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Safety and pharmacodynamics of intranasal GSK 2245035, a TLR 7 agonist for allergic rhinitis: A randomized trial

https://doi.org/10.1111/cea.12974
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesisin vitro
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Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement
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Recruitment of plasmacytoid dendritic cells to skin regulates treatment responsiveness of actinic keratosis to imiquimod
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TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways
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Effective long-term α-interferon treatment for hypereosinophilic syndrome
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Understanding the symptoms of the common cold and influenza
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Discovery of 6-Amino-2-{[(1 S )-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8 H -purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
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The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
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Targeting Toll-like receptors: emerging therapeutics?
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Immunotherapy with a Ragweed–Toll-Like Receptor 9 Agonist Vaccine for Allergic Rhinitis
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Molecular and cellular mechanisms of allergic disease.
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Safety of Once-Daily Ciclesonide Nasal Spray in Children 2 to 5 Years of Age with Perennial Allergic Rhinitis
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Efficacy and Safety of Once-Daily Ciclesonide Nasal Spray in Children With Allergic Rhinitis
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The regulation of allergy and asthma
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Assessment of clinical efficacy of CYT003‐QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study
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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
inferredcites →https://doi.org/10.1136/thx.2007.094128openalex-snapshot
Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
inferredcites →https://doi.org/10.1152/ajplung.00440.2005openalex-snapshot
TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway
inferredcites →https://doi.org/10.1159/000090230openalex-snapshot
The Role of T Lymphocytes in Asthma
inferredcites →https://doi.org/10.1159/000362553openalex-snapshot
A New Era of Targeting the Ancient Gatekeepers of the Immune System: Toll-Like Agonists in the Treatment of Allergic Rhinitis and Asthma
inferredcites →https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4184openalex-snapshot
The Effects Of The Novel Toll-Like Receptor 7 (TLR7) Agonist AZD8848 On Allergen-Induced Responses In Patients With Mild Asthma
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Chronic Asthma–induced Airway Remodeling Is Prevented by Toll-like Receptor-7/8 Ligand S28463
inferredcites →https://doi.org/10.1164/rccm.200908-1255ocopenalex-snapshot
Toll-like Receptor 7–triggered Immune Response in the Lung Mediates Acute and Long-Lasting Suppression of Experimental Asthma
inferredcites →https://doi.org/10.1164/rccm.201312-2235ocopenalex-snapshot
The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial
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Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
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Efficacy, safety, and optimal dose selection of beclomethasone dipropionate nasal aerosol for seasonal allergic rhinitis in adolescents and adults
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The Antiviral Activity of Toll-Like Receptor 7 and 7/8 Agonists
inferredcites →https://doi.org/10.1517/13543784.2011.583237openalex-snapshot
VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis
inferredcites →https://doi.org/10.1517/14656566.2013.824424openalex-snapshot
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inferredcites →https://doi.org/10.2165/00002018-200427100-00005openalex-snapshot
Haematological Effects of Interferon-??-1a (Rebif??) Therapy in Multiple Sclerosis
inferredcites →https://doi.org/10.2174/187152812803589967openalex-snapshot
The Therapeutic Potential of Toll-Like Receptor 7 Stimulation in Asthma
inferredcites →https://doi.org/10.2500/aap.2012.33.3571openalex-snapshot
Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis
inferredcites →https://doi.org/10.2500/aap.2012.33.3593openalex-snapshot
Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis
inferredcites →https://doi.org/10.4049/jimmunol.1000469openalex-snapshot
Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3
inferredcites →https://doi.org/10.4049/jimmunol.1101331openalex-snapshot
Mechanism of Action of Inhibition of Allergic Immune Responses by a Novel Antedrug TLR7 Agonist
inferredcites →https://doi.org/10.4049/jimmunol.174.3.1259openalex-snapshot
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
inferredcites →https://doi.org/10.4161/hv.24631openalex-snapshot
Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Recent clinical trends in Toll‐like receptor targeting therapeutics
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Pattern recognition receptors as potential drug targets in inflammatory disorders
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Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
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Clinical symptoms and biomarkers of Bermuda grass–induced allergic rhinitis using the nasal allergen challenge model
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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options
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Pharmacokinetics and Pharmacodynamics Following Repeat Dosing of neffy (Epinephrine Nasal Spray) Versus Intramuscular Injection During Induced Allergic Rhinitis
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Discovery of PLD4 modulators by high-throughput screening and kinetic analysis
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Immunomodulatory Response of Toll-like Receptor Ligand–Peptide Conjugates in Food Allergy
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Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study
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The use of Allergoids and Adjuvants in Allergen Immunotherapy
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Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy
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Modulating Th2 Cell Immunity for the Treatment of Asthma
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Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma
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Advances in molecular innate immune regulation in the development and therapeutic strategies of allergic rhinitis vaccines
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The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation
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In Silico Approach in the Evaluation of Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds through Binding Affinity to the Human Toll-Like Receptor 4
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Theranostic Small-Molecule Prodrug Conjugates for Targeted Delivery and Controlled Release of Toll-like Receptor 7 Agonists
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Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods
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Anti-IgE: A treatment option in allergic rhinitis?
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