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Intestinal alkaline phosphatase at the crossroad of intestinal health and disease – a putative role in type 1 diabetes
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1 of the 48 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1371/journal.pone.0032841 (notice 2019-10-30).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s00125-003-1194-5openalex-snapshot
Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients
inferredcites →https://doi.org/10.1007/s00428-011-1188-5openalex-snapshot
Decreased mucosal expression of intestinal alkaline phosphatase in children with coeliac disease
inferredcites →https://doi.org/10.1007/s00592-014-0641-8openalex-snapshot
High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells
inferredcites →https://doi.org/10.1016/0009-8981(80)90295-8openalex-snapshot
Intestinal alkaline phosphatase and the abo blood group system — a new aspect
inferredcites →https://doi.org/10.1016/0009-8981(91)90303-topenalex-snapshot
Serum levels of human alkaline phosphatase isozymes in relation to blood groups
inferredcites →https://doi.org/10.1016/j.amjmed.2012.03.015openalex-snapshot
Are Patients with Inflammatory Bowel Disease at Increased Risk of Coronary Artery Disease?
inferredcites →https://doi.org/10.1016/j.bbadis.2013.07.016openalex-snapshot
A novel hypothesis for an alkaline phosphatase ‘rescue’ mechanism in the hepatic acute phase immune response
inferredcites →https://doi.org/10.1016/j.bbrc.2005.12.145openalex-snapshot
Involvement of intestinal alkaline phosphatase in serum apolipoprotein B-48 level and its association with ABO and secretor blood group types
inferredcites →https://doi.org/10.1016/j.ebiom.2015.11.027openalex-snapshot
A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity
inferredcites →https://doi.org/10.1016/j.ejphar.2010.01.023openalex-snapshot
Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage
inferredcites →https://doi.org/10.1016/j.jamcollsurg.2015.12.006openalex-snapshot
Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels
inferredcites →https://doi.org/10.1016/s0009-8981(98)00102-8openalex-snapshot
Changes in intestinal alkaline phosphatase isoforms in healthy subjects bearing the blood group secretor and non-secretor
inferredcites →https://doi.org/10.1038/ni.2552openalex-snapshot
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses
inferredcites →https://doi.org/10.1038/nrendo.2015.218openalex-snapshot
The role of the intestinal microbiota in type 1 diabetes mellitus
inferredcites →https://doi.org/10.1046/j.1365-2796.2000.00656.xopenalex-snapshot
Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis
inferredcites →https://doi.org/10.1056/nejmoa1408214openalex-snapshot
Glycemic Control and Excess Mortality in Type 1 Diabetes
inferredcites →https://doi.org/10.1073/pnas.1220180110openalex-snapshot
Intestinal alkaline phosphatase prevents metabolic syndrome in mice
inferredcites →https://doi.org/10.1080/07853890802482452openalex-snapshot
Enhanced systemic matrix metalloproteinase response inHelicobacter pylorigastritis
inferredcites →https://doi.org/10.1089/ars.2012.4535openalex-snapshot
Carbamyl Adducts on Low-Density Lipoprotein Induce IgG Response in LDLR −/− Mice and Bind Plasma Autoantibodies in Humans Under Enhanced Carbamylation
inferredcites →https://doi.org/10.1093/intimm/dxt022openalex-snapshot
Natural antibodies of newborns recognize oxidative stress-related malondialdehyde acetaldehyde adducts on apoptotic cells and atherosclerotic plaques
inferredcites →https://doi.org/10.1093/molbev/msp108openalex-snapshot
A Natural History of FUT2 Polymorphism in Humans
inferredcites →https://doi.org/10.1111/j.1349-7006.2011.01907.xopenalex-snapshot
ABO blood group alleles and the risk of pancreatic cancer in a Japanese population
inferredcites →https://doi.org/10.1111/j.1753-4887.2010.00292.xopenalex-snapshot
Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet
inferredcites →https://doi.org/10.1111/tan.12016openalex-snapshot
Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population
inferredcites →https://doi.org/10.1128/iai.21.2.532-539.1978openalex-snapshot
Increase in the Population of Duodenal Immunoglobulin A Plasmocytes in Axenic Mice Associated with Different Living or Dead Bacterial Strains of Intestinal Origin
inferredcites →https://doi.org/10.1136/gutjnl-2013-304833openalex-snapshot
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
inferredcites →https://doi.org/10.1155/2014/928461openalex-snapshot
Role of Th17 Cells in the Pathogenesis of Human IBD
