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Recent clinical trends in Toll‐like receptor targeting therapeutics
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.2013.2194openalex-snapshot
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
inferredcites →https://doi.org/10.1001/jamainternmed.2016.6008openalex-snapshot
Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results
inferredcites →https://doi.org/10.1002/1529-0131(200003)43:3<593::aid-anr16>3.0.co;2-1openalex-snapshot
Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
inferredcites →https://doi.org/10.1002/1529-0131(200010)43:10<2160::aid-anr3>3.0.co;2-topenalex-snapshot
Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines
inferredcites →https://doi.org/10.1002/cpt.522openalex-snapshot
Evidence of NI‐0101 pharmacological activity, an anti‐TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS
inferredcites →https://doi.org/10.1002/cpt.938openalex-snapshot
First‐in‐Human Study With the Inhaled TLR9 Oligonucleotide Agonist AZD1419 Results in Interferon Responses in the Lung, and Is Safe and Well‐Tolerated
inferredcites →https://doi.org/10.1002/ibd.20880openalex-snapshot
Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
inferredcites →https://doi.org/10.1002/ibd.21527openalex-snapshot
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
inferredcites →https://doi.org/10.1007/978-3-319-67199-4_101496openalex-snapshot
Interferon Regulatory Factor
inferredcites →https://doi.org/10.1007/978-3-319-67199-4_101947openalex-snapshot
Tristetraprolin (ZFP36) and TIS11B (ZFP36-L1)
inferredcites →https://doi.org/10.1007/978-3-319-67199-4_608openalex-snapshot
Toll-Like Receptor Adaptor Protein Family Members
inferredcites →https://doi.org/10.1007/978-3-319-67199-4_639openalex-snapshot
TLR5 (Toll-Like Receptor 5)
inferredcites →https://doi.org/10.1007/s00281-006-0034-3openalex-snapshot
The role of toll-like receptors in systemic lupus erythematosus
inferredcites →https://doi.org/10.1007/s10637-014-0117-2openalex-snapshot
Phase 2, open-label, 1:1 randomized controlled trial exploring the efficacy of EMD 1201081 in combination with cetuximab in second-line cetuximab-naïve patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)
inferredcites →https://doi.org/10.1016/j.addr.2007.11.005openalex-snapshot
TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2010.08.064openalex-snapshot
DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes
inferredcites →https://doi.org/10.1016/j.bcp.2009.06.096openalex-snapshot
GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation
inferredcites →https://doi.org/10.1016/j.biomaterials.2017.02.023openalex-snapshot
TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation
inferredcites →https://doi.org/10.1016/j.cancergen.2010.12.006openalex-snapshot
Enhanced detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide in combination with pokeweed mitogen and phorbol myristate acetate
inferredcites →https://doi.org/10.1016/j.ccr.2012.02.007openalex-snapshot
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
inferredcites →https://doi.org/10.1016/j.cell.2006.02.015openalex-snapshot
Pathogen Recognition and Innate Immunity
inferredcites →https://doi.org/10.1016/j.cell.2007.08.002openalex-snapshot
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
inferredcites →https://doi.org/10.1016/j.cell.2007.09.008openalex-snapshot
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
inferredcites →https://doi.org/10.1016/j.cellimm.2010.10.008openalex-snapshot
Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro
inferredcites →https://doi.org/10.1016/j.cellsig.2014.07.035openalex-snapshot
TLRs: Linking inflammation and breast cancer
inferredcites →https://doi.org/10.1016/j.chom.2013.07.011openalex-snapshot
The Second Messenger Phosphatidylinositol-5-Phosphate Facilitates Antiviral Innate Immune Signaling
inferredcites →https://doi.org/10.1016/j.coi.2012.03.008openalex-snapshot
Adjuvants for human vaccines
inferredcites →https://doi.org/10.1016/j.ctrv.2016.08.004openalex-snapshot
RNA-targeted therapeutics in cancer clinical trials: Current status and future directions
inferredcites →https://doi.org/10.1016/j.cyto.2007.11.020openalex-snapshot
A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands
