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The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel

https://doi.org/10.1111/cbdd.12979
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cm.21153openalex-snapshot
Mechanisms of inhibition of endothelial cell migration by taxanes
inferredcites →https://doi.org/10.1002/ijc.24305openalex-snapshot
Novel antivascular efficacy of metronomic docetaxel therapy in prostate cancer: hnRNP K as a player
inferredcites →https://doi.org/10.1002/ijc.25839openalex-snapshot
3,3′‐diindolylmethane enhances taxotere‐induced growth inhibition of breast cancer cells through downregulation of FoxM1
inferredcites →https://doi.org/10.1002/ijc.29210openalex-snapshot
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05097.xopenalex-snapshot
Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.
inferredcites →https://doi.org/10.1002/jcp.20948openalex-snapshot
Regulation of matrix metalloproteinase gene expression
inferredcites →https://doi.org/10.1002/jcp.21666openalex-snapshot
The Ape‐1/Ref‐1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis
inferredcites →https://doi.org/10.1002/pmic.200800638openalex-snapshot
Genome‐wide analysis and proteomic studies reveal APE1/Ref‐1 multifunctional role in mammalian cells
inferredcites →https://doi.org/10.1007/bf00873957openalex-snapshot
Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublinesin vitro
inferredcites →https://doi.org/10.1007/s00018-010-0486-4openalex-snapshot
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment
inferredcites →https://doi.org/10.1007/s10565-009-9120-3openalex-snapshot
Oxidative injury in V79 Chinese hamster cells: protective role of the superoxide dismutase mimetic MnTM-4-PyP
inferredcites →https://doi.org/10.1016/j.bbcan.2007.10.004openalex-snapshot
Taxanes, microtubules and chemoresistant breast cancer
inferredcites →https://doi.org/10.1016/j.bbrc.2015.03.163openalex-snapshot
Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement
inferredcites →https://doi.org/10.1016/j.cell.2006.11.001openalex-snapshot
Cancer Metastasis: Building a Framework
inferredcites →https://doi.org/10.1016/j.cell.2011.09.024openalex-snapshot
Tumor Metastasis: Molecular Insights and Evolving Paradigms
inferredcites →https://doi.org/10.1016/j.cell.2011.11.016openalex-snapshot
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
inferredcites →https://doi.org/10.1016/j.ctrv.2009.12.006openalex-snapshot
Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer
inferredcites →https://doi.org/10.1016/j.exphem.2010.08.011openalex-snapshot
Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis
inferredcites →https://doi.org/10.1016/j.exphem.2010.12.012openalex-snapshot
Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro
inferredcites →https://doi.org/10.1016/j.fct.2015.11.018openalex-snapshot
Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints
inferredcites →https://doi.org/10.1016/j.mrgentox.2013.08.003openalex-snapshot
Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxicity in MDA-MB-231 human breast cancer cells
inferredcites →https://doi.org/10.1016/j.mrrev.2012.08.001openalex-snapshot
In vitro cell migration and invasion assays
inferredcites →https://doi.org/10.1016/j.redox.2014.01.023openalex-snapshot
Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization
inferredcites →https://doi.org/10.1016/j.visres.2010.10.008openalex-snapshot
Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo
inferredcites →https://doi.org/10.1016/s0002-9610(26)90068-8openalex-snapshot
Breast cancer metastasis
inferredcites →https://doi.org/10.1016/s0305-7372(03)00097-5openalex-snapshot
Mode of action of docetaxel – a basis for combination with novel anticancer agents
inferredcites →https://doi.org/10.1021/acs.biochem.5b00928openalex-snapshot
Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry
inferredcites →https://doi.org/10.1021/bi101248sopenalex-snapshot
Interactions of Apurinic/Apyrimidinic Endonuclease with a Redox Inhibitor: Evidence for an Alternate Conformation of the Enzyme
inferredcites →https://doi.org/10.1021/bi201034zopenalex-snapshot
Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease
inferredcites →https://doi.org/10.1021/bi400179mopenalex-snapshot
Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited
inferredcites →https://doi.org/10.1023/a:1006762425323openalex-snapshot
Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro
inferredcites →https://doi.org/10.1038/78496openalex-snapshot
High-performance affinity beads for identifying drug receptors
inferredcites →https://doi.org/10.1038/bjc.1995.232openalex-snapshot
S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells
inferredcites →https://doi.org/10.1038/bjc.1998.194openalex-snapshot
Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis
inferredcites →https://doi.org/10.1038/nrc1075openalex-snapshot
Tumour-cell invasion and migration: diversity and escape mechanisms
inferredcites →https://doi.org/10.1038/nrc1670openalex-snapshot
Breast cancer metastasis: markers and models
inferredcites →https://doi.org/10.1038/nrc3078openalex-snapshot
Chemotaxis in cancer
inferredcites →https://doi.org/10.1038/sj.onc.1208513openalex-snapshot
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
inferredcites →https://doi.org/10.1038/sj.onc.1210102openalex-snapshot
Molecular profiling of docetaxel cytotoxicity in breast cancer cells: uncoupling of aberrant mitosis and apoptosis
inferredcites →https://doi.org/10.1074/jbc.271.50.32253openalex-snapshot
Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit
inferredcites →https://doi.org/10.1074/jbc.m202970200openalex-snapshot
Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo
inferredcites →https://doi.org/10.1080/10715760400028423openalex-snapshot
Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: Evidence for an autoregulatory loop
inferredcites →https://doi.org/10.1089/ars.2008.2120openalex-snapshot
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
inferredcites →https://doi.org/10.1089/ars.2010.3410openalex-snapshot
Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1
inferredcites →https://doi.org/10.1089/dna.1993.12.265openalex-snapshot
Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism
inferredcites →https://doi.org/10.1093/annonc/mds232openalex-snapshot
Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
inferredcites →https://doi.org/10.1093/emboj/18.20.5609openalex-snapshot
Ref‐1 regulates the transactivation and pro‐apoptotic functions of p53 in vivo
inferredcites →https://doi.org/10.1101/gad.11.5.558openalex-snapshot
Identification of redox/repair protein Ref-1 as a potent activator of p53.
