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Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1

https://doi.org/10.1111/jphp.13087
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.10297openalex-snapshot
Reconstructing eukaryotic NAD metabolism
inferredcites →https://doi.org/10.1002/oby.21086openalex-snapshot
Resveratrol attenuates microvascular inflammation in sepsis via SIRT‐1‐Induced modulation of adhesion molecules in ob/ob mice
inferredcites →https://doi.org/10.1016/0140-6736(91)91452-zopenalex-snapshot
Septic shock: pathogenesis
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2011.06.041openalex-snapshot
Cardiovascular actions and therapeutic potential of tanshinone IIA
inferredcites →https://doi.org/10.1016/j.intimp.2015.07.004openalex-snapshot
Tanshinone IIA attenuates cardiac dysfunction in endotoxin-induced septic mice via inhibition of NADPH oxidase 2-related signaling pathway
inferredcites →https://doi.org/10.1016/j.jep.2017.08.028openalex-snapshot
Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury
inferredcites →https://doi.org/10.1016/j.joca.2012.11.017openalex-snapshot
SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
inferredcites →https://doi.org/10.1016/j.molcel.2004.08.031openalex-snapshot
Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
inferredcites →https://doi.org/10.1016/j.neulet.2013.08.020openalex-snapshot
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
inferredcites →https://doi.org/10.1016/j.phymed.2009.08.010openalex-snapshot
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression
inferredcites →https://doi.org/10.1016/s0092-8674(01)00527-xopenalex-snapshot
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
inferredcites →https://doi.org/10.1038/aps.2014.112openalex-snapshot
Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice
inferredcites →https://doi.org/10.1038/nature03354openalex-snapshot
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
inferredcites →https://doi.org/10.1038/nature06268openalex-snapshot
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
inferredcites →https://doi.org/10.1038/nature07813openalex-snapshot
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
inferredcites →https://doi.org/10.1038/sj.emboj.7600244openalex-snapshot
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
inferredcites →https://doi.org/10.1038/srep04220openalex-snapshot
Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
inferredcites →https://doi.org/10.1038/srep15971openalex-snapshot
Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
inferredcites →https://doi.org/10.1038/srep36698openalex-snapshot
Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β
inferredcites →https://doi.org/10.1056/nejm199305203282005openalex-snapshot
Shock and Multiple-Organ Dysfunction after Self-Administration of Salmonella Endotoxin
inferredcites →https://doi.org/10.1056/nejm199501053320106openalex-snapshot
The Acute Respiratory Distress Syndrome
inferredcites →https://doi.org/10.1056/nejmoa1202290openalex-snapshot
Drotrecogin Alfa (Activated) in Adults with Septic Shock
inferredcites →https://doi.org/10.1097/shk.0000000000000528openalex-snapshot
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS
inferredcites →https://doi.org/10.1111/bph.13386openalex-snapshot
Trimetazidine prevents macrophage‐mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1
inferredcites →https://doi.org/10.1111/j.1440-1843.2008.01344.xopenalex-snapshot
Low‐dose dexamethasone alleviates lipopolysaccharide‐induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors
inferredcites →https://doi.org/10.1111/jcmm.13350openalex-snapshot
RETRACTED: Tanshinone IIA alleviates lipopolysaccharide‐induced acute lung injury by downregulating TRPM7 and pro‐inflammatory factors
inferredcites →https://doi.org/10.1126/science.1094637openalex-snapshot
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
inferredcites →https://doi.org/10.1126/science.1099196openalex-snapshot
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
inferredcites →https://doi.org/10.1126/science.1169956openalex-snapshot
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
inferredcites →https://doi.org/10.1126/scitranslmed.3008782openalex-snapshot
PCSK9 is a critical regulator of the innate immune response and septic shock outcome
inferredcites →https://doi.org/10.1152/ajpcell.00173.2017openalex-snapshot
Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1
inferredcites →https://doi.org/10.1152/ajplung.00274.2014openalex-snapshot
Sirt1 restrains lung inflammasome activation in a murine model of sepsis
inferredcites →https://doi.org/10.1155/2013/756519openalex-snapshot
The Effect of Sodium Tanshinone IIA Sulfate and Simvastatin on Elevated Serum Levels of Inflammatory Markers in Patients with Coronary Heart Disease: A Study Protocol for a Randomized Controlled Trial
inferredcites →https://doi.org/10.1155/2016/7296092openalex-snapshot
SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model
inferredcites →https://doi.org/10.1159/000452537openalex-snapshot
Tanshinone II A Attenuates TNF-α-Induced Expression of VCAM-1 and ICAM-1 in Endothelial Progenitor Cells by Blocking Activation of NF-κB
inferredcites →https://doi.org/10.1248/bpb.34.1052openalex-snapshot
Tanshinone IIA Attenuates Seawater Aspiration-Induced Lung Injury by Inhibiting Macrophage Migration Inhibitory Factor
