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Tanshinone IIA attenuates Aβ25–35-induced spatial memory impairment via upregulating receptors for activated C kinase1 and inhibiting autophagy in hippocampus
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bies.201400002openalex-snapshot
Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
inferredcites →https://doi.org/10.1002/hipo.20000openalex-snapshot
Aging‐related alterations in the distribution of Ca2+‐dependent PKC isoforms in rabbit hippocampus
inferredcites →https://doi.org/10.1002/ptr.5015openalex-snapshot
Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM‐5 Leukemia Cells
inferredcites →https://doi.org/10.1007/s11033-012-1477-3openalex-snapshot
Tanshinone IIA protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway
inferredcites →https://doi.org/10.1007/s11064-016-1857-5openalex-snapshot
The Neuroprotective Effects of Justicidin A on Amyloid Beta25–35-Induced Neuronal Cell Death Through Inhibition of Tau Hyperphosphorylation and Induction of Autophagy in SH-SY5Y Cells
inferredcites →https://doi.org/10.1007/s12264-015-1546-4openalex-snapshot
Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice
inferredcites →https://doi.org/10.1016/j.brainres.2015.11.040openalex-snapshot
Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice
inferredcites →https://doi.org/10.1016/j.celrep.2015.10.011openalex-snapshot
RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK
inferredcites →https://doi.org/10.1016/j.ebiom.2015.12.019openalex-snapshot
The Impact of Alzheimer's Disease on the Chinese Economy
inferredcites →https://doi.org/10.1016/j.ejphar.2007.04.031openalex-snapshot
Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis
inferredcites →https://doi.org/10.1016/j.ejphar.2007.07.042openalex-snapshot
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice
inferredcites →https://doi.org/10.1016/j.expneurol.2009.09.005openalex-snapshot
Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35
inferredcites →https://doi.org/10.1016/j.intimp.2014.02.036openalex-snapshot
Madecassoside prevents Aβ25–35-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway
inferredcites →https://doi.org/10.1016/j.jalz.2015.02.003openalex-snapshot
2015 Alzheimer's disease facts and figures
inferredcites →https://doi.org/10.1016/j.jalz.2015.08.154openalex-snapshot
DT‐01‐04: The efficacy of RVT‐101, a 5‐ht6 receptor antagonist, as an adjunct to donepezil in adults with mild‐to‐moderate Alzheimer's disease: Completer analysis of a phase 2b study
inferredcites →https://doi.org/10.1016/j.jalz.2016.03.001openalex-snapshot
2016 Alzheimer's disease facts and figures
inferredcites →https://doi.org/10.1016/j.lfs.2016.02.014openalex-snapshot
Deficit of RACK1 contributes to the spatial memory impairment via upregulating BECLIN1 to induce autophagy
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2013.11.019openalex-snapshot
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy
inferredcites →https://doi.org/10.1016/j.neuropharm.2010.08.013openalex-snapshot
The neuroprotective effects of tanshinone IIA on β-amyloid-induced toxicity in rat cortical neurons
inferredcites →https://doi.org/10.1016/j.neuroscience.2014.12.028openalex-snapshot
Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8
inferredcites →https://doi.org/10.1038/nature06639openalex-snapshot
Autophagy fights disease through cellular self-digestion
inferredcites →https://doi.org/10.1038/nm.3232openalex-snapshot
The role of autophagy in neurodegenerative disease
inferredcites →https://doi.org/10.1038/nn.3028openalex-snapshot
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
inferredcites →https://doi.org/10.1046/j.1471-4159.1996.67062471.xopenalex-snapshot
Functional Impairment in Protein Kinase C by RACK1 (Receptor for Activated C Kinase 1) Deficiency in Aged Rat Brain Cortex
inferredcites →https://doi.org/10.1073/pnas.012485299openalex-snapshot
Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
inferredcites →https://doi.org/10.1073/pnas.0700036104openalex-snapshot
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
inferredcites →https://doi.org/10.1093/jnen/64.2.113openalex-snapshot
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study
inferredcites →https://doi.org/10.1097/01.wnr.0000233095.74913.88openalex-snapshot
Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats
inferredcites →https://doi.org/10.1097/brs.0b013e3182028c3aopenalex-snapshot
Induction of Autophagy and Autophagic Cell Death in Damaged Neural Tissue After Acute Spinal Cord Injury in Mice
inferredcites →https://doi.org/10.1097/fjc.0b013e3181671439openalex-snapshot
Sodium Tanshinone IIA Sulfonate Protects Cardiomyocytes Against Oxidative Stress-mediated Apoptosis Through Inhibiting JNK Activation
inferredcites →https://doi.org/10.1111/ejn.12169openalex-snapshot
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00378.xopenalex-snapshot
Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal‐regulated kinase signalling pathway
inferredcites →https://doi.org/10.1155/2015/161020openalex-snapshot
PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
inferredcites →https://doi.org/10.1172/jci20039openalex-snapshot
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
inferredcites →https://doi.org/10.1186/1472-6882-14-23openalex-snapshot
Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins
inferredcites →https://doi.org/10.1186/1750-1326-4-16openalex-snapshot
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
inferredcites →https://doi.org/10.1196/annals.1356.011openalex-snapshot
Protein Kinase C Signal Transduction Regulation in Physiological and Pathological Aging
inferredcites →https://doi.org/10.1248/bpb.34.1319openalex-snapshot
Intranasal Ginsenoside Rb1 Targets the Brain and Ameliorates Cerebral Ischemia/Reperfusion Injury in Rats
inferredcites →https://doi.org/10.1371/journal.pone.0134486openalex-snapshot
Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells
inferredcites →https://doi.org/10.2174/138920007780655441openalex-snapshot
Transport of Cryptotanshinone, a Major Active Triterpenoid in Salvia Miltiorrhiza Bunge Widely Used in the Treatment of Stroke and Alzheimers Disease, Across the Blood-Brain Barrier
inferredcites →https://doi.org/10.2174/138920310790274626openalex-snapshot
Conformations and Biological Activities of Amyloid Beta Peptide 25-35
inferredcites →https://doi.org/10.3390/nu8050256openalex-snapshot
Mixture of Peanut Skin Extract and Fish Oil Improves Memory in Mice via Modulation of Anti-Oxidative Stress and Regulation of BDNF/ERK/CREB Signaling Pathways
inferredcites →https://doi.org/10.3892/etm.2014.1919openalex-snapshot
Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats
inferredcites →https://doi.org/10.3892/mmr.2014.2254openalex-snapshot
Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease
inferredcites →https://doi.org/10.4161/auto.26508openalex-snapshot
Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models
inferredcites →https://doi.org/10.4161/auto.3678openalex-snapshot
Methods for Monitoring Autophagy from Yeast to Human
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4662337openalex-extracted
Systemic LPS-Induced RACK1 Downregulation Contributes to Neuronal Necroptosis in the Limbic System in Mice: A Mechanism of Sepsis-Associated Encephalopathy and a Potential Target of Tanshinone IIA
inferred← citeshttps://doi.org/10.1007/s00210-025-04118-7openalex-snapshot
Protective effects of Tanshinone IIA preconditioning against hypobaric hypoxia-induced lung injury in a rat model
inferred← citeshttps://doi.org/10.1007/s00210-026-05664-4openalex-snapshot
Unraveling potent therapeutic potentials of tanshinones, lipophilic abietane diterpenes: a holistic literature review
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110599openalex-snapshot
Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases
inferred← citeshttps://doi.org/10.1016/j.cbi.2023.110830openalex-snapshot
Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.09.030openalex-snapshot
Tanshinone IIA loaded chitosan nanoparticles decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.intimp.2018.08.004openalex-snapshot
Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro
inferred← citeshttps://doi.org/10.1016/j.jddst.2018.10.024openalex-snapshot
Anticancer activity and pharmacokinetics of TanshinoneⅡA derivative supramolecular hydrogels
inferred← citeshttps://doi.org/10.1016/j.jep.2023.116677openalex-snapshot
Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway
inferred← citeshttps://doi.org/10.1016/j.neulet.2019.134477openalex-snapshot
Receptor for activated C kinase 1 mediates the chronic constriction injury-induced neuropathic pain in the rats’ peripheral and central nervous system
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2020.01.026openalex-snapshot
Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155032openalex-snapshot
Effects and mechanisms of tanshinone IIA on PTSD-like symptoms
inferred← citeshttps://doi.org/10.1080/01616412.2018.1480921openalex-snapshot
Silencing of LncRNA BDNF-AS attenuates Aβ25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress
inferred← citeshttps://doi.org/10.1111/jfbc.13375openalex-snapshot
Naringenin alleviates cognition deficits in high‐fat diet‐fed SAMP8 mice
inferred← citeshttps://doi.org/10.1166/jbt.2022.3045openalex-snapshot
Retinoid Drugs Improve Autophagy of Medulloblastoma Cells via Hedgehog-Gli Signaling Pathway
inferred← citeshttps://doi.org/10.1186/s40709-019-0102-1openalex-snapshot
Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells
inferred← citeshttps://doi.org/10.2147/dddt.s266911openalex-snapshot
Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases
inferred← citeshttps://doi.org/10.2174/1389557520666200429103225openalex-snapshot
Tanshinones and their Derivatives: Heterocyclic Ring-Fused Diterpenes of Biological Interest
inferred← citeshttps://doi.org/10.3389/fphar.2022.1059360openalex-snapshot
Recent advances of tanshinone in regulating autophagy for medicinal research
inferred← citeshttps://doi.org/10.3389/fphar.2022.823732openalex-snapshot
Activation of CNR1/PI3K/AKT Pathway by Tanshinone IIA Protects Hippocampal Neurons and Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in Rats
inferred← citeshttps://doi.org/10.3892/etm.2020.8552openalex-snapshot
Hydroxysafflor yellow�A induces autophagy in human liver cancer cells by regulating Beclin�1 and ERK expression
inferred← citeshttps://doi.org/10.3892/ijmm.2017.3339openalex-snapshot
MicroRNA-107 prevents amyloid-β-induced neurotoxicity and memory impairment in mice
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