α: A review
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A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect
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Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators
inferredcites →https://doi.org/10.1021/acs.biochem.6b00338openalex-extracted
Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase
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Prostaglandin F2α Formation from Prostaglandin H2 by Prostaglandin F Synthase (PGFS): Crystal Structure of PGFS Containing Bimatoprost,
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Prostaglandin D2 and Reproduction
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Lipid mediator class switching during acute inflammation: signals in resolution
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Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome
inferredcites →https://doi.org/10.1038/nature11042openalex-extracted
Infection regulates pro-resolving mediators that lower antibiotic requirements
inferredcites →https://doi.org/10.1038/s41598-022-09618-7openalex-extracted
Oxylipin profile in saliva from patients with cystic fibrosis reveals a balance between pro-resolving and pro-inflammatory molecules
inferredcites →https://doi.org/10.1056/nejmoa1807120openalex-extracted
VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
inferredcites →https://doi.org/10.1073/pnas.1521453113openalex-extracted
CYP450-derived oxylipins mediate inflammatory resolution
inferredcites →https://doi.org/10.1073/pnas.1610242114openalex-extracted
Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators
inferredcites →https://doi.org/10.1073/pnas.87.23.9383openalex-extracted
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
inferredcites →https://doi.org/10.1073/pnas.96.24.13995openalex-extracted
A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr −/− mice
inferredcites →https://doi.org/10.1074/jbc.273.4.1855openalex-extracted
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
inferredcites →https://doi.org/10.1074/jbc.m106599200openalex-extracted
Positive and Negative Regulation of NF-κB by COX-2
inferredcites →https://doi.org/10.1074/jbc.m109.044131openalex-extracted
Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis
inferredcites →https://doi.org/10.1074/jbc.m300218200openalex-extracted
Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells
inferredcites →https://doi.org/10.1074/jbc.m512072200openalex-extracted
Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTRΔ508 in the Lung
inferredcites →https://doi.org/10.1084/jem.20081880openalex-extracted
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
inferredcites →https://doi.org/10.1093/nar/gkab382openalex-extracted
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
inferredcites →https://doi.org/10.1101/cshperspect.a009498openalex-extracted
The CFTR Ion Channel: Gating, Regulation, and Anion Permeation
inferredcites →https://doi.org/10.1101/cshperspect.a016311openalex-extracted
Lipid Mediators in the Resolution of Inflammation
inferredcites →https://doi.org/10.1111/bph.12859openalex-extracted
Roscovitine is a proteostasis regulator that corrects the trafficking defect of F 508del‐ CFTR by a CDK ‐independent mechanism
inferredcites →https://doi.org/10.1111/j.1749-6632.2012.06580.xopenalex-extracted
Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions
inferredcites →https://doi.org/10.1124/pr.110.003517openalex-extracted
International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress
inferredcites →https://doi.org/10.1126/sciadv.aar8320openalex-extracted
PGE 2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo
inferredcites →https://doi.org/10.1128/mcb.25.12.5242-5252.2005openalex-extracted
Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin
inferredcites →https://doi.org/10.1152/ajplung.00383.2017openalex-extracted
An epoxide hydrolase secreted byPseudomonas aeruginosadecreases mucociliary transport and hinders bacterial clearance from the lung
inferredcites →https://doi.org/10.1152/ajplung.00466.2004openalex-extracted
Impact of CFTR ΔF508 mutation on prostaglandin E2production and type IIA phospholipase A2expression by pulmonary epithelial cells
inferredcites →https://doi.org/10.1159/000149783openalex-extracted
Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels
inferredcites →https://doi.org/10.1161/atvbaha.112.249508openalex-extracted
Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci
inferredcites →https://doi.org/10.1161/circresaha.116.307308openalex-extracted
Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology
inferredcites →https://doi.org/10.1164/ajrccm.151.4.7697234openalex-extracted
Early Pulmonary Inflammation in Infants with Cystic Fibrosis
inferredcites →https://doi.org/10.1164/rccm.201708-1616ocopenalex-extracted
Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets
inferredcites →https://doi.org/10.1165/rcmb.2009-0361ocopenalex-extracted
Prostaglandin E2 Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Activity and Airway Surface Liquid Volume Requires Gap Junctional Communication
inferredcites →https://doi.org/10.1172/jci.insight.138722openalex-extracted
Distinctive lipid signatures of bronchial epithelial cells associated with cystic fibrosis drugs, including Trikafta
inferredcites →https://doi.org/10.1183/09031936.00106013openalex-extracted
Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4ratio in children with cystic fibrosis
inferredcites →https://doi.org/10.1194/jlr.m700388-jlr200openalex-extracted
Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism
inferredcites →https://doi.org/10.1194/jlr.m800035-jlr200openalex-extracted
A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA
inferredcites →https://doi.org/10.1371/journal.pone.0077561openalex-extracted
The Development of a Specific and Sensitive LC-MS-Based Method for the Detection and Quantification of Hydroperoxy- and Hydroxydocosahexaenoic Acids as a Tool for Lipidomic Analysis
inferredcites →https://doi.org/10.1530/rep-10-0240openalex-extracted
Prostaglandin F2α (PGF2α) stimulates PTGS2 expression and PGF2α synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats
inferredcites →https://doi.org/10.1530/rep-14-0381openalex-extracted
Multiple roles of the prostaglandin D2 signaling pathway in reproduction
inferredcites →https://doi.org/10.2147/tcrm.s147164openalex-extracted
Triplet CFTR modulators: future prospects for treatment of cystic fibrosis
inferredcites →https://doi.org/10.2174/138920111795909087openalex-extracted
Lipid Mediator Profiling in Pulmonary Disease
inferredcites →https://doi.org/10.3389/fimmu.2022.915261openalex-extracted
CF Patients’ Airway Epithelium and Sex Contribute to Biosynthesis Defects of Pro-Resolving Lipids
inferredcites →https://doi.org/10.3389/fphar.2012.00165openalex-extracted
Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking
inferredcites →https://doi.org/10.3389/fphys.2021.619442openalex-extracted
CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells
inferredcites →https://doi.org/10.3390/molecules27165324openalex-extracted
Cystic Fibrosis and Oxidative Stress: The Role of CFTR
inferredcites →https://doi.org/10.3945/an.114.007732openalex-extracted
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs
inferredcites →https://doi.org/10.3945/jn.109.110999openalex-extracted
Increased Tissue Arachidonic Acid and Reduced Linoleic Acid in a Mouse Model of Cystic Fibrosis Are Reversed by Supplemental Glycerophospholipids Enriched in Docosahexaenoic Acid1–3
inferredcites →https://doi.org/10.4049/jimmunol.170.5.2688openalex-extracted
Lipoxin A4 and Aspirin-Triggered 15-epi-Lipoxin A4 Inhibit Human Neutrophil Migration: Comparisons Between Synthetic 15 Epimers in Chemotaxis and Transmigration with Microvessel Endothelial Cells and Epithelial Cells
inferredcites →https://doi.org/10.5863/1551-6776-18.1.8openalex-extracted
Ivacaftor: A Novel Gene-Based Therapeutic Approach for Cystic Fibrosis
inferredcites →https://doi.org/10.1164/ajrccm/151.4.1075openalex-snapshot
Early Pulmonary Inflammation in Infants with Cystic Fibrosis
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