inferredcites →https://doi.org/10.1016/j.cyto.2008.01.006openalex-snapshot
LPS/TLR4 signal transduction pathway
inferredcites →https://doi.org/10.1016/j.imbio.2008.02.005openalex-snapshot
TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
inferredcites →https://doi.org/10.1016/j.immuni.2006.07.013openalex-snapshot
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
inferredcites →https://doi.org/10.1016/j.immuni.2009.09.018openalex-snapshot
Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer
inferredcites →https://doi.org/10.1016/j.immuni.2011.05.006openalex-snapshot
Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
inferredcites →https://doi.org/10.1016/j.immuni.2016.09.011openalex-snapshot
Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
inferredcites →https://doi.org/10.1016/j.immuni.2016.10.003openalex-snapshot
TLR7 Structure: Cut in Z-Loop
inferredcites →https://doi.org/10.1016/j.intimp.2018.03.002openalex-snapshot
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
inferredcites →https://doi.org/10.1016/j.jaci.2017.06.027openalex-snapshot
Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study
inferredcites →https://doi.org/10.1016/j.jaut.2009.11.001openalex-snapshot
Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
inferredcites →https://doi.org/10.1016/j.jhep.2017.10.027openalex-snapshot
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B
inferredcites →https://doi.org/10.1016/j.molcel.2011.09.015openalex-snapshot
Direct, Noncatalytic Mechanism of IKK Inhibition by A20
inferredcites →https://doi.org/10.1016/j.molmed.2007.09.002openalex-snapshot
Signaling to NF-κB by Toll-like receptors
inferredcites →https://doi.org/10.1016/j.pupt.2015.02.003openalex-snapshot
Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics
inferredcites →https://doi.org/10.1016/j.str.2011.02.004openalex-snapshot
The Structural Biology of Toll-like Receptors
inferredcites →https://doi.org/10.1016/j.vaccine.2010.08.002openalex-snapshot
TLR-based immune adjuvants
inferredcites →https://doi.org/10.1016/j.vaccine.2011.05.001openalex-snapshot
Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)
inferredcites →https://doi.org/10.1016/j.vaccine.2013.05.078openalex-snapshot
Montanide ISA™ 201 adjuvanted FMD vaccine induces improved immune responses and protection in cattle
inferredcites →https://doi.org/10.1016/s0092-8674(00)00126-4openalex-snapshot
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
inferredcites →https://doi.org/10.1016/s0167-4781(00)00289-xopenalex-snapshot
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
inferredcites →https://doi.org/10.1016/s1097-2765(03)00053-4openalex-snapshot
Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members
inferredcites →https://doi.org/10.1016/s1473-3099(14)70728-5openalex-snapshot
Imiquimod is not an effective drug for molluscum contagiosum
inferredcites →https://doi.org/10.1021/acs.jmedchem.5b01647openalex-snapshot
Discovery of 6-Amino-2-{[(1 S )-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8 H -purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00419openalex-snapshot
Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities
inferredcites →https://doi.org/10.1021/ja111312hopenalex-snapshot
Small-Molecule Inhibitors of the TLR3/dsRNA Complex
inferredcites →https://doi.org/10.1038/35085597openalex-snapshot
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
inferredcites →https://doi.org/10.1038/90609openalex-snapshot
Toll-like receptors: critical proteins linking innate and acquired immunity
inferredcites →https://doi.org/10.1038/clpt.2013.150openalex-snapshot
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody
inferredcites →https://doi.org/10.1038/cmi.2018.4openalex-snapshot
TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy
inferredcites →https://doi.org/10.1038/emm.2013.28openalex-snapshot
Negative regulatory approaches to the attenuation of Toll-like receptor signaling
inferredcites →https://doi.org/10.1038/nature07830openalex-snapshot
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
inferredcites →https://doi.org/10.1038/nature09121openalex-snapshot
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
inferredcites →https://doi.org/10.1038/nature14138openalex-snapshot
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