inferredcites →https://doi.org/10.1161/01.atv.0000148324.63685.6aopenalex-snapshot
Association Between Elevated Liver Enzymes and C-Reactive Protein
inferredcites →https://doi.org/10.1161/atvbaha.107.154831openalex-snapshot
Serum Matrix Metalloproteinase-8 Concentrations Are Associated With Cardiovascular Outcome in Men
inferredcites →https://doi.org/10.1186/1743-7075-11-28openalex-snapshot
Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals
inferredcites →https://doi.org/10.1371/journal.pone.0032841openalex-snapshot
Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery
inferredcites →https://doi.org/10.1371/journal.pone.0107440openalex-snapshot
Unique Antibody Responses to Malondialdehyde-Acetaldehyde (MAA)-Protein Adducts Predict Coronary Artery Disease
inferredcites →https://doi.org/10.1371/journal.pone.0121979openalex-snapshot
Increased Autoimmune Diabetes in pIgR-Deficient NOD Mice Is Due to a "Hitchhiking" Interval that Refines the Genetic Effect of Idd5.4
inferredcites →https://doi.org/10.1515/cclm.2010.052openalex-snapshot
Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006
inferredcites →https://doi.org/10.2217/imt.13.130openalex-snapshot
Influence of Host Immunoregulatory Genes, ER Stress and Gut Microbiota on the Shared Pathogenesis of Inflammatory Bowel Disease and Type 1 Diabetes
inferredcites →https://doi.org/10.2337/dc09-0467openalex-snapshot
Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes
inferredcites →https://doi.org/10.3382/ps.2009-00124openalex-snapshot
Impaired intestinal mucosal immunity in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus
inferredcites →https://doi.org/10.3382/ps.2013-03398openalex-snapshot
Effect of γ-aminobutyric acid on digestive enzymes, absorption function, and immune function of intestinal mucosa in heat-stressed chicken
inferredcites →https://doi.org/10.3389/fnint.2013.00086openalex-snapshot
Stress modulates intestinal secretory immunoglobulin A
inferredcites →https://doi.org/10.3748/wjg.v18.i25.3254openalex-snapshot
Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.
inferredcites →https://doi.org/10.3748/wjg.v20.i42.15650openalex-snapshot
Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity
inferredcites →https://doi.org/10.4049/jimmunol.1000788openalex-snapshot
IL-17 Immunity in Human Type 1 Diabetes
inferredcites →https://doi.org/10.4049/jimmunol.1200955openalex-snapshot
Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis
inferredcites →https://doi.org/10.4049/jimmunol.142.2.381openalex-snapshot
Late events in B cell activation. Expression of membrane alkaline phosphatase activity.
inferredcites →https://doi.org/10.4049/jimmunol.142.9.3187openalex-snapshot
Expression of alkaline phosphatase in murine B lymphocytes. Correlation with B cell differentiation into Ig secretion.
inferredcites →https://doi.org/10.4049/jimmunol.147.11.3690openalex-snapshot
Alkaline phosphatase on activated B cells characterization of the expression of alkaline phosphatase on activated B cells. Kinetics and membrane anchor
inferredcites →https://doi.org/10.4049/jimmunol.155.4.1685openalex-snapshot
Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness
inferredcites →https://doi.org/10.4161/gmic.19625openalex-snapshot
Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4664335openalex-extracted
The Beneficial Effects of Dendrobium Officinale National Herbal Drink on Gut-Liver Axis Metabolic Immune Crosstalk Via Regulate Gut Scfas-Th17/Treg Immune Homeostasis
inferred← citeshttps://doi.org/10.1002/mnfr.70374openalex-snapshot
Association of Butyrate Supplementation with Cardiovascular Disease:A Narrative Review
inferred← citeshttps://doi.org/10.1007/5584_2020_515openalex-snapshot
Dietary SCFAs Immunotherapy: Reshaping the Gut Microbiota in Diabetes
inferred← citeshttps://doi.org/10.1007/s00604-017-2541-4openalex-snapshot
Inner filter effect based fluorometric determination of the activity of alkaline phosphatase by using carbon dots codoped with boron and nitrogen
inferred← citeshttps://doi.org/10.1007/s10853-019-03565-xopenalex-snapshot
A polymer dots fluorescent sensor for detection of alkaline phosphatase activity and inhibitor evaluation
inferred← citeshttps://doi.org/10.1007/s13167-020-00228-9openalex-snapshot
Intestinal alkaline phosphatase modulation by food components: predictive, preventive, and personalized strategies for novel treatment options in chronic kidney disease
inferred← citeshttps://doi.org/10.1007/s40620-020-00759-4openalex-snapshot
Omics research in diabetic kidney disease: new biomarker dimensions and new understandings?