inferredcites →https://doi.org/10.1111/cbdd.12521openalex-snapshot
Role of the Copper( II ) Complex Cu[15]pyN5 in Intracellular ROS and Breast Cancer Cell Motility and Invasion
inferredcites →https://doi.org/10.1111/cbdd.12826openalex-snapshot
Structure‐based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1
inferredcites →https://doi.org/10.1111/j.1349-7006.2010.01540.xopenalex-snapshot
Docetaxel suppresses invasiveness of head and neck cancer cells in vitro
inferredcites →https://doi.org/10.1152/ajpheart.00965.2012openalex-snapshot
Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1464openalex-snapshot
Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective
inferredcites →https://doi.org/10.1158/1055-9965.epi-15-0535openalex-snapshot
International Variation in Female Breast Cancer Incidence and Mortality Rates
inferredcites →https://doi.org/10.1158/1078-0432.ccr-0842-03openalex-snapshot
Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0113openalex-snapshot
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0107openalex-snapshot
Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
inferredcites →https://doi.org/10.1158/1535-7163.mct-16-0253openalex-snapshot
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models
inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0139openalex-snapshot
Mechanisms of Motility in Metastasizing Cells
inferredcites →https://doi.org/10.1167/iovs.14-14451openalex-snapshot
Suppression of Choroidal Neovascularization Through Inhibition of APE1/Ref-1 Redox Activity
inferredcites →https://doi.org/10.1186/1471-2407-7-197openalex-snapshot
Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy
inferredcites →https://doi.org/10.1186/1472-6904-6-2openalex-snapshot
High sensitivity assays for docetaxel and paclitaxel in plasma using solid-phase extraction and high-performance liquid chromatography with UV detection
inferredcites →https://doi.org/10.1186/bcr3199openalex-snapshot
CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity
inferredcites →https://doi.org/10.1186/bcr3493openalex-snapshot
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
inferredcites →https://doi.org/10.1371/journal.pone.0047462openalex-snapshot
APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
inferredcites →https://doi.org/10.1371/journal.pone.0070909openalex-snapshot
Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines
inferredcites →https://doi.org/10.1634/theoncologist.9-suppl_2-24openalex-snapshot
Docetaxel and Paclitaxel in the Treatment of Breast Cancer: A Review of Clinical Experience
inferredcites →https://doi.org/10.1634/theoncologist.9-suppl_2-3openalex-snapshot
Preclinical Pharmacology of the Taxanes: Implications of the Differences
inferredcites →https://doi.org/10.2174/1874467211205010036openalex-snapshot
APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1
inferredcites →https://doi.org/10.3109/10715760903555844openalex-snapshot
Protective role ofortho-substituted Mn(III)N-alkylpyridylporphyrins against the oxidative injury induced bytert-butylhydroperoxide
inferredcites →https://doi.org/10.3892/ijo.2015.3048openalex-snapshot
Ape1 regulates WNT/β-catenin signaling through its redox functional domain in pancreatic cancer cells
inferredcites →https://doi.org/10.3892/or.2015.3976openalex-snapshot
Lentiviral-mediated short hairpin RNA silencing of APE1 suppresses hepatocellular carcinoma proliferation and migration: A potential therapeutic target for hepatoma treatment

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4638517openalex-extracted
Activation of APE1 Modulates Nrf2, Inhibits Hepatocyte Ferroptosis and Promotes Hepatocyte Autophagy, Thereby Protecting Against Acute Liver Injury
inferred← citeshttps://doi.org/10.1002/cbin.70094openalex-snapshot
Synergistic Reduction of Breast Cancer Cell Viability and Aggressiveness Through Dual Inhibition of APE1 Redox Function and STAT3 Signaling
inferred← citeshttps://doi.org/10.1007/978-981-96-2763-9_13openalex-snapshot
Role of Signaling Pathways Regulating Genomic Stability in Cancer
inferred← citeshttps://doi.org/10.1007/s11033-023-08946-9openalex-snapshot
The APE1/REF-1 and the hallmarks of cancer
inferred← citeshttps://doi.org/10.1007/s12035-024-04086-8openalex-snapshot
Antitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects
inferred← citeshttps://doi.org/10.1016/j.cclet.2017.10.010openalex-snapshot
A simple and sensitive assay for apurinic/apyrimidinic endonuclease 1 activity based on host-guest interaction of β-cyclodextrin polymer and pyrene