inferredcites →https://doi.org/10.1038/nchembio.2518openalex-snapshot
Small-molecule inhibition of TLR8 through stabilization of its resting state
inferredcites →https://doi.org/10.1038/ni.1727openalex-snapshot
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway
inferredcites →https://doi.org/10.1038/ni.1863openalex-snapshot
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
inferredcites →https://doi.org/10.1038/ni.1908openalex-snapshot
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
inferredcites →https://doi.org/10.1038/ni.2064openalex-snapshot
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
inferredcites →https://doi.org/10.1038/ni1347openalex-snapshot
Negative regulation of interferon-regulatory factor 3–dependent innate antiviral response by the prolyl isomerase Pin1
inferredcites →https://doi.org/10.1038/ni1569openalex-snapshot
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
inferredcites →https://doi.org/10.1038/ni1577openalex-snapshot
TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation
inferredcites →https://doi.org/10.1038/nrd.2016.135openalex-snapshot
Biotech R&D spend jumps by more than 15%
inferredcites →https://doi.org/10.1038/nri3095openalex-snapshot
TLR-dependent T cell activation in autoimmunity
inferredcites →https://doi.org/10.1038/nri3598openalex-snapshot
Innate immunity to Toxoplasma gondii infection
inferredcites →https://doi.org/10.1038/nrrheum.2016.61openalex-snapshot
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments
inferredcites →https://doi.org/10.1038/nsmb.2943openalex-snapshot
Toll-like receptor 8 senses degradation products of single-stranded RNA
inferredcites →https://doi.org/10.1038/onc.2013.302openalex-snapshot
The Yin and Yang of Toll-like receptors in cancer
inferredcites →https://doi.org/10.1038/onc.2017.346openalex-snapshot
Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy
inferredcites →https://doi.org/10.1038/srep18239openalex-snapshot
The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development
inferredcites →https://doi.org/10.1038/srep40878openalex-snapshot
A conserved TLR5 binding and activation hot spot on flagellin
inferredcites →https://doi.org/10.1056/nejmoa1701632openalex-snapshot
Airway Mucin Concentration as a Marker of Chronic Bronchitis
inferredcites →https://doi.org/10.1073/pnas.0400937101openalex-snapshot
Recognition of single-stranded RNA viruses by Toll-like receptor 7
inferredcites →https://doi.org/10.1073/pnas.0605200103openalex-snapshot
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
inferredcites →https://doi.org/10.1073/pnas.1410293111openalex-snapshot
Human TLR10 is an anti-inflammatory pattern-recognition receptor
inferredcites →https://doi.org/10.1073/pnas.1510760112openalex-snapshot
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation
inferredcites →https://doi.org/10.1073/pnas.1516000113openalex-snapshot
Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
inferredcites →https://doi.org/10.1073/pnas.1525639113openalex-snapshot
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS
inferredcites →https://doi.org/10.1074/jbc.m512525200openalex-snapshot
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides
inferredcites →https://doi.org/10.1074/jbc.r114.619304openalex-snapshot
Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns
inferredcites →https://doi.org/10.1080/21645515.2015.1105415openalex-snapshot
Dendritic cell targeted vaccines: Recent progresses and challenges
inferredcites →https://doi.org/10.1084/jem.20050914openalex-snapshot
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
inferredcites →https://doi.org/10.1084/jem.20101355openalex-snapshot
IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis
inferredcites →https://doi.org/10.1097/00003246-199812000-00045openalex-snapshot
Has the mortality of septic shock changed with time?
inferredcites →https://doi.org/10.1101/gad.13.8.1015openalex-snapshot
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
inferredcites →https://doi.org/10.1101/gad.1360605openalex-snapshot
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
inferredcites →https://doi.org/10.1101/gad.183434.111openalex-snapshot
NF-κB, the first quarter-century: remarkable progress and outstanding questions
inferredcites →https://doi.org/10.1111/all.12501openalex-snapshot