inferred← citeshttps://doi.org/10.1016/j.bbi.2025.02.006openalex-snapshot
Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2021.127909openalex-snapshot
Rapid and facile electrospray preparation of CsPbBr3@PMMA fluorescent microspheres for fluorescent detection of ALP in biological samples
inferred← citeshttps://doi.org/10.1016/j.inoche.2023.111288openalex-snapshot
Fluorescence switch-on detection of alkaline phosphatase activity and adenosine triphosphate using vitamin B6 cofactor conjugated Mn-doped ZnS QDs
inferred← citeshttps://doi.org/10.1016/j.lfs.2025.124113openalex-snapshot
The protective role of intestinal alkaline phosphatase in inflammatory bowel disease-associated non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.mehy.2026.112012openalex-snapshot
Non-secretor status as a saliva-based risk marker for cancer susceptibility: a hypothesis
inferred← citeshttps://doi.org/10.1016/j.micpath.2026.108645openalex-snapshot
Alleviating effect of intestinal alkaline phosphatase on Enterotoxigenic Escherichia coli K99-induced diarrhea
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155816openalex-snapshot
Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg
inferred← citeshttps://doi.org/10.1016/j.saa.2021.120087openalex-snapshot
Ratiometric fluorescent sensor based on MoS2 QDs and AuNCs for determination and bioimaging of alkaline phosphatase
inferred← citeshttps://doi.org/10.1016/j.soard.2020.10.021openalex-snapshot
Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.talanta.2018.07.031openalex-snapshot
Rapid aqueous synthesis of CuInS/ZnS quantum dots as sensor probe for alkaline phosphatase detection and targeted imaging in cancer cells
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c05119openalex-snapshot
Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects
inferred← citeshttps://doi.org/10.1038/s41401-020-0402-xopenalex-snapshot
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine
inferred← citeshttps://doi.org/10.1038/s41598-021-94094-8openalex-snapshot
Roux-en-Y gastric bypass potentially improved intestinal permeability by regulating gut innate immunity in diet-induced obese mice
inferred← citeshttps://doi.org/10.1038/s41598-021-94747-8openalex-snapshot
Faecal biomarkers in type 1 diabetes with and without diabetic nephropathy
inferred← citeshttps://doi.org/10.1039/d5fo03526kopenalex-snapshot
Intestinal alkaline phosphatase and gut health: insights into homeostasis, barrier protection, and immune signaling
inferred← citeshttps://doi.org/10.1080/19490976.2025.2551117openalex-snapshot
Review: microbial metabolites – a key to address gut inflammation and barrier dysfunction in the premature infant
inferred← citeshttps://doi.org/10.1080/21688370.2021.1996830openalex-snapshot
Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions
inferred← citeshttps://doi.org/10.1088/2050-6120/abf988openalex-snapshot
Review on the recent progress in the development of fluorescent probes targeting enzymes
inferred← citeshttps://doi.org/10.1093/nutrit/nuz015openalex-snapshot
Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000570openalex-snapshot
Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease
inferred← citeshttps://doi.org/10.1101/2022.05.04.490595openalex-snapshot
The Radio-Protective Effects of (-)-Epigallocatechin-3-Gallate (EGCG): Regulating Macrophage Function in Radiation-Induced Intestinal Injury
inferred← citeshttps://doi.org/10.1101/2024.08.28.604371openalex-snapshot
Maternal humoral factors modulate offspring gut immune homeostasis to mitigate diabetes development
inferred← citeshttps://doi.org/10.1111/jdi.70248openalex-snapshot
Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes
inferred← citeshttps://doi.org/10.1111/ped.70260openalex-snapshot
Clinical features of low serum alkaline phosphatase levels in children: A retrospective study
inferred← citeshttps://doi.org/10.1111/prd.12433openalex-snapshot
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
inferred← citeshttps://doi.org/10.1136/bmjdrc-2021-002643openalex-snapshot
Intestinal alkaline phosphatase deficiency increases the risk of diabetes
inferred← citeshttps://doi.org/10.11569/wcjd.v27.i23.1441openalex-snapshot
Role of intestinal alkaline phosphatase in intestinal mucosal barrier
inferred← citeshttps://doi.org/10.1161/circresaha.120.317144openalex-snapshot
Over-Expression of Intestinal Alkaline Phosphatase Attenuates Atherosclerosis
inferred← citeshttps://doi.org/10.1177/03946320251327621openalex-snapshot
Causal association between type 1 diabetes and autoimmune cholestasis: A bi-directional Mendelian randomized study
inferred← citeshttps://doi.org/10.12873/451lopezopenalex-snapshot
Efecto del consumo de polifenoles sobre biomarcadores de inflamación y endotoxemia en personas con obesidad: una revisión sistemática.
