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The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

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LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells

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Transcriptomic analysis reveals suppression of steroidogenic acute regulatory protein in gender-specific differences in Alzheimer's disease

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Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation

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Porphyromonas gingivalis interaction with Candida albicans allows for aerobic escape, virulence and adherence

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Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life

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The di-leucine motif in the host defense peptide LL-37 is essential for initiation of autophagy in human macrophages

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Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

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Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines

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Role of the peripheral innate immune system in the development of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.expneurol.2009.09.002openalex-snapshot

Signaling effect of amyloid-β42 on the processing of AβPP

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The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

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LL-37, the master antimicrobial peptide, its multifaceted role from combating infections to cancer immunity

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Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

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The antimicrobial protection hypothesis of Alzheimer's disease

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Extracellular vesicles derived from Porphyromonas gingivalis induce trigeminal nerve-mediated cognitive impairment

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Apolipoprotein E3 and E4 isoforms exhibit differing effects in countering endotoxins

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Neonatal vaccination with bacillus Calmette–Guérin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats

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Effects of ketogenic diet on cognitive function of patients with Alzheimer's disease: a systematic review and meta-analysis

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Sodium butyrate up-regulates cathelicidin gene expression via activator protein-1 and histone acetylation at the promoter region in a human lung epithelial cell line, EBC-1

inferredcites →https://doi.org/10.1016/j.molimm.2006.09.016openalex-snapshot

Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells

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Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways

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Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain

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Herpes simplex virus infection causes cellular β-amyloid accumulation and secretase upregulation

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Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

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Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial

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Exosomes and their roles in immune regulation and cancer

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Interaction of hagfish cathelicidin antimicrobial peptides with model lipid membranes

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Tight junction proteins

inferredcites →https://doi.org/10.1016/s0378-1097(03)00178-2openalex-snapshot

The collagenase activity ofPorphyromonas gingivalisis due to Arg-gingipain

inferredcites →https://doi.org/10.1038/nbt.1807openalex-snapshot

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

inferredcites →https://doi.org/10.1038/nm1407openalex-snapshot

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

inferredcites →https://doi.org/10.1038/npjvaccines.2016.22openalex-snapshot

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

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α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

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Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease

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Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

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Exosomes deliver ROS for regeneration

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ApoE attenuates unresolvable inflammation by complex formation with activated C1q

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Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids

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Adhesive protein-mediated cross-talk between Candida albicans and Porphyromonas gingivalis in dual species biofilm protects the anaerobic bacterium in unfavorable oxic environment

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Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties

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Specific Neurochemical Derangements of Brain Projecting Neurons in Apolipoprotein E‐Deficient Mice

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Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic

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Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

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Biogeography of a human oral microbiome at the micron scale

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Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa

inferredcites →https://doi.org/10.1074/jbc.m805533200openalex-snapshot

Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles

inferredcites →https://doi.org/10.1074/jbc.r116.757955openalex-snapshot

Exosomes in the Pathology of Neurodegenerative Diseases

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Human Cathelicidin (LL-37), a Multifunctional Peptide, is Expressed by Ocular Surface Epithelia and has Potent Antibacterial and Antiviral Activity

inferredcites →https://doi.org/10.1080/15548627.2015.1075110openalex-snapshot

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages

inferredcites →https://doi.org/10.1080/20002297.2018.1487742openalex-snapshot

Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease

inferredcites →https://doi.org/10.1080/21688370.2016.1154641openalex-snapshot

Junctional proteins of the blood-brain barrier: New insights into function and dysfunction

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Keratinocyte junctions and the epidermal barrier

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Function of β‐amyloid in cholesterol transport: a lead to neurotoxicity

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Cathelicidins positively regulate pancreatic β‐cell functions

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Role of Glial Cells in the Functional Expression of LL-37/Rat Cathelin-Related Antimicrobial Peptide in Meningitis

inferredcites →https://doi.org/10.1099/jmm.0.47679-0openalex-snapshot

Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis

inferredcites →https://doi.org/10.1101/cshperspect.a006296openalex-snapshot

The Genetics of Alzheimer Disease

inferredcites →https://doi.org/10.1111/1751-7915.13388openalex-snapshot

Dismantling the bacterial virulence program

inferredcites →https://doi.org/10.1111/j.1365-2958.2004.04357.xopenalex-snapshot

The C‐terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities

inferredcites →https://doi.org/10.1111/j.1462-5822.2011.01644.xopenalex-snapshot

Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages

inferredcites →https://doi.org/10.1111/j.1755-3768.2015.0188openalex-snapshot

Peptide versus gene therapy: Cathelicidin LL ‐37 and HSV ‐1 corneal infection

inferredcites →https://doi.org/10.1111/jcpe.13966openalex-snapshot

Gingipains may be one of the key virulence factors of Porphyromonas gingivalis to impair cognition and enhance blood–brain barrier permeability: An animal study

inferredcites →https://doi.org/10.1111/omi.12488openalex-snapshot

Detection of Amyloid‐β Peptides in Gingival Crevicular Fluid and Its Effect on Oral Pathogens