Differential activation of dendritic cells by toll‐like receptors causes diverse differentiation of naïve CD 4 + T cells from allergic patients
inferredcites →https://doi.org/10.1111/all.12663openalex-snapshot
CYT 003, a TLR 9 agonist, in persistent allergic asthma – a randomized placebo‐controlled Phase 2b study
inferredcites →https://doi.org/10.1111/cea.12974openalex-snapshot
Safety and pharmacodynamics of intranasal GSK 2245035, a TLR 7 agonist for allergic rhinitis: A randomized trial
inferredcites →https://doi.org/10.1111/febs.12541openalex-snapshot
Structure and dynamic behavior of T oll‐like receptor 2 subfamily triggered by malarial glycosylphosphatidylinositols of P lasmodium falciparum
inferredcites →https://doi.org/10.1111/imm.12306openalex-snapshot
Mycobacterium indicus pranii and Mycobacterium bovis BCG lead to differential macrophage activation in T oll‐like receptor‐dependent manner
inferredcites →https://doi.org/10.1111/j.1365-2249.2006.03311.xopenalex-snapshot
Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndrome
inferredcites →https://doi.org/10.1111/j.1365-2567.2012.03587.xopenalex-snapshot
Regulation of B‐cell responses by Toll‐like receptors
inferredcites →https://doi.org/10.1111/j.1442-200x.2006.02229.xopenalex-snapshot
Topical treatment of molluscum contagiosum with imiquimod 5% cream in Turkish children
inferredcites →https://doi.org/10.1111/j.1462-5822.2007.00914.xopenalex-snapshot
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors
inferredcites →https://doi.org/10.1111/sji.12368openalex-snapshot
TLR ‐7 and ‐9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines
inferredcites →https://doi.org/10.1126/science.1093620openalex-snapshot
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
inferredcites →https://doi.org/10.1126/science.1094351openalex-snapshot
A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
inferredcites →https://doi.org/10.1126/science.1115253openalex-snapshot
Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain
inferredcites →https://doi.org/10.1126/science.1139111openalex-snapshot
Crystal Structures of Human MD-2 and Its Complex with Antiendotoxic Lipid IVa
inferredcites →https://doi.org/10.1126/science.1145918openalex-snapshot
A Deubiquitinase That Regulates Type I Interferon Production
inferredcites →https://doi.org/10.1126/science.1155406openalex-snapshot
Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA
inferredcites →https://doi.org/10.1126/science.1229159openalex-snapshot
Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands
inferredcites →https://doi.org/10.1128/iai.00004-09openalex-snapshot
Lipopolysaccharide-Trap-Fc, a Multifunctional Agent To Battle Gram-Negative Bacteria
inferredcites →https://doi.org/10.1128/iai.00022-11openalex-snapshot
The Toll-Like Receptor 4 Agonist Monophosphoryl Lipid A Augments Innate Host Resistance to Systemic Bacterial Infection
inferredcites →https://doi.org/10.1128/iai.00047-08openalex-snapshot
Toll-Like Receptor 9-Dependent Immune Activation by Unmethylated CpG Motifs in Aspergillus fumigatus DNA
inferredcites →https://doi.org/10.1128/iai.01506-06openalex-snapshot
How Flagellin and Toll-Like Receptor 5 Contribute to Enteric Infection
inferredcites →https://doi.org/10.1128/iai.02870-14openalex-snapshot
Toll-Like Receptor 2 (TLR2) and TLR9 Play Opposing Roles in Host Innate Immunity against Salmonella enterica Serovar Typhimurium Infection
inferredcites →https://doi.org/10.1128/jvi.01956-12openalex-snapshot
Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells
inferredcites →https://doi.org/10.1128/jvi.79.22.14355-14370.2005openalex-snapshot
The Toll-Like Receptor 7 (TLR7) Agonist, Imiquimod, and the TLR9 Agonist, CpG ODN, Induce Antiviral Cytokines and Chemokines but Do Not Prevent Vaginal Transmission of Simian Immunodeficiency Virus When Applied Intravaginally to Rhesus Macaques
inferredcites →https://doi.org/10.1136/ard.2004.028324openalex-snapshot
Toll-like receptors in rheumatoid arthritis joint destruction mediated by two distinct pathways
inferredcites →https://doi.org/10.1146/annurev-immunol-030409-101335openalex-snapshot
Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics
inferredcites →https://doi.org/10.1146/annurev.immunol.21.120601.141126openalex-snapshot