inferredcites →https://doi.org/10.1371/journal.pgen.0020040openalex-snapshot
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
inferredcites →https://doi.org/10.1371/journal.pone.0040165openalex-snapshot
Neuroprotection of Tanshinone IIA against Cerebral Ischemia/Reperfusion Injury through Inhibition of Macrophage Migration Inhibitory Factor in Rats
inferredcites →https://doi.org/10.1371/journal.pone.0046364openalex-snapshot
SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
inferredcites →https://doi.org/10.1586/eri.11.141openalex-snapshot
Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment
inferredcites →https://doi.org/10.18632/oncotarget.19742openalex-snapshot
MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)
inferredcites →https://doi.org/10.3109/08820139.2016.1157814openalex-snapshot
Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators
inferredcites →https://doi.org/10.33549/physiolres.933531openalex-snapshot
Intravenous Dexamethasone Attenuated Inflammation and Influenced Apoptosis of Lung Cells in an Experimental Model of Acute Lung Injury
inferredcites →https://doi.org/10.3892/mmr.2016.5861openalex-snapshot
Resveratrol alleviates sepsis-induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF-α and myocardial apoptosis via activation of Sirt1
inferredcites →https://doi.org/10.3892/mmr.2018.9281openalex-snapshot
Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4662337openalex-extracted
Systemic LPS-Induced RACK1 Downregulation Contributes to Neuronal Necroptosis in the Limbic System in Mice: A Mechanism of Sepsis-Associated Encephalopathy and a Potential Target of Tanshinone IIA
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.03.103openalex-snapshot
GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e37083openalex-snapshot
Acacetin protects against acute lung injury by upregulating SIRT1/ NF-κB pathway
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.134853openalex-snapshot
Role of sirtuins in sepsis and sepsis-induced organ dysfunction: A review
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105224openalex-snapshot
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
inferred← citeshttps://doi.org/10.1016/j.taap.2022.116173openalex-snapshot
Melatonin attenuates LPS-induced ovarian toxicity via modulation of SIRT-1, PI3K/pAkt, pErk1/2 and NFĸB/COX-2 expressions
inferred← citeshttps://doi.org/10.1038/s41392-025-02127-9openalex-snapshot
Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies
inferred← citeshttps://doi.org/10.1080/10715762.2020.1863393openalex-snapshot
MicroRNA-499-5p targets SIRT1 to aggravate lipopolysaccharide-induced acute lung injury
inferred← citeshttps://doi.org/10.1111/php.13399openalex-snapshot
Efficient Anticancer Effect on Choroidal Melanoma Cells Induced by Tanshinone IIA Photosensitization
inferred← citeshttps://doi.org/10.1142/s0192415x26500102openalex-snapshot
Tanshinone IIA Alleviates Pyroptosis through SIRT1/NLRP3 Pathway to Improve Diabetic Nephropathy
inferred← citeshttps://doi.org/10.1155/2021/5543185openalex-snapshot
Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury
inferred← citeshttps://doi.org/10.1186/s10020-023-00687-6openalex-snapshot
Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume
inferred← citeshttps://doi.org/10.1186/s11658-025-00773-zopenalex-snapshot
Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction
inferred← citeshttps://doi.org/10.1186/s12864-024-10550-5openalex-snapshot
Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp
inferred← citeshttps://doi.org/10.1186/s12950-021-00271-xopenalex-snapshot
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway
inferred← citeshttps://doi.org/10.1186/s12974-020-01874-6openalex-snapshot
Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis
inferred← citeshttps://doi.org/10.19852/j.cnki.jtcm.20230727.003openalex-snapshot
Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction: a literature review.
inferred← citeshttps://doi.org/10.2147/ott.s221228openalex-snapshot
Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway
inferred← citeshttps://doi.org/10.2174/1568026623666230829164156openalex-snapshot
Natural Products: A Potential New Hope to Defeat Post-acute Sequelae of COVID-19
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1394925openalex-snapshot
The role and therapeutic potential of SIRTs in sepsis
inferred← citeshttps://doi.org/10.3389/fmed.2021.595634openalex-snapshot
SIRT1-Related Signaling Pathways and Their Association With Bronchopulmonary Dysplasia
inferred← citeshttps://doi.org/10.3389/fphar.2021.778847openalex-snapshot
Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA
inferred← citeshttps://doi.org/10.3389/fphar.2025.1505672openalex-snapshot
Progress of tanshinone IIA against respiratory diseases: therapeutic targets and potential mechanisms
inferred← citeshttps://doi.org/10.3892/mmr.2025.13573openalex-snapshot
Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review)
inferred← citeshttps://doi.org/10.5812/ijpr-169885openalex-snapshot
Tanshinone IIA Alleviates Mitochondrial Dysfunction in Lipopolysaccharide-Induced Acute Kidney Injury in Mice by Activating SIRT1/PINK1-Mediated Mitophagy
inferred← citeshttps://doi.org/10.6084/m9.figshare.26741807openalex-snapshot
Additional file 1 of Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp
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