inferred← citeshttps://doi.org/10.1016/j.dnarep.2018.08.015openalex-snapshot
Targeting BER enzymes in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.dnarep.2019.102675openalex-snapshot
Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway
inferred← citeshttps://doi.org/10.1016/j.fct.2019.111076openalex-snapshot
A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102384openalex-snapshot
APE1 deficiency drives lens epithelial cell senescence in age-related cataract formation
inferred← citeshttps://doi.org/10.1016/j.genrep.2025.102141openalex-snapshot
Antitumor activity of celecoxib with docetaxel on human triple-negative breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111529openalex-snapshot
Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112672openalex-snapshot
Inhibitors of APE1 redox and ATM synergistically sensitize osteosarcoma cells to ionizing radiation by inducing ferroptosis
inferred← citeshttps://doi.org/10.1016/j.jdermsci.2020.08.012openalex-snapshot
APE1 promotes proliferation and migration of cutaneous squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2020.111992openalex-snapshot
The redox function of apurinic/apyrimidinic endonuclease 1 as key modulator in photodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.06.011openalex-snapshot
Benefits and limitations of nanomedicine treatment of brain cancers and age-dependent neurodegenerative disorders
inferred← citeshttps://doi.org/10.1016/j.tips.2018.05.002openalex-snapshot
Hypoxia and Noncoding RNAs in Taxane Resistance
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c03866openalex-snapshot
Enzyme-Activated Biosensor Assisted by Enzymatic Rolling Circle Amplification for Sensitive Detection of APE1 and Imaging in Vivo
inferred← citeshttps://doi.org/10.1038/s41392-021-00648-7openalex-snapshot
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
inferred← citeshttps://doi.org/10.1038/s41419-022-04550-0openalex-snapshot
Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib
inferred← citeshttps://doi.org/10.1093/narcan/zcaf048openalex-snapshot
Contrasting roles of APE1 and APE2 in genome maintenance, cancer development, and therapeutic targeting
inferred← citeshttps://doi.org/10.1158/0008-5472.can-19-0237openalex-snapshot
APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma
inferred← citeshttps://doi.org/10.12703/r/10-8openalex-snapshot
Recent advances in understanding the role of metabolic heterogeneities in cell migration
inferred← citeshttps://doi.org/10.1590/1414-431x2024e13250openalex-snapshot
The inhibitor of the redox activity of APE1/REF-1, APX2009, reduces the malignant phenotype of breast cancer cells
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3907908/v1openalex-snapshot
Synergistic inhibition of APE1 redox activity and ATM activation sensitizes osteosarcoma cells to ionizing radiation by inducing ferroptosis
inferred← citeshttps://doi.org/10.2174/0109298665338519241114103223openalex-snapshot
Targeting APE1: Advancements in the Diagnosis and Treatment of Tumors
inferred← citeshttps://doi.org/10.3390/antiox11112198openalex-snapshot
MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
inferred← citeshttps://doi.org/10.3390/antiox8100490openalex-snapshot
The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
inferred← citeshttps://doi.org/10.3390/antiox9060550openalex-snapshot
Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion
inferred← citeshttps://doi.org/10.3390/biom10010158openalex-snapshot
Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/biom10020233openalex-snapshot
Anticancer Activity of Rutin and Its Combination with Ionic Liquids on Renal Cells
inferred← citeshttps://doi.org/10.3390/cancers15153814openalex-snapshot
The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP5+, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin
inferred← citeshttps://doi.org/10.3390/cells12141895openalex-snapshot
Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons
inferred← citeshttps://doi.org/10.3390/ijms20205109openalex-snapshot
Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models
inferred← citeshttps://doi.org/10.3390/ijms21186684openalex-snapshot
Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach
inferred← citeshttps://doi.org/10.3390/molecules27092672openalex-snapshot
Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma
inferred← citeshttps://doi.org/10.3390/pharmaceutics10040288openalex-snapshot
Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility
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