Toll-Like Receptors
inferredcites →https://doi.org/10.1152/ajpheart.00328.2013openalex-snapshot
Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension
inferredcites →https://doi.org/10.1155/2012/836485openalex-snapshot
The Effects of TLR Activation on T-Cell Development and Differentiation
inferredcites →https://doi.org/10.1158/0008-5472.can-07-5219openalex-snapshot
Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-1625openalex-snapshot
VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-1453openalex-snapshot
Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy
inferredcites →https://doi.org/10.1161/circinterventions.111.967596openalex-snapshot
Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs
inferredcites →https://doi.org/10.1177/1753425912459975openalex-snapshot
TLR3 activation efficiency by high or low molecular mass poly I:C
inferredcites →https://doi.org/10.1183/13993003.00739-2017openalex-snapshot
Toll-like receptors in COPD
inferredcites →https://doi.org/10.1186/1741-7007-8-61openalex-snapshot
When failure should be the option
inferredcites →https://doi.org/10.1186/2051-1426-1-s1-p260openalex-snapshot
DPV-001 an autophagosome-enriched cancer vaccine in phase II clinical trials contains 25 putative cancer antigens, DAMPS, HSPS and agonists for TLR 2, 3, 4, 7 and 9
inferredcites →https://doi.org/10.1186/s12885-016-2474-zopenalex-snapshot
Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier
inferredcites →https://doi.org/10.1186/s13063-017-1870-2openalex-snapshot
Why clinical trial outcomes fail to translate into benefits for patients
inferredcites →https://doi.org/10.1189/jlb.0808503openalex-snapshot
Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
inferredcites →https://doi.org/10.1189/jlb.69.3.474openalex-snapshot
Differential expression of Toll-like receptor 2 in human cells
inferredcites →https://doi.org/10.12688/f1000research.10010.1openalex-snapshot
The TrialsTracker: Automated ongoing monitoring of failure to share clinical trial results by all major companies and research institutions
inferredcites →https://doi.org/10.12688/f1000research.9970.1openalex-snapshot
Recent advances in (therapeutic protein) drug development
inferredcites →https://doi.org/10.12703/p6-97openalex-snapshot
MyD88: a central player in innate immune signaling
inferredcites →https://doi.org/10.1371/journal.pone.0041144openalex-snapshot
Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140
inferredcites →https://doi.org/10.1371/journal.pone.0100543openalex-snapshot
Role of TLR5 and Flagella in Bacillus Intraocular Infection
inferredcites →https://doi.org/10.1371/journal.pone.0132336openalex-snapshot
Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis
inferredcites →https://doi.org/10.1371/journal.pone.0132921openalex-snapshot
Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes
inferredcites →https://doi.org/10.1586/eri.12.50openalex-snapshot
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes
inferredcites →https://doi.org/10.1634/theoncologist.2008-0097openalex-snapshot
The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy
inferredcites →https://doi.org/10.1667/rr14514.1openalex-snapshot
Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation
inferredcites →https://doi.org/10.18632/oncotarget.5281openalex-snapshot
Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity
inferredcites →https://doi.org/10.18632/oncotarget.6500openalex-snapshot
The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism
inferredcites →https://doi.org/10.2147/copd.s105156openalex-snapshot
Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants
inferredcites →https://doi.org/10.2147/itt.s89795openalex-snapshot
Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments
inferredcites →https://doi.org/10.2174/0929867323666160907162546openalex-snapshot
Osteoimmunology and Beyond
inferredcites →https://doi.org/10.2174/138920212803759712openalex-snapshot
Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
inferredcites →https://doi.org/10.2174/1566524023362159openalex-snapshot
Toll-like Receptor 9, CpG DNA and Innate Immunity
inferredcites →https://doi.org/10.3109/08830185.2014.921164openalex-snapshot
TLR Cross-talk Confers Specificity to Innate Immunity
inferredcites →https://doi.org/10.3109/08923973.2013.861481openalex-snapshot