inferredcites →https://doi.org/10.1124/pr.110.002980openalex-snapshot

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

inferredcites →https://doi.org/10.1126/sciadv.aau3333openalex-snapshot

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

inferredcites →https://doi.org/10.1126/science.8346443openalex-snapshot

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

inferredcites →https://doi.org/10.1128/aac.00818-09openalex-snapshot

Phenylbutyrate Induces Antimicrobial Peptide Expression

inferredcites →https://doi.org/10.1128/cvi.00178-08openalex-snapshot

Expression and Secretion of Cathelicidin LL-37 in Human Epithelial Cells after Infection byMycobacterium bovisBacillus Calmette-Guerin

inferredcites →https://doi.org/10.1128/iai.00966-10openalex-snapshot

Adsorption of Components of the Plasma Kinin-Forming System on the Surface of Porphyromonas gingivalis Involves Gingipains as the Major Docking Platforms

inferredcites →https://doi.org/10.1128/iai.01043-06openalex-snapshot

Induction of the Antimicrobial Peptide CRAMP in the Blood-Brain Barrier and Meninges after Meningococcal Infection

inferredcites →https://doi.org/10.1128/jb.01530-06openalex-snapshot

Does the Importance of the C-Terminal Residues in the Maturation of RgpB from Porphyromonas gingivalis Reveal a Novel Mechanism for Protein Export in a Subgroup of Gram-Negative Bacteria?

inferredcites →https://doi.org/10.1128/mbio.00298-25openalex-snapshot

Lys-specific gingipain (Kgp) of P. gingivalis promotes viral infection by disabling the interferon pathway

inferredcites →https://doi.org/10.1128/spectrum.00567-25openalex-snapshot

Commensal colonization of Candida albicans in the mouse gastrointestinal tract is mediated via expression of candidalysin and adhesins

inferredcites →https://doi.org/10.1136/gut.52.5.735openalex-snapshot

Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways

inferredcites →https://doi.org/10.1148/radiol.2016152244openalex-snapshot

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

inferredcites →https://doi.org/10.1152/ajpcell.00158.2010openalex-snapshot

Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability

inferredcites →https://doi.org/10.1155/2015/137357openalex-snapshot

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease

inferredcites →https://doi.org/10.1159/000355931openalex-snapshot

Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37 Expression

inferredcites →https://doi.org/10.1159/000362789openalex-snapshot

The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function

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Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

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Porphyromonas gingivalis Impairs Microglial Aβ Clearance in a Mouse Model

inferredcites →https://doi.org/10.1177/13872877241302498openalex-snapshot

Alzheimer's disease-like pathology induced by Porphyromonas gingivalis in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis

inferredcites →https://doi.org/10.1186/1471-2164-10-321openalex-snapshot

Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates

inferredcites →https://doi.org/10.1186/1742-2094-11-68openalex-snapshot

Exosomes as mediators of neuroinflammation

inferredcites →https://doi.org/10.1186/s12974-016-0670-zopenalex-snapshot

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

inferredcites →https://doi.org/10.1186/s12979-017-0110-7openalex-snapshot

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

inferredcites →https://doi.org/10.1186/s12987-019-0123-zopenalex-snapshot

Claudin-5: gatekeeper of neurological function

inferredcites →https://doi.org/10.1186/s13195-017-0241-2openalex-snapshot

Role of neuroinflammation in neurodegeneration: new insights

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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives

inferredcites →https://doi.org/10.1212/wnl.43.8.1467openalex-snapshot

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

inferredcites →https://doi.org/10.1371/journal.pone.0009505openalex-snapshot

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

inferredcites →https://doi.org/10.1371/journal.pone.0016610openalex-snapshot

BCG Vaccine-Induced Neuroprotection in a Mouse Model of Parkinson's Disease

inferredcites →https://doi.org/10.1371/journal.pone.0101364openalex-snapshot

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

inferredcites →https://doi.org/10.1371/journal.pone.0138340openalex-snapshot

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

inferredcites →https://doi.org/10.1371/journal.pone.0151081openalex-snapshot

Periodontitis and Cognitive Decline in Alzheimer’s Disease

inferredcites →https://doi.org/10.1371/journal.pone.0152711openalex-snapshot

Circulating Cathelicidin Concentrations in a Cohort of Healthy Children: Influence of Age, Body Composition, Gender and Vitamin D Status

inferredcites →https://doi.org/10.1371/journal.pone.0204941openalex-snapshot

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

inferredcites →https://doi.org/10.1371/journal.pone.0224433openalex-snapshot

Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patients

inferredcites →https://doi.org/10.1371/journal.ppat.1001010openalex-snapshot

Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37

inferredcites →https://doi.org/10.1515/bmc-2016-0029openalex-snapshot

Alzheimer’s disease as an inflammatory disease

inferredcites →https://doi.org/10.1519/jsc.0000000000000828openalex-snapshot

Exercise, But Not Acute Sleep Loss, Increases Salivary Antimicrobial Protein Secretion

inferredcites →https://doi.org/10.1523/jneurosci.22-12-04833.2002openalex-snapshot