inferred← citeshttps://doi.org/10.1371/journal.pone.0269561openalex-snapshot
Fecal microbiota in congenital chloride diarrhea and inflammatory bowel disease
inferred← citeshttps://doi.org/10.14814/phy2.13790openalex-snapshot
Intestine-specific expression of human chimeric intestinal alkaline phosphatase attenuates Western diet-induced barrier dysfunction and glucose intolerance
inferred← citeshttps://doi.org/10.20517/mrr.2024.45openalex-snapshot
Host-microbiota interactions in the infant gut revealed by daily faecal sample time series
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2780541/v1openalex-snapshot
Association of endotoxaemia with low grade inflammation, metabolic syndrome and distinct response to lipopolysaccharide in type 1 diabetes
inferred← citeshttps://doi.org/10.2337/dc18-0777openalex-snapshot
Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes
inferred← citeshttps://doi.org/10.2478/enr-2023-0024openalex-snapshot
Role of liver parameters in diabetes mellitus – a narrative review
inferred← citeshttps://doi.org/10.26717/bjstr.2024.55.008698openalex-snapshot
"Biological Activities and Clinical Applications of Alkaline Phosphatase: A Minireview"
inferred← citeshttps://doi.org/10.29219/fnr.v67.9575openalex-snapshot
Randomized controlled pilot study: effect of carrageenan emulsifier on inflammation and gastrointestinal symptoms in quiescent ulcerative colitis
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1873700openalex-snapshot
Childhood type 1 diabetes mellitus and gut microbiota: from microbiome characteristics to prevention and treatment strategies
inferred← citeshttps://doi.org/10.3389/fendo.2018.00553openalex-snapshot
The Gut-Kidney Axis: Putative Interconnections Between Gastrointestinal and Renal Disorders
inferred← citeshttps://doi.org/10.3389/fendo.2019.00818openalex-snapshot
Metabolomic Assessment Reveals Alteration in Polyols and Branched Chain Amino Acids Associated With Present and Future Renal Impairment in a Discovery Cohort of 637 Persons With Type 1 Diabetes
inferred← citeshttps://doi.org/10.3389/fimmu.2022.927272openalex-snapshot
Intestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance
inferred← citeshttps://doi.org/10.3389/fnut.2020.606171openalex-snapshot
Can the FUT2 Non-secretor Phenotype Associated With Gut Microbiota Increase the Children Susceptibility for Type 1 Diabetes? A Mini Review
inferred← citeshttps://doi.org/10.3389/fvets.2022.891429openalex-snapshot
Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis
inferred← citeshttps://doi.org/10.3389/fvets.2024.1328513openalex-snapshot
Fecal microbiota composition, serum metabolomics, and markers of inflammation in dogs fed a raw meat-based diet compared to those on a kibble diet
inferred← citeshttps://doi.org/10.3390/biom15040557openalex-snapshot
Fecal Calprotectin as a Prognostic Biomarker for Mortality and Renal Outcomes in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3390/biomedicines11102679openalex-snapshot
Progression of Diabetic Kidney Disease and Gastrointestinal Symptoms in Patients with Type I Diabetes
inferred← citeshttps://doi.org/10.3390/biomedicines11123269openalex-snapshot
Association of Endotoxemia with Low-Grade Inflammation, Metabolic Syndrome and Distinct Response to Lipopolysaccharide in Type 1 Diabetes
inferred← citeshttps://doi.org/10.3390/foods11091212openalex-snapshot
Protective Effect of Alkaline Phosphatase Supplementation on Infant Health
inferred← citeshttps://doi.org/10.3390/ijms231810256openalex-snapshot
Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset
inferred← citeshttps://doi.org/10.3390/jcm11133573openalex-snapshot
Effects of Butyrate Supplementation on Inflammation and Kidney Parameters in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
inferred← citeshttps://doi.org/10.3390/molecules29122791openalex-snapshot
Beneficial In Vitro Effects of Polysaccharide and Non-Polysaccharide Components of Dendrobium huoshanense on Gut Microbiota of Rats with Type 1 Diabetes as Opposed to Metformin
inferred← citeshttps://doi.org/10.3390/nu14020385openalex-snapshot
Effect of Type 2 Diabetes and Impaired Glucose Tolerance on Digestive Enzymes and Glucose Absorption in the Small Intestine of Young Rats
inferred← citeshttps://doi.org/10.51755/turkvetj.1780858openalex-snapshot
Bağırsakta bağırır: Atopik dermatitli köpeklerde ‘bağırsak-beyin-deri ekseninde’ fekal intestinal alkalen fosfataz aktivitesinin ve çinko seviyelerinin ölçümü
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