Safety of Toll-like receptor 9 agonists: a systematic review and meta-analysis
inferredcites →https://doi.org/10.3109/10409238.2015.1033511openalex-snapshot
Advances in Toll-like receptor biology: Modes of activation by diverse stimuli
inferredcites →https://doi.org/10.3389/fimmu.2013.00387openalex-snapshot
Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases
inferredcites →https://doi.org/10.3389/fimmu.2014.00614openalex-snapshot
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
inferredcites →https://doi.org/10.3389/fimmu.2018.00457openalex-snapshot
The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker
inferredcites →https://doi.org/10.3389/fphys.2011.00041openalex-snapshot
Similar Structures but Different Roles – An Updated Perspective on TLR Structures
inferredcites →https://doi.org/10.3389/fphys.2017.00508openalex-snapshot
Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics
inferredcites →https://doi.org/10.4049/jimmunol.0901517openalex-snapshot
TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients
inferredcites →https://doi.org/10.4049/jimmunol.0902592openalex-snapshot
TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus
inferredcites →https://doi.org/10.4049/jimmunol.1000702openalex-snapshot
Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines
inferredcites →https://doi.org/10.4049/jimmunol.1002156openalex-snapshot
Flagellin as an Adjuvant: Cellular Mechanisms and Potential
inferredcites →https://doi.org/10.4049/jimmunol.1002424openalex-snapshot
Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface
inferredcites →https://doi.org/10.4049/jimmunol.165.12.7096openalex-snapshot
Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways
inferredcites →https://doi.org/10.4049/jimmunol.174.3.1259openalex-snapshot
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
inferredcites →https://doi.org/10.4049/jimmunol.178.5.2655openalex-snapshot
Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs
inferredcites →https://doi.org/10.4049/jimmunol.180.11.7764openalex-snapshot
Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease
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R848 or influenza virus can induce potent innate immune responses in the lungs of neonatal mice
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Inhibition of RNA-binding proteins with small molecules
inferred← citeshttps://doi.org/10.1038/s41573-022-00538-9openalex-snapshot
The expanding role for small molecules in immuno-oncology
inferred← citeshttps://doi.org/10.1038/s41698-023-00364-1openalex-snapshot
Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer
inferred← citeshttps://doi.org/10.1038/s42003-021-01978-6openalex-snapshot
A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications
inferred← citeshttps://doi.org/10.1038/s44319-025-00444-2openalex-snapshot
TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
inferred← citeshttps://doi.org/10.1039/c9bm00871copenalex-snapshot
Particulate carrier systems as adjuvants for cancer vaccines
inferred← citeshttps://doi.org/10.1039/d1cc01834eopenalex-snapshot
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability
inferred← citeshttps://doi.org/10.1039/d1md00031dopenalex-snapshot
Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles
inferred← citeshttps://doi.org/10.1039/d2cs00848copenalex-snapshot
Adjuvant physiochemistry and advanced nanotechnology for vaccine development
inferred← citeshttps://doi.org/10.1039/d2ra03286dopenalex-snapshot
Precise immunological evaluation rationalizes the design of a self-adjuvanting vaccine composed of glycan antigen, TLR1/2 ligand, and T-helper cell epitope
inferred← citeshttps://doi.org/10.1039/d3md00096fopenalex-snapshot
Druggable targets for the immunopathy of Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/d3nr00333gopenalex-snapshot
Tuning innate immune function using microneedles containing multiple classes of toll-like receptor agonists
inferred← citeshttps://doi.org/10.1039/d4cc00462kopenalex-snapshot
Synthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2
inferred← citeshttps://doi.org/10.1039/d4na00561aopenalex-snapshot
Dendritic cell activation by iron oxide nanoparticles depends on the extracellular environment
inferred← citeshttps://doi.org/10.1039/d6cs00494fopenalex-snapshot
