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Pyrophosphate therapy prevents trauma‐induced calcification in the mouse model of neurogenic heterotopic ossification

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/path.4519openalex-snapshot
Neurological heterotopic ossification following spinal cord injury is triggered by macrophage‐mediated inflammation in muscle
inferredcites →https://doi.org/10.1007/s00223-018-0502-5openalex-snapshot
Trauma-Induced Nanohydroxyapatite Deposition in Skeletal Muscle is Sufficient to Drive Heterotopic Ossification
inferredcites →https://doi.org/10.1016/0003-9861(84)90356-4openalex-snapshot
Can biological calcification occur in the presence of pyrophosphate?
inferredcites →https://doi.org/10.1016/j.ajpath.2017.02.009openalex-snapshot
Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice
inferredcites →https://doi.org/10.1016/j.bone.2017.05.015openalex-snapshot
Neurological heterotopic ossification: Current understanding and future directions
inferredcites →https://doi.org/10.1016/j.jid.2018.07.030openalex-snapshot
Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6 Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI
inferredcites →https://doi.org/10.1016/j.jneumeth.2011.09.003openalex-snapshot
A mouse model of human repetitive mild traumatic brain injury
inferredcites →https://doi.org/10.1016/j.mri.2012.05.001openalex-snapshot
3D Slicer as an image computing platform for the Quantitative Imaging Network
inferredcites →https://doi.org/10.1016/j.tibs.2018.10.005openalex-snapshot
PXE, a Mysterious Inborn Error Clarified
inferredcites →https://doi.org/10.1038/195911a0openalex-snapshot
Mechanism of Calcification: Inhibitory Role of Pyrophosphate
inferredcites →https://doi.org/10.1038/212901a0openalex-snapshot
Effect of Pyrophosphate on Hydroxyapatite and Its Implications in Calcium Homeostasis
inferredcites →https://doi.org/10.1038/ncomms10006openalex-snapshot
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
inferredcites →https://doi.org/10.1038/sj.onc.1207676openalex-snapshot
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
inferredcites →https://doi.org/10.1073/pnas.1319582110openalex-snapshot
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release
inferredcites →https://doi.org/10.1073/pnas.1910972116openalex-snapshot
ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson–Gilford progeria syndrome
inferredcites →https://doi.org/10.1097/ta.0000000000000883openalex-snapshot
Trauma-induced heterotopic bone formation and the role of the immune system
inferredcites →https://doi.org/10.1111/jcmm.15240openalex-snapshot
Heterotopic ossification of tendon and ligament
inferredcites →https://doi.org/10.1126/science.165.3899.1264openalex-snapshot
Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivo
inferredcites →https://doi.org/10.1126/scitranslmed.aal1669openalex-snapshot
Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase
inferredcites →https://doi.org/10.1128/mcb.25.18.8299-8310.2005openalex-snapshot
Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues
inferredcites →https://doi.org/10.1161/atvbaha.114.304017openalex-snapshot
ABCC6–Mediated ATP Secretion by the Liver Is the Main Source of the Mineralization Inhibitor Inorganic Pyrophosphate in the Systemic Circulation—Brief Report
inferredcites →https://doi.org/10.1172/jci.insight.96034openalex-snapshot
Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications
inferredcites →https://doi.org/10.1186/s13287-018-1107-7openalex-snapshot
BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification
inferredcites →https://doi.org/10.1302/2046-3758.23.2000152openalex-snapshot
Heterotopic ossification after central nervous system trauma
inferredcites →https://doi.org/10.15252/emmm.201707532openalex-snapshot
Oral administration of pyrophosphate inhibits connective tissue calcification
inferredcites →https://doi.org/10.1634/stemcells.2008-0576openalex-snapshot
Dysregulation of Local Stem/Progenitor Cells as a Common Cellular Mechanism for Heterotopic Ossification
inferredcites →https://doi.org/10.2106/jbjs.h.00792openalex-snapshot
Heterotopic Ossification in High-Energy Wartime Extremity Injuries: Prevalence and Risk Factors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3986891openalex-extracted
Sustained Local Ionic Homeostatic Imbalance (SLIHI) Caused by Calcification Modulates Inflammation to Trigger Ectopic Bone Formation
inferred← citeshttps://doi.org/10.1007/s11064-024-04118-8openalex-snapshot
The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification
inferred← citeshttps://doi.org/10.1016/j.actbio.2022.03.057openalex-snapshot
Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification
inferred← citeshttps://doi.org/10.1016/j.jot.2026.101176openalex-snapshot
Neurogenic heterotopic ossification: from molecular mechanisms to clinical treatment
inferred← citeshttps://doi.org/10.1038/s41536-021-00178-4openalex-snapshot
Macrophages in heterotopic ossification: from mechanisms to therapy
inferred← citeshttps://doi.org/10.1080/10790268.2026.2639854openalex-snapshot
Trends and risk factors for spinal cord injury-induced heterotopic ossification: A retrospective population-based cross-sectional study using the 2016–2021 National Inpatient Sample (NIS)
inferred← citeshttps://doi.org/10.1093/jbmr/zjae097openalex-snapshot
Downregulation of TGF-β1 in fibro-adipogenic progenitors initiates muscle ectopic mineralization
inferred← citeshttps://doi.org/10.1096/fj.202501170rropenalex-snapshot
The Role of Collagen Matrix in the Development and Progression of Heterotopic Ossification in Tendon and Its Biological Mechanisms
inferred← citeshttps://doi.org/10.1097/cm9.0000000000003244openalex-snapshot
Heterotopic ossification: Current developments and emerging potential therapies
inferred← citeshttps://doi.org/10.15476/elte.2021.156openalex-snapshot
Therapeutic options in the treatment of ectopic calcification
inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-25-01263openalex-snapshot
M1 macrophage-derived CXCL12 drives neurogenic heterotopic ossification following spinal cord injury
inferred← citeshttps://doi.org/10.70675/53a7d3b9z29c3z4227zae73z5810b3bf6448openalex-snapshot
Effet anti-calcifiant et anti-inflammatoire du Thiosulfate de sodium dans les calcifications ectopiques
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