A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

inferredcites →https://doi.org/10.15252/embr.202256467openalex-snapshot

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

inferredcites →https://doi.org/10.1590/1980-57642018dn12-020004openalex-snapshot

Olfactory dysfunction in Alzheimer’s disease Systematic review and meta-analysis

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Antiviral Activities of Human Host Defense Peptides

inferredcites →https://doi.org/10.2174/1381612821666150710144829openalex-snapshot

The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy

inferredcites →https://doi.org/10.2217/fmb-2018-0026openalex-snapshot

Heterologous effects of infant bacille Calmette-Guérin vaccination: potential mechanisms of immunity

inferredcites →https://doi.org/10.3233/jad-150652openalex-snapshot

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

inferredcites →https://doi.org/10.3233/jad-160388openalex-snapshot

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

inferredcites →https://doi.org/10.3233/jad-161304openalex-snapshot

Alterations in the Peripheral Immune System in Dementia

inferredcites →https://doi.org/10.3233/jad-170046openalex-snapshot

Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?

inferredcites →https://doi.org/10.3233/jad-170223openalex-snapshot

Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly

inferredcites →https://doi.org/10.3233/jad-2008-13403openalex-snapshot

Chlamydophila Pneumoniae and the Etiology of Late-Onset Alzheimer's Disease

inferredcites →https://doi.org/10.3233/jad-215143openalex-snapshot

Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury

inferredcites →https://doi.org/10.3233/jad-220287openalex-snapshot

Potential Involvement of Varicella Zoster Virus in Alzheimer’s Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1

inferredcites →https://doi.org/10.3389/fchem.2019.00043openalex-snapshot

Reassessing the Host Defense Peptide Landscape

inferredcites →https://doi.org/10.3389/fcimb.2019.00138openalex-snapshot

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

inferredcites →https://doi.org/10.3389/fcimb.2020.561761openalex-snapshot

LL-37-Induced Autophagy Contributed to the Elimination of Live Porphyromonas gingivalis Internalized in Keratinocytes

inferredcites →https://doi.org/10.3389/fcimb.2025.1552395openalex-snapshot

Synergistic effects of Candida albicans and Porphyromonas gingivalis biofilms on epithelial barrier function in a 3D aspiration pneumonia model

inferredcites →https://doi.org/10.3389/fgene.2018.00362openalex-snapshot

Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

inferredcites →https://doi.org/10.3389/fimmu.2020.588036openalex-snapshot

Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

inferredcites →https://doi.org/10.3389/fimmu.2022.880961openalex-snapshot

Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis

inferredcites →https://doi.org/10.3389/fnagi.2017.00336openalex-snapshot

Periodontitis, Microbiomes and their Role in Alzheimer’s Disease

inferredcites →https://doi.org/10.3389/fnagi.2018.00224openalex-snapshot

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

inferredcites →https://doi.org/10.3389/fnagi.2019.00070openalex-snapshot

Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome

inferredcites →https://doi.org/10.3389/fphys.2020.00914openalex-snapshot

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

inferredcites →https://doi.org/10.3390/ijms160921294openalex-snapshot

MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging

inferredcites →https://doi.org/10.3390/jcm13226831openalex-snapshot

Impact of Protein Citrullination by Periodontal Pathobionts on Oral and Systemic Health: A Systematic Review of Preclinical and Clinical Studies

inferredcites →https://doi.org/10.3390/medicina58060723openalex-snapshot

Co-Infection of Oral Candida albicans and Porphyromonas gingivalis Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People

inferredcites →https://doi.org/10.3390/vaccines9050491openalex-snapshot

Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer’s Disease and Parkinson’s Disease

inferredcites →https://doi.org/10.4049/jimmunol.1303062openalex-snapshot

Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis

inferredcites →https://doi.org/10.4049/jimmunol.181.8.5537openalex-snapshot

Binding of Complement Inhibitor C4b-Binding Protein Contributes to Serum Resistance of Porphyromonas gingivalis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.5281/zenodo.23052193zenodo-depositor-declared

inferred← citeshttps://doi.org/10.5281/zenodo.23053947zenodo-depositor-declared

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.153320openalex-snapshot

Gingipains as macromolecular mediators at the periodontal-brain interface: Mechanistic, diagnostic, and therapeutic evidence in Alzheimer's and Parkinson's diseases

inferred← citeshttps://doi.org/10.1111/jre.70137openalex-snapshot

Viruses, Periodontitis, and Systemic Diseases

inferred← citeshttps://doi.org/10.1186/s40001-026-04846-3openalex-snapshot

Ageing-driven periodontitis: molecular mechanisms and emerging anti-ageing interventions

inferred← citeshttps://doi.org/10.3390/cells15171590openalex-snapshot

The Ocular Microbiome and Alzheimer’s Disease: Emerging Insights

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