Targeting toll-like receptors in the immunotherapy era: the chemistry behind TLR modulators
inferred← citeshttps://doi.org/10.1039/d6mh00654jopenalex-snapshot
Nanomedicine-mediated programmed necrosis for cancer immunosurveillance
inferred← citeshttps://doi.org/10.1053/j.seminoncol.2019.10.004openalex-snapshot
Coley's immunotherapy revived: Innate immunity as a link in priming cancer cells for an attack by adaptive immunity
inferred← citeshttps://doi.org/10.1053/j.semtcvs.2021.07.033openalex-snapshot
Toll-like Receptor 4 Mediates Reflux-Induced Inflammation in a Murine Reflux Model
inferred← citeshttps://doi.org/10.1073/pnas.2536559123openalex-snapshot
Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins
inferred← citeshttps://doi.org/10.1080/1061186x.2021.1878364openalex-snapshot
Delivery of toll-like receptor agonists by complement C3-targeted liposomes activates immune cells and reduces tumour growth
inferred← citeshttps://doi.org/10.1080/14760584.2021.1974298openalex-snapshot
Immunoinformatics driven construction of multi-epitope vaccine candidate against Ascaris lumbricoides using its entire immunogenic epitopes
inferred← citeshttps://doi.org/10.1080/17425247.2020.1783237openalex-snapshot
Drug delivery to macrophages: a review of nano-therapeutics targeted approach for inflammatory disorders and cancer
inferred← citeshttps://doi.org/10.1080/17460441.2021.1898369openalex-snapshot
Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics
inferred← citeshttps://doi.org/10.1080/1750743x.2026.2728542openalex-snapshot
Cancer vaccines as targeted therapies: translational advances and challenges
inferred← citeshttps://doi.org/10.1080/24750263.2023.2278291openalex-snapshot
Kidney cell culture of Rana dybowskii and study molecules of TRIF in Rana dybowskii cells under the stress of Aeromonas hydrophila
inferred← citeshttps://doi.org/10.1080/25785826.2022.2132683openalex-snapshot
Association of TLR2 and TLR9 gene polymorphisms with atopic dermatitis: a systematic review and meta-analysis with trial sequential analysis
inferred← citeshttps://doi.org/10.1089/vim.2023.0077openalex-snapshot
Toll-Like Receptors 7/8: A Paradigm for the Manipulation of Immunologic Reactions for Immunotherapy
inferred← citeshttps://doi.org/10.1093/eurheartj/ehad379openalex-snapshot
Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO–ACS study
inferred← citeshttps://doi.org/10.1096/fj.202402423rropenalex-snapshot
Inhibition of the MyD88 / NF ‐ κB pathway alters the Th1/Th2 balance to exacerbate liver injury and hepatic fibrosis in alveolar echinococcosis
inferred← citeshttps://doi.org/10.1097/aci.0000000000001010openalex-snapshot
Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis
inferred← citeshttps://doi.org/10.1097/crd.0000000000000437openalex-snapshot
The Biological Parallels Between Atherosclerosis and Cardiac Allograft Vasculopathy: Implications for Solid Organ Chronic Rejection
inferred← citeshttps://doi.org/10.11005/jbm.2020.27.4.227openalex-snapshot
The Role of Toll-Like Receptors in Osteoclastogenesis
inferred← citeshttps://doi.org/10.1101/2023.03.23.533909openalex-snapshot
Cancer Immunotherapy through Tissue Adhering Polymers
inferred← citeshttps://doi.org/10.1101/2025.05.31.657109openalex-snapshot
Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins
inferred← citeshttps://doi.org/10.1107/s2059798320006518openalex-snapshot
Targeting the innate immune receptor TLR8 using small-molecule agents
inferred← citeshttps://doi.org/10.1111/ajt.16256openalex-snapshot
Bacterial products in donor airways prevent the induction of lung transplant tolerance
inferred← citeshttps://doi.org/10.1111/fcp.70059openalex-snapshot
Differential Antipyretic Effects of Toll‐Like Receptor 4 Signal Inhibitors in Male Rats
inferred← citeshttps://doi.org/10.1111/imr.12951openalex-snapshot
Host‐directed therapy to combat mycobacterial infections*
inferred← citeshttps://doi.org/10.1111/jcmm.18554openalex-snapshot
Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches
inferred← citeshttps://doi.org/10.1111/sji.12954openalex-snapshot
Insights into the toll‐like receptors in sexually transmitted infections
inferred← citeshttps://doi.org/10.1126/sciimmunol.abk0182openalex-snapshot
Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.
inferred← citeshttps://doi.org/10.1126/scitranslmed.ade2909openalex-snapshot
Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors
inferred← citeshttps://doi.org/10.1128/cmr.00147-24openalex-snapshot
Tackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action
inferred← citeshttps://doi.org/10.1128/msystems.00336-21openalex-snapshot
Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
inferred← citeshttps://doi.org/10.1136/bmjgast-2023-001148openalex-snapshot
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation
inferred← citeshttps://doi.org/10.1136/jitc-2022-004799openalex-snapshot
Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade
inferred← citeshttps://doi.org/10.1155/2020/7418342openalex-snapshot
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development
inferred← citeshttps://doi.org/10.1155/2021/9912188openalex-snapshot
Toll-Like Receptor-Based Strategies for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1155/2021/9914854openalex-snapshot
Toll-Like Receptors: General Molecular and Structural Biology
inferred← citeshttps://doi.org/10.1159/000510385openalex-snapshot
Immune Modulation in Lung Cancer: Current Concepts and Future Strategies
inferred← citeshttps://doi.org/10.11606/t.42.2020.tde-16122019-161916openalex-snapshot
O papel dos neutrófilos e dos receptores TLR-2 e TLR-4 na cromoblastomicose experimental em infecção por >i /i<
inferred← citeshttps://doi.org/10.1177/11795549221130549openalex-snapshot
The Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer
inferred← citeshttps://doi.org/10.1183/23120541.00199-2024openalex-snapshot
Evaluation of Intranasal TLR2/6 agonist INNA-051: Safety, Tolerability and Proof of Pharmacology
inferred← citeshttps://doi.org/10.1183/23120541.01044-2024openalex-snapshot
Priming mucosal pathogen-agnostic innate immunity with an intranasal TLR2/6 agonist in an aged population
inferred← citeshttps://doi.org/10.1186/s12969-026-01197-5openalex-snapshot
Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization
inferred← citeshttps://doi.org/10.1186/s13024-024-00703-1openalex-snapshot
Brain clearance of protein aggregates: a close-up on astrocytes
inferred← citeshttps://doi.org/10.1186/s13601-020-00347-6openalex-snapshot
Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
inferred← citeshttps://doi.org/10.1186/s40001-024-02169-9openalex-snapshot
SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway
inferred← citeshttps://doi.org/10.14264/uql.2020.64openalex-snapshot
The impact of asthma, toll-like receptors 7 and 8, genetic and clinical determinants on antiviral immune response
inferred← citeshttps://doi.org/10.1515/biol-2022-0704openalex-snapshot
The sequencing of the key genes and end products in the TLR4 signaling pathway from the kidney of Rana dybowskii exposed to Aeromonas hydrophila
inferred← citeshttps://doi.org/10.1615/critrevtherdrugcarriersyst.2022038827openalex-snapshot
An Overview on Macrophage Targeting: A Promising Approach
inferred← citeshttps://doi.org/10.17305/bb.2024.10550openalex-snapshot
Impact of TLR9 and TLR7 gene polymorphisms on prognosis and survival of patients with oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.18466/cbayarfbe.1593863openalex-snapshot
Recent Advancements in Computational Approaches for Tailoring Toll-like Receptors and Antimicrobial Peptides Against Candida Infections
inferred← citeshttps://doi.org/10.18632/aging.203560openalex-snapshot
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
inferred← citeshttps://doi.org/10.21203/rs.3.rs-334157/v1openalex-snapshot
Exploring the mechanism of astaxanthin against lipopolysaccharide-induced acute lung injury by network pharmacology and experimental validation
inferred← citeshttps://doi.org/10.2147/copd.s249131openalex-snapshot
The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.2147/dmso.s274844openalex-snapshot
Toll-like Receptors as a Potential Drug Target for Diabetes Mellitus and Diabetes-associated Complications
inferred← citeshttps://doi.org/10.2147/itt.s288547openalex-snapshot
Contribution of Toll-Like Receptors and the NLRP3 Inflammasome in Rheumatoid Arthritis Pathophysiology
inferred← citeshttps://doi.org/10.2147/jpr.s246883openalex-snapshot
The Role of Neuro-Immune Interactions in Chronic Pain: Implications for Clinical Practice
inferred← citeshttps://doi.org/10.2174/0115743624341069241112091959openalex-snapshot
Revisiting the Significance of TLRs: Current Understanding and Future Scope for Therapeutic Implications
inferred← citeshttps://doi.org/10.2174/9789815124606123010007openalex-snapshot
Immunotherapy and Cancer Stem Cells
inferred← citeshttps://doi.org/10.22038/ijbms.2022.65377.14387openalex-snapshot
Chromone derivatives suppress neuroinflammation and improve mitochondrial function in the sporadic form of Alzheimer's disease under experimental conditions.
inferred← citeshttps://doi.org/10.2217/epi-2020-0186openalex-snapshot
EZH2 Inhibition: A Promising Strategy to Prevent Cancer Immune Editing
inferred← citeshttps://doi.org/10.2217/fvl-2021-0218openalex-snapshot
Targeting Host Factors of virus-induced Inflammation: A Strategy for Tackling Future Epidemics by Rna Viruses
inferred← citeshttps://doi.org/10.23937/2378-3672/1410043openalex-snapshot
Purine Nucleoside Phosphorylase Inhibitors as Novel Immuno-Oncology Agent and Vaccine Adjuvant
inferred← citeshttps://doi.org/10.24198/obgynia.v4i2.289openalex-snapshot
Relationship